{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:05:15Z","timestamp":1785326715709,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.wneu.2024.04.146","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T03:00:36Z","timestamp":1714705236000},"page":"e683-e699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["An Evaluation of Risk Factors for Intracranial Metastases of Sarcomas: A Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7663-9836","authenticated-orcid":false,"given":"Alexander","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-4952","authenticated-orcid":false,"given":"Chance","family":"Fleeting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3301-8066","authenticated-orcid":false,"given":"Aashay","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Bazett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Hey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil","family":"Mandavali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6025-346X","authenticated-orcid":false,"given":"Nolan J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Woolridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5551-7061","authenticated-orcid":false,"given":"Marco","family":"Foreman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-4080","authenticated-orcid":false,"given":"Brandon","family":"Lucke-Wold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 5","key":"10.1016\/j.wneu.2024.04.146_bib1","first-page":"v52","article-title":"Management of brain metastases in lung cancer: evolving roles for radiation and systemic treatment in the era of targeted and immune therapies","volume":"3","author":"Myall","year":"2021","journal-title":"Neurooncol Adv"},{"key":"10.1016\/j.wneu.2024.04.146_bib2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11060-009-0085-0","article-title":"Sarcoma metastatic to the brain: a series of 35 cases and considerations from 27 years of experience","volume":"98","author":"Salvati","year":"2010","journal-title":"J\u00a0Neuro Oncol"},{"issue":"Suppl 5","key":"10.1016\/j.wneu.2024.04.146_bib3","first-page":"962","article-title":"Sarcoma brain metastases: 28 Years of experience at a single institution","volume":"23","author":"Al","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib4","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.18632\/oncotarget.26809","article-title":"Sarcomas in the United States: recent trends and a call for improved staging","volume":"10","author":"Gage","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.wneu.2024.04.146_bib5","first-page":"147","article-title":"Epidemiology and therapies for metastatic sarcoma","volume":"5","author":"Amankwah","year":"2013","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.wneu.2024.04.146_bib6","doi-asserted-by":"crossref","DOI":"10.1177\/20363613211026151","article-title":"Outcomes of brain metastasis in high-grade bone and soft tissue sarcoma: an analysis of clinicopathological characteristics and survival data","volume":"13","author":"Gusho","year":"2021","journal-title":"Rare Tumors"},{"key":"10.1016\/j.wneu.2024.04.146_bib7","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1634\/theoncologist.2017-0136","article-title":"Brain metastases from adult sarcoma: prognostic factors and impact of treatment. A retrospective analysis from the French sarcoma group (GSF\/GETO)","volume":"23","author":"Chaigneau","year":"2018","journal-title":"Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib8","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1111\/ajco.12111","article-title":"Brain metastasis in sarcoma: does metastasectomy or aggressive multi-disciplinary treatment improve survival outcomes","volume":"12","author":"Chua","year":"2016","journal-title":"Asia Pac J Clin Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/475175","article-title":"Brain metastasis in bone and soft tissue cancers: a review of incidence, interventions, and outcomes","volume":"2014","author":"Shweikeh","year":"2014","journal-title":"Sarcoma"},{"key":"10.1016\/j.wneu.2024.04.146_bib10","series-title":"Pain Management Interventions for Hip Fracture","author":"Abou-Setta","year":"2011"},{"key":"10.1016\/j.wneu.2024.04.146_bib26","first-page":"1","article-title":"Survival outcomes of patients with brain metastasis of osteosarcoma can be improved by aggressive multi-disciplinary interventions including chemotherapy","author":"Zhu","year":"2021","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.wneu.2024.04.146_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0090-3019(00)00293-7","article-title":"Brain metastasis in patients with sarcoma: an analysis of histological subtypes, clinical characteristics, and outcomes","volume":"54","author":"Yoshida","year":"2000","journal-title":"Surg Neurol"},{"key":"10.1016\/j.wneu.2024.04.146_bib27","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/BF02306371","article-title":"Resection of brain metastases from sarcoma","volume":"2","author":"Wro\u0144ski","year":"1995","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10585-015-9713-6","article-title":"Postoperative brain metastases in soft tissue sarcomas","volume":"32","author":"Urakawa","year":"2015","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.wneu.2024.04.146_bib29","first-page":"5779","article-title":"Brain metastatic alveolar soft-part sarcoma: Clinicopathological profiles, management and outcomes","volume":"14","author":"Tao","year":"2017","journal-title":"Oncol Lett"},{"key":"10.1016\/j.wneu.2024.04.146_bib30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11060-009-0085-0","article-title":"Sarcoma metastatic to the brain: a series of 35 cases and considerations from 27 years of experience","volume":"98","author":"Salvati","year":"2010","journal-title":"J Neurooncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000072336","article-title":"Central nervous system involvement in children with sarcoma","volume":"65","author":"Postovsky","year":"2003","journal-title":"Oncology"},{"key":"10.1016\/j.wneu.2024.04.146_bib32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0360-3016(03)00502-9","article-title":"Brain metastasis in children with sarcoma, neuroblastoma, and Wilms\u2019 tumor","volume":"57","author":"Paulino","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.wneu.2024.04.146_bib33","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/00043426-199909000-00007","article-title":"Brain metastases in pediatric Ewing sarcoma and rhabdomyosarcoma: the St. Jude Children\u2019s Research Hospital experience","volume":"21","author":"Parasuraman","year":"1999","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jpedsurg.2005.10.023","article-title":"Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults","volume":"41","author":"Kayton","year":"2006","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.wneu.2024.04.146_bib35","first-page":"532","article-title":"Integrated therapy for Ewing\u2019s sarcoma. Am J Roentgenol Radium Ther Nucl","volume":"114","author":"Johnson","year":"1972","journal-title":"Med"},{"key":"10.1016\/j.wneu.2024.04.146_bib36","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/1097-0142(19870201)59:3<396::AID-CNCR2820590307>3.0.CO;2-W","article-title":"Hepatic undifferentiated (embryonal) sarcoma and rhabdomyosarcoma in children. Results of therapy","volume":"59","author":"Horowitz","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2024.04.146_bib37","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/08880010290057363","article-title":"Intracranial manifestation of osteosarcoma","volume":"19","author":"Hettmer","year":"2002","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib38","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.3390\/cancers12061675","article-title":"Primary and metastatic intracranial Ewing sarcoma at diagnosis: retrospective International study and systematic review","volume":"12","author":"Haveman","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.wneu.2024.04.146_bib39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/01.mph.0000155119.12818.7e","article-title":"Incidence and survival of central nervous system involvement in childhood malignancies: Hungarian experience","volume":"27","author":"Hauser","year":"2005","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib12","article-title":"Brain metastases in patients with soft-tissue sarcomas: management and survival\u2014a SEER population-based cohort study","volume":"5","author":"Gonzalez","year":"2021","journal-title":"J\u00a0Am Acad Orthop Surg Glob Res Rev"},{"key":"10.1016\/j.wneu.2024.04.146_bib40","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/1097-0142(197511)36:5<1843::AID-CNCR2820360541>3.0.CO;2-V","article-title":"Increased incidence of cerebral metastases in sarcoma patients with prolonged survival from chemotherapy. Report of cases of leiomysarcoma and chondrosarcoma","volume":"36","author":"Gercovich","year":"1975","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2024.04.146_bib41","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/00000478-199310000-00001","article-title":"Primary angiosarcoma of the spleen. A clinicopathologic study of 40 cases","volume":"17","author":"Falk","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.wneu.2024.04.146_bib42","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s10147-020-01740-8","article-title":"Surgical outcome and graded prognostic assessment of patients with brain metastasis from adult sarcoma: multi-institutional retrospective study in Japan","volume":"25","author":"Deguchi","year":"2020","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26710","article-title":"Central nervous system relapse of rhabdomyosarcoma","volume":"65","author":"De","year":"2018","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.wneu.2024.04.146_bib44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1477-7819-6-71","article-title":"Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases","volume":"6","author":"Daigeler","year":"2008","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF01402114","article-title":"CNS involvement in Ewing\u2019s sarcoma. A report of 12 cases","volume":"113","author":"Colak","year":"1991","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.wneu.2024.04.146_bib46","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/jso.22011","article-title":"Brain, the last fortress of sarcoma: similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma","volume":"104","author":"Chou","year":"2011","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib47","doi-asserted-by":"crossref","first-page":"321896","DOI":"10.1155\/2015\/321896","article-title":"Surgical Treatment and Prognosis of Angiosarcoma of the Scalp: A Retrospective Analysis of 14 Patients in a Single Institution","volume":"2015","author":"Choi","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.wneu.2024.04.146_bib48","doi-asserted-by":"crossref","DOI":"10.1177\/2036361320960060","article-title":"Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes","volume":"12","author":"Chan","year":"2020","journal-title":"Rare Tumors"},{"key":"10.1016\/j.wneu.2024.04.146_bib49","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/(SICI)1097-0142(19970115)79:2<403::AID-CNCR25>3.0.CO;2-3","article-title":"Brain metastases in children with solid tumors","volume":"79","author":"Bouffet","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2024.04.146_bib50","doi-asserted-by":"crossref","first-page":"1456473","DOI":"10.1155\/2017\/1456473","article-title":"CNS metastases from bone and soft tissue sarcomas in children, adolescents, and young adults. Are they really so rare?","volume":"2017","author":"Bekiesinska-Figatowska","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.wneu.2024.04.146_bib13","series-title":"StatPearls","article-title":"Sarcoma","author":"Popovich","year":"2023"},{"key":"10.1016\/j.wneu.2024.04.146_bib14","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.4065\/82.11.1409","article-title":"Sarcoma","volume":"82","author":"Skubitz","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.wneu.2024.04.146_bib15","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00685912","article-title":"High-dose VP16 cisplatinum in soft tissue sarcoma of children","volume":"33","author":"Grabois","year":"1994","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.wneu.2024.04.146_bib16","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1007\/s00018-015-1930-2","article-title":"An integrative view on sex differences in brain tumors","volume":"72","author":"Sun","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.wneu.2024.04.146_bib17","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1002\/cncr.10554","article-title":"Soft tissue sarcoma brain metastases","volume":"94","author":"Espat","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2024.04.146_bib18","article-title":"Brain metastases from adult sarcomas: a retrospective cohort study from the hellenic group of sarcomas and rare cancers (HGSRC)","volume":"10","author":"Kokkali","year":"2021","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.wneu.2024.04.146_bib19","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.21873\/anticanres.15376","article-title":"Brain metastasis in soft tissue sarcoma at initial presentation","volume":"41","author":"Itoga","year":"2021","journal-title":"Anticancer Res"},{"key":"10.1016\/j.wneu.2024.04.146_bib20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1227\/00006123-199408000-00002","article-title":"Sarcoma metastatic to the brain: results of surgical treatment","volume":"35","author":"Bindal","year":"1994","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2024.04.146_bib21","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.21873\/anticanres.14858","article-title":"Clinical outcome of the patients with brain metastasis from soft tissue sarcomas","volume":"41","author":"Takemori","year":"2021","journal-title":"Anticancer Res"},{"key":"10.1016\/j.wneu.2024.04.146_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12964-020-0530-4","article-title":"Tumor microenvironment complexity and therapeutic implications at a glance","volume":"18","author":"Baghban","year":"2020","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.wneu.2024.04.146_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.983878","article-title":"Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application","volume":"12","author":"Aili","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1470-2045(19)30153-6","article-title":"Axitinib plus pembrolizumab in patients with advanced sarcomas including alveolar soft-part sarcoma: a single-centre, single-arm, phase 2 trial","volume":"20","author":"Wilky","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.wneu.2024.04.146_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/23809000.2018.1472524","article-title":"The importance of patient-reported outcomes in cancer studies","volume":"3","author":"Retzer","year":"2018","journal-title":"Expert Review of Quality of Life in Cancer Care"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024007204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024007204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T01:21:17Z","timestamp":1749691277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875024007204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":50,"alternative-id":["S1878875024007204"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2024.04.146","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Evaluation of Risk Factors for Intracranial Metastases of Sarcomas: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2024.04.146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}