{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:47:16Z","timestamp":1771872436572,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.wneu.2022.10.053","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T04:39:25Z","timestamp":1666154365000},"page":"e89-e95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Long-Term Clinical Outcomes of Patients with Colorectal Cancer with Metastatic Epidural Spinal Cord Compression Treated with Hybrid Therapy (Surgery Followed by Stereotactic Body Radiation Therapy)"],"prefix":"10.1016","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-6571","authenticated-orcid":false,"given":"Vikram B.","family":"Chakravarthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9052-7575","authenticated-orcid":false,"given":"Ben","family":"Schachner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anubhav","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne S.","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Higginson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya","family":"Laufer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Bilsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4037-8716","authenticated-orcid":false,"given":"Ori","family":"Barzilai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2022.10.053_bib1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0029-1242458","article-title":"Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors","volume":"22","author":"Haggar","year":"2009","journal-title":"Clin Colon Rectal Surg"},{"key":"10.1016\/j.wneu.2022.10.053_bib2","first-page":"89","article-title":"Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz Gastroenterol"},{"key":"10.1016\/j.wneu.2022.10.053_bib3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/cam4.2673","article-title":"Metastatic patterns and survival outcomes in patients with stage IV colon cancer: a population-based analysis","volume":"9","author":"Wang","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.wneu.2022.10.053_bib4","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s00268-015-3296-x","article-title":"The characteristics of bone metastasis in patients with colorectal cancer: a long-term report from a single institution","volume":"40","author":"Baek","year":"2016","journal-title":"World J Surg"},{"key":"10.1016\/j.wneu.2022.10.053_bib5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.5858\/2008-132-931-MPOCRF","article-title":"Metastatic patterns of cancers: results from a large autopsy study","volume":"132","author":"Disibio","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.wneu.2022.10.053_bib6","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF02367787","article-title":"Bone metastasis from colorectal cancer in autopsy cases","volume":"30","author":"Katoh","year":"1995","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.wneu.2022.10.053_bib7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0002-9610(86)90102-9","article-title":"Osseous metastases from colorectal carcinoma","volume":"151","author":"Bonnheim","year":"1986","journal-title":"Am J Surg"},{"key":"10.1016\/j.wneu.2022.10.053_bib8","first-page":"449","article-title":"Bone metastases in carcinoma of the rectum: a clinical and pathological review","volume":"15","author":"Talbot","year":"1989","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.wneu.2022.10.053_bib9","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1002\/ijc.31785","article-title":"An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients","volume":"143","author":"Brouwer","year":"2018","journal-title":"Int J Cancer"},{"key":"10.1016\/j.wneu.2022.10.053_bib10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1634\/theoncologist.2012-0293","article-title":"The NOMS framework: approach to the treatment of spinal metastatic tumors","volume":"18","author":"Laufer","year":"2013","journal-title":"Oncologist"},{"key":"10.1016\/j.wneu.2022.10.053_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1006312306713","article-title":"Metastatic spinal cord compression in patients with colorectal cancer","volume":"44","author":"Brown","year":"1999","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2022.10.053_bib12","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/2016.9.FOCUS16369","article-title":"The impact of histology and delivered dose on local control of spinal metastases treated with stereotactic radiosurgery","volume":"42","author":"Yamada","year":"2017","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2022.10.053_bib13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1227\/NEU.0000000000001780","article-title":"Hybrid therapy (surgery and radiosurgery) for the treatment of renal cell carcinoma spinal metastases","volume":"90","author":"Hussain","year":"2022","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2022.10.053_bib14","first-page":"104","article-title":"Hybrid surgery-radiosurgery therapy for metastatic epidural spinal cord compression: a prospective evaluation using patient-reported outcomes","volume":"5","author":"Barzilai","year":"2018","journal-title":"Neurooncol Pract"},{"key":"10.1016\/j.wneu.2022.10.053_bib15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/ons\/opy137","article-title":"Hybrid therapy for metastatic epidural spinal cord compression: technique for separation surgery and spine radiosurgery","volume":"16","author":"Barzilai","year":"2019","journal-title":"Oper Neurosurg (Hagerstown)"},{"key":"10.1016\/j.wneu.2022.10.053_bib16","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.hoc.2006.09.009","article-title":"Surgical approach to epidural spinal cord compression","volume":"20","author":"Bilsky","year":"2006","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.wneu.2022.10.053_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijrobp.2016.09.014","article-title":"Consensus contouring guidelines for postoperative stereotactic body radiation therapy for metastatic solid tumor malignancies to the spine","volume":"97","author":"Redmond","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.wneu.2022.10.053_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3171\/2012.11.SPINE12111","article-title":"Local disease control for spinal metastases following \"separation surgery\" and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients","volume":"18","author":"Laufer","year":"2013","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2022.10.053_bib19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4184\/asj.2014.8.3.267","article-title":"Outcomes after surgery for spinal metastasis of colorectal origin: case series","volume":"8","author":"Leach","year":"2014","journal-title":"Asian Spine J"},{"issue":"22 Suppl","key":"10.1016\/j.wneu.2022.10.053_bib20","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1097\/BRS.0b013e3181b8b6f5","article-title":"Radiotherapy and radiosurgery for metastatic spine disease: what are the options, indications, and outcomes?","volume":"34","author":"Gerszten","year":"2009","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2022.10.053_bib21","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1200\/JCO.2005.08.193","article-title":"Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial","volume":"23","author":"Maranzano","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.wneu.2022.10.053_bib22","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0360-3016(98)00288-0","article-title":"Clinical results of nonsurgical treatment for spinal metastases","volume":"42","author":"Katagiri","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.wneu.2022.10.053_bib23","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0360-3016(95)00572-G","article-title":"Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial","volume":"32","author":"Maranzano","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.wneu.2022.10.053_bib24","doi-asserted-by":"crossref","first-page":"9433","DOI":"10.1073\/pnas.122612899","article-title":"Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer","volume":"99","author":"Smith","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.wneu.2022.10.053_bib28","doi-asserted-by":"crossref","DOI":"10.1177\/1073274819870549","article-title":"The targeted therapies era beyond the surgical point of view: what spine surgeons should know before approaching spinal metastases","volume":"26","author":"Cofano","year":"2019","journal-title":"Cancer Control"},{"key":"10.1016\/j.wneu.2022.10.053_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw332","article-title":"Multiple roles of APC and its therapeutic implications in colorectal cancer","volume":"109","author":"Zhang","year":"2017","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.wneu.2022.10.053_bib27","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1002\/cncr.32420","article-title":"Association of neurologic deficits with surgical outcomes and health-related quality of life after treatment for metastatic epidural spinal cord compression","volume":"125","author":"Barzilai","year":"2019","journal-title":"Cancer"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022014693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022014693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:14:58Z","timestamp":1761815698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875022014693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":27,"alternative-id":["S1878875022014693"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2022.10.053","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-Term Clinical Outcomes of Patients with Colorectal Cancer with Metastatic Epidural Spinal Cord Compression Treated with Hybrid Therapy (Surgery Followed by Stereotactic Body Radiation Therapy)","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2022.10.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}