{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:58:31Z","timestamp":1780667911581,"version":"3.54.1"},"reference-count":76,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21OD031907"],"award-info":[{"award-number":["R21OD031907"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18CDA34080527"],"award-info":[{"award-number":["18CDA34080527"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["202360399"],"award-info":[{"award-number":["202360399"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H06828"],"award-info":[{"award-number":["JP16H06828"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.xcrm.2023.101337","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T10:46:01Z","timestamp":1702982761000},"page":"101337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single-cell transcriptomics identifies adipose tissue CD271+ progenitors for enhanced angiogenesis in limb ischemia"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-8981","authenticated-orcid":false,"given":"Oto","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Goten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Hashimuko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosei","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ootsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Iino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Takemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasi","family":"Halurkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Woong","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Hwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Sanchez-Gurmaches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Usui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Takamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2023.101337_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015","volume":"70","author":"Roth","year":"2017","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.xcrm.2023.101337_bib2","first-page":"81","article-title":"Inter-society consensus for the management of peripheral arterial disease","volume":"26","author":"Norgren","year":"2007","journal-title":"Int. Angiol."},{"key":"10.1016\/j.xcrm.2023.101337_bib3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jvs.2010.08.060","article-title":"Treatment of peripheral arterial disease using stem and progenitor cell therapy","volume":"53","author":"Lawall","year":"2011","journal-title":"J.\u00a0Vasc. Surg."},{"key":"10.1016\/j.xcrm.2023.101337_bib4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrcardio.2013.70","article-title":"Therapeutic angiogenesis for critical limb ischaemia","volume":"10","author":"Annex","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.xcrm.2023.101337_bib5","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/sctm.17-0129","article-title":"Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine","volume":"6","author":"Samsonraj","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.xcrm.2023.101337_bib6","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.108.176826","article-title":"Paracrine mechanisms in adult stem cell signaling and therapy","volume":"103","author":"Gnecchi","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.xcrm.2023.101337_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/stem.2751","article-title":"Concise Review: Cell Therapy for Critical Limb Ischemia: An Integrated Review of Preclinical and Clinical Studies","volume":"36","author":"Qadura","year":"2018","journal-title":"Stem Cell."},{"key":"10.1016\/j.xcrm.2023.101337_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1161\/01.CIR.0000135466.16823.D0","article-title":"Improvement of Postnatal Neovascularization by Human Adipose Tissue-Derived Stem Cells","volume":"110","author":"Miranville","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.xcrm.2023.101337_bib9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/mt.2012.213","article-title":"Aging-related Decrease of Human ASC Angiogenic Potential Is Reversed by Hypoxia Preconditioning Through ROS Production","volume":"21","author":"De Barros","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.xcrm.2023.101337_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22052335","article-title":"Current status of angiogenic cell therapy and related strategies applied in critical limb ischemia","volume":"22","author":"Beltr\u00e1n-Camacho","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.xcrm.2023.101337_bib11","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1161\/CIRCRESAHA.110.218396","article-title":"CD31+ cells represent highly angiogenic and vasculogenic cells in bone marrow: novel role of nonendothelial CD31+ cells in neovascularization and their therapeutic effects on ischemic vascular disease","volume":"107","author":"Kim","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.xcrm.2023.101337_bib12","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1161\/CIRCRESAHA.116.309045","article-title":"Autologous Cell Therapy for Peripheral Arterial Disease","volume":"120","author":"Rigato","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.xcrm.2023.101337_bib13","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.3390\/cells10123307","article-title":"Autologous stem cell therapy for chronic lower extremity wounds: A meta-analysis of randomized controlled trials","volume":"10","author":"Chiang","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.xcrm.2023.101337_bib14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/CIRCINTERVENTIONS.112.968321","article-title":"A randomized, controlled pilot study of autologous CD34+ cell therapy for critical limb ischemia","volume":"5","author":"Losordo","year":"2012","journal-title":"Circ. Cardiovasc. Interv."},{"key":"10.1016\/j.xcrm.2023.101337_bib15","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/sctm.17-0252","article-title":"A Five-Year Study of the Efficacy of Purified CD34+ Cell Therapy for Angiitis-Induced No-Option Critical Limb Ischemia","volume":"7","author":"Fang","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.xcrm.2023.101337_bib16","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.jcyt.2014.07.011","article-title":"Bilateral administration of autologous CD133+ cells in ambulatory patients with refractory critical limb ischemia: lessons learned from a pilot randomized, double-blind, placebo-controlled trial","volume":"16","author":"Raval","year":"2014","journal-title":"Cytotherapy"},{"key":"10.1016\/j.xcrm.2023.101337_bib17","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.stem.2014.10.015","article-title":"Quantitative single-cell approaches to stem cell research","volume":"15","author":"Etzrodt","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xcrm.2023.101337_bib18","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.stem.2015.04.004","article-title":"Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations","volume":"16","author":"Wilson","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xcrm.2023.101337_bib19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-2157-4","article-title":"Construction of a human cell landscape at single-cell level","volume":"581","author":"Han","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2023.101337_bib20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41586-020-2856-x","article-title":"snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis","volume":"587","author":"Sun","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2023.101337_bib21","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A single-cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2023.101337_bib22","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/s41591-020-1061-7","article-title":"Characteristics of anti-CD19 CAR T\u00a0cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas","volume":"26","author":"Deng","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.xcrm.2023.101337_bib23","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41467-021-21168-6","article-title":"Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy","volume":"12","author":"Rabilloud","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2023.101337_bib24","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.stem.2021.12.007","article-title":"TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity","volume":"29","author":"Muto","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xcrm.2023.101337_bib25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s43587-022-00198-9","article-title":"Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty","volume":"2","author":"Luo","year":"2022","journal-title":"Nat. Aging"},{"key":"10.1016\/j.xcrm.2023.101337_bib26","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41590-021-00922-4","article-title":"Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity","volume":"22","author":"Hildreth","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.xcrm.2023.101337_bib27","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s13059-020-02210-0","article-title":"Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs","volume":"21","author":"He","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.xcrm.2023.101337_bib28","doi-asserted-by":"crossref","first-page":"eabh2169","DOI":"10.1126\/sciadv.abh2169","article-title":"A single\u2013cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.xcrm.2023.101337_bib29","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1634\/stemcells.2008-0034","article-title":"IFATS collection: in\u00a0vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury","volume":"26","author":"Banas","year":"2008","journal-title":"Stem cells (Dayton, Ohio)"},{"key":"10.1016\/j.xcrm.2023.101337_bib30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12031-017-1008-8","article-title":"Human Umbilical Cord Blood CD45(+) Pan-Hematopoietic Cells Induced a Neurotherapeutic Effect in Mice with Traumatic Brain Injury: Immunophenotyping, Comparison of Maternal and Neonatal Parameters, and Immunomodulation","volume":"64","author":"Gincberg","year":"2018","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.xcrm.2023.101337_bib43","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","author":"Thomas","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xcrm.2023.101337_bib31","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/leu.2011.389","article-title":"Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?","volume":"26","author":"Ratajczak","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.xcrm.2023.101337_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1755-1536-5-13","article-title":"Diabetic angiopathy and angiogenic defects","volume":"5","author":"Xu","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.xcrm.2023.101337_bib33","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1111\/jcmm.12164","article-title":"A systems biology view of blood vessel growth and remodelling","volume":"18","author":"Logsdon","year":"2014","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.xcrm.2023.101337_bib34","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.7150\/jca.44313","article-title":"Angiogenesis in Breast Cancer Progression, Diagnosis, and Treatment","volume":"11","author":"Madu","year":"2020","journal-title":"J.\u00a0Cancer"},{"key":"10.1016\/j.xcrm.2023.101337_bib35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/CIRCRESAHA.107.159475","article-title":"A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks","volume":"102","author":"Traktuev","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.xcrm.2023.101337_bib36","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jcyt.2013.02.006","article-title":"Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal\/stem cells: A joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International So","volume":"15","author":"Bourin","year":"2013","journal-title":"Cytotherapy"},{"key":"10.1016\/j.xcrm.2023.101337_bib37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.stemcr.2013.06.001","article-title":"LNGFR+THY-1+VCAM-1hi+ Cells Reveal Functionally Distinct Subpopulations in Mesenchymal Stem Cells","volume":"1","author":"Mabuchi","year":"2013","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.xcrm.2023.101337_bib38","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1091\/mbc.e02-02-0105","article-title":"Human adipose tissue is a source of multipotent stem cells","volume":"13","author":"Zuk","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.xcrm.2023.101337_bib39","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13287-021-02177-0","article-title":"The angiogenic potential of CD271+ human adipose tissue-derived mesenchymal stem cells","volume":"12","author":"Smith","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.xcrm.2023.101337_bib40","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1634\/stemcells.2007-0180","article-title":"Chemotaxis and differentiation of human adipose tissue CD34+\/CD31- progenitor cells: role of stromal derived factor-1 released by adipose tissue capillary endothelial cells","volume":"25","author":"Sengen\u00e8s","year":"2007","journal-title":"Stem cells (Dayton, Ohio)"},{"key":"10.1016\/j.xcrm.2023.101337_bib41","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrn1078","article-title":"Neurotrophins and their receptors: A convergence point for many signalling pathways","volume":"4","author":"Chao","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.xcrm.2023.101337_bib42","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR Signaling in Growth Control and Disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2023.101337_bib44","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41586-018-0590-4","article-title":"Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris","volume":"562","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2023.101337_bib45","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123235","article-title":"Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants","volume":"3","author":"Ryan","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.xcrm.2023.101337_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101307","article-title":"Single cell functional genomics reveals plasticity of subcutaneous white adipose tissue (WAT) during early postnatal development","volume":"53","author":"Rondini","year":"2021","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.xcrm.2023.101337_bib47","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0092-8674(92)90286-L","article-title":"Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system","volume":"69","author":"Lee","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2023.101337_bib48","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1242\/dev.120.4.1027","article-title":"p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF","volume":"120","author":"Lee","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.xcrm.2023.101337_bib49","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.clinbiochem.2007.05.009","article-title":"Fasting serum insulin and the homeostasis model of insulin resistance (HOMA-IR) in the monitoring of lifestyle interventions in obese persons","volume":"40","author":"Vogeser","year":"2007","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.xcrm.2023.101337_bib50","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s42255-019-0152-6","article-title":"Single-cell analysis of human adipose tissue identifies depot and disease specific cell types","volume":"2","author":"Vijay","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.xcrm.2023.101337_bib51","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s10456-022-09844-7","article-title":"Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial","volume":"25","author":"Shimizu","year":"2022","journal-title":"Angiogenesis"},{"key":"10.1016\/j.xcrm.2023.101337_bib52","first-page":"e686","article-title":"2016 AHA\/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"135","author":"Gerhard-Herman","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.xcrm.2023.101337_bib53","doi-asserted-by":"crossref","first-page":"702636","DOI":"10.3389\/fimmu.2021.702636","article-title":"Exploiting Single-Cell Tools in Gene and Cell Therapy","volume":"12","author":"Bode","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.xcrm.2023.101337_bib56","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1038\/s41598-019-39715-z","article-title":"CD271-selected mesenchymal stem cells from adipose tissue enhance cartilage repair and are less angiogenic than plastic adherent mesenchymal stem cells","volume":"9","author":"Kohli","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2023.101337_bib57","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3389\/fcell.2020.00635","article-title":"Neurogenesis From Neural Crest Cells: Molecular Mechanisms in the Formation of Cranial Nerves and Ganglia","volume":"8","author":"M\u00e9ndez-Maldonado","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.xcrm.2023.101337_bib58","doi-asserted-by":"crossref","first-page":"ra44","DOI":"10.1126\/scisignal.2005482","article-title":"Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition","volume":"8","author":"Xie","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.xcrm.2023.101337_bib59","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12933-018-0762-4","article-title":"Association between insulin resistance and the development of cardiovascular disease","volume":"17","author":"Ormazabal","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.xcrm.2023.101337_bib60","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/B978-0-12-411619-1.00002-1","article-title":"Imaging White Adipose Tissue With Confocal Microscopy","volume":"17","author":"Martinez-Santiba\u00f1ez","year":"2014","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.xcrm.2023.101337_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24031957","article-title":"NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome","volume":"24","author":"Samario-Rom\u00e1n","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.xcrm.2023.101337_bib62","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nature02866","article-title":"Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity","volume":"431","author":"Um","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2023.101337_bib67","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/stem.629","article-title":"Concise Review: Adipose-Derived Stromal Vascular Fraction Cells and Stem Cells: Let's Not Get Lost in Translation","volume":"29","author":"Gimble","year":"2011","journal-title":"Stem Cell."},{"key":"10.1016\/j.xcrm.2023.101337_bib68","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13287-017-0483-8","article-title":"Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy","volume":"8","author":"Varghese","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.xcrm.2023.101337_bib69","doi-asserted-by":"crossref","DOI":"10.1186\/scrt468","article-title":"Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations","volume":"5","author":"Rennert","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.xcrm.2023.101337_bib70","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.bbrc.2019.07.081","article-title":"Diabetes impairs the angiogenic capacity of human adipose-derived stem cells by reducing the CD271(+) subpopulation in adipose tissue","volume":"517","author":"Inoue","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.xcrm.2023.101337_bib71","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1089\/scd.2011.0722","article-title":"Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells","volume":"21","author":"Strioga","year":"2012","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.xcrm.2023.101337_bib72","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11259-019-09757-9","article-title":"Comparative analysis of in\u00a0vitro proliferative, migratory and pro-angiogenic potentials of bovine fetal mesenchymal stem cells derived from bone marrow and adipose tissue","volume":"43","author":"Jervis","year":"2019","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.xcrm.2023.101337_bib73","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nmeth.4380","article-title":"Simultaneous epitope and transcriptome measurement in single cells","volume":"14","author":"Stoeckius","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.xcrm.2023.101337_bib82","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s43587-023-00379-0","article-title":"Insufficient epitope-specific T\u00a0cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults.","volume":"3","author":"Xiao","year":"2023","journal-title":"Nat Aging"},{"key":"10.1016\/j.xcrm.2023.101337_bib77","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1182\/bloodadvances.2021005828","article-title":"HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2\/M inhibition","volume":"6","author":"Moison","year":"2022","journal-title":"Blood Adv."},{"key":"10.1016\/j.xcrm.2023.101337_bib75","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1038\/s41598-020-73096-y","article-title":"Therapeutic angiogenesis using autologous adipose-derived regenerative cells in patients with critical limb ischaemia in Japan: a clinical pilot study","volume":"10","author":"Katagiri","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2023.101337_bib76","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41591-022-01696-4","article-title":"Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy","volume":"28","author":"Ganan-Gomez","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.xcrm.2023.101337_bib78","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.xcrm.2023.101337_bib79","article-title":"Venice: A New Algorithm for Finding Marker Genes in Single-Cell Transcriptomic Data","author":"Vuong","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.xcrm.2023.101337_bib74","doi-asserted-by":"crossref","first-page":"D258","DOI":"10.1093\/nar\/gkh036","article-title":"The Gene Ontology (GO) database and informatics resource","volume":"32","author":"Harris","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xcrm.2023.101337_bib80","article-title":"BBrowser: Making single-cell data easily accessible","author":"Le","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.xcrm.2023.101337_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67289-8","article-title":"Angiogenesis Analyzer for ImageJ - A comparative morphometric analysis of \"Endothelial Tube Formation Assay\" and \"Fibrin Bead Assay\"","volume":"10","author":"Carpentier","year":"2020","journal-title":"Sci. Rep."}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379123005542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379123005542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T23:00:54Z","timestamp":1762988454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379123005542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":76,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S2666379123005542"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2023.101337","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.02.09.527726","asserted-by":"object"}]},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell transcriptomics identifies adipose tissue CD271+ progenitors for enhanced angiogenesis in limb ischemia","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2023.101337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"101337"}}