{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:17:44Z","timestamp":1780366664613,"version":"3.54.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772661"],"award-info":[{"award-number":["81772661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019538","name":"Science Fund for Distinguished Young Scholars of Sichuan Province","doi-asserted-by":"publisher","award":["2023-JC-JQ-68"],"award-info":[{"award-number":["2023-JC-JQ-68"]}],"id":[{"id":"10.13039\/501100019538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.wneu.2024.08.128","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T01:04:15Z","timestamp":1724979855000},"page":"e346-e355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Prognostic Factors for Patients with Primary Gliosarcoma: A Single-Center Retrospective Study"],"prefix":"10.1016","volume":"191","author":[{"given":"Chen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peigang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaochun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9224-7195","authenticated-orcid":false,"given":"Jinghui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2024.08.128_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1215\/15228517-2008-076","article-title":"Adult gliosarcoma: epidemiology, natural history, and factors associated with outcome","volume":"11","author":"Kozak","year":"2009","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib2","first-page":"425","article-title":"Clinical outcome of gliosarcoma compared with glioblastoma multiforme: north Central Cancer Treatment Group results","volume":"89","author":"Galanis","year":"1998","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.wneu.2024.08.128_bib4","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41571-020-00447-z","article-title":"EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood","volume":"18","author":"Weller","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib6","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.6004\/jnccn.2020.0052","article-title":"Central nervous system cancers, version 3.2020, NCCN clinical practice guidelines in oncology","volume":"18","author":"Nabors","year":"2020","journal-title":"J\u00a0Natl Compr Cancer Netw"},{"key":"10.1016\/j.wneu.2024.08.128_bib7","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.3389\/fonc.2019.01425","article-title":"Clinical characteristics of gliosarcoma and outcomes from standardized treatment relative to conventional glioblastoma","volume":"9","author":"Frandsen","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1080\/02688697.2021.1872773","article-title":"Primary and secondary gliosarcoma: differences in treatment and outcome","volume":"38","author":"Hong","year":"2021","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2020.106348","article-title":"Demographic, radiographic, molecular and clinical characteristics of primary gliosarcoma and differences to glioblastoma","volume":"200","author":"Pierscianek","year":"2021","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11060-006-9295-x","article-title":"Gliosarcoma with multiple extracranial metastases: case report and review of the literature","volume":"83","author":"Beaumont","year":"2007","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-97454-6","article-title":"Genomic landscape of gliosarcoma: distinguishing features and targetable alterations","volume":"11","author":"Zaki","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.wneu.2024.08.128_bib12","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1007\/s13760-020-01533-w","article-title":"Treatments of gliosarcoma of the brain: a systematic review and meta-analysis","volume":"121","author":"Wang","year":"2021","journal-title":"Acta Neurol Belg"},{"key":"10.1016\/j.wneu.2024.08.128_bib13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11060-015-1930-y","article-title":"Primary and secondary gliosarcomas: clinical, molecular and survival characteristics","volume":"125","author":"Cachia","year":"2015","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib14","first-page":"990","article-title":"Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patients","volume":"112","author":"Han","year":"2010","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib15","article-title":"Prognostic and predictive factors of secondary gliosarcoma: a single-institution series of 18 cases combined with 89 cases from literature","volume":"12","author":"Liu","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib16","first-page":"851","article-title":"Extent of resection in patients with glioblastoma: limiting factors, perception of resectability, and effect on survival","volume":"117","author":"Orringer","year":"2012","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib17","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1200\/JCO.2009.26.3541","article-title":"Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group","volume":"28","author":"Wen","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib18","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/cncr.24857","article-title":"Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients","volume":"116","author":"Han","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2024.08.128_bib19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11060-010-0267-9","article-title":"O6-methylguanine DNA methyltransferase status determined by promoter methylation and immunohistochemistry in gliosarcoma and their clinical implications","volume":"101","author":"Kang","year":"2011","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.4103\/0019-509X.178407","article-title":"Clinical outcome of patients with primary gliosarcoma treated with concomitant and adjuvant temozolomide: a single institutional analysis of 27 cases","volume":"52","author":"Rath","year":"2015","journal-title":"Indian J Cancer"},{"key":"10.1016\/j.wneu.2024.08.128_bib21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11060-016-2117-x","article-title":"Radiotherapy plus concomitant temozolomide in primary gliosarcoma","volume":"128","author":"Adeberg","year":"2016","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11060-016-2142-9","article-title":"Prognostic and therapeutic factors of gliosarcoma from a multi-institutional series","volume":"129","author":"Castelli","year":"2016","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.wneu.2017.06.073","article-title":"Analysis of outcomes of multidisciplinary management of gliosarcoma: a single-center study, 2000-2013","volume":"106","author":"Jain","year":"2017","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jocn.2017.07.002","article-title":"Gliosarcoma in septuagenarians and octogenarians: what is the impact of adjuvant chemoradiation?","volume":"45","author":"Shin","year":"2017","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.wneu.2024.08.128_bib25","article-title":"Evaluating the association between the extent of resection and survival in gliosarcoma","volume":"11","author":"Ahmed","year":"2019","journal-title":"Cureus"},{"key":"10.1016\/j.wneu.2024.08.128_bib26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/02688697.2019.1699903","article-title":"Prognostic factors and clinical outcomes in adult primary gliosarcoma patients: a Surveillance, Epidemiology, and End Results (SEER) analysis from 2004 to 2015","volume":"34","author":"Huang","year":"2020","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib27","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s10143-020-01285-4","article-title":"The clinical, radiological, and immunohistochemical characteristics and outcomes of primary intracranial gliosarcoma: a retrospective single-centre study","volume":"44","author":"Zhang","year":"2021","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.wneu.2024.08.128_bib28","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00066-021-01884-0","article-title":"Chasing a rarity: a retrospective single-center evaluation of prognostic factors in primary gliosarcoma","volume":"198","author":"Dejonckheere","year":"2022","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.wneu.2024.08.128_bib29","doi-asserted-by":"crossref","first-page":"e483","DOI":"10.1016\/j.wneu.2023.12.123","article-title":"Competing risk model to determine the prognostic factors for patients with gliosarcoma","volume":"183","author":"Chen","year":"2024","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib30","first-page":"341","article-title":"Primary gliosarcoma: epidemiology, clinical presentation, management, and survival","volume":"64","author":"Ma","year":"2020","journal-title":"J\u00a0Neurosurg Sci"},{"key":"10.1016\/j.wneu.2024.08.128_bib31","first-page":"587","article-title":"Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. Clinical article","volume":"114","author":"Chaichana","year":"2011","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib32","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jocn.2012.07.016","article-title":"Factors associated with survival for patients with glioblastoma with poor pre-operative functional status","volume":"20","author":"Chaichana","year":"2013","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.wneu.2024.08.128_bib33","first-page":"220","article-title":"Treatment outcomes for patients with glioblastoma multiforme and a low Karnofsky Performance Scale score on presentation to a tertiary care institution. Clinical article","volume":"115","author":"Marina","year":"2011","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11060-014-1640-x","article-title":"The relative value of postoperative versus preoperative Karnofsky Performance Scale scores as a predictor of survival after surgical resection of glioblastoma multiforme","volume":"121","author":"Chambless","year":"2015","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib35","first-page":"1133","article-title":"Patterns of care and outcomes in gliosarcoma: an analysis of the National Cancer Database","volume":"128","author":"Frandsen","year":"2018","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2024.08.128_bib36","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s11060-011-0790-3","article-title":"Clinicopathologic and genomic features of gliosarcomas","volume":"107","author":"Lee","year":"2012","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11060-012-1029-7","article-title":"Temozolomide use in adult patients with gliosarcoma: an evolving clinical practice","volume":"112","author":"Walker","year":"2013","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11060-022-04016-5","article-title":"Survival outcomes associated with MGMT promoter methylation and temozolomide in gliosarcoma patients","volume":"158","author":"Kavouridis","year":"2022","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib39","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1001\/jama.2017.18718","article-title":"Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial","volume":"318","author":"Stupp","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.wneu.2024.08.128_bib40","doi-asserted-by":"crossref","first-page":"10152","DOI":"10.1073\/pnas.0702916104","article-title":"Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors","volume":"104","author":"Kirson","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.wneu.2024.08.128_bib41","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/cns.13750","article-title":"Exploring the efficacy of tumor electric field therapy against glioblastoma: an in\u00a0vivo and in\u00a0vitro study","volume":"27","author":"Wu","year":"2021","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.wneu.2024.08.128_bib42","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1440-1789.2012.01297.x","article-title":"A\u00a0study of clinico-pathological parameters and O\u2076-methylguanine DNA methyltransferase (MGMT) promoter methylation status in the prognostication of gliosarcoma","volume":"32","author":"Singh","year":"2012","journal-title":"Neuropathology"},{"key":"10.1016\/j.wneu.2024.08.128_bib43","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s11060-019-03304-x","article-title":"Treatment strategies for glioblastoma in older patients: age is just a number","volume":"145","author":"Youssef","year":"2019","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib44","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s11060-015-2046-0","article-title":"Clinical outcome of gliosarcoma compared with glioblastoma multiforme: a clinical study in Chinese patients","volume":"127","author":"Zhang","year":"2016","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2024.08.128_bib45","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jocn.2013.07.042","article-title":"Clinical management and survival outcomes of gliosarcomas in the era of multimodality therapy","volume":"21","author":"Damodaran","year":"2014","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.wneu.2024.08.128_bib46","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N\u00a0Engl J Med"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024014979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024014979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:16:08Z","timestamp":1762560968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875024014979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":46,"alternative-id":["S1878875024014979"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2024.08.128","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic Factors for Patients with Primary Gliosarcoma: A Single-Center Retrospective Study","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2024.08.128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}