{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T04:40:06Z","timestamp":1747456806413,"version":"3.40.5"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.wneu.2025.123877","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T17:11:09Z","timestamp":1741367469000},"page":"123877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Neuroprotective Effects of Halofuginone in Rat's Sciatic Nerve Injury"],"prefix":"10.1016","volume":"197","author":[{"given":"\u00d6mer","family":"\u015eahin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuncer","family":"Ta\u015fc\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015feg\u00fcl","family":"F\u0131rat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Sel\u00e7uk","family":"S\u00fcr\u00fcc\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzaffer","family":"\u00c7aydere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9192-6674","authenticated-orcid":false,"given":"Duran Berker","family":"Cemil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2025.123877_bib1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3944\/AOTT.2008.278","article-title":"Electrophysiologic and histopathologic evaluation of peripheral nerve regeneration at different nerve segments and with different repair techniques","volume":"42","author":"Kar\u015fida\u011f","year":"2008","journal-title":"Acta Orthop Traumatol Turc"},{"key":"10.1016\/j.wneu.2025.123877_bib2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.prp.2011.06.011","article-title":"Curcumin protects the dorsal root ganglion and sciatic nerve after crush in rat","volume":"207","author":"Noorafshan","year":"2011","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.wneu.2025.123877_bib3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.micron.2011.01.002","article-title":"Effects of curcumin on the dorsal root ganglion structure and functional recovery after sciatic nerve crush in rat","volume":"42","author":"Noorafshan","year":"2011","journal-title":"Micron"},{"key":"10.1016\/j.wneu.2025.123877_bib4","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/SAP.0000000000000026","article-title":"An experimental comparison of the effects of propolis, curcumin, and methylprednisolone on crush injuries of the sciatic nerve","volume":"74","author":"Y\u00fcce","year":"2015","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.wneu.2025.123877_bib5","first-page":"45","article-title":"Efficacy of static magnetic field therapy on pain intensity, functional disability, sleep quality, and depressive symptoms in patients with mechanical neck and low back pain","volume":"32","author":"Gencler","year":"2024","journal-title":"Complement Med Res"},{"key":"10.1016\/j.wneu.2025.123877_bib6","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10143-009-0193-5","article-title":"Comparison of collagen biomatrix and omentum effectiveness on peripheral nerve regeneration","volume":"32","author":"Cemil","year":"2009","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.wneu.2025.123877_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nchembio.790","article-title":"Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase","volume":"8","author":"Keller","year":"2012","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.wneu.2025.123877_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/molecules20010573","article-title":"Halofuginone - the multifaceted molecule","volume":"20","author":"Pines","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.wneu.2025.123877_bib9","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1126\/science.1172638","article-title":"Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response","volume":"324","author":"Sundrud","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.wneu.2025.123877_bib10","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.ejca.2005.12.027","article-title":"New Drug Development Group (NDDG). Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours","volume":"42","author":"de Jonge","year":"2006","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.wneu.2025.123877_bib11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/01616412.2022.2143617","article-title":"Levetiracetam treatment in an experimental model of sciatic nerve injury: a randomized controlled trial","volume":"45","author":"Apaydin","year":"2023","journal-title":"Neurol Res"},{"key":"10.1016\/j.wneu.2025.123877_bib12","first-page":"30","article-title":"Halofuginone reduces the occurrence of renal fibrosis in 5\/6 nephrectomized rats","volume":"9","author":"Benchetrit","year":"2007","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.wneu.2025.123877_bib13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0014-4886(88)90209-9","article-title":"Functional consequences of experimental nerve lesions: effects of reinnervation blend","volume":"100","author":"de Medinaceli","year":"1988","journal-title":"Exp Neurol"},{"key":"10.1016\/j.wneu.2025.123877_bib14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/micr.1920110221","article-title":"Use of sciatic function index and walking track assessment","volume":"11","author":"De Medinaceli","year":"1990","journal-title":"Microsurgery"},{"key":"10.1016\/j.wneu.2025.123877_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00006534-199202000-00009","article-title":"Walking track analysis: a long-term assessment of peripheral nerve recovery","volume":"89","author":"Hare","year":"1992","journal-title":"Plastreconstr Surg"},{"key":"10.1016\/j.wneu.2025.123877_bib16","first-page":"49","article-title":"Ultrastructural scoring of graded acute spinal cord injury in the rat","volume":"97","author":"Kaptanoglu","year":"2002","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2025.123877_bib17","first-page":"1089","article-title":"Post-injury regeneration in rat sciatic nerve facilitated by neurotrophic factors secreted by amniotic fluid mesenchymal stem cells","volume":"14","author":"Pan","year":"2007","journal-title":"J Clinneurosci"},{"key":"10.1016\/j.wneu.2025.123877_bib18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jss.2009.06.002","article-title":"The effects of exogenous melatonin on peripheral nerve regeneration and collagen formation in rats","volume":"166","author":"Atik","year":"2011","journal-title":"J Surg Res"},{"key":"10.1016\/j.wneu.2025.123877_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117015","article-title":"Effect of mesenchymal stem cells and melatonin on experimentally induced peripheral nerve injury in rats","volume":"177","author":"Khodir","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.wneu.2025.123877_bib20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2147\/JN.S140614","article-title":"Melatonin and sciatic nerve injury repair: a current perspective","volume":"6","author":"Altunkaynak","year":"2018","journal-title":"J Neurorestoratol"},{"key":"10.1016\/j.wneu.2025.123877_bib21","first-page":"2018","article-title":"Human umbilical cord blood-derived mesenchymal stem cells promote regeneration of crush-injured rat sciatic nerves","volume":"7","author":"Sung","year":"2012","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.wneu.2025.123877_bib22","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.jcms.2017.05.004","article-title":"Possible effects of some agents on the injured nerve in obese rats: a stereological and electron microscopic study","volume":"45","author":"Onger","year":"2017","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.wneu.2025.123877_bib23","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.3382\/ps.0701559","article-title":"Increased skin tearing in broilers and reduced collagen synthesis in skin in vivo and in vitro in response to the coccidiostathalofuginone","volume":"70","author":"Granot","year":"1991","journal-title":"Poult Sci"},{"key":"10.1016\/j.wneu.2025.123877_bib24","first-page":"47","article-title":"Smad3 as a mediator of the fibrotic response","volume":"85","author":"Flanders","year":"2004","journal-title":"Int J Exppathol"},{"key":"10.1016\/j.wneu.2025.123877_bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1189\/jlb.0705409","article-title":"Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells","volume":"80","author":"Leiba","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.wneu.2025.123877_bib27","first-page":"200","article-title":"Effect of mexiletine on lipid peroxidation and early ultrastructural findings in experimental spinal cord injury","volume":"91","author":"Kaptanoglu","year":"1999","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2025.123877_bib28","first-page":"77","article-title":"Comparison of the effects of melatonin and methylprednisolone in experimental spinal cord injury","volume":"93","author":"Kaptanoglu","year":"2000","journal-title":"J Neurosurg"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875025002335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875025002335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T04:06:38Z","timestamp":1747454798000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875025002335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":27,"alternative-id":["S1878875025002335"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2025.123877","relation":{},"ISSN":["1878-8750"],"issn-type":[{"type":"print","value":"1878-8750"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective Effects of Halofuginone in Rat's Sciatic Nerve Injury","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2025.123877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"123877"}}