{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:05:23Z","timestamp":1791389123009,"version":"4.3.3"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.wneu.2024.06.133","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T20:43:52Z","timestamp":1720039432000},"page":"99-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Leukoencephalopathy with Cerebral Calcifications and Cysts: The Neurosurgical Perspective. Literature Review"],"prefix":"10.1016","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-9907","authenticated-orcid":false,"given":"Federica","family":"Novegno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2367-9418","authenticated-orcid":false,"given":"Andrea","family":"Iaquinandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ruggiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Salvati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2024.06.133_bib1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neurol.2019.06.006","article-title":"Leukoencephalopathy with calcifications and cysts (LCC): 5 cases and literature review","volume":"176","author":"Osman","year":"2020","journal-title":"Rev Neurol (Paris)"},{"key":"10.1016\/j.wneu.2024.06.133_bib2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jocn.2019.08.006","article-title":"Adult-onset leukoencephalopathy, cerebral calcifications, and cysts: an 8-year neuroimaging follow-up of disease progression and histopathological correlation","volume":"69","author":"Chiang","year":"2019","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.wneu.2024.06.133_bib3","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1212\/WNL.46.5.1297","article-title":"Extensive brain calcifications, leukodystrophy, and formation of parenchymal cysts: a new progressive disorder due to diffuse cerebral microangiopathy","volume":"46","author":"Labrune","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.wneu.2024.06.133_bib4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00381-021-05208-6","article-title":"Paediatric neurosurgical implications of a ribosomopathy: illustrative case and literature review","volume":"38","author":"Murphy","year":"2022","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2024.06.133_bib5","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00381-020-04861-7","article-title":"Surgical considerations in Labrune syndrome","volume":"37","author":"Kobets","year":"2021","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2024.06.133_bib6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.wneu.2019.02.008","article-title":"Leukoencephalopathy, intracranial calcifications, cysts, and SNORD118 mutation (Labrune syndrome) with obstructive hydrocephalus","volume":"125","author":"Shtaya","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2024.06.133_bib7","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.prp.2017.07.007","article-title":"A\u00a055-year-old female with leukoencephalopathy with cerebral calcifications and cysts: case report and radiopathologic description","volume":"213","author":"Novo","year":"2017","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.wneu.2024.06.133_bib8","article-title":"Leukoencephalopathy with calcifications and cysts: a case report","volume":"96","author":"Ma","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.wneu.2024.06.133_bib9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jns.2016.12.014","article-title":"Leukoencephalopathy, cerebral calcifications, and cysts: a clinical case involving a long-term follow-up and literature review","volume":"373","author":"Tamura","year":"2017","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.wneu.2024.06.133_bib10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jns.2016.09.048","article-title":"Leukoencephalopathy with cerebral calcification and cysts: cases report and literature review","volume":"370","author":"Wang","year":"2016","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.wneu.2024.06.133_bib11","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.wneu.2015.09.049","article-title":"Adult-onset leukoencephalopathy with calcifications and cysts: focusing on hemorrhagic propensity and cysts development","volume":"85","author":"Li","year":"2016","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2024.06.133_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s13760-015-0501-5","article-title":"Leukoencephalopathy with cerebral calcifications and cysts: clinical and pathological features in two adults","volume":"116","author":"Liu","year":"2016","journal-title":"Acta Neurol Belg"},{"key":"10.1016\/j.wneu.2024.06.133_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12883-016-0543-1","article-title":"Late-onset leukoencephalopathy with cerebral calcifications and cysts: case report and review of the literature","volume":"16","author":"Stephani","year":"2016","journal-title":"BMC Neurol"},{"key":"10.1016\/j.wneu.2024.06.133_bib14","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.pediatrneurol.2014.06.007","article-title":"Leukoencephalopathy, cerebral calcifications, and cysts in two sisters","volume":"51","author":"Ogles","year":"2014","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.wneu.2024.06.133_bib15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3171\/2013.5.PEDS1328","article-title":"Repeated cyst formation in a patient with leukoencephalopathy, cerebral calcifications, and cysts: effectiveness of stereotactic aspiration with Ommaya reservoir placement","volume":"12","author":"Ooba","year":"2013","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2024.06.133_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1590\/S0004-282X2012000300016","article-title":"Leukoencephalopathy with cerebral calcifications and cyst: Labrune syndrome","volume":"70","author":"Pessoa","year":"2012","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.wneu.2024.06.133_bib17","first-page":"319","article-title":"Late onset of leucoencephalopathy with cerebral calcifications and cysts","volume":"38","author":"Coeytaux","year":"2011","journal-title":"J\u00a0Neuroradiol"},{"key":"10.1016\/j.wneu.2024.06.133_bib18","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1590\/S0004-282X2011000500027","article-title":"Leukoencephalopathy, cerebral calcifications, and cysts: an entity that can mimic a neoplasm","volume":"69","author":"Bertotti","year":"2011","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.wneu.2024.06.133_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/2152-7806.89867","article-title":"Neurosurgical management of leukoencephalopathy, cerebral calcifications, and cysts: a case report and literature review","volume":"2","author":"Berry-Candelario","year":"2011","journal-title":"Surg Neurol Int"},{"key":"10.1016\/j.wneu.2024.06.133_bib20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4103\/0972-2327.74198","article-title":"Leukoencephalopathy with intracranial calcifications and cysts in an adult: case report and review of the literature","volume":"13","author":"Ummer","year":"2010","journal-title":"Ann Indian Acad Neurol"},{"key":"10.1016\/j.wneu.2024.06.133_bib21","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1468-1331.2008.02392.x","article-title":"A\u00a0case of late onset leukoencephalopathy with cerebral calcifications and cysts in a 59-year-old woman","volume":"16","author":"Kaffenberger","year":"2009","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.wneu.2024.06.133_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.surneu.2008.02.042","article-title":"Cerebral leukoencephalopathy with calcifications and cysts operated for signs of increased intracranial pressure: case report","volume":"72","author":"Daglioglu","year":"2009","journal-title":"Surg Neurol"},{"key":"10.1016\/j.wneu.2024.06.133_bib23","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1136\/jnnp.2008.148429","article-title":"Late presentation of leucoencephalopathy with calcifications and cysts: report of two cases","volume":"79","author":"Marelli","year":"2008","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.wneu.2024.06.133_bib24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ajmg.a.32080","article-title":"Cerebroretinal microangiopathy with calcifications and cysts (CRMCC)","volume":"146A","author":"Briggs","year":"2008","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.wneu.2024.06.133_bib25","first-page":"200","article-title":"Leukoencephalopathy, cerebral calcifications, and cysts","volume":"27","author":"Sener","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.wneu.2024.06.133_bib26","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1212\/01.wnl.0000244470.06748.18","article-title":"An adult case of leukoencephalopathy with intracranial calcifications and cysts","volume":"67","author":"Corboy","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.wneu.2024.06.133_bib27","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1212\/01.WNL.0000119341.59445.CF","article-title":"Leukoencephalopathy, cerebral calcifications, and cysts: new observations","volume":"62","author":"Nagae-Poetscher","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.wneu.2024.06.133_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12883-021-02531-y","article-title":"Leukoencephalopathy with brain calcifications and cysts (Labrune syndrome) case report: diagnosis and management of a rare neurological disease","volume":"22","author":"Paff","year":"2022","journal-title":"BMC Neurol"},{"key":"10.1016\/j.wneu.2024.06.133_bib29","article-title":"Case report: moderate therapeutic response to Bevacizumab in late-onset Labrune syndrome","volume":"13","author":"Wang","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.wneu.2024.06.133_bib30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pediatrneurol.2017.03.008","article-title":"Treatment of leukoencephalopathy with calcifications and cysts with bevacizumab","volume":"71","author":"Fay","year":"2017","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.wneu.2024.06.133_bib31","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/ng.3661","article-title":"Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts","volume":"48","author":"Jenkinson","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.wneu.2024.06.133_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ajmg.a.61907","article-title":"Leukoencephalopathy with calcifications and cysts: genetic and phenotypic spectrum","volume":"185","author":"Crow","year":"2021","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.wneu.2024.06.133_bib33","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1111\/ene.14313","article-title":"Systemic involvement in adult-onset leukoencephalopathy with intracranial calcifications and cysts (Labrune syndrome) with a novel mutation of the SNORD118 gene","volume":"27","author":"Bonomo","year":"2020","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.wneu.2024.06.133_bib34","first-page":"1911","article-title":"Leukoencephalopathy, cerebral calcifications and cysts: a family study","volume":"261","author":"Karlinger","year":"2014","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.wneu.2024.06.133_bib35","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3390\/brainsci10110869","article-title":"Leukoencephalopathy with calcifications and cysts-the first polish patient with Labrune syndrome","volume":"10","author":"Machnikowska-Soko\u0142owska","year":"2020","journal-title":"Brain Sci"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024010933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024010933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T01:24:13Z","timestamp":1749691453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875024010933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":35,"alternative-id":["S1878875024010933"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2024.06.133","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leukoencephalopathy with Cerebral Calcifications and Cysts: The Neurosurgical Perspective. Literature Review","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2024.06.133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}