{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:32:55Z","timestamp":1770337975966,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.wneu.2025.124023","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T16:11:48Z","timestamp":1745856708000},"page":"124023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Comparative Analysis of the Health-Related Quality of Life Between Patients with Familial and Sporadic Forms of Cerebral Cavernous Malformation"],"prefix":"10.1016","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-975X","authenticated-orcid":false,"given":"Alexandre Martins","family":"Cunha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-8417","authenticated-orcid":false,"given":"Gustavo","family":"da Fontoura Galv\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-8239","authenticated-orcid":false,"given":"Jorge","family":"Marcondes de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2025.124023_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jamaneurol.2017.0439","article-title":"Population-based prevalence of cerebral cavernous malformations in older adult","volume":"74","author":"Flemming","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.wneu.2025.124023_bib2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nrneurol.2009.177","article-title":"Cavernous Malformations: natural history, diagnosis and treatment","volume":"5","author":"Batra","year":"2009","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.wneu.2025.124023_bib3","first-page":"547","article-title":"Pathological heterogeneity of angiographically occult vascular malformations of the brain","volume":"33","author":"Robinson","year":"1993","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2025.124023_bib4","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1227\/01.NEU.0000249188.38409.03","article-title":"Spectrum of genotype and clinical manifestations in cerebral cavernous malformations","volume":"59","author":"Gault","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2025.124023_bib5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1474-4422(07)70053-4","article-title":"Genetics of cavernous angiomas","volume":"6","author":"Labauge","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.wneu.2025.124023_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1474-4422(12)70004-2","article-title":"Untreated clinical course of cerebral cavernous malformation: a prospective, population-base cohort study","volume":"11","author":"Al-Shahi Salman","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.wneu.2025.124023_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2019.3.JNS181724","article-title":"Cavernous angiomas: deconstructing a neurosurgical disease","volume":"131","author":"Awad","year":"2019","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2025.124023_bib8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3174\/ajnr.A0748","article-title":"Susceptibility-Weighted Imaging for the evaluation of patients with familial cerebral cavernous malformations: a comparison with T2-Weighted Fast Spin-Echo and Gradient-Echo sequences","volume":"29","author":"Souza","year":"2008","journal-title":"AJNR"},{"key":"10.1016\/j.wneu.2025.124023_bib9","series-title":"GeneReviews [Internet]","article-title":"Familial cerebral cavernous malformations","author":"Flemming","year":"1993"},{"key":"10.1016\/j.wneu.2025.124023_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.dhjo.2017.04.008","article-title":"People with multiple sclerosis report significantly worse symptons and health related quality of life than the US general population as measured by PROMIS and NeuroQoL outcome measures","volume":"11","author":"Amtmann","year":"2018","journal-title":"Disabil Health J"},{"key":"10.1016\/j.wneu.2025.124023_bib11","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jval.2019.02.004","article-title":"PROMIS adult health profiles: efficient short-form measures of seven health domains","volume":"22","author":"Cella","year":"2019","journal-title":"Value Health"},{"key":"10.1016\/j.wneu.2025.124023_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/CIRCOUTCOMES.118.004753","article-title":"Clinical utility of patient-reported outcome measurement information system domain scales","volume":"12","author":"Lapin","year":"2019","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.wneu.2025.124023_bib13","first-page":"1","article-title":"Use of patient-reported outcomes measurement information system measures in clinical researches in patients with stroke: a systematic literature review","volume":"4","author":"Arwert","year":"2022","journal-title":"Arch Rehabil Res Clin Transl"},{"key":"10.1016\/j.wneu.2025.124023_bib14","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.3171\/2010.6.FOCUS10127","article-title":"Patient-assessed satisfaction and outcome after microsurgical resection of cavernomas causing epilepsy","volume":"29","author":"Van Gompel","year":"2010","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2025.124023_bib15","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1227\/NEU.0b013e31821d31b7","article-title":"Quality of life after brainstem cavernoma surgery in 71 patients","volume":"69","author":"Dukatz","year":"2011","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2025.124023_bib16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.wneu.2016.08.014","article-title":"Quality of life after surgery for cerebral cavernoma: brainstem versus nonbrainstem location","volume":"95","author":"Cornelius","year":"2016","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2025.124023_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000480125","article-title":"Cerebral cavernous malformations: patient-reported outcome validates conservative management","volume":"44","author":"Bicalho","year":"2017","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.wneu.2025.124023_bib18","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1007\/s00701-019-04075-0","article-title":"Affected health domains in patients with brainstem cavernous malformations","volume":"161","author":"Kumar","year":"2019","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.wneu.2025.124023_bib19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/ene.14546","article-title":"Health-related quality of life in patients with untreated cavernous malformations of the central nervous system","volume":"28","author":"Herten","year":"2020","journal-title":"Europ J Neurol"},{"key":"10.1016\/j.wneu.2025.124023_bib20","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1161\/STROKEAHA.120.033487","article-title":"Baseline characteristics of patients with cavernous angiomas with symptomatic hemorrhage in multisite trial readiness project","volume":"52","author":"Kim","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2025.124023_bib21","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s10143-021-01572-8","article-title":"Long-term outcome and quality of life after CNS cavernoma resection: eloquent vs. non-eloquent areas","volume":"45","author":"Shoubash","year":"2022","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.wneu.2025.124023_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/brb3.2595","article-title":"Quality of life and mood assessment in conservartively treated cavernous malformation-related epilepsy","volume":"12","author":"Rauschenbach","year":"2022","journal-title":"Brain Behav"},{"key":"10.1016\/j.wneu.2025.124023_bib23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/STROKEAHA.123.044068","article-title":"Trial readiness of cavernous malformations with symptomatic hemorrhage, Part I: event rates and clinical outcome","volume":"55","author":"Flemming","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2025.124023_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1338941","article-title":"Patient-report outcome measures in patients with familial cerebral cavernous malformations: results from the Treat_CCM trial","volume":"15","author":"Meessen","year":"2024","journal-title":"Front Neurol"},{"key":"10.1016\/j.wneu.2025.124023_bib25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1474-4422(24)00096-6","article-title":"Medical management and surgery versus medical management alone for symptomatic cerebral cavernous malformation (CARE): a feasibility study and randomised, open, pragmatic, pilot phase trial","volume":"23","year":"2024","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.wneu.2025.124023_bib26","doi-asserted-by":"crossref","first-page":"e1210","DOI":"10.1212\/WNL.0000000000012569","article-title":"Seizure incidence rates in children and adults with familial cerebral cavernous malformations","volume":"97","author":"Fox","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.wneu.2025.124023_bib27","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.027572","article-title":"Intracranial hemorrhage rate and lesion burden in patients with familial cerebral cavernous malformation","volume":"12","author":"Weinsheimer","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.wneu.2025.124023_bib28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/neuros\/nyx091","article-title":"Synopsis of guidelines for the clinical management of cerebral cavernous malformations: consensus recommendations based on systematic literature review by the Angioma Alliance scientific advisory board clinical experts panel","volume":"80","author":"Akers","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2025.124023_bib29","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1161\/STROKEAHA.108.515544","article-title":"Hemorrhage from cavernous malformations of the brain: definition and reporting standards","volume":"39","author":"Al-Shahi Salman","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2025.124023_bib30","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3171\/jns.2000.93.6.0981","article-title":"Dynamic nature of cavernous malformations: a prospective magnetic resonance imaging study with volumetric analysis","volume":"93","author":"Clatterbuck","year":"2000","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2025.124023_bib31","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.3171\/2023.1.JNS222434","article-title":"Clinical presentation, hemorrhage risk, and outcome in patients with familial cavernous malformations: a pragmatic prospective analysis of 75 patients","volume":"139","author":"Alalfi","year":"2023","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2025.124023_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.108041","article-title":"Clinical features, hemorrhage risk and epilepsy outcomes of familial cerebral cavernous malformation: a 20-year observational pragmatic single-center study","volume":"33","author":"Galv\u00e3o","year":"2024","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.wneu.2025.124023_bib33","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00415-024-12805-3","article-title":"Patient-reported outcomes in conservatively managed cerebral cavernous malformations","volume":"272","author":"Sandmann","year":"2025","journal-title":"J Neurol"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875025003791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875025003791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T13:15:27Z","timestamp":1750857327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875025003791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":33,"alternative-id":["S1878875025003791"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2025.124023","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative Analysis of the Health-Related Quality of Life Between Patients with Familial and Sporadic Forms of Cerebral Cavernous Malformation","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2025.124023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"124023"}}