{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T05:25:32Z","timestamp":1794288332667,"version":"4.9.0"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.wneu.2026.125317","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:14:17Z","timestamp":1789085657000},"page":"125317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Feasibility of Real-Time Cellular Imaging Using a Miniaturized Epifluorescence Widefield Microscope for Intraoperative Margin Assessment in Intracranial Tumor Resection: A Pilot Study"],"prefix":"10.1016","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8089-6075","authenticated-orcid":false,"given":"Fei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5524-5756","authenticated-orcid":false,"given":"Jiacheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjia","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohao","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchu","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bixi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-0845","authenticated-orcid":false,"given":"Zhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2026.125317_bib1","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s10143-020-01337-9","article-title":"State-of-the-art imaging for glioma surgery","volume":"44","author":"Verburg","year":"2021","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.wneu.2026.125317_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2019.105512","article-title":"Intraoperative contrast-enhanced ultrasound for cerebral glioma resection and the relationship between microvascular perfusion and microvessel density","volume":"186","author":"Wang","year":"2019","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.wneu.2026.125317_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076988","article-title":"5-Aminolevulinic acid induced fluorescence is a powerful intraoperative marker for precise histopathological grading of gliomas with non-significant contrast-enhancement","volume":"8","author":"Widhalm","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.wneu.2026.125317_bib4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3171\/2022.5.JNS2282","article-title":"Intraoperative confocal laser endomicroscopy: prospective in vivo feasibility study of a clinical-grade system for brain tumors","volume":"138","author":"Abramov","year":"2023","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2026.125317_bib5","doi-asserted-by":"crossref","first-page":"E1104","DOI":"10.1055\/s-0043-117948","article-title":"Implementation of real-time probe-based confocal laser endomicroscopy (pCLE) for differentiation of colorectal polyps during routine colonoscopy","volume":"5","author":"Belderbos","year":"2017","journal-title":"Endosc Int Open"},{"key":"10.1016\/j.wneu.2026.125317_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.606574","article-title":"Ex vivo fluorescein-assisted confocal laser Endomicroscopy (CONVIVO\u00ae System) in patients with glioblastoma: results from a prospective Study","volume":"10","author":"Acerbi","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.wneu.2026.125317_bib7","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.29.5.050501","article-title":"Use of topical methylene blue to image nuclear morphometry with a low-cost scanning darkfield microendoscope","volume":"29","author":"Hou","year":"2024","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.wneu.2026.125317_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1750-3639.2012.00626.x","article-title":"Dye-Enhanced multimodal confocal imaging as a novel approach to intraoperative diagnosis of brain tumors","volume":"23","author":"Snuderl","year":"2013","journal-title":"Brain Pathol"},{"key":"10.1016\/j.wneu.2026.125317_bib9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11864-017-0487-8","article-title":"Surgical considerations in the optimal management of patients with malignant brain tumors","volume":"18","author":"Renfrow","year":"2017","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.wneu.2026.125317_bib10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2463\/mrms.rev.2021-0116","article-title":"Intraoperative MR imaging during glioma resection","volume":"21","author":"Matsumae","year":"2022","journal-title":"Magn Reson Med Sci"},{"key":"10.1016\/j.wneu.2026.125317_bib11","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3171\/2009.2.JNS08535","article-title":"Reliability of intraoperative high-resolution 2D ultrasound as an alternative to high-field strength MR imaging for tumor resection control: a prospective comparative study","volume":"111","author":"Gerganov","year":"2009","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2026.125317_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13058-018-1002-2","article-title":"Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery","volume":"20","author":"Shipp","year":"2018","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.wneu.2026.125317_bib13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3389\/fonc.2019.00583","article-title":"Confocal-Assisted multispectral fluorescent microscopy for brain tumor surgery","volume":"9","author":"Charalampaki","year":"2019","journal-title":"Front Oncol"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875026005334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875026005334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T05:18:38Z","timestamp":1794287918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875026005334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":13,"alternative-id":["S1878875026005334"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2026.125317","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Feasibility of Real-Time Cellular Imaging Using a Miniaturized Epifluorescence Widefield Microscope for Intraoperative Margin Assessment in Intracranial Tumor Resection: A Pilot Study","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2026.125317","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"125317"}}