{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:33:48Z","timestamp":1791329628623,"version":"4.3.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.wneu.2024.03.047","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T07:24:23Z","timestamp":1710746663000},"page":"e28-e34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Use of Recombinant Human Bone Morphogenetic Protein-2 After Anterior Cervical Corpectomy and Fusion for the Treatment of Vertebral Osteomyelitis"],"prefix":"10.1016","volume":"187","author":[{"given":"Adriana Vazquez","family":"Medina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Murray Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Estronza Ojeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-2204","authenticated-orcid":false,"given":"Aixa","family":"de Jesus Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-8735","authenticated-orcid":false,"given":"Emil A.","family":"Pastrana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2024.03.047_bib1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2012-002412","article-title":"Incidence and risk factors for mortality of vertebral osteomyelitis: a retrospective analysis using the Japanese diagnosis procedure combination database","volume":"3","author":"Akiyama","year":"2013","journal-title":"BMJ Open"},{"key":"10.1016\/j.wneu.2024.03.047_bib2","doi-asserted-by":"crossref","first-page":"E102","DOI":"10.1097\/BSD.0000000000000597","article-title":"The epidemiology of vertebral osteomyelitis in the United States from 1998 to 2013","volume":"31","author":"Issa","year":"2018","journal-title":"Clin Spine Surg"},{"key":"10.1016\/j.wneu.2024.03.047_bib3","series-title":"Handbook of Neurosurgery","author":"Greenberg","year":"2020"},{"key":"10.1016\/j.wneu.2024.03.047_bib4","doi-asserted-by":"crossref","first-page":"E132","DOI":"10.1097\/BRS.0b013e3181657ee3","article-title":"Surgical treatment of vertebral osteomyelitis with recombinant human bone morphogenetic protein-2","volume":"33","author":"O\u2019Shaughnessy","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.03.047_bib5","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/2018.10.FOCUS18464","article-title":"Anterior cervical spine surgery for the treatment of subaxial cervical spondylodiscitis: a report of 30 consecutive patients","volume":"46","author":"Burkhardt","year":"2019","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2024.03.047_bib6","series-title":"Neuroimaging Pharmacopoeia","first-page":"415","article-title":"Recombinant human bone morphogenetic protein","author":"Reed","year":"2022"},{"key":"10.1016\/j.wneu.2024.03.047_bib7","first-page":"549","article-title":"The controversy surrounding bone morphogenetic proteins in the spine: a review of current research","volume":"87","author":"Hustedt","year":"2014","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.wneu.2024.03.047_bib9","doi-asserted-by":"crossref","first-page":"890","DOI":"10.7326\/0003-4819-158-12-201306180-00006","article-title":"Effectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion","volume":"158","author":"Fu","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.wneu.2024.03.047_bib10","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1097\/BRS.0b013e31815cde3e","article-title":"Bone morphogenetic protein-2 (BMP-2) in the treatment of pyogenic vertebral osteomyelitis","volume":"32","author":"Allen","year":"2007","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.03.047_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3171\/spi.2007.6.1.23","article-title":"Corpectomy followed by the placement of instrumentation with titanium cages and recombinant human bone morphogenetic protein\u20132 for vertebral osteomyelitis","volume":"6","author":"Aryan","year":"2007","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2024.03.047_bib12","series-title":"National diabetes Statistics report","year":"2023"},{"key":"10.1016\/j.wneu.2024.03.047_bib13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/BRS.0000000000001263","article-title":"Comparison of 1-level versus 2-level anterior cervical discectomy and fusion","volume":"41","author":"Zigler","year":"2016","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.03.047_bib14","first-page":"496","article-title":"Outcomes and revision rates following multilevel anterior cervical discectomy and fusion","volume":"4","author":"Laratta","year":"2018","journal-title":"J\u00a0Spine Surg"},{"key":"10.1016\/j.wneu.2024.03.047_bib15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3171\/spi.2007.6.4.2","article-title":"Anterior approaches to fusion of the cervical spine: a metaanalysis of fusion rates","volume":"6","author":"Fraser","year":"2007","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2024.03.047_bib16","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00586-006-0251-4","article-title":"Surgical treatment of pyogenic vertebral osteomyelitis with spinal instrumentation","volume":"16","author":"Chen","year":"2007","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2024.03.047_bib17","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.spinee.2020.01.001","article-title":"Early adherence and biofilm formation of Cutibacterium acnes (formerly Propionibacterium acnes) on spinal implant materials","volume":"20","author":"Garcia","year":"2020","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2024.03.047_bib18","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fendo.2020.00386","article-title":"Modulation of the inflammatory response and bone healing","volume":"11","author":"Maruyama","year":"2020","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.wneu.2024.03.047_bib19","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1097\/01.BRS.0000065486.22141.CA","article-title":"A\u00a0prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SRTM Allograft ring and the ATLANTISTM anterior cervical plate","volume":"28","author":"Baskin","year":"2003","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.03.047_bib20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/01.brs.0000201424.27509.72","article-title":"Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 Use in anterior cervical spine fusion","volume":"31","author":"Shields","year":"2006","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.03.047_bib21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4103\/2152-7806.114813","article-title":"Complications due to the use of BMP\/INFUSE in spine surgery: the evidence continues to mount","volume":"4","author":"Epstein","year":"2013","journal-title":"Surg Neurol Int"},{"key":"10.1016\/j.wneu.2024.03.047_bib22","doi-asserted-by":"crossref","first-page":"877","DOI":"10.7326\/0003-4819-158-12-201306180-00005","article-title":"Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion","volume":"158","author":"Simmonds","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.wneu.2024.03.047_bib23","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/BRS.0000000000003218","article-title":"Incidence of surgical site infection after spine surgery","volume":"45","author":"Zhou","year":"2020","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.03.047_bib24","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/2021.3.FOCUS2171","article-title":"Safety and efficacy of low-dose rhBMP-2 use for anterior cervical fusion","volume":"50","author":"Mendenhall","year":"2021","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2024.03.047_bib25","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3171\/2015.4.SPINE141086","article-title":"Exploratory meta-analysis on dose-related efficacy and morbidity of bone morphogenetic protein in spinal arthrodesis surgery","volume":"24","author":"Hofstetter","year":"2016","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2024.03.047_bib26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jot.2020.01.002","article-title":"Exploratory meta-analysis on dose-related efficacy and complications of rhBMP-2 in anterior cervical discectomy and fusion: 1,539,021 cases from 2003 to 2017 studies","volume":"24","author":"Wen","year":"2020","journal-title":"J\u00a0Orthop Translat"},{"key":"10.1016\/j.wneu.2024.03.047_bib27","doi-asserted-by":"crossref","first-page":"e562","DOI":"10.1016\/j.wneu.2018.08.129","article-title":"Cervical spine osteomyelitis: a systematic review of instrumented fusion in the Modern era","volume":"120","author":"Wang","year":"2018","journal-title":"World Neurosurg"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024004315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024004315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T01:02:12Z","timestamp":1749690132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875024004315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":26,"alternative-id":["S1878875024004315"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2024.03.047","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of Recombinant Human Bone Morphogenetic Protein-2 After Anterior Cervical Corpectomy and Fusion for the Treatment of Vertebral Osteomyelitis","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2024.03.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}