{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:24:27Z","timestamp":1761816267294,"version":"build-2065373602"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.wneu.2022.09.032","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T02:33:44Z","timestamp":1663036424000},"page":"e1345-e1353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mapping the Landscape of Neurofibromatosis: A Bibliometric Evaluation Highlighting Our Current Understanding, Emerging Therapies, and Global Research Trends"],"prefix":"10.1016","volume":"167","author":[{"given":"Sulaman","family":"Durrani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4036-8788","authenticated-orcid":false,"given":"William","family":"Mualem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Shoushtari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-7011","authenticated-orcid":false,"given":"Karim Rizwan","family":"Nathani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-396X","authenticated-orcid":false,"given":"Mohamad","family":"Bydon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2022.09.032_bib1","first-page":"339","article-title":"Neurofibromatosis in 13th century Austria?","volume":"1","author":"Madigan","year":"1988","journal-title":"Neurofibromatosis"},{"key":"10.1016\/j.wneu.2022.09.032_bib2","first-page":"53","article-title":"Report of a neurofibromatosis-like case: Monstrorum Historia, 1642","volume":"2","author":"Madigan","year":"1989","journal-title":"Neurofibromatosis"},{"key":"10.1016\/j.wneu.2022.09.032_bib3","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/00005072-199211000-00010","article-title":"Neurofibromatosis, phenotype, natural history, and pathogenesis","volume":"51","author":"Riccardi","year":"1992","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.wneu.2022.09.032_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0011-3840(77)80002-6","article-title":"Neurofibromatosis","volume":"14","author":"Wander","year":"1977","journal-title":"Curr Probl Surg"},{"first-page":"95","year":"1970","author":"Foster","key":"10.1016\/j.wneu.2022.09.032_bib5"},{"key":"10.1016\/j.wneu.2022.09.032_bib6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/archderm.1963.01590220014002","article-title":"The dermal elastoses","volume":"88","author":"Smith","year":"1963","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.wneu.2022.09.032_bib7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ana.410010114","article-title":"Handbook of clinical neurology Edited by P. J. Vinken and G. W. Bruyn, North Holland Publishing Company. Amsterdam","volume":"1","author":"Plum","year":"1977","journal-title":"Ann Neurol"},{"key":"10.1016\/j.wneu.2022.09.032_bib8","first-page":"98","article-title":"Neurofibromatosis: a review of NF1, NF2, and schwannomatosis","volume":"5","author":"Kresak","year":"2016","journal-title":"J\u00a0Pediatr Genet"},{"key":"10.1016\/j.wneu.2022.09.032_bib9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF00197259","article-title":"Preferential mutation of the neurofibromatosis type 1 gene in paternally derived chromosomes","volume":"88","author":"Stephens","year":"1992","journal-title":"Hum Genet"},{"key":"10.1016\/j.wneu.2022.09.032_bib10","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1212\/WNL.46.4.1072","article-title":"Schwannomatosis: a clinical and pathologic study","volume":"46","author":"MacCollin","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.wneu.2022.09.032_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/02688690500081206","article-title":"Management of the patient and family with neurofibromatosis 2: a consensus conference statement","volume":"19","author":"Evans","year":"2005","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.wneu.2022.09.032_bib12","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/jama.2009.1307","article-title":"Comparisons of citations in Web of Science, Scopus, and Google Scholar for articles published in general medical journals","volume":"302","author":"Kulkarni","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.wneu.2022.09.032_bib13","first-page":"508","article-title":"The relative citation ratio: what is it and why should medical librarians care?","volume":"106","author":"Surkis","year":"2018","journal-title":"J\u00a0Med Libr Assoc"},{"key":"10.1016\/j.wneu.2022.09.032_bib14","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix : an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J\u00a0Informetrics"},{"key":"10.1016\/j.wneu.2022.09.032_bib15","first-page":"575","article-title":"Neurofibromatosis. Conference statement. National Institutes of Health consensus development conference","volume":"45","year":"1988","journal-title":"Arch Neurol"},{"key":"10.1016\/j.wneu.2022.09.032_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.2134734","article-title":"Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients","volume":"249","author":"Wallace","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.wneu.2022.09.032_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jama.1997.03550010065042","article-title":"The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2","volume":"278","author":"Gutmann","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.wneu.2022.09.032_bib18","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/humu.22044","article-title":"Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis","volume":"33","author":"Upadhyaya","year":"2012","journal-title":"Hum Mutat"},{"key":"10.1016\/j.wneu.2022.09.032_bib19","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/ajmg.a.35422","article-title":"Severe plexiform facial neurofibromatosis, type 1 with underdeveloped eyes and a novel NF1 mutation","volume":"158A","author":"Kantaputra","year":"2012","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.wneu.2022.09.032_bib20","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/neuonc\/nos124","article-title":"MicroRNA-204 critically regulates carcinogenesis in malignant peripheral nerve sheath tumors","volume":"14","author":"Gong","year":"2012","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.wneu.2022.09.032_bib21","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1158\/0008-5472.CAN-13-2625","article-title":"Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence","volume":"74","author":"Nissan","year":"2014","journal-title":"Cancer Res"},{"key":"10.1016\/j.wneu.2022.09.032_bib22","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/ana.24157","article-title":"Gender as a disease modifier in neurofibromatosis type 1 optic pathway glioma","volume":"75","author":"Fisher","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1016\/j.wneu.2022.09.032_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ana.24093","article-title":"Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1","volume":"75","author":"Diggs-Andrews","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1016\/j.wneu.2022.09.032_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/onc.2012.579","article-title":"EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors","volume":"33","author":"Wu","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.wneu.2022.09.032_bib25","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/onc.2015.207","article-title":"Runx1 contributes to neurofibromatosis type 1 neurofibroma formation","volume":"35","author":"Li","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.wneu.2022.09.032_bib26","first-page":"319","article-title":"Patterns of recurrence and survival in sporadic, neurofibromatosis Type 1-associated, and radiation-associated malignant peripheral nerve sheath tumors","volume":"126","author":"Watson","year":"2017","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2022.09.032_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ajhg.2017.12.001","article-title":"Genotype-Phenotype correlation in NF1: evidence for a more severe phenotype Associated with missense mutations affecting NF1 codons 844-848","volume":"102","author":"Koczkowska","year":"2018","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.wneu.2022.09.032_bib28","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41436-018-0269-0","article-title":"Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype-phenotype correlation [published correction appears in Genet Med. 2019 Mar;213:764-765]","volume":"21","author":"Koczkowska","year":"2019","journal-title":"Genet Med"},{"key":"10.1016\/j.wneu.2022.09.032_bib29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/humu.23929","article-title":"Clinical spectrum of individuals with pathogenic NF1 missense variants affecting p.Met1149, p.Arg1276, and p.Lys1423: genotype-phenotype study in neurofibromatosis type 1","volume":"41","author":"Koczkowska","year":"2020","journal-title":"Hum Mutat"},{"key":"10.1016\/j.wneu.2022.09.032_bib30","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1056\/NEJMoa1912735","article-title":"Selumetinib in children with inoperable plexiform neurofibromas [published correction appears in N Engl J med. 2020 Sep 24;383(13):1290]","volume":"382","author":"Gross","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2022.09.032_bib31","doi-asserted-by":"crossref","first-page":"13814","DOI":"10.1038\/s41598-022-17873-x","article-title":"Cortical inhibition in neurofibromatosis type 1 is modulated by lovastatin, as demonstrated by a randomized, triple-blind, placebo-controlled clinical trial","volume":"12","author":"Bernardino","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.wneu.2022.09.032_bib32","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/exd.14514","article-title":"Concomitant variants in NF1, LZTR1 and GNAZ genes probably contribute to the aggressiveness of plexiform neurofibroma and warrant treatment with MEK inhibitor","volume":"31","author":"Cohen-Barak","year":"2022","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.wneu.2022.09.032_bib40","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0092-8674(93)90406-G","article-title":"A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor","volume":"72","author":"Trofatter","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.wneu.2022.09.032_bib41","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1056\/NEJM198112313052704","article-title":"von Recklinghausen neurofibromatosis","volume":"305","author":"Riccardi","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/j.wneu.2022.09.032_bib42","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0092-8674(90)90253-B","article-title":"A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations","volume":"62","author":"Cawthon","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.wneu.2022.09.032_bib43","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0092-8674(90)90024-9","article-title":"The neurofibromatosis type 1 gene encodes a protein related to GAP","volume":"62","author":"Xu","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.wneu.2022.09.032_bib44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0092-8674(90)90252-A","article-title":"Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus","volume":"62","author":"Viskochil","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.wneu.2022.09.032_bib45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.39.5.311","article-title":"Malignant peripheral nerve sheath tumours in neurofibromatosis 1","volume":"39","author":"Evans","year":"2002","journal-title":"J Med Gen"},{"key":"10.1016\/j.wneu.2022.09.032_bib46","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(90)90150-D","article-title":"The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21","volume":"63","author":"Martin","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.wneu.2022.09.032_bib47","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1055\/s-2008-1067785","article-title":"Diagnose der von-Recklinghausenschen Neurofibromatose [Diagnosis of Recklinghausen\u2019s neurofibromatosis]","volume":"113","author":"Mautner VF","year":"1988","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.wneu.2022.09.032_bib48","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/archderm.1996.03890350075012","article-title":"Usefulness of screening investigations in neurofibromatosis type 1. A study of 152 patients","volume":"132","author":"Wolkenstein P","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.wneu.2022.09.032_bib49","first-page":"225","article-title":"Neurofibromatosis type 1","volume":"5","author":"Legius E","year":"1994","journal-title":"Genet Couns"},{"key":"10.1016\/j.wneu.2022.09.032_bib50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0165-4608(99)00006-0","article-title":"Allelic loss of the NF1 gene in NF1-associated plexiform neurofibromas","volume":"113","author":"Kluwe L","year":"1999","journal-title":"Cancer Genet Cytogen"},{"key":"10.1016\/j.wneu.2022.09.032_bib51","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/(SICI)1098-1004(1997)10:3<248::AID-HUMU14>3.0.CO;2-#","article-title":"Six novel mutations in the neurofibromatosis type 1 (NF1) gene","volume":"10","author":"Upadhyaya M","year":"1997","journal-title":"Hum Mutat"},{"key":"10.1016\/j.wneu.2022.09.032_bib52","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3171\/2010.11.SPINE10350","article-title":"Spinal ependymomas in neurofibromatosis Type 2: a retrospective analysis of 55 patients","volume":"14","author":"Plotkin","year":"2011","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.wneu.2022.09.032_bib53","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/ana.410270312","article-title":"Mitogen accumulation in von Recklinghausen neurofibromatosis","volume":"27","author":"Ratner N","year":"1990","journal-title":"Ann Neurol"},{"key":"10.1016\/j.wneu.2022.09.032_bib33","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.3390\/ijms22115850","article-title":"Current understanding of neurofibromatosis type 1, 2, and schwannomatosis","volume":"22","author":"Tamura","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.wneu.2022.09.032_bib34","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrclinonc.2013.144","article-title":"Advances in the treatment of neurofibromatosis-associated tumours","volume":"10","author":"Lin","year":"2013","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.wneu.2022.09.032_bib35","doi-asserted-by":"crossref","first-page":"e1109","DOI":"10.1634\/theoncologist.2020-0069","article-title":"The use of MEK inhibitors in neurofibromatosis type 1\u2013associated tumors and management of toxicities","volume":"25","author":"Klesse","year":"2020","journal-title":"Oncologist"},{"key":"10.1016\/j.wneu.2022.09.032_bib36","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/j.pain.0000000000001486","article-title":"Towards a neurobiological understanding of pain in neurofibromatosis type 1: mechanisms and implications for treatment","volume":"160","author":"Bellampalli","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.wneu.2022.09.032_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00439-016-1753-8","article-title":"The molecular pathogenesis of schwannomatosis, a paradigm for the co-involvement of multiple tumour suppressor genes in tumorigenesis","volume":"136","author":"Kehrer-Sawatzki","year":"2017","journal-title":"Hum Genet"},{"key":"10.1016\/j.wneu.2022.09.032_bib38","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1038\/s41431-021-00892-z","article-title":"Identifying challenges in neurofibromatosis: a modified Delphi procedure","volume":"29","author":"Dhaenens","year":"2021","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.wneu.2022.09.032_bib39","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1586\/14737175.2014.953931","article-title":"Cognitive and behavioral problems in children with neurofibromatosis type 1: challenges and future directions","volume":"14","author":"Schwetye","year":"2014","journal-title":"Expert Rev Neurother"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022012992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022012992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:22:21Z","timestamp":1761816141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875022012992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":53,"alternative-id":["S1878875022012992"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2022.09.032","relation":{},"ISSN":["1878-8750"],"issn-type":[{"type":"print","value":"1878-8750"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mapping the Landscape of Neurofibromatosis: A Bibliometric Evaluation Highlighting Our Current Understanding, Emerging Therapies, and Global Research Trends","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2022.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}