{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:25:17Z","timestamp":1785871517682,"version":"3.56.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1101802-2"],"award-info":[{"award-number":["2021YFA1101802-2"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004610","name":"Science and Technology Support Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20210970"],"award-info":[{"award-number":["BK20210970"]}],"id":[{"id":"10.13039\/501100004610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["JX10231804"],"award-info":[{"award-number":["JX10231804"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.wneu.2023.04.032","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T18:49:37Z","timestamp":1681584577000},"page":"e841-e854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Primary Skull Base Chordomas: A Clinicopathological Analysis of 94 Patients"],"prefix":"10.1016","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6929-8413","authenticated-orcid":false,"given":"Lin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-jun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-ping","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2023.04.032_bib1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/lary.24420","article-title":"Incidence and survival patterns of cranial chordoma in the United States","volume":"124","author":"Chambers","year":"2014","journal-title":"Laryngoscope"},{"key":"10.1016\/j.wneu.2023.04.032_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11864-021-00838-z","article-title":"Surgical management of skull base and spine chordomas","volume":"22","author":"Passer","year":"2021","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.wneu.2023.04.032_bib3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11060-020-03497-6","article-title":"Advances in the management of primary bone sarcomas of the skull base","volume":"150","author":"Edem","year":"2020","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2023.04.032_bib4","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41467-021-21026-5","article-title":"Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival","volume":"12","author":"Bai","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.wneu.2023.04.032_bib5","article-title":"Clinical implication of systemic immune-inflammation index and prognostic nutritional index in skull base chordoma patients","volume":"11","author":"Li","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.wneu.2023.04.032_bib6","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1080\/00016489.2020.1748225","article-title":"Endoscopic endonasal resection and radiotherapy as treatment for skull base chordomas","volume":"140","author":"Li","year":"2020","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.wneu.2023.04.032_bib7","first-page":"1","article-title":"The management of clival chordomas: an Italian multicentric study","volume":"4","author":"Cavallo","year":"2020","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2023.04.032_bib8","first-page":"1","article-title":"A nomogram to predict the progression-free survival of clival chordoma","volume":"4","author":"Zhai","year":"2019","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2023.04.032_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11060-017-2706-3","article-title":"SNF5 as a prognostic factor in skull base chordoma","volume":"137","author":"Li","year":"2018","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2023.04.032_bib10","doi-asserted-by":"crossref","first-page":"8337","DOI":"10.2147\/OTT.S257779","article-title":"Prognostic value of cumulative score based on preoperative fibrinogen and albumin level in skull base chordoma","volume":"13","author":"Li","year":"2020","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.wneu.2023.04.032_bib11","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/neuonc\/noaa169","article-title":"Proton and carbon ion therapy for skull base chordomas","volume":"22","author":"Trifiletti","year":"2020","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.wneu.2023.04.032_bib12","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s11060-020-03464-1","article-title":"Carbon ion radiotherapy for skull base chordomas and chondrosarcomas: a systematic review and meta-analysis of local control, survival, and toxicity outcomes","volume":"147","author":"Lu","year":"2020","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2023.04.032_bib13","first-page":"1429","article-title":"Analysis of clinical factors and PDGFR-\u03b2 in predicting prognosis of patients with clival chordoma","volume":"129","author":"Zhai","year":"2018","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2023.04.032_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3171\/2012.7.PEDS12179","article-title":"Clinical features and treatment of World Health Organization grade II and III meningiomas in childhood: report of 23 cases","volume":"10","author":"Wang","year":"2012","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2023.04.032_bib15","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.wneu.2023.04.032_bib16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3340\/jkns.2021.0240","article-title":"Clinical grading system, surgical outcomes and prognostic analysis of cranial base chordomas","volume":"65","author":"Wang","year":"2022","journal-title":"J\u00a0Korean Neurosurg Soc"},{"key":"10.1016\/j.wneu.2023.04.032_bib17","first-page":"1","article-title":"Management strategies in clival and craniovertebral junction chordomas: a 29-year experience","volume":"21","author":"Passeri","year":"2022","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2023.04.032_bib18","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1016\/j.wneu.2019.05.110","article-title":"Predictive value of transforming growth factor-\u03b1 and Ki-67 for the prognosis of skull base chordoma","volume":"129","author":"Zhang","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2023.04.032_bib19","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/NEN.0b013e3182a065d0","article-title":"Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis","volume":"72","author":"Kitamura","year":"2013","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.wneu.2023.04.032_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00701-009-0535-7","article-title":"Long-term control of clival chordoma with initial aggressive surgical resection and gamma knife radiosurgery for recurrence","volume":"152","author":"Ito","year":"2010","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.wneu.2023.04.032_bib21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.dld.2010.02.003","article-title":"Tissue microarray constructs to predict a response to chemoradiation in rectal cancer","volume":"42","author":"Huerta","year":"2010","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.wneu.2023.04.032_bib22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00259-002-0978-z","article-title":"FDG-PET for prediction of tumour aggressiveness and response to intra-arterial chemotherapy and radiotherapy in head and neck cancer","volume":"30","author":"Kitagawa","year":"2003","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.wneu.2023.04.032_bib23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1006\/gyno.2000.5950","article-title":"Assessment of proliferation index with MIB-1 as a prognostic factor in radiation therapy for cervical cancer","volume":"79","author":"Suzuki","year":"2000","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.wneu.2023.04.032_bib24","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/1097-0142(20001001)89:7<1526::AID-CNCR16>3.0.CO;2-2","article-title":"High growth fraction at 9 grays of radiotherapy is associated with a good prognosis for patients with cervical squamous cell carcinoma","volume":"89","author":"Oka","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2023.04.032_bib25","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s10143-020-01318-y","article-title":"Microsurgical versus endoscopic trans-sphenoidal approaches for clivus chordoma: a pooled and meta-analysis","volume":"44","author":"Cannizzaro","year":"2021","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.wneu.2023.04.032_bib26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/jso.25502","article-title":"A\u00a0prospective clinical trial of proton therapy for chordoma and chondrosarcoma: feasibility assessment","volume":"120","author":"Baumann","year":"2019","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.wneu.2023.04.032_bib27","doi-asserted-by":"crossref","first-page":"E742","DOI":"10.1097\/BRS.0000000000003406","article-title":"The role of radiotherapy for chordoma patients managed with surgery: analysis of the national cancer database","volume":"45","author":"Dial","year":"2020","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2023.04.032_bib28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ijrobp.2005.02.023","article-title":"Results of spot-scanning proton radiation therapy for chordoma and chondrosarcoma of the skull base: the Paul Scherrer Institut experience","volume":"63","author":"Weber","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.wneu.2023.04.032_bib29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12957-021-02178-6","article-title":"Chordomas and chondrosarcomas of the skull base: treatment and outcome analysis in a consecutive case series of 24 patients","volume":"19","author":"Metcalfe","year":"2021","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.wneu.2023.04.032_bib30","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10143-009-0194-4","article-title":"Proton therapy in chordoma of the base of the skull: a systematic review","volume":"32","author":"Amichetti","year":"2009","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.wneu.2023.04.032_bib31","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/cncr.31958","article-title":"The role of dose escalation and proton therapy in perioperative or definitive treatment of chondrosarcoma and chordoma: an analysis of the National Cancer Data Base","volume":"125","author":"Palm","year":"2019","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2023.04.032_bib32","first-page":"Cd013224","article-title":"Protons versus photons for the treatment of chordoma","volume":"7","author":"El Sayed","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.wneu.2023.04.032_bib33","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13014-021-01825-2","article-title":"Retrospective analysis of recurrence patterns and clinical outcome of grade II meningiomas following postoperative radiotherapy","volume":"16","author":"Hoffmann","year":"2021","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.wneu.2023.04.032_bib34","first-page":"319","article-title":"Chordomas of the skull base: surgical management and outcome","volume":"107","author":"Samii","year":"2007","journal-title":"J\u00a0Neurosurg"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875023005168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875023005168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:54:47Z","timestamp":1778831687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875023005168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":34,"alternative-id":["S1878875023005168"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2023.04.032","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary Skull Base Chordomas: A Clinicopathological Analysis of 94 Patients","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2023.04.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}