{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:02:20Z","timestamp":1791511340684,"version":"4.3.4"},"reference-count":96,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.xcrm.2024.101554","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T10:44:12Z","timestamp":1715251452000},"page":"101554","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma"],"prefix":"10.1016","volume":"5","author":[{"given":"Chang-Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Quan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Qi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zhen","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Qian","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2941-4667","authenticated-orcid":false,"given":"Chang-Mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2024.101554_bib1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41583-018-0001-8","article-title":"Intrinsic mechanisms of neuronal axon regeneration","volume":"19","author":"Mahar","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib2","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xcrm.2024.101554_bib3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-neuro-061010-113723","article-title":"Neuronal intrinsic mechanisms of axon regeneration","volume":"34","author":"Liu","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib4","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2174\/1570159X14666161227150250","article-title":"Exploring Optic Nerve Axon Regeneration","volume":"15","author":"Li","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.xcrm.2024.101554_bib5","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev-cellbio-100617-062508","article-title":"Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside","volume":"34","author":"Curcio","year":"2018","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.xcrm.2024.101554_bib6","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/dneu.22637","article-title":"Intrinsic Determinants of Axon Regeneration","volume":"78","author":"Fawcett","year":"2018","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.xcrm.2024.101554_bib7","doi-asserted-by":"crossref","first-page":"a001867","DOI":"10.1101\/cshperspect.a001867","article-title":"Guidance molecules in axon regeneration","volume":"2","author":"Giger","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.xcrm.2024.101554_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/mcne.1999.0818","article-title":"Sema3C and netrin-1 differentially affect axon growth in the hippocampal formation","volume":"15","author":"Steup","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib9","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.tins.2019.05.006","article-title":"Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair","volume":"42","author":"Rust","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nn.3070","article-title":"NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans","volume":"15","author":"Dickendesher","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib11","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1523\/JNEUROSCI.5119-03.2004","article-title":"Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state","volume":"24","author":"Fischer","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.conb.2014.02.012","article-title":"Myelin-associated inhibitors in axonal growth after CNS injury","volume":"27","author":"Geoffroy","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.xcrm.2024.101554_bib13","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/emboj.2011.55","article-title":"Myelin suppresses axon regeneration by PIR-B\/SHP-mediated inhibition of Trk activity","volume":"30","author":"Fujita","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.xcrm.2024.101554_bib14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.conb.2004.01.004","article-title":"Nogo and axon regeneration","volume":"14","author":"Schwab","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.xcrm.2024.101554_bib15","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1167\/iovs.19-26732","article-title":"Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm","volume":"60","author":"Concei\u00e7\u00e3o","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.xcrm.2024.101554_bib16","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1073\/pnas.1011258108","article-title":"Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules","volume":"108","author":"Hur","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2024.101554_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5851914","article-title":"Repulsive Environment Attenuation during Adult Mouse Optic Nerve Regeneration","volume":"2018","author":"Goulart","year":"2018","journal-title":"Neural Plast."},{"key":"10.1016\/j.xcrm.2024.101554_bib18","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.nbd.2014.09.019","article-title":"Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons","volume":"73","author":"Li","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.xcrm.2024.101554_bib19","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2024.101554_bib20","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature10594","article-title":"Sustained axon regeneration induced by co-deletion of PTEN and SOCS3","volume":"480","author":"Sun","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2024.101554_bib21","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.neuron.2017.05.035","article-title":"Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others","volume":"94","author":"Norsworthy","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2024.101554_bib22","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.celrep.2018.07.105","article-title":"Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration","volume":"24","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.xcrm.2024.101554_bib23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2019.04.033","article-title":"Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs","volume":"103","author":"Zhang","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2024.101554_bib24","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.neuron.2019.05.044","article-title":"Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells","volume":"103","author":"Bray","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2024.101554_bib25","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1098\/rstb.2006.1882","article-title":"Intracellular control of developmental and regenerative axon growth","volume":"361","author":"Zhou","year":"2006","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.xcrm.2024.101554_bib26","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.febslet.2015.04.046","article-title":"Growth control mechanisms in neuronal regeneration","volume":"589","author":"Doron-Mandel","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.xcrm.2024.101554_bib27","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1007\/s00018-021-03814-w","article-title":"Genetic control of retinal ganglion cell genesis","volume":"78","author":"Lyu","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.xcrm.2024.101554_bib28","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrn3767","article-title":"Intrinsically different retinal progenitor cells produce specific types of progeny","volume":"15","author":"Cepko","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/35053522","article-title":"Vertebrate neural cell-fate determination: lessons from the retina","volume":"2","author":"Livesey","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib30","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1038\/ncomms3633","article-title":"Cross-talk between KLF4 and STAT3 regulates axon regeneration","volume":"4","author":"Qin","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2024.101554_bib31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","article-title":"Reprogramming to recover youthful epigenetic information and restore vision","volume":"588","author":"Lu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2024.101554_bib32","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1016\/j.neuron.2022.06.003","article-title":"Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells","volume":"110","author":"Tian","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2024.101554_bib33","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1073\/pnas.1107488109","article-title":"Injury-independent induction of reactive gliosis in retina by loss of function of the LIM homeodomain transcription factor Lhx2","volume":"109","author":"de Melo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2024.101554_bib34","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1523\/JNEUROSCI.3145-15.2016","article-title":"Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling","volume":"36","author":"de Melo","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2018.02.046","article-title":"Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development","volume":"1705","author":"Chou","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.xcrm.2024.101554_bib36","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1242\/dev.041202","article-title":"Lhx2 links the intrinsic and extrinsic factors that control optic cup formation","volume":"136","author":"Yun","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.xcrm.2024.101554_bib37","doi-asserted-by":"crossref","first-page":"12197","DOI":"10.1523\/JNEUROSCI.1494-13.2013","article-title":"Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina","volume":"33","author":"Gordon","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib38","article-title":"Ldb1- and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina","volume":"145","author":"de Melo","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.xcrm.2024.101554_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001830","article-title":"Awakening dormant neurons long after spinal cord injury","volume":"20","author":"Tapia","year":"2022","journal-title":"PLoS Biol."},{"key":"10.1016\/j.xcrm.2024.101554_bib40","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1167\/iovs.16-19873","article-title":"Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice","volume":"58","author":"Yungher","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.xcrm.2024.101554_bib41","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.neuroscience.2016.12.027","article-title":"AAV-mediated transfer of RhoA shRNA and CNTF promotes retinal ganglion cell survival and axon regeneration","volume":"343","author":"Cen","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.xcrm.2024.101554_bib42","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/sj.gt.3302791","article-title":"AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells","volume":"13","author":"Leaver","year":"2006","journal-title":"Gene Ther."},{"key":"10.1016\/j.xcrm.2024.101554_bib43","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1093\/brain\/awm257","article-title":"Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation","volume":"130","author":"M\u00fcller","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.xcrm.2024.101554_bib44","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.nbd.2012.11.011","article-title":"Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve","volume":"51","author":"Pernet","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.xcrm.2024.101554_bib45","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000514441","article-title":"Neuroprotective Factors of the Retina and Their Role in Promoting Survival of Retinal Ganglion Cells: A Review","volume":"64","author":"Fudalej","year":"2021","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.xcrm.2024.101554_bib46","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1442-9071.2006.01146.x","article-title":"Possible role of excitotoxicity in the pathogenesis of glaucoma","volume":"34","author":"RJ","year":"2006","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.xcrm.2024.101554_bib47","doi-asserted-by":"crossref","first-page":"9391","DOI":"10.1073\/pnas.0812884106","article-title":"Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in\u00a0vivo glaucoma model","volume":"106","author":"EM","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2024.101554_bib48","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/S0161-6420(99)90497-9","article-title":"Early Manifest Glaucoma Trial: design and baseline data","volume":"106","author":"Leske","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xcrm.2024.101554_bib49","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1001\/archopht.1981.03930010635009","article-title":"Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage","volume":"99","author":"Quigley","year":"1981","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.xcrm.2024.101554_bib50","doi-asserted-by":"crossref","DOI":"10.3791\/53731-v","article-title":"A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice","author":"Ito","year":"2016","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.xcrm.2024.101554_bib51","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.expneurol.2009.09.027","article-title":"Glutamate, excitotoxicity, and programmed cell death in Parkinson disease","volume":"220","author":"Caudle","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.xcrm.2024.101554_bib52","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1152\/physrev.00011.2017","article-title":"Neuronal Cell Death","volume":"98","author":"Fricker","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.xcrm.2024.101554_bib53","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jphs.2020.07.011","article-title":"Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells","volume":"144","author":"Iovino","year":"2020","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.xcrm.2024.101554_bib54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/glia.10082","article-title":"Glutamate transporters and retinal excitotoxicity","volume":"39","author":"Izumi","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.xcrm.2024.101554_bib55","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1442-9071.2006.01146.x","article-title":"Possible role of excitotoxicity in the pathogenesis of glaucoma","volume":"34","author":"Casson","year":"2006","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.xcrm.2024.101554_bib56","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10633-007-9059-8","article-title":"The mouse pattern electroretinogram","volume":"115","author":"Porciatti","year":"2007","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.xcrm.2024.101554_bib57","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1007\/s10792-020-01515-0","article-title":"The photopic negative response (PhNR): measurement approaches and utility in glaucoma","volume":"40","author":"Prencipe","year":"2020","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.xcrm.2024.101554_bib58","first-page":"13.11","article-title":"Initiation of the optokinetic response (OKR) in mice","volume":"10","author":"Tabata","year":"2010","journal-title":"J.\u00a0Vis."},{"key":"10.1016\/j.xcrm.2024.101554_bib59","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11903","article-title":"GSK3beta regulates AKT-induced central nervous system axon regeneration via an eIF2Bepsilon-dependent, mTORC1-independent pathway","volume":"5","author":"Guo","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.xcrm.2024.101554_bib60","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1460-9568.2007.05718.x","article-title":"PI3K\/akt, JAK\/STAT and MEK\/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury","volume":"26","author":"Luo","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib61","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuron.2015.03.060","article-title":"Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics","volume":"86","author":"Belin","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2024.101554_bib62","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nn1898","article-title":"Raf kinase signaling functions in sensory neuron differentiation and axon growth in\u00a0vivo","volume":"10","author":"Zhong","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0896-6273(02)00752-3","article-title":"Raf and Akt Mediate Distinct Aspects of Sensory Axon Growth - ScienceDirect","volume":"35","author":"Annette","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2024.101554_bib64","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3389\/fncel.2014.00328","article-title":"A perspective on the role of class III semaphorin signaling in central nervous system trauma","volume":"8","author":"Mecollari","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib65","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijdevneu.2005.10.007","article-title":"Differential impact of semaphorin 3E and 3A on CNS axons","volume":"24","author":"Steffensky","year":"2006","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib66","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.cub.2014.08.028","article-title":"EphA4 receptor shedding regulates spinal motor axon guidance","volume":"24","author":"Gatto","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.xcrm.2024.101554_bib67","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1074\/jbc.M115.668996","article-title":"Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration","volume":"291","author":"Landowski","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.xcrm.2024.101554_bib68","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/01677060802447585","article-title":"An axon regeneration signature in a Charcot-Marie-Tooth disease type 2 patient","volume":"23","author":"Cavalcanti","year":"2009","journal-title":"J.\u00a0Neurogenet."},{"key":"10.1016\/j.xcrm.2024.101554_bib69","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1007\/s12035-021-02589-2","article-title":"Dysregulated miR-29a-3p\/PMP22 Modulates Schwann Cell Proliferation and Migration During Peripheral Nerve Regeneration","volume":"59","author":"Shen","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.xcrm.2024.101554_bib70","doi-asserted-by":"crossref","first-page":"7753","DOI":"10.1093\/nar\/gkt567","article-title":"LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1","volume":"41","author":"Hou","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xcrm.2024.101554_bib71","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1523\/JNEUROSCI.5851-11.2012","article-title":"The Lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors","volume":"32","author":"Marcos-Mond\u00e9jar","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib72","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neulet.2008.01.048","article-title":"Expression of Semaphorin3C in axotomized rodent facial and rubrospinal neurons","volume":"434","author":"Oschipok","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.xcrm.2024.101554_bib73","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41586-018-0847-y","article-title":"Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex","volume":"565","author":"Poulopoulos","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2024.101554_bib74","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41467-018-05134-3","article-title":"Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes","volume":"9","author":"Rheaume","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2024.101554_bib75","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.ymthe.2020.04.010","article-title":"Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury","volume":"28","author":"Nathan","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.xcrm.2024.101554_bib76","article-title":"An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity","volume":"147","author":"Kinare","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.xcrm.2024.101554_bib77","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.stem.2013.06.018","article-title":"Architectural niche organization by LHX2 is linked to hair follicle stem cell function","volume":"13","author":"Folgueras","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xcrm.2024.101554_bib78","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1210\/en.2006-1088","article-title":"Activation of the thyroid-stimulating hormone beta-subunit gene by LIM homeodomain transcription factor Lhx2","volume":"148","author":"Kim","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.xcrm.2024.101554_bib79","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.yexcr.2014.11.009","article-title":"LIM homeobox transcription factor Lhx2 inhibits skeletal muscle differentiation in part via transcriptional activation of Msx1 and Msx2","volume":"331","author":"Kodaka","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.xcrm.2024.101554_bib80","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/cdd.2014.71","article-title":"Lhx2 regulates bone remodeling in mice by modulating RANKL signaling in osteoclasts","volume":"21","author":"Kim","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.xcrm.2024.101554_bib81","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1158\/1078-0432.CCR-09-1810","article-title":"Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis","volume":"15","author":"Gaur","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.xcrm.2024.101554_bib82","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/tvst.10.10.16","article-title":"Inhibition of Sema-3A Promotes Cell Migration, Axonal Growth, and Retinal Ganglion Cell Survival","volume":"10","author":"Nitzan","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.xcrm.2024.101554_bib83","doi-asserted-by":"crossref","first-page":"49799","DOI":"10.1074\/jbc.M204793200","article-title":"Anti-semaphorin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy","volume":"277","author":"Shirvan","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.xcrm.2024.101554_bib84","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev-vision-022720-094953","article-title":"Axon Regeneration in the Mammalian Optic Nerve","volume":"6","author":"Williams","year":"2020","journal-title":"Annu. Rev. Vis. Sci."},{"key":"10.1016\/j.xcrm.2024.101554_bib85","doi-asserted-by":"crossref","first-page":"8367","DOI":"10.1523\/JNEUROSCI.19-19-08367.1999","article-title":"Optic Nerve Crush Axonal Responses in Wild-Type and bcl-2","volume":"19","author":"Chierzi","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib86","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.addr.2019.05.003","article-title":"Translational challenges in advancing regenerative therapy for treating neurological disorders using nanotechnology","volume":"148","author":"Nemeth","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.xcrm.2024.101554_bib87","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/nbdi.2000.0359","article-title":"Spinal cord repair: strategies to promote axon regeneration","volume":"8","author":"McKerracher","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.xcrm.2024.101554_bib88","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fncel.2020.00119","article-title":"Strategies to Promote Long-Distance Optic Nerve Regeneration","volume":"14","author":"Yang","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib89","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-12-407178-0.00007-7","article-title":"Combinatorial therapy stimulates long-distance regeneration, target reinnervation, and partial recovery of vision after optic nerve injury in mice","volume":"106","author":"de Lima","year":"2012","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.xcrm.2024.101554_bib90","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/embr.201337723","article-title":"Cell intrinsic control of axon regeneration","volume":"15","author":"Mar","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.xcrm.2024.101554_bib91","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2009.11.021","article-title":"SOCS3 deletion promotes optic nerve regeneration in\u00a0vivo","volume":"64","author":"Smith","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2024.101554_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107537","article-title":"Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration","volume":"31","author":"Wang","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.xcrm.2024.101554_bib93","doi-asserted-by":"crossref","first-page":"15654","DOI":"10.1523\/JNEUROSCI.4340-10.2010","article-title":"Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion","volume":"30","author":"Kurimoto","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.xcrm.2024.101554_bib94","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1016\/j.cell.2021.06.031","article-title":"Preservation of vision after CaMKII-mediated protection of retinal ganglion cells","volume":"184","author":"Guo","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2024.101554_bib95","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1007\/s10571-022-01280-x","article-title":"Human Pro370Leu Mutant Myocilin Induces the Phenotype of Open-Angle Glaucoma in Transgenic Mice","volume":"43","author":"Cheng","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.xcrm.2024.101554_bib96","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.ymthe.2022.01.035","article-title":"NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function","volume":"30","author":"Fang","year":"2022","journal-title":"Mol. Ther."}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379124002465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379124002465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T15:17:11Z","timestamp":1733757431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379124002465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":96,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S2666379124002465"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2024.101554","relation":{},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2024.101554","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101554"}}