{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:40:56Z","timestamp":1792798856664,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["AJOG Global Reports"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.xagr.2026.100660","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:52:56Z","timestamp":1781279576000},"page":"100660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical resiniferatoxin for the treatment of vestibulodynia: a prospective observational trial"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9966-6448","authenticated-orcid":false,"given":"Filippo","family":"Murina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Fochesato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Slanzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Donini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicla","family":"Toni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Savasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.xagr.2026.100660_bib0001","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jsxm.2015.12.021","article-title":"Vulvodynia: definition, prevalence, impact, and pathophysiological factors","volume":"13","author":"Pukall","year":"2016","journal-title":"J Sex Med"},{"issue":"4","key":"10.1016\/j.xagr.2026.100660_bib0002","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jsxm.2016.02.167","article-title":"2015 ISSVD, ISSWSH, and IPPS consensus terminology and classification of persistent vulvar pain and vulvodynia","volume":"13","author":"Bornstein","year":"2016","journal-title":"J Sex Med"},{"key":"10.1016\/j.xagr.2026.100660_bib0003","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jad.2023.10.025","article-title":"Assessment of anxiety, depression and somatization in women with vulvodynia: a systematic review and META-analysis","volume":"344","author":"Dagostin Ferraz","year":"2024","journal-title":"J Affect Disord"},{"issue":"1","key":"10.1016\/j.xagr.2026.100660_bib0004","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41572-020-0164-2","article-title":"Vulvodynia","volume":"6","author":"Bergeron","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"10.1016\/j.xagr.2026.100660_bib0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ca.23966","article-title":"Innervation of the human vulvar vestibule: a comprehensive review","volume":"36","author":"Velikonja","year":"2023","journal-title":"Clin Anat"},{"issue":"5","key":"10.1016\/j.xagr.2026.100660_bib0006","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/jsxmed\/qdae030","article-title":"Immunohistochemical staining with CD117 and PGP9.5 of excised vestibular tissue from patients with neuroproliferative vestibulodynia","volume":"21","author":"Drian","year":"2024","journal-title":"J Sex Med"},{"issue":"2","key":"10.1016\/j.xagr.2026.100660_bib0007","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1090-3801(03)00085-5","article-title":"Increased vanilloid receptor VR1 innervation in vulvodynia","volume":"8","author":"Tympanidis","year":"2004","journal-title":"Eur J Pain"},{"issue":"1","key":"10.1016\/j.xagr.2026.100660_bib0008","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/brain\/awae228","article-title":"Inflammation-induced mast cell-derived nerve growth factor: a key player in chronic vulvar pain?","volume":"148","author":"Awad-Igbaria","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.xagr.2026.100660_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1215380","article-title":"Immune mechanisms in vulvodynia: key roles for mast cells and fibroblasts","volume":"13","author":"Tonc","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"10.1016\/j.xagr.2026.100660_bib0010","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/LGT.0000000000000904","article-title":"A morpho-functional assessment of the vulvar vestibule in patients with vestibulodynia: a case-control study","volume":"29","author":"Murina","year":"2025","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.xagr.2026.100660_bib0011","first-page":"2178","article-title":"Active and passive components of pelvic floor muscle tone in women with provoked vestibulodynia: a perspective based on a review of the literature","volume":"12","author":"Thibault-Gagnon","year":"2015","journal-title":"JSexMed"},{"key":"10.1016\/j.xagr.2026.100660_bib0012","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jsxm.2017.02.012","article-title":"Heightened pelvic floor muscle tone and altered contractility in women with provoked vestibulodynia","volume":"14","author":"Morin","year":"2017","journal-title":"J Sex Med"},{"key":"10.1016\/j.xagr.2026.100660_bib0013","article-title":"A scoping review of vulvodynia research: diagnosis, treatment, and care experiences","volume":"21","author":"Lountzi","year":"2025","journal-title":"Womens Health (Lond)"},{"key":"10.1016\/j.xagr.2026.100660_bib0014","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2147\/TCRM.S58844","article-title":"Building a diagnostic algorithm on localized neuropathic pain (LNP) and targeted topical treatment: focus on 5% lidocaine-medicated plaster","volume":"10","author":"Casale","year":"2014","journal-title":"Ther Clin Risk Manag"},{"issue":"1","key":"10.1016\/j.xagr.2026.100660_bib0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2217\/pmt.11.77","article-title":"What is localized neuropathic pain? A first proposal to characterize and define a widely used term","volume":"2","author":"Mick","year":"2012","journal-title":"Pain Manag"},{"issue":"3","key":"10.1016\/j.xagr.2026.100660_bib0016","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11916-017-0615-y","article-title":"Topical treatments for localized neuropathic pain","volume":"21","author":"Casale","year":"2017","journal-title":"Curr Pain Headache Rep"},{"issue":"5","key":"10.1016\/j.xagr.2026.100660_bib0017","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s40265-019-01085-1","article-title":"Treatment of vulvodynia: pharmacological and non-pharmacological approaches","volume":"79","author":"Rosen","year":"2019","journal-title":"Drugs"},{"issue":"10","key":"10.1016\/j.xagr.2026.100660_bib0018","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.3390\/biomedicines13102440","article-title":"Efficacy and safety of topical 5% cannabidiol plus myrcene for the treatment of vestibulodynia: a multi-centric randomized controlled trial","volume":"13","author":"Murina","year":"2025","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.xagr.2026.100660_bib0019","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/ijgo.14815","article-title":"Vulvodynia: a practical guide in treatment strategies","volume":"163","author":"Santangelo","year":"2023","journal-title":"Int J Gynaecol Obstet"},{"issue":"20","key":"10.1016\/j.xagr.2026.100660_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015042","article-title":"Resiniferatoxin: nature's precision medicine to silence TRPV1-positive afferents","volume":"24","author":"Szallasi","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.xagr.2026.100660_bib0021","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/j.pain.0000000000002765","article-title":"Evaluation of a polymer-coated nanoparticle cream formulation of resiniferatoxin for the treatment of painful diabetic peripheral neuropathy","volume":"164","author":"Baskaran","year":"2023","journal-title":"Pain"},{"issue":"Supplement_1","key":"10.1016\/j.xagr.2026.100660_bib0022","doi-asserted-by":"crossref","DOI":"10.1093\/jsxmed\/qdaf068.026","article-title":"Key outcomes of the vulvodynia summit: identifying therapeutic options for further research study in the treatment of provoked vestibulodynia","volume":"22","author":"Krapf","year":"2025","journal-title":"J Sex Med"},{"issue":"4","key":"10.1016\/j.xagr.2026.100660_bib0023","first-page":"348","article-title":"Role of TRPV1 in health and disease","volume":"8","author":"Jaffal","year":"2023","journal-title":"J Explor Res Pharmacol"},{"key":"10.1016\/j.xagr.2026.100660_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2024.102447","article-title":"Targeting TRP channels for pain relief: a review of current evidence from bench to bedside","volume":"75","author":"Koivisto","year":"2024","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"10.1016\/j.xagr.2026.100660_bib0025","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/ph9030047","article-title":"Resiniferatoxin: the evolution of the \"Molecular Scalpel\" for chronic pain relief","volume":"9","author":"Brown","year":"2016","journal-title":"Pharmaceuticals (Basel)"},{"issue":"6","key":"10.1016\/j.xagr.2026.100660_bib0026","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/jsxmed\/qdad040","article-title":"Characterizing the innervation of the vulvar vestibule and the immunohistochemical features of neuroproliferative vestibulodynia","volume":"20","author":"Tomalty","year":"2023","journal-title":"J Sex Med"},{"key":"10.1016\/j.xagr.2026.100660_bib0027","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-3-642-54215-2_9","article-title":"TRPV1","volume":"222","author":"Bevan","year":"2014","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.xagr.2026.100660_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.551786","article-title":"Regulation of pain genes\u2014capsaicin vs resiniferatoxin: reassessment of transcriptomic data","volume":"11","author":"Singla","year":"2020","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.xagr.2026.100660_bib0029","article-title":"A survey of patient tolerance and satisfaction with capsaicin for neuroproliferative vestibulodynia","volume":"12","author":"Kopits","year":"2024","journal-title":"Sex Med"},{"issue":"5","key":"10.1016\/j.xagr.2026.100660_bib0030","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.ajog.2004.10.626","article-title":"Capsaicin for the treatment of vulvar vestibulitis","volume":"192","author":"Steinberg","year":"2005","journal-title":"Am J ObstetGynecol"},{"issue":"4","key":"10.1016\/j.xagr.2026.100660_bib0031","first-page":"48","article-title":"Capsaicin and the treatment of vulvar vestibulitis syndrome: a valuable alternative?","volume":"6","author":"Murina","year":"2004","journal-title":"MedGenMed"},{"issue":"2","key":"10.1016\/j.xagr.2026.100660_bib0032","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0304-3959(92)90259-E","article-title":"Painful neuropathy: altered central processing maintained dynamically by peripheral input","volume":"51","author":"Gracely","year":"1992","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.xagr.2026.100660_bib0033","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0169-328X(89)90025-9","article-title":"Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord","volume":"6","author":"Draisci","year":"1989","journal-title":"Brain Res Mol Brain Res"}],"container-title":["AJOG Global Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666577826000584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666577826000584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:08:30Z","timestamp":1792796910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666577826000584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2666577826000584"],"URL":"https:\/\/doi.org\/10.1016\/j.xagr.2026.100660","relation":{},"ISSN":["2666-5778"],"issn-type":[{"value":"2666-5778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical resiniferatoxin for the treatment of vestibulodynia: a prospective observational trial","name":"articletitle","label":"Article Title"},{"value":"AJOG Global Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xagr.2026.100660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100660"}}