{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:24:55Z","timestamp":1773264295619,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.wneu.2024.02.001","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T16:56:07Z","timestamp":1707411367000},"page":"e342-e350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Hematologic and Inflammatory Predictors of Outcome in Patients with Brain Arteriovenous Malformations"],"prefix":"10.1016","volume":"185","author":[{"given":"Stefan W.","family":"Koester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon K.","family":"Hoglund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0082-2026","authenticated-orcid":false,"given":"Olga","family":"Ciobanu-Caraus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joelle N.","family":"Hartke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4435-202X","authenticated-orcid":false,"given":"Mark A.","family":"Pacult","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan A.","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua S.","family":"Catapano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Lawton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2024.02.001_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.8","article-title":"Brain arteriovenous malformations","volume":"1","author":"Lawton","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.wneu.2024.02.001_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/B978-0-444-64034-5.00020-1","article-title":"Brain arteriovenous malformations","volume":"176","author":"Rutledge","year":"2021","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.wneu.2024.02.001_bib3","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.3171\/2014.6.FOCUS14250","article-title":"Natural history of brain arteriovenous malformations: a systematic review","volume":"37","author":"Abecassis","year":"2014","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2024.02.001_bib4","first-page":"437","article-title":"Natural history of cerebral arteriovenous malformations: a meta-analysis","volume":"118","author":"Gross","year":"2013","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2024.02.001_bib5","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0140-6736(13)62302-8","article-title":"Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial","volume":"383","author":"Mohr","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2024.02.001_bib6","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1227\/00006123-198411000-00003","article-title":"Natural history of arteriovenous malformations of the brain: a clinical study","volume":"15","author":"Fults","year":"1984","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2024.02.001_bib7","first-page":"352","article-title":"The natural history of unruptured intracranial arteriovenous malformations","volume":"68","author":"Brown","year":"1988","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2024.02.001_bib8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/brain\/awn318","article-title":"Outcome after spontaneous and arteriovenous malformation-related intracerebral haemorrhage: population-based studies","volume":"132","author":"van Beijnum","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.wneu.2024.02.001_bib9","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/2022.4.FOCUS2291","article-title":"Emerging pathogenic mechanisms in human brain arteriovenous malformations: a contemporary review in the multiomics era","volume":"53","author":"Winkler","year":"2022","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2024.02.001_bib10","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/neuros\/nyaa192","article-title":"An update on medications for brain arteriovenous malformations","volume":"87","author":"Raper","year":"2020","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2024.02.001_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/science.abi7377","article-title":"A\u00a0single-cell atlas of the normal and malformed human brain vasculature","volume":"375","author":"Winkler","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.wneu.2024.02.001_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/jcbfm.2014.179","article-title":"Biology of cerebral arteriovenous malformations with a focus on inflammation","volume":"35","author":"Mouchtouris","year":"2015","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.wneu.2024.02.001_bib13","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1227\/01.neu.0000333306.64683.b5","article-title":"Evidence of inflammatory cell involvement in brain arteriovenous malformations","volume":"62","author":"Chen","year":"2008","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2024.02.001_bib14","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1002\/jcp.30226","article-title":"Neurovascular inflammation in the pathogenesis of brain arteriovenous malformations","volume":"236","author":"Krithika","year":"2021","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.wneu.2024.02.001_bib15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/neu.2010.1673","article-title":"The anti-inflammatory drug carprofen improves long-term outcome and induces gliogenesis after traumatic brain injury","volume":"29","author":"Thau-Zuchman","year":"2012","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.wneu.2024.02.001_bib16","doi-asserted-by":"crossref","first-page":"e411","DOI":"10.1016\/j.wneu.2018.12.107","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in predicting the 6-month outcome of patients with traumatic brain injury: a retrospective study","volume":"124","author":"Zhao","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2024.02.001_bib17","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s41440-023-01195-0","article-title":"Systemic inflammation markers and the prevalence of hypertension: a NHANES cross-sectional study","volume":"46","author":"Xu","year":"2023","journal-title":"Hypertens Res"},{"key":"10.1016\/j.wneu.2024.02.001_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.atherosclerosis.2007.12.058","article-title":"Relation of smoking status to a panel of inflammatory markers: the Framingham offspring","volume":"201","author":"Levitzky","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.wneu.2024.02.001_bib19","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1097\/QAI.0000000000001270","article-title":"Brief report: the relationship between injection drug use risk behaviors and markers of immune activation","volume":"75","author":"Deren","year":"2017","journal-title":"J\u00a0Acquir Immune Defic Syndr"},{"key":"10.1016\/j.wneu.2024.02.001_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28646-w","article-title":"Reference values for white blood-cell-based inflammatory markers in the Rotterdam Study: a population-based prospective cohort study","volume":"8","author":"Fest","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.wneu.2024.02.001_bib21","first-page":"476","article-title":"A\u00a0proposed grading system for arteriovenous malformations","volume":"65","author":"Spetzler","year":"1986","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2024.02.001_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-3-7091-0693-8_14","article-title":"Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm","volume":"111","author":"Kim","year":"2011","journal-title":"Acta Neurochir Suppl"},{"issue":"3 Suppl","key":"10.1016\/j.wneu.2024.02.001_bib23","first-page":"S95","article-title":"Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development","volume":"40","author":"Kim","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2024.02.001_bib24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10456-016-9519-4","article-title":"Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation","volume":"19","author":"Zhang","year":"2016","journal-title":"Angiogenesis"},{"key":"10.1016\/j.wneu.2024.02.001_bib25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/ATVBAHA.112.300485","article-title":"Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain","volume":"33","author":"Chen","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.wneu.2024.02.001_bib26","article-title":"Inflammation and vascular remodeling","volume":"2012","author":"Aihara","year":"2012","journal-title":"Int J Vasc Med"},{"key":"10.1016\/j.wneu.2024.02.001_bib27","first-page":"173","article-title":"Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhage","volume":"111","author":"Sansing","year":"2011","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.wneu.2024.02.001_bib28","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1212\/01.WNL.0000133204.81153.AC","article-title":"Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors","volume":"63","author":"Leira","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.wneu.2024.02.001_bib29","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1161\/STROKEAHA.116.013627","article-title":"Neutrophil-to-lymphocyte ratio predicts the outcome of acute intracerebral hemorrhage","volume":"47","author":"Lattanzi","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2024.02.001_bib30","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1161\/01.STR.0000061888.71524.DF","article-title":"Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations","volume":"34","author":"Hashimoto","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2024.02.001_bib31","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.2741\/2037","article-title":"MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations","volume":"11","author":"Chen","year":"2006","journal-title":"Front Biosci"},{"key":"10.1016\/j.wneu.2024.02.001_bib32","first-page":"1259","article-title":"Prognostic role of neutrophil-to-lymphocyte ratio in patients with brain arteriovenous malformations","volume":"5","author":"Zhang","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.wneu.2024.02.001_bib33","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1161\/STROKEAHA.110.596718","article-title":"Molecular pathophysiology of cerebral hemorrhage: secondary brain injury","volume":"42","author":"Aronowski","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2024.02.001_bib34","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/01.WCB.0000073905.87928.6D","article-title":"Heme and iron metabolism: role in cerebral hemorrhage","volume":"23","author":"Wagner","year":"2003","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.wneu.2024.02.001_bib35","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1161\/01.STR.0000103140.52838.45","article-title":"Iron and iron-handling proteins in the brain after intracerebral hemorrhage","volume":"34","author":"Wu","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2024.02.001_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brainres.2005.01.036","article-title":"Oxidative DNA injury after experimental intracerebral hemorrhage","volume":"1039","author":"Nakamura","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.wneu.2024.02.001_bib37","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000065703","article-title":"Protein oxidation and heme oxygenase-1 induction in porcine white matter following intracerebral infusions of whole blood or plasma","volume":"24","author":"Wagner","year":"2002","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.wneu.2024.02.001_bib38","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/s00701-015-2521-6","article-title":"Brain arteriovenous malformations in elderly patients: clinical features and treatment outcome","volume":"157","author":"Tong","year":"2015","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.wneu.2024.02.001_bib39","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1161\/STROKEAHA.106.481515","article-title":"Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage","volume":"38","author":"Lee","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2024.02.001_bib40","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1161\/01.STR.0000129334.05181.b6","article-title":"Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model","volume":"35","author":"Lee","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2024.02.001_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2377-5-1","article-title":"Suppression of MMP-9 by doxycycline in brain arteriovenous malformations","volume":"5","author":"Hashimoto","year":"2005","journal-title":"BMC Neurol"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024001979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024001979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:56:02Z","timestamp":1749689762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875024001979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":41,"alternative-id":["S1878875024001979"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2024.02.001","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hematologic and Inflammatory Predictors of Outcome in Patients with Brain Arteriovenous Malformations","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2024.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}