{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:43:03Z","timestamp":1793256183482,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.xcrm.2020.100155","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T11:52:49Z","timestamp":1608637969000},"page":"100155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Stimulation of B Cell Immunity in Flavivirus-Naive Individuals by the Tetravalent Live Attenuated Dengue Vaccine TV003"],"prefix":"10.1016","volume":"1","author":[{"given":"Huy A.","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha K.","family":"Nivarthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy R.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Eisenhauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Delacruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen K.","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Boyson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason W.","family":"Botten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth D.","family":"Kirkpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna P.","family":"Durbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravinda M.","family":"deSilva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean A.","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2020.100155_bib1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2020.100155_bib2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(18)32560-1","article-title":"Dengue","volume":"393","author":"Wilder-Smith","year":"2019","journal-title":"Lancet"},{"issue":"Suppl 1","key":"10.1016\/j.xcrm.2020.100155_bib3","first-page":"E48","article-title":"Antibodies determine virulence in dengue","volume":"1171","author":"Halstead","year":"2009","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.xcrm.2020.100155_bib4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4269\/ajtmh.1990.42.179","article-title":"Dengue hemorrhagic fever in Cuba, 1981: a retrospective seroepidemiologic study","volume":"42","author":"Guzm\u00e1n","year":"1990","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.xcrm.2020.100155_bib5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri3916","article-title":"New insights into the immunopathology and control of dengue virus infection","volume":"15","author":"Screaton","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.xcrm.2020.100155_bib6","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1016\/j.vaccine.2013.06.079","article-title":"Identifying protective dengue vaccines: guide to mastering an empirical process","volume":"31","author":"Halstead","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.xcrm.2020.100155_bib7","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1128\/CVI.00131-10","article-title":"Correlates of protection induced by vaccination","volume":"17","author":"Plotkin","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.xcrm.2020.100155_bib8","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/S0140-6736(12)61428-7","article-title":"Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial","volume":"380","author":"Sabchareon","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.xcrm.2020.100155_bib9","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/S0140-6736(14)61060-6","article-title":"Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial","volume":"384","author":"Capeding","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.xcrm.2020.100155_bib10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1056\/NEJMoa1411037","article-title":"Efficacy of a tetravalent dengue vaccine in children in Latin America","volume":"372","author":"Villar","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.xcrm.2020.100155_bib11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa1800820","article-title":"Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy","volume":"379","author":"Sridhar","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.xcrm.2020.100155_bib12","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1056\/NEJMoa1903869","article-title":"Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents","volume":"381","author":"Biswal","year":"2019","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.xcrm.2020.100155_bib13","doi-asserted-by":"crossref","first-page":"e0005584","DOI":"10.1371\/journal.pntd.0005584","article-title":"In a randomized trial, the live attenuated tetravalent dengue vaccine TV003 is well-tolerated and highly immunogenic in subjects with flavivirus exposure prior to vaccination","volume":"11","author":"Whitehead","year":"2017","journal-title":"PLOS Negl. Trop. Dis."},{"key":"10.1016\/j.xcrm.2020.100155_bib14","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.1016\/j.vaccine.2011.07.023","article-title":"Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine","volume":"29","author":"Durbin","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.xcrm.2020.100155_bib15","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/infdis\/jis936","article-title":"A single dose of any of four different live attenuated tetravalent dengue vaccines is safe and immunogenic in flavivirus-naive adults: a randomized, double-blind clinical trial","volume":"207","author":"Durbin","year":"2013","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.xcrm.2020.100155_bib16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/infdis\/jiv082","article-title":"Robust and Balanced Immune Responses to All 4 Dengue Virus Serotypes Following Administration of a Single Dose of a Live Attenuated Tetravalent Dengue Vaccine to Healthy, Flavivirus-Naive Adults","volume":"212","author":"Kirkpatrick","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.xcrm.2020.100155_bib17","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/infdis\/jiw067","article-title":"A 12-Month-Interval Dosing Study in Adults Indicates That a Single Dose of the National Institute of Allergy and Infectious Diseases Tetravalent Dengue Vaccine Induces a Robust Neutralizing Antibody Response","volume":"214","author":"Durbin","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.xcrm.2020.100155_bib18","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S1473-3099(20)30023-2","article-title":"Safety and immunogenicity of the tetravalent, live-attenuated dengue vaccine Butantan-DV in adults in Brazil: a two-step, double-blind, randomised placebo-controlled phase 2 trial","volume":"20","author":"Kallas","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.xcrm.2020.100155_bib19","doi-asserted-by":"crossref","first-page":"330ra36","DOI":"10.1126\/scitranslmed.aaf1517","article-title":"The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model","volume":"8","author":"Kirkpatrick","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.xcrm.2020.100155_bib20","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/imm.12713","article-title":"Massive plasmablast response elicited in the acute phase of hantavirus pulmonary syndrome","volume":"151","author":"Garc\u00eda","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.xcrm.2020.100155_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/imr.12502","article-title":"B-cell responses to HIV infection","volume":"275","author":"Moir","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.xcrm.2020.100155_bib22","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1128\/JVI.06075-11","article-title":"Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans","volume":"86","author":"Wrammert","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.xcrm.2020.100155_bib23","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nature06890","article-title":"Rapid cloning of high-affinity human monoclonal antibodies against influenza virus","volume":"453","author":"Wrammert","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2020.100155_bib24","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1073\/pnas.1502619112","article-title":"Human Ebola virus infection results in substantial immune activation","volume":"112","author":"McElroy","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2020.100155_bib25","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ebiom.2019.02.060","article-title":"Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model","volume":"41","author":"Nivarthi","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.xcrm.2020.100155_bib26","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.4049\/jimmunol.1201688","article-title":"Plasmablasts generated during repeated dengue infection are virus glycoprotein-specific and bind to multiple virus serotypes","volume":"189","author":"Xu","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.xcrm.2020.100155_bib27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ni.3058","article-title":"A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus","volume":"16","author":"Dejnirattisai","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.xcrm.2020.100155_bib28","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4049\/jimmunol.1103350","article-title":"Association between magnitude of the virus-specific plasmablast response and disease severity in dengue patients","volume":"190","author":"Garcia-Bates","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.xcrm.2020.100155_bib29","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.immuni.2013.08.031","article-title":"Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses","volume":"39","author":"Locci","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.xcrm.2020.100155_bib30","doi-asserted-by":"crossref","first-page":"983","DOI":"10.4049\/jimmunol.1600318","article-title":"A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood","volume":"197","author":"Dan","year":"2016","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.xcrm.2020.100155_bib31","doi-asserted-by":"crossref","first-page":"E4256","DOI":"10.1073\/pnas.1505956112","article-title":"Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T\u00a0cells associated with protective immunity","volume":"112","author":"Weiskopf","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2020.100155_bib32","doi-asserted-by":"crossref","first-page":"e02147-16","DOI":"10.1128\/JVI.02147-16","article-title":"Human CD4+ T Cell Responses to an Attenuated Tetravalent Dengue Vaccine Parallel Those Induced by Natural Infection in Magnitude, HLA Restriction, and Antigen Specificity","volume":"91","author":"Angelo","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.xcrm.2020.100155_bib33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3389\/fimmu.2020.00479","article-title":"Rapid Induction and Maintenance of Virus-Specific CD8+ TEMRA and CD4+ TEM Cells Following Protective Vaccination Against Dengue Virus Challenge in Humans","volume":"11","author":"Graham","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.xcrm.2020.100155_bib34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nm.2071","article-title":"Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming","volume":"16","author":"Kwakkenbos","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.xcrm.2020.100155_bib35","doi-asserted-by":"crossref","first-page":"e124588","DOI":"10.1172\/jci.insight.124588","article-title":"Human antibody response to Zika targets type-specific quaternary structure epitopes","volume":"4","author":"Collins","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.xcrm.2020.100155_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/infdis\/jiz109","article-title":"Beyond Neutralizing Antibody Levels: The Epitope Specificity of Antibodies Induced by National Institutes of Health Monovalent Dengue Virus Vaccines","volume":"220","author":"Swanstrom","year":"2019","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.xcrm.2020.100155_bib37","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/infdis\/jiy063","article-title":"Analyzing the Human Serum Antibody Responses to a Live Attenuated Tetravalent Dengue Vaccine Candidate","volume":"217","author":"Swanstrom","year":"2018","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.xcrm.2020.100155_bib38","first-page":"351","article-title":"Dissecting Antibodies Induced by a Chimeric Yellow Fever-Dengue, Live-Attenuated, Tetravalent Dengue Vaccine (CYD-TDV) in Naive and Dengue-Exposed Individuals","volume":"215","author":"Henein","year":"2017","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.xcrm.2020.100155_bib39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10875-008-9267-3","article-title":"Human immune memory to yellow fever and smallpox vaccination","volume":"29","author":"Wrammert","year":"2009","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.xcrm.2020.100155_bib40","doi-asserted-by":"crossref","first-page":"e00867","DOI":"10.1128\/JVI.00867-17","article-title":"Potent Plasmablast-Derived Antibodies Elicited by the National Institutes of Health Dengue Vaccine","volume":"91","author":"Magnani","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.xcrm.2020.100155_bib41","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.chom.2014.06.001","article-title":"Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation","volume":"16","author":"Kwissa","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.xcrm.2020.100155_bib42","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.aaa8651","article-title":"DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers","volume":"349","author":"Fibriansah","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2020.100155_bib43","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1073\/pnas.1200566109","article-title":"Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions","volume":"109","author":"de Alwis","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2020.100155_bib44","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chom.2010.08.007","article-title":"The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity","volume":"8","author":"Beltramello","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.xcrm.2020.100155_bib45","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1128\/JVI.06335-11","article-title":"Persistence of circulating memory B cell clones with potential for dengue virus disease enhancement for decades following infection","volume":"86","author":"Smith","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.xcrm.2020.100155_bib46","doi-asserted-by":"crossref","first-page":"12233","DOI":"10.1128\/JVI.00247-14","article-title":"Isolation of dengue virus-specific memory B cells with live virus antigen from human subjects following natural infection reveals the presence of diverse novel functional groups of antibody clones","volume":"88","author":"Smith","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.xcrm.2020.100155_bib47","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1093\/infdis\/jit119","article-title":"Human monoclonal antibodies derived from memory B cells following live attenuated dengue virus vaccination or natural infection exhibit similar characteristics","volume":"207","author":"Smith","year":"2013","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.xcrm.2020.100155_bib48","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/jvh.12336","article-title":"Skewed B cells in chronic hepatitis C virus infection maintain their ability to respond to virus-induced activation","volume":"22","author":"Oliviero","year":"2015","journal-title":"J.\u00a0Viral Hepat."},{"key":"10.1016\/j.xcrm.2020.100155_bib49","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jcv.2014.01.023","article-title":"Hepatitis C virus (HCV)-specific memory B-cell responses in transiently and chronically infected HIV positive individuals","volume":"59","author":"Reiche","year":"2014","journal-title":"J.\u00a0Clin. Virol."},{"key":"10.1016\/j.xcrm.2020.100155_bib50","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ebiom.2016.09.003","article-title":"Plasmablasts During Acute Dengue Infection Represent a Small Subset of a Broader Virus-specific Memory B Cell Pool","volume":"12","author":"Appanna","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.xcrm.2020.100155_bib51","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/ni.3533","article-title":"Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination","volume":"17","author":"Ellebedy","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.xcrm.2020.100155_bib52","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/JVI.02129-14","article-title":"The human CD8+ T\u00a0cell responses induced by a live attenuated tetravalent dengue vaccine are directed against highly conserved epitopes","volume":"89","author":"Weiskopf","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.xcrm.2020.100155_bib53","doi-asserted-by":"crossref","first-page":"e02041","DOI":"10.1128\/JVI.02041-16","article-title":"Mapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to Dengue Virus Serotype 4 Infection and Vaccination","volume":"91","author":"Nivarthi","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.xcrm.2020.100155_bib54","doi-asserted-by":"crossref","first-page":"e0005554","DOI":"10.1371\/journal.pntd.0005554","article-title":"Dissecting the human serum antibody response to secondary dengue virus infections","volume":"11","author":"Patel","year":"2017","journal-title":"PLOS Negl. Trop. Dis."},{"key":"10.1016\/j.xcrm.2020.100155_bib55","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1126\/science.1076071","article-title":"Maintenance of serological memory by polyclonal activation of human memory B cells","volume":"298","author":"Bernasconi","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2020.100155_bib56","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jim.2003.12.015","article-title":"Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system","volume":"286","author":"Crotty","year":"2004","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.xcrm.2020.100155_bib57","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00873-13","article-title":"The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope protein","volume":"4","author":"Smith","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.xcrm.2020.100155_bib58","first-page":"1","article-title":"Fitting Linear Mixed-Effects Models Using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J.\u00a0Stat. Softw."}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379120302020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379120302020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:46:00Z","timestamp":1762987560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379120302020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S2666379120302020"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2020.100155","relation":{},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stimulation of B Cell Immunity in Flavivirus-Naive Individuals by the Tetravalent Live Attenuated Dengue Vaccine TV003","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2020.100155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"100155"}}