{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:54:03Z","timestamp":1784883243051,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.wneu.2024.12.015","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T04:28:58Z","timestamp":1735360138000},"page":"123556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Noninvasive Skin Autofluorescence of Advanced Glycation End Products in Patients with Degenerative Cervical Myelopathy"],"prefix":"10.1016","volume":"194","author":[{"given":"Toru","family":"Doi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sugaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Horii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichiro","family":"Tozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4908-309X","authenticated-orcid":false,"given":"Hiroyuki","family":"Nakarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Ohtomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-5361","authenticated-orcid":false,"given":"Koji","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosei","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7564-5944","authenticated-orcid":false,"given":"Naoki","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6929-9619","authenticated-orcid":false,"given":"Hideki","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-123X","authenticated-orcid":false,"given":"Yuki","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Matsubayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakae","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2024.12.015_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41582-019-0303-0","article-title":"Degenerative cervical myelopathy - update and future directions","volume":"16","author":"Badhiwala","year":"2020","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.wneu.2024.12.015_bib2","doi-asserted-by":"crossref","first-page":"k186","DOI":"10.1136\/bmj.k186","article-title":"Degenerative cervical myelopathy","volume":"360","author":"Davies","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.wneu.2024.12.015_bib3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.spinee.2013.02.005","article-title":"Correlation of magnetic resonance diffusion tensor imaging and clinical findings of cervical myelopathy","volume":"13","author":"Yoo","year":"2013","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2024.12.015_bib4","article-title":"Monitoring for myelopathic progression with multiparametric quantitative MRI","volume":"13","author":"Martin","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.wneu.2024.12.015_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-019809","article-title":"Can microstructural MRI detect subclinical tissue injury in subjects with asymptomatic cervical spinal cord compression? A prospective cohort study","volume":"8","author":"Martin","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.wneu.2024.12.015_bib6","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3174\/ajnr.A5163","article-title":"Clinically feasible microstructural MRI to quantify cervical spinal cord tissue injury using DTI, MT, and T2\u2217-weighted imaging: assessment of normative data and reliability","volume":"38","author":"Martin","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.wneu.2024.12.015_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/srep24636","article-title":"Voxel-based analysis of grey and white matter degeneration in cervical spondylotic myelopathy","volume":"6","author":"Grabher","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.wneu.2024.12.015_bib8","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1089\/neu.2017.4980","article-title":"Neurodegeneration in the spinal ventral horn prior to motor impairment in cervical spondylotic myelopathy","volume":"34","author":"Grabher","year":"2017","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.wneu.2024.12.015_bib9","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.spinee.2022.06.012","article-title":"Cerebrospinal fluid biomarkers of white matter injury and astrogliosis are associated with the severity and surgical outcome of degenerative cervical spondylotic myelopathy","volume":"22","author":"Tsitsopoulos","year":"2022","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2024.12.015_bib10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3171\/2020.8.SPINE20965","article-title":"Cerebrospinal fluid biomarkers of glial and axonal injury in cervical spondylotic myelopathy","volume":"34","author":"Tsitsopoulos","year":"2021","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2024.12.015_bib11","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.jocn.2014.04.021","article-title":"Phosphorylated neurofilament subunit NF-H becomes elevated in the cerebrospinal fluid of patients with acutely worsening symptoms of compression myelopathy","volume":"21","author":"Takahashi","year":"2014","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.wneu.2024.12.015_bib12","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00701-009-0408-0","article-title":"Significance of serial S100b and NSE serum measurements in surgically treated patients with spondylotic cervical myelopathy","volume":"151","author":"Marquardt","year":"2009","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.wneu.2024.12.015_bib13","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.jocn.2015.03.047","article-title":"Phosphorylated neurofilament subunit levels in the serum of cervical compressive myelopathy patients","volume":"22","author":"Kato","year":"2015","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.wneu.2024.12.015_bib14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/MOL.0b013e32835aea13","article-title":"Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity","volume":"24","author":"Gaens","year":"2013","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.wneu.2024.12.015_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cmet.2018.08.014","article-title":"The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality","volume":"28","author":"Chaudhuri","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.wneu.2024.12.015_bib16","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJM198805193182007","article-title":"Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications","volume":"318","author":"Brownlee","year":"1988","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2024.12.015_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.med.46.1.223","article-title":"Advanced protein glycosylation in diabetes and aging","volume":"46","author":"Brownlee","year":"1995","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.wneu.2024.12.015_bib18","doi-asserted-by":"crossref","first-page":"E40","DOI":"10.1097\/BRS.0000000000004516","article-title":"Noninvasive skin autofluorescence of advanced glycation end products for detecting ossification of the posterior longitudinal ligament in the thoracic spine","volume":"48","author":"Doi","year":"2023","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2024.12.015_bib19","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1007\/s00125-004-1451-2","article-title":"Simple non-invasive assessment of advanced glycation endproduct accumulation","volume":"47","author":"Meerwaldt","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.wneu.2024.12.015_bib20","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3390\/antiox9080755","article-title":"Advanced glycation end product accumulation in subjects with open-angle glaucoma with and without exfoliation","volume":"9","author":"Shirakami","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.wneu.2024.12.015_bib21","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/gerona\/gly233","article-title":"Advanced glycation end product accumulation is associated with low skeletal muscle mass, weak muscle strength, and reduced bone density: the nagahama study","volume":"74","author":"Tabara","year":"2019","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.wneu.2024.12.015_bib22","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.3390\/antiox9111100","article-title":"Evaluation of relevance between advanced glycation end products and diabetic retinopathy stages using skin autofluorescence","volume":"9","author":"Takayanagi","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.wneu.2024.12.015_bib23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3164\/jcbn.15-132","article-title":"Non-invasive measurement of skin autofluorescence to evaluate diabetic complications","volume":"58","author":"Yamanaka","year":"2016","journal-title":"J\u00a0Clin Biochem Nutr"},{"key":"10.1016\/j.wneu.2024.12.015_bib24","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.spinee.2019.06.001","article-title":"Increased advanced glycation end products in hypertrophied ligamentum flavum of diabetes mellitus patients","volume":"19","author":"Maruf","year":"2019","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2024.12.015_bib25","doi-asserted-by":"crossref","first-page":"E337","DOI":"10.1097\/01.brs.0000263417.17526.35","article-title":"Immunohistochemical demonstration of advanced glycation end products and the effects of advanced glycation end products in ossified ligament tissues in\u00a0vitro","volume":"32","author":"Yokosuka","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2024.12.015_bib26","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00198-013-2489-0","article-title":"Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: a 3-year follow-up of the ROAD study","volume":"25","author":"Yoshimura","year":"2014","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.wneu.2024.12.015_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jocn.2020.12.005","article-title":"Percutaneously-quantified advanced glycation end-products (AGEs) accumulation associates with low back pain and lower extremity symptoms in middle-aged low back pain patients","volume":"84","author":"Umimura","year":"2021","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.wneu.2024.12.015_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00003086-198404000-00010","article-title":"Ossification of the posterior longitudinal ligament of the spine","volume":"184","author":"Tsuyama","year":"1984","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.wneu.2024.12.015_bib29","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1097\/BRS.0000000000001643","article-title":"Prevalence, concomitance, and distribution of ossification of the spinal ligaments: results of whole spine ct scans in 1500 Japanese patients","volume":"41","author":"Fujimori","year":"2016","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2024.12.015_bib30","doi-asserted-by":"crossref","first-page":"E394","DOI":"10.1097\/BRS.0000000000000791","article-title":"Ossification of the posterior longitudinal ligament of the cervical spine in 3161 patients: a CT-based study","volume":"40","author":"Fujimori","year":"2015","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2024.12.015_bib31","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/BRS.0000000000004612","article-title":"Effect of early postoperative resolution of MRI signal intensity Changes on the outcomes of degenerative cervical myelopathy","volume":"48","author":"Tozawa","year":"2023","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2024.12.015_bib32","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/00007632-199903150-00022","article-title":"The optimal radiologic method for assessing spinal canal compromise and cord compression in patients with cervical spinal cord injury. Part I: an evidence-based analysis of the published literature","volume":"24","author":"Rao","year":"1999","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2024.12.015_bib33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/BRS.0b013e3182672307","article-title":"Reliability of quantitative magnetic resonance imaging methods in the assessment of spinal canal stenosis and cord compression in cervical myelopathy","volume":"38","author":"Karpova","year":"2013","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2024.12.015_bib34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ncl.2007.01.004","article-title":"Epidemiology and risk factors for spine pain","volume":"25","author":"Rubin","year":"2007","journal-title":"Neurol Clin"},{"key":"10.1016\/j.wneu.2024.12.015_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2487924","article-title":"Relationship between neuropathic pain and obesity","volume":"2016","author":"Hozumi","year":"2016","journal-title":"Pain Res Manag"},{"key":"10.1016\/j.wneu.2024.12.015_bib36","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/00007632-199011010-00002","article-title":"Clinical value of magnetic resonance imaging for cervical myelopathy","volume":"15","author":"Nagata","year":"1990","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2024.12.015_bib37","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2174\/138161208784139774","article-title":"Role of advanced glycation end products in diabetic neuropathy","volume":"14","author":"Sugimoto","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.wneu.2024.12.015_bib38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2106\/JBJS.O.00297","article-title":"Diabetes is related to worse patient-reported outcomes at two years following spine surgery","volume":"98","author":"Armaghani","year":"2016","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.wneu.2024.12.015_bib39","doi-asserted-by":"crossref","first-page":"E708","DOI":"10.1097\/BRS.0000000000001947","article-title":"Characteristics of Residual symptoms after Laminoplasty in diabetic patients with cervical spondylotic myelopathy: a prospective cohort study","volume":"42","author":"Machino","year":"2017","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2024.12.015_bib40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbi.2014.06.199","article-title":"Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain","volume":"42","author":"Allette","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.wneu.2024.12.015_bib41","article-title":"Association between the accumulation of pentosidine at the sciatic nerve and Cutaneous Hindpaw hypersensitivity in a rat Ovariectomy model","volume":"14","author":"Umimura","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.wneu.2024.12.015_bib42","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-031486","article-title":"Recovery priorities in degenerative cervical myelopathy: a cross-sectional survey of an international, online community of patients","volume":"9","author":"Davies","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.wneu.2024.12.015_bib43","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1177\/2192568220986143","article-title":"Moving beyond the neck and arm: the pain Experience of People with degenerative cervical myelopathy who have pain","volume":"12","author":"Boerger","year":"2022","journal-title":"Global Spine J"},{"key":"10.1016\/j.wneu.2024.12.015_bib44","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/BRS.0000000000004359","article-title":"Clinical indicators of surgical outcomes after Laminoplasty for patients with cervical ossification of the posterior longitudinal ligament: a prospective Multicenter study","volume":"47","author":"Nagoshi","year":"2022","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2024.12.015_bib45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41572-019-0092-1","article-title":"Diabetic neuropathy","volume":"5","author":"Feldman","year":"2019","journal-title":"Nat Rev Dis Primers"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024020060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875024020060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T06:04:41Z","timestamp":1750226681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875024020060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":45,"alternative-id":["S1878875024020060"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2024.12.015","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Noninvasive Skin Autofluorescence of Advanced Glycation End Products in Patients with Degenerative Cervical Myelopathy","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2024.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"123556"}}