{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:08:47Z","timestamp":1790874527864,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.wneu.2025.123791","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T04:22:04Z","timestamp":1742271724000},"page":"123791","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Clinical and Radiographic Presentation and Surgical Outcomes of T-Box Pituitary Transcription Factor (TPIT) Silent Corticotroph Pituitary Neuroendocrine Tumors: A Multi-institutional Experience and Review of the Literature"],"prefix":"10.1016","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6480-663X","authenticated-orcid":false,"given":"Spencer","family":"Raub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Fixman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4971-4853","authenticated-orcid":false,"given":"Thomas","family":"Hanks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-5873","authenticated-orcid":false,"given":"Dominic","family":"Nistal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Racheal","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Eaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniya","family":"Tyrtova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8424-8331","authenticated-orcid":false,"given":"Luis","family":"Gonzalez-Cuyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"DeSantis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Alan","family":"Failor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Wisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Norman E.","family":"Garrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1994-2878","authenticated-orcid":false,"given":"Samuel","family":"Emerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Cote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Zada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Manuel","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Ruzevick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2025.123791_bib1","first-page":"1706","article-title":"Silent corticotroph pituitary adenomas: clinical characteristics, long-term outcomes, and management of disease recurrence","volume":"135","author":"Strickland","year":"2021","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2025.123791_bib2","first-page":"723","article-title":"Clinically silent corticotroph tumors of the pituitary gland","volume":"47","author":"Scheithauer","year":"2000","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2025.123791_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11102-014-0624-3","article-title":"Silent corticotroph adenomas","volume":"18","author":"Cooper","year":"2015","journal-title":"Pituitary"},{"key":"10.1016\/j.wneu.2025.123791_bib4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1101\/gad.1065703","article-title":"Tpit determines alternate fates during pituitary cell differentiation","volume":"17","author":"Pulichino","year":"2003","journal-title":"Genes Dev"},{"key":"10.1016\/j.wneu.2025.123791_bib5","first-page":"1009","article-title":"Mutations du facteur de transcription Tpitet diff\u00e9renciation hypophysaire","volume":"20","author":"Pulichino","year":"2004","journal-title":"M-S (Med Sci)"},{"key":"10.1016\/j.wneu.2025.123791_bib6","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/cancers12020514","article-title":"How to classify pituitary neuroendocrine tumors (PitNET)s in 2020","volume":"12","author":"Trouillas","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.wneu.2025.123791_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","article-title":"Overview of the 2022 WHO classification of pituitary tumors","volume":"33","author":"Asa","year":"2022","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.wneu.2025.123791_bib8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.5858\/arpa.2021-0479-OA","article-title":"Transcription factor immunohistochemistry in the classification of pituitary neuroendocrine tumor\/adenoma: proposal in a limited-resource setting","volume":"148","author":"Sood","year":"2023","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.wneu.2025.123791_bib9","article-title":"Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET","volume":"4","author":"Zhang","year":"2023","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.wneu.2025.123791_bib10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11102-018-0864-8","article-title":"Silent corticotroph adenomas","volume":"21","author":"Ben-Shlomo","year":"2018","journal-title":"Pituitary"},{"key":"10.1016\/j.wneu.2025.123791_bib11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1227\/NEU.0b013e318257c1f0","article-title":"Silent corticotroph adenomas: emory university cohort and comparison with ACTH-negative nonfunctioning pituitary adenomas","volume":"71","author":"Ioachimescu","year":"2012","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2025.123791_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1365-2265.2003.01674.x","article-title":"Non-functioning pituitary adenomas with positive immunoreactivity for ACTH behave more aggressively than ACTH immunonegative tumours but do not recur more frequently","volume":"58","author":"Bradley","year":"2003","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.wneu.2025.123791_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/02688690500081230","article-title":"A\u00a0spectrum of behaviour in silent corticotroph pituitary adenomas","volume":"19","author":"Baldeweg","year":"2005","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.wneu.2025.123791_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1227\/01.neu.0000429858.96652.1e","article-title":"A\u00a0comprehensive long-term retrospective analysis of silent corticotrophic adenomas vs hormone-negative adenomas","volume":"73","author":"Jahangiri","year":"2013","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2025.123791_bib15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12022-015-9398-z","article-title":"The complementary role of transcription factors in the accurate diagnosis of clinically nonfunctioning pituitary adenomas","volume":"26","author":"Nishioka","year":"2015","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.wneu.2025.123791_bib16","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s00701-021-04911-2","article-title":"A\u00a0clinicoradiological analysis of silent corticotroph adenomas after the introduction of pituitary-specific transcription factors","volume":"163","author":"Goyal-Honavar","year":"2021","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.wneu.2025.123791_bib17","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s11102-021-01133-8","article-title":"Clinical profiles of silent corticotroph adenomas compared with silent gonadotroph adenomas after adopting the 2017 WHO pituitary classification system","volume":"24","author":"Jiang","year":"2021","journal-title":"Pituitary"},{"key":"10.1016\/j.wneu.2025.123791_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J\u00a0Biomed Inform"},{"key":"10.1016\/j.wneu.2025.123791_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J\u00a0Biomed Inform"},{"key":"10.1016\/j.wneu.2025.123791_bib20","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1093\/neuros\/nyaa548","article-title":"Neuropathology of pituitary adenomas and sellar lesions","volume":"88","author":"Kobalka","year":"2021","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2025.123791_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1530\/EJE-10-0076","article-title":"Clinical, hormonal and molecular characterization of pituitary ACTH adenomas without (silent corticotroph adenomas) and with Cushing\u2019s disease","volume":"163","author":"Raverot","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.wneu.2025.123791_bib23","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1210\/jc.2018-00688","article-title":"Clinical and pathological aspects of silent pituitary adenomas","volume":"104","author":"Drummond","year":"2019","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.wneu.2025.123791_bib24","doi-asserted-by":"crossref","first-page":"592","DOI":"10.5858\/arpa.2020-0091-OA","article-title":"The role of T-box transcription factor in a pituitary adenoma diagnostic algorithm","volume":"145","author":"McDonald","year":"2021","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.wneu.2025.123791_bib25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s11060-017-2379-y","article-title":"Molecular markers in glioma","volume":"134","author":"Ludwig","year":"2017","journal-title":"J\u00a0Neuro Oncol"},{"key":"10.1016\/j.wneu.2025.123791_bib26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1089\/scd.2013.0419","article-title":"Interactions of mesenchymal stem cells with endothelial cells","volume":"23","author":"Nassiri","year":"2014","journal-title":"Stem Cells Dev"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875025001470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875025001470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T19:47:34Z","timestamp":1757533654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875025001470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":25,"alternative-id":["S1878875025001470"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2025.123791","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and Radiographic Presentation and Surgical Outcomes of T-Box Pituitary Transcription Factor (TPIT) Silent Corticotroph Pituitary Neuroendocrine Tumors: A Multi-institutional Experience and Review of the Literature","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2025.123791","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"123791"}}