{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:54:42Z","timestamp":1775836482545,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.wneu.2024.04.035","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T06:28:07Z","timestamp":1713248887000},"page":"e702-e706","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Age is Associated with Level of First-Time Anterior Cervical Discectomy and Fusion: An Ordinal Analysis of Factors Influencing Timing of Cervical Degeneration"],"prefix":"10.1016","volume":"186","author":[{"given":"James P.","family":"Caruso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remi","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9982-3522","authenticated-orcid":false,"given":"Luke","family":"Dosselman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Eakin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-228X","authenticated-orcid":false,"given":"Chandrasekhar","family":"Sundarrajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9447-1441","authenticated-orcid":false,"given":"Ammar","family":"Adenwalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed K.","family":"Almekkawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3499-7569","authenticated-orcid":false,"given":"Salah G.","family":"Aoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2041-5273","authenticated-orcid":false,"given":"Carlos A.","family":"Bagley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Van Hal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazin","family":"Al Tamimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2024.04.035_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1302\/0301-620X.80B1.0800019","article-title":"MRI of cervical intervertebral discs in asymptomatic subjects","volume":"80","author":"Matsumoto","year":"1998","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.wneu.2024.04.035_bib2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.21037\/atm.2019.07.80","article-title":"Prevalence of cervical spine degenerative changes in elderly population and its weak association with aging, neck pain, and osteoporosis","volume":"7","author":"Wang","year":"2019","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.wneu.2024.04.035_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/BRS.0b013e3181604501","article-title":"Kinematic analysis of the relationship between the grade of disc degeneration and motion unit of the cervical spine","volume":"33","author":"Miyazaki","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.04.035_bib4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0030-5898(20)31113-5","article-title":"Pathology of degenerative disease of the cervical spine","volume":"2","author":"Fenlin","year":"1971","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.wneu.2024.04.035_bib5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/BRS.0000000000003231","article-title":"Are outcomes of anterior cervical discectomy and fusion influenced by Presurgical Depression symptoms on the mental component score of the short form-12 survey?","volume":"45","author":"Divi","year":"2020","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.04.035_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1177\/2192568219890292","article-title":"Does smoking status influence health-related quality of life outcome measures in patients undergoing ACDF?","volume":"11","author":"Mangan","year":"2021","journal-title":"Global Spine J"},{"issue":"1 Supp1 1","key":"10.1016\/j.wneu.2024.04.035_bib7","first-page":"S7","article-title":"Cervical spondylosis anatomy: pathophysiology and biomechanics","volume":"60","author":"Shedid","year":"2007","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2024.04.035_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJMra2003558","article-title":"Degenerative cervical spondylosis","volume":"383","author":"Theodore","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2024.04.035_bib9","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s11999-014-3774-8","article-title":"Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions?","volume":"473","author":"Kadow","year":"2015","journal-title":"Clin Orthop Relat Res"},{"issue":"Suppl 2","key":"10.1016\/j.wneu.2024.04.035_bib10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00586-013-2839-9","article-title":"Risk factors for development of myelopathy in patients with cervical spondylotic cord compression","volume":"24","author":"Matsunaga","year":"2015","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2024.04.035_bib11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1177\/2192568217719436","article-title":"Patterns of cervical disc degeneration: analysis of magnetic resonance imaging of over 1000 symptomatic subjects","volume":"8","author":"Suzuki","year":"2018","journal-title":"Global Spine J"},{"key":"10.1016\/j.wneu.2024.04.035_bib12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00007632-198705000-00010","article-title":"A\u00a0morphometric study of human lumbar and selected thoracic vertebrae","volume":"12","author":"Berry","year":"1987","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.04.035_bib13","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1097\/00007632-199108000-00001","article-title":"Cervical human vertebrae. Quantitative three-dimensional anatomy of the middle and lower regions","volume":"16","author":"Panjabi","year":"1991","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.04.035_bib14","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/00007632-199108000-00006","article-title":"Thoracic human vertebrae. Quantitative three-dimensional anatomy","volume":"16","author":"Panjabi","year":"1991","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.04.035_bib15","series-title":"Clinical Biomechanics of the Spine","author":"White","year":"1990"},{"key":"10.1016\/j.wneu.2024.04.035_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00007632-198501000-00009","article-title":"The orientation of laminae and facet joints in the lower lumbar spine","volume":"10","author":"Van Schaik","year":"1985","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.04.035_bib17","series-title":"Surgical anatomy of the thoracic and lumbar spine. Manual of Internal Fixation of the Spine","author":"Rauschning","year":"1996"},{"key":"10.1016\/j.wneu.2024.04.035_bib18","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1097\/00007632-200005150-00002","article-title":"Internal morphology of human cervical pedicles","volume":"25","author":"Panjabi","year":"2000","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.04.035_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2106\/00004623-197860010-00006","article-title":"Mechanical response of the lumbar intervertebral joint under physiological (complex) loading","volume":"60","author":"Lin","year":"1978","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.wneu.2024.04.035_bib20","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/00007632-198807000-00003","article-title":"Three-dimensional movements of the upper cervical spine","volume":"13","author":"Panjabi","year":"1988","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.04.035_bib21","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/00007632-200004010-00006","article-title":"Cervical myelopathy caused by C3-C4 spondylosis in elderly patients: a radiographic analysis of pathogenesis","volume":"25","author":"Mihara","year":"2000","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.04.035_bib22","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00264-010-1169-3","article-title":"Cervical spinal canal stenosis: the differences between stenosis at the lower cervical and multiple segment levels","volume":"35","author":"Morishita","year":"2011","journal-title":"Int Orthop"},{"key":"10.1016\/j.wneu.2024.04.035_bib23","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/BRS.0000000000001874","article-title":"Anterior cervical discectomy and fusion provides better surgical outcomes than posterior laminoplasty in elderly patients with C3-4 level myelopathy","volume":"42","author":"Tamai","year":"2017","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2024.04.035_bib24","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0009-9260(03)00255-1","article-title":"Magnetic resonance imaging of the cervical spine: frequency of degenerative changes in the intervertebral disc with relation to age","volume":"58","author":"Abdulkarim","year":"2003","journal-title":"Clin Radiol"},{"key":"10.1016\/j.wneu.2024.04.035_bib25","author":"Fakhoury"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024005977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024005977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T03:41:11Z","timestamp":1719891671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875024005977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":25,"alternative-id":["S1878875024005977"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2024.04.035","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age is Associated with Level of First-Time Anterior Cervical Discectomy and Fusion: An Ordinal Analysis of Factors Influencing Timing of Cervical Degeneration","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2024.04.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}