{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:49:14Z","timestamp":1792986554004,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Zhejiang Provincial Health Commission","doi-asserted-by":"publisher","award":["2022KY1185"],"award-info":[{"award-number":["2022KY1185"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.wneu.2024.02.115","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T11:53:26Z","timestamp":1708775606000},"page":"e713-e720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Clinicopathological Analysis of Densely and Sparsely Granulated Somatotroph Tumors of Pituitary"],"prefix":"10.1016","volume":"185","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoman","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenning","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-5432","authenticated-orcid":false,"given":"Rong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2024.02.115_bib1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/cancers12020514","article-title":"How to classify pituitary neuroendocrine tumors (PitNET)s in 2020","volume":"12","author":"Trouillas","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.wneu.2024.02.115_bib2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ecl.2020.04.002","article-title":"The epidemiology of pituitary adenomas","volume":"49","author":"Adrian","year":"2020","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.wneu.2024.02.115_bib3","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1038\/s41379-021-00820-y","article-title":"Pituitary neuroendocrine tumors: a model for neuroendocrine tumor classification","volume":"34","author":"Asa","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.wneu.2024.02.115_bib4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12022-017-9498-z","article-title":"Overview of the 2017 WHO classification of pituitary tumors","volume":"28","author":"Mete","year":"2017","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.wneu.2024.02.115_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-022-04272-1","article-title":"Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas\/somatotroph pituitary neuroendocrine tumors","volume":"5","author":"Yamato","year":"2022","journal-title":"Commun Biol"},{"key":"10.1016\/j.wneu.2024.02.115_bib6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s11102-023-01353-0","article-title":"Clinical and prognostic significance of granulation patterns in somatotroph adenomas\/tumors of the pituitary: a meta-analysis","volume":"26","author":"Vuong","year":"2023","journal-title":"Pituitary"},{"key":"10.1016\/j.wneu.2024.02.115_bib7","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.1210\/jc.2005-0998","article-title":"The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly","volume":"90","author":"Bhayana","year":"2005","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.wneu.2024.02.115_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.pathol.4.110807.092259","article-title":"The pathogenesis of pituitary tumors","volume":"4","author":"Sylvia","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.wneu.2024.02.115_bib9","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s11102-020-01096-2","article-title":"Clinical, biological, radiological, and pathological comparison of sparsely and densely granulated somatotroph adenomas: a single center experience from a cohort of 131 patients with acromegaly","volume":"24","author":"Swanson","year":"2020","journal-title":"Pituitary"},{"key":"10.1016\/j.wneu.2024.02.115_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12022-008-9029-z","article-title":"Clinicopathological features of growth hormone-producing pituitary adenomas: difference among various types defined by cytokeratin distribution pattern including a transitional form","volume":"19","author":"Obari","year":"2008","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.wneu.2024.02.115_bib11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1507\/endocrj.EJ11-0177","article-title":"Differential expression of genes related to drug responsiveness between sparsely and densely granulated somatotroph adenomas","volume":"59","author":"Kato","year":"2012","journal-title":"Endocr J"},{"key":"10.1016\/j.wneu.2024.02.115_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/01616412.2017.1296653","article-title":"Efficacy of transsphenoidal surgery in achieving biochemical cure of growth hormone-secreting pituitary adenomas among patients with cavernous sinus invasion: a systematic review and meta-analysis","volume":"39","author":"Briceno","year":"2017","journal-title":"Neurol Res"},{"key":"10.1016\/j.wneu.2024.02.115_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1365-2265.2011.04163.x","article-title":"Adenoma granulation pattern correlates with clinical variables and effect of somatostatin analogue treatment in a large series of patients with acromegaly","volume":"76","author":"Fougner","year":"2012","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.wneu.2024.02.115_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrendo.2014.64","article-title":"Aggressive pituitary adenomas--diagnosis and emerging treatments","volume":"10","author":"Di Ieva","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.wneu.2024.02.115_bib15","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s00701-019-03879-4","article-title":"Ki-67 labeling index and expression of p53 are non-predictive for invasiveness and tumor size in functional and nonfunctional pituitary adenomas","volume":"161","author":"Grimm","year":"2019","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.wneu.2024.02.115_bib16","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.3390\/cells11233846","article-title":"Transcriptomic classification of pituitary neuroendocrine tumors causing acromegaly","volume":"11","author":"Rymuza","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.wneu.2024.02.115_bib17","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/330566a0","article-title":"Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas","volume":"330","author":"Vallar","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.wneu.2024.02.115_bib18","doi-asserted-by":"crossref","first-page":"5738","DOI":"10.1172\/JCI138540","article-title":"DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas","volume":"130","author":"Ben-Shlomo","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.wneu.2024.02.115_bib19","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMra062453","article-title":"Medical progress: acromegaly","volume":"355","author":"Melmed","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2024.02.115_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3390\/cancers15010267","article-title":"The prognostic-based approach in growth hormone-secreting pituitary neuroendocrine tumors (PitNET): tertiary reference center, single senior surgeon, and long-term follow-up","volume":"15","author":"Ferr\u00e9s","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.wneu.2024.02.115_bib21","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.surneu.2007.05.057","article-title":"Biochemical remission and recurrence rate of secreting pituitary adenomas after transsphenoidal adenomectomy","volume":"68","author":"Santoro","year":"2007","journal-title":"Surg Neurol"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024003280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024003280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:14:53Z","timestamp":1762560893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875024003280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":21,"alternative-id":["S1878875024003280"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2024.02.115","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathological Analysis of Densely and Sparsely Granulated Somatotroph Tumors of Pituitary","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2024.02.115","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}