{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:47:00Z","timestamp":1792180020952,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.xcrm.2024.101883","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T16:07:15Z","timestamp":1735661235000},"page":"101883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The direct and indirect inhibition of proinflammatory adipose tissue macrophages by acarbose in diet-induced obesity"],"prefix":"10.1016","volume":"6","author":[{"given":"Xiaohui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhe","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxiong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hufeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3404-5173","authenticated-orcid":false,"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2024.101883_bib1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: global epidemiology and pathogenesis","volume":"15","author":"Bluher","year":"2019","journal-title":"Nat.\u00a0Rev. Endocrinol."},{"key":"10.1016\/j.xcrm.2024.101883_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0140-6736(16)30175-1","article-title":"Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents","volume":"388","author":"Di Angelantonio","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.xcrm.2024.101883_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health Effects of Overweight and Obesity in 195 Countries over 25 Years","volume":"377","author":"Afshin","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.xcrm.2024.101883_bib4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.xcrm.2024.101883_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.xcrm.2024.101883_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/imr.12853","article-title":"Adipose tissue macrophages: Unique polarization and bioenergetics in obesity","volume":"295","author":"Caslin","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.xcrm.2024.101883_bib7","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.xcrm.2024.101883_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.xcrm.2024.101883_bib9","first-page":"19","article-title":"Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders","volume":"27","author":"Singh","year":"2021","journal-title":"J.\u00a0Neurogastroenterol."},{"key":"10.1016\/j.xcrm.2024.101883_bib10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41577-019-0198-4","article-title":"The intestinal microbiota fuelling metabolic inflammation","volume":"20","author":"Tilg","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.xcrm.2024.101883_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3158","article-title":"Standards of medical care for type 2 diabetes in China 2019","volume":"35","author":"Jia","year":"2019","journal-title":"Diabetes. Metab. Res. Rev."},{"key":"10.1016\/j.xcrm.2024.101883_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1586\/14779072.6.2.153","article-title":"Acarbose: oral anti-diabetes drug with additional cardiovascular benefits","volume":"6","author":"Hanefeld","year":"2008","journal-title":"Expert Rev. Cardiovasc Ther."},{"key":"10.1016\/j.xcrm.2024.101883_bib13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5114\/aoms.2018.75255","article-title":"MARCH: factors associated with weight loss in patients with newly diagnosed type 2 diabetes treated with acarbose or metformin","volume":"15","author":"Wang","year":"2019","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.xcrm.2024.101883_bib14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fendo.2020.00288","article-title":"Acarbose With Comparable Glucose-Lowering but Superior Weight-Loss Efficacy to Dipeptidyl Peptidase-4 Inhibitors: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.xcrm.2024.101883_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41387-021-00152-5","article-title":"Effects of alpha-glucosidase-inhibiting drugs on acute postprandial glucose and insulin responses: a systematic review and meta-analysis","volume":"11","author":"Alssema","year":"2021","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.xcrm.2024.101883_bib16","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1038\/s41467-017-01682-2","article-title":"Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment","volume":"8","author":"Gu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2024.101883_bib17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.intimp.2016.02.001","article-title":"Oral administration of acarbose ameliorates imiquimod-induced psoriasis-like dermatitis in a mouse model","volume":"33","author":"Chen","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.xcrm.2024.101883_bib18","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2024.101883_bib19","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2024.101883_bib20","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s00125-017-4209-3","article-title":"Associations between hepatic miRNA expression, liver triacylglycerols and gut microbiota during metabolic adaptation to high-fat diet in mice","volume":"60","author":"Blasco-Baque","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.xcrm.2024.101883_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/s40795-020-00398-9","article-title":"Increasing levels of Parasutterella in the gut microbiome correlate with improving low-density lipoprotein levels in healthy adults consuming resistant potato starch during a randomised trial","volume":"6","author":"Bush","year":"2020","journal-title":"BMC Nutr."},{"key":"10.1016\/j.xcrm.2024.101883_bib22","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1099\/ijs.0.002519-0","article-title":"Parasutterella excrementihominis gen. nov., sp nov., a member of the family Alcaligenaceae isolated from human faeces","volume":"59","author":"Nagai","year":"2009","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.xcrm.2024.101883_bib23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/j.gastro.2013.04.056","article-title":"Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice","volume":"145","author":"Kim","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.xcrm.2024.101883_bib24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2024.101883_bib25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.molcel.2004.10.004","article-title":"Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae","volume":"16","author":"Lemaire","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.xcrm.2024.101883_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73008-0","article-title":"Activation of the G-protein coupled receptor GPR35 by human milk oligosaccharides through different pathways","volume":"10","author":"Foata","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2024.101883_bib27","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1046\/j.1463-1326.2003.00239.x","article-title":"Influence of treatment with acarbose or glibenclamide on insulin sensitivity in type 2 diabetic patients","volume":"5","author":"Fischer","year":"2003","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.xcrm.2024.101883_bib28","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1093\/ibd\/izad004","article-title":"Microbial Dynamics in Newly Diagnosed and Treatment Naive IBD Patients in the Mediterranean","volume":"29","author":"Rausch","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.xcrm.2024.101883_bib29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/ibd\/izac182","article-title":"Quantitative Fecal Microbiota Profiles Relate to Therapy Response During Induction With Tumor Necrosis Factor alpha Antagonist Infliximab in Pediatric Inflammatory Bowel Disease","volume":"29","author":"Hoyhtya","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.xcrm.2024.101883_bib30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13073-022-01099-7","article-title":"Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome","volume":"14","author":"Jacobs","year":"2022","journal-title":"Genome Med."},{"key":"10.1016\/j.xcrm.2024.101883_bib31","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.2337\/db17-0067","article-title":"Hypothalamic Inflammation in Human Obesity Is Mediated by Environmental and Genetic Factors","volume":"66","author":"Kreutzer","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.xcrm.2024.101883_bib32","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nm.4358","article-title":"Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention","volume":"23","author":"Liu","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.xcrm.2024.101883_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49462-w","article-title":"Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities","volume":"9","author":"Zeng","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2024.101883_bib34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s13300-017-0226-y","article-title":"Effects of Acarbose on the Gut Microbiota of Prediabetic Patients: A Randomized, Double-blind, Controlled Crossover Trial","volume":"8","author":"Zhang","year":"2017","journal-title":"Diabetes Ther."},{"key":"10.1016\/j.xcrm.2024.101883_bib35","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s00125-022-05768-5","article-title":"Metagenomic analysis reveals crosstalk between gut microbiota and glucose-lowering drugs targeting the gastrointestinal tract in Chinese patients with type 2 diabetes: a 6\u00a0month, two-arm randomised trial","volume":"65","author":"Zhang","year":"2022","journal-title":"Diabetologia"},{"key":"10.1016\/j.xcrm.2024.101883_bib36","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2214484120","article-title":"Infection-elicited microbiota promotes host adaptation to nutrient restriction","volume":"120","author":"Siqueira","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2024.101883_bib37","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s41423-021-00661-4","article-title":"Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases","volume":"18","author":"Yang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.xcrm.2024.101883_bib38","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.2337\/db14-1213","article-title":"Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPARgamma-Dependent Switch From Lipogenesis to Fat Oxidation","volume":"64","author":"den Besten","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.xcrm.2024.101883_bib39","article-title":"Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2024.101883_bib40","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2024.101883_bib41","first-page":"549","article-title":"Effects of dietary propionate on carbohydrate and lipid metabolism in healthy volunteers","volume":"85","author":"Venter","year":"1990","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.xcrm.2024.101883_bib42","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2362.2011.02590.x","article-title":"Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects","volume":"42","author":"Al-Lahham","year":"2012","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.xcrm.2024.101883_bib43","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/eurheartj\/ehab644","article-title":"Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism","volume":"43","author":"Haghikia","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.xcrm.2024.101883_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/obr.12242","article-title":"Macrophage recruitment in obese adipose tissue","volume":"16","author":"Bai","year":"2015","journal-title":"Obes. Rev."},{"key":"10.1016\/j.xcrm.2024.101883_bib45","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3389\/fimmu.2017.01063","article-title":"Gut REG3\u03b3-Associated Induces Anti-inflammatory Macrophages to Maintain Adipose Tissue Homeostasis","volume":"8","author":"Huang","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.xcrm.2024.101883_bib46","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/imcb.12409","article-title":"Impact of prebiotics on immune response: from the bench to the clinic","volume":"99","author":"Pujari","year":"2021","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.xcrm.2024.101883_bib47","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3945\/an.115.010090","article-title":"Human Milk Components Modulate Toll-Like Receptor-Mediated Inflammation","volume":"7","author":"He","year":"2016","journal-title":"Adv. Nutr."}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379124006542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379124006542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T04:10:44Z","timestamp":1740888644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379124006542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S2666379124006542"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2024.101883","relation":{},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The direct and indirect inhibition of proinflammatory adipose tissue macrophages by acarbose in diet-induced obesity","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2024.101883","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101883"}}