{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:58:46Z","timestamp":1776103126775,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.wneu.2022.11.099","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T15:54:49Z","timestamp":1669391689000},"page":"e716-e723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Intradermal and Intramuscular Bupivacaine Reduces Opioid Use Following Noninstrumented Spine Surgery"],"prefix":"10.1016","volume":"170","author":[{"given":"Daniel R.","family":"Cleary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-4375","authenticated-orcid":false,"given":"Hao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Ciacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2022.11.099_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/0974-8237.161589","article-title":"Pain management following spinal surgeries: an appraisal of the available options","volume":"6","author":"Bajwa","year":"2015","journal-title":"J\u00a0Craniovertebr Junction Spine"},{"key":"10.1016\/j.wneu.2022.11.099_bib3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s00586-009-1005-x","article-title":"The patient\u2019s perspective on complications after spine surgery","volume":"18","author":"Grob","year":"2009","journal-title":"Euro Spine J"},{"key":"10.1016\/j.wneu.2022.11.099_bib4","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1007\/s11999-015-4193-1","article-title":"Incidence of low back pain after lumbar discectomy for herniated disc and its effect on patient-reported outcomes","volume":"473","author":"Parker","year":"2015","journal-title":"Clin Orthop Relat Res"},{"issue":"Suppl 2","key":"10.1016\/j.wneu.2022.11.099_bib5","first-page":"S154","article-title":"Multimodal analgesia in pain management after spine surgery","volume":"5","author":"Yoo","year":"2019","journal-title":"J\u00a0Spine Surg"},{"key":"10.1016\/j.wneu.2022.11.099_bib6","doi-asserted-by":"crossref","first-page":"24978","DOI":"10.52965\/001c.24978","article-title":"An update on postoperative opioid use and alternative pain control following spine surgery","volume":"13","author":"Berardino","year":"2021","journal-title":"Orthop Rev"},{"key":"10.1016\/j.wneu.2022.11.099_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bpa.2018.06.004","article-title":"Neuromuscular blockers and reversal agents and their impact on anesthesia practice","volume":"32","author":"Zafirova","year":"2018","journal-title":"Best Prac Res Clin Anaesthesiol"},{"key":"10.1016\/j.wneu.2022.11.099_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jpainsymman.2003.11.001","article-title":"Dose-response relationship between opioid use and adverse effects after ambulatory surgery","volume":"28","author":"Zhao","year":"2004","journal-title":"J\u00a0Pain Symptom Manag"},{"key":"10.1016\/j.wneu.2022.11.099_bib9","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.spinee.2016.06.013","article-title":"Liposomal bupivacaine incisional injection in single-level lumbar spine surgery","volume":"16","author":"Puffer","year":"2016","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2022.11.099_bib10","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1097\/BSD.0000000000001006","article-title":"Intramuscular liposomal bupivacaine decreases length of stay and opioid usage following lumbar spinal fusion","volume":"33","author":"Roh","year":"2020","journal-title":"Clinical Spine Surgery"},{"key":"10.1016\/j.wneu.2022.11.099_bib11","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.spinee.2021.02.014","article-title":"Efficacy of liposomal bupivacaine in spine surgery: a systematic review","volume":"21","author":"Nguyen","year":"2021","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2022.11.099_bib13","series-title":"vaFssPharmPrices.xlsx","article-title":"Pharmaceutical Prices","year":"2022"},{"key":"10.1016\/j.wneu.2022.11.099_bib14","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/ALN.0b013e31828866b3","article-title":"Pain intensity on the first day after surgery","volume":"118","author":"Peelen","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.wneu.2022.11.099_bib15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-147-8-200710160-00010","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"147","author":"Von Elm","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.wneu.2022.11.099_bib16","series-title":"Local anesthetics: Miller\u2019s Anesthesia","first-page":"913","author":"Berde","year":"2010"},{"key":"10.1016\/j.wneu.2022.11.099_bib17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1213\/01.ANE.0000093310.47375.44","article-title":"The pharmacokinetics and efficacy of ropivacaine continuous wound instillation after spine fusion surgery","volume":"98","author":"Bianconi","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1016\/j.wneu.2022.11.099_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00000542-200407000-00027","article-title":"Quality of postoperative pain using an intraoperatively placed epidural catheter after major lumbar spinal surgery","volume":"101","author":"Gottschalk","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.wneu.2022.11.099_bib19","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1097\/00007632-199708150-00016","article-title":"Postoperative pain control after lumbar spine fusion: patient-controlled analgesia versus continuous epidural analgesia","volume":"22","author":"Cohen","year":"1997","journal-title":"Spine"},{"issue":"Suppl. 1","key":"10.1016\/j.wneu.2022.11.099_bib20","first-page":"42","article-title":"Gabapentin for acute and chronic post-surgical pain","volume":"2","author":"Melemeni","year":"2007","journal-title":"Signa Vitae"},{"key":"10.1016\/j.wneu.2022.11.099_bib21","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00000542-200203000-00032","article-title":"A\u00a0qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief: the role of timing of analgesia","volume":"96","author":"M\u00f8iniche","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.wneu.2022.11.099_bib22","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3892\/etm.2017.4058","article-title":"Bupivacaine effectively relieves inflammation-induced pain by suppressing activation of the NF-\u03baB signalling pathway and inhibiting the activation of spinal microglia and astrocytes","volume":"13","author":"Zhang","year":"2017","journal-title":"Exper Ther Med"},{"key":"10.1016\/j.wneu.2022.11.099_bib23","first-page":"e85704","article-title":"Sympatholytic and anti-inflammatory effects of ropivacaine and bupivacaine after infraclavicular block in arterio venous fistula surgery","volume":"9","author":"Behnaz","year":"2019","journal-title":"Anesthes Pain Med"},{"key":"10.1016\/j.wneu.2022.11.099_bib24","first-page":"1001","article-title":"Continuous regional anesthesia and inflammation: a new target","volume":"81","author":"Grosu","year":"2015","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.wneu.2022.11.099_bib25","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/00007632-200103150-00021","article-title":"Postoperative narcotic requirement after microscopic lumbar discectomy is not affected by intraoperative ketorolac or bupivacaine","volume":"26","author":"Mack","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2022.11.099_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/oxfordjournals.bja.a013387","article-title":"Wound infiltration with bupivacaine after surgery to the cervical spine using a posterior approach","volume":"84","author":"Pobereskin","year":"2000","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.wneu.2022.11.099_bib27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/00007632-200202150-00003","article-title":"Perioperative use of corticosteroid and bupivacaine combination in lumbar disc surgery: a randomized controlled trial","volume":"27","author":"Mirzai","year":"2002","journal-title":"Spine (Phila Pa. 1976)"},{"key":"10.1016\/j.wneu.2022.11.099_bib28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1749-6632.2001.tb05822.x","article-title":"Central neuroplasticity and pathological pain","volume":"933","author":"Melzack","year":"2001","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.wneu.2022.11.099_bib29","doi-asserted-by":"crossref","first-page":"6695741","DOI":"10.1155\/2021\/6695741","article-title":"An objective pain score for chronic pain clinic patients","volume":"2021","author":"Pace","year":"2021","journal-title":"Pain Res Manag"},{"key":"10.1016\/j.wneu.2022.11.099_bib30","first-page":"1","article-title":"Accuracy of critical care pain observation tool and behavioral pain scale to assess pain in critically ill conscious and unconscious patients: prospective, observational study","volume":"4","author":"Severgnini","year":"2016","journal-title":"J\u00a0Intensive Care"},{"key":"10.1016\/j.wneu.2022.11.099_bib31","doi-asserted-by":"crossref","first-page":"e12443","DOI":"10.1097\/MD.0000000000012443","article-title":"Validation of the behavioral pain scale to assess pain intensity in adult, intubated postcardiac surgery patients: a cohort observational study-POL-BPS","volume":"97","author":"Kotfis","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.wneu.2022.11.099_bib32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12017-007-8018-6","article-title":"The sympathetic nervous system and pain","volume":"10","author":"Schlereth","year":"2008","journal-title":"NeuroMolecular Med"},{"key":"10.1016\/j.wneu.2022.11.099_bib33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1399-6576.1993.tb03600.x","article-title":"Blood pressure and heart rate during orthostatic stress and walking with continuous postoperative thoracic epidural bupivacaine\/morphine","volume":"37","author":"M\u00f8iniche S","year":"1993","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.wneu.2022.11.099_bib34","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/2019.1.FOCUS18700","article-title":"Enhanced recovery after spine surgery: a systematic review","volume":"46","author":"Elsarrag","year":"2019","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2022.11.099_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.wneu.2019.06.181","article-title":"Enhanced recovery after surgery (ERAS) for spine surgery: a systematic review","volume":"130","author":"Dietz","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2022.11.099_bib36","doi-asserted-by":"crossref","first-page":"260","DOI":"10.5435\/JAAOS-D-16-00049","article-title":"The role of multimodal analgesia in spine surgery","volume":"25","author":"Kurd","year":"2017","journal-title":"J\u00a0Am Acad Orthop Surg"},{"key":"10.1016\/j.wneu.2022.11.099_bib37","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1053\/j.semss.2017.11.005","article-title":"Enhanced recovery after surgery (ERAS)\u2014concepts, components, and application to spine surgery","volume":"30","author":"Wainwright","year":"2018","journal-title":"Semin Spine Surg"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022016515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022016515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:16:21Z","timestamp":1761815781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875022016515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":35,"alternative-id":["S1878875022016515"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2022.11.099","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intradermal and Intramuscular Bupivacaine Reduces Opioid Use Following Noninstrumented Spine Surgery","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2022.11.099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}