{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:02:39Z","timestamp":1793826159406,"version":"4.6.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.xcrm.2025.102134","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T10:47:12Z","timestamp":1747738032000},"page":"102134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6939-5077","authenticated-orcid":false,"given":"Rimjhim","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda H.","family":"C\u00f4rtes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Villalpando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella N.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Isela","family":"G\u00e1lvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Grifoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia M.","family":"Romero-Vivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Heise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmanane","family":"Premkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Falconar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2968-7371","authenticated-orcid":false,"given":"Daniela","family":"Weiskopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2025.102134_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add2536","article-title":"Molecular architecture of the Chikungunya virus replication complex","volume":"8","author":"Tan","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.xcrm.2025.102134_bib2","series-title":"Chikungunya Virus: Advances in Biology, Pathogenesis, and Treatment","first-page":"63","article-title":"Function of Chikungunya Virus Structural Proteins","author":"Metz","year":"2016"},{"key":"10.1016\/j.xcrm.2025.102134_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1017\/S0022172400044442","article-title":"The Newala epidemic: III. The virus: isolation, pathogenic properties and relationship to the epidemic","volume":"54","author":"Ross","year":"1956","journal-title":"J. Hyg."},{"key":"10.1016\/j.xcrm.2025.102134_bib4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/jmv.20168","article-title":"Epidemic resurgence of Chikungunya virus in democratic Republic of the Congo: Identification of a new central African strain","volume":"74","author":"Pastorino","year":"2004","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.xcrm.2025.102134_bib5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3201\/eid0707.017703","article-title":"Emerging viral diseases of Southeast Asia and the Western Pacific","volume":"7","author":"Mackenzie","year":"2001","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.xcrm.2025.102134_bib6","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1017\/S0950268808001167","article-title":"Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005\u20132006 outbreak on R\u00e9union","volume":"137","author":"Economopoulou","year":"2009","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.xcrm.2025.102134_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007213","article-title":"Global expansion and redistribution of Aedes-borne virus transmission risk with climate change","volume":"13","author":"Ryan","year":"2019","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.xcrm.2025.102134_bib8","first-page":"1323","article-title":"Chikungunya: A Paradigm of Emergence and Globalization of Vector-Borne Diseases","volume":"92","author":"Simon","year":"2008","journal-title":"Med. Clin."},{"key":"10.1016\/j.xcrm.2025.102134_bib9","unstructured":"Chikungunya worldwide overview; 2023. https:\/\/www.ecdc.europa.eu\/en\/publications-data\/chikungunya-virus-disease-cases-january-december-2023#:\u223c:text=In%202023%20and%20as%20of,deaths%20had%20been%20reported%20worldwide."},{"key":"10.1016\/j.xcrm.2025.102134_bib10","article-title":"Persistent arthralgia and related risks factors in laboratory-confirmed cases of Chikungunya virus infection in Mexico","volume":"41","author":"Murillo-Zamora","year":"2017","journal-title":"Rev. Panam. Salud P\u00fablic"},{"key":"10.1016\/j.xcrm.2025.102134_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/850ee20f-2641-46ac-b0c6-ef4ae79b6de6","article-title":"Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study","volume":"7","author":"Schilte","year":"2013","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.xcrm.2025.102134_bib12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1086\/590003","article-title":"Persistent Arthralgia Associated with Chikungunya Virus: A Study of 88 Adult Patients on Reunion Island","volume":"47","author":"Borgherini","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.xcrm.2025.102134_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jcv.2009.11.014","article-title":"Factors associated with persistence of arthralgia among chikungunya virus-infected travellers: Report of 42 French cases","volume":"47","author":"Larrieu","year":"2010","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.xcrm.2025.102134_bib14","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/rheumatology\/kes015","article-title":"Impaired quality of life after chikungunya virus infection: a 2-year follow-up study","volume":"51","author":"Couturier","year":"2012","journal-title":"Rheumatology"},{"key":"10.1016\/j.xcrm.2025.102134_bib15","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1172\/JCI40104","article-title":"Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages","volume":"120","author":"Labadie","year":"2010","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.xcrm.2025.102134_bib16","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jbspin.2009.08.005","article-title":"A report of 21 cases of rheumatoid arthritis following Chikungunya fever. A mean follow-up of two years","volume":"76","author":"Bouquillard","year":"2009","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.xcrm.2025.102134_bib17","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/S0140-6736(23)00641-4","article-title":"Safety and immunogenicity of a single-shot live-attenuated chikungunya vaccine: a double-blind, multicentre, randomised, placebo-controlled, phase 3 trial","volume":"401","author":"Schneider","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.xcrm.2025.102134_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005891","article-title":"Dysregulated TGF-\u03b2 Production Underlies the Age-Related Vulnerability to Chikungunya Virus","volume":"12","author":"Uhrlaub","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.xcrm.2025.102134_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002343","article-title":"Chikungunya Virus Infection Results in Higher and Persistent Viral Replication in Aged Rhesus Macaques Due to Defects in Anti-Viral Immunity","volume":"7","author":"Messaoudi","year":"2013","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.xcrm.2025.102134_bib20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/art.40383","article-title":"Chikungunya Arthritis Mechanisms in the Americas","volume":"70","author":"Chang","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.xcrm.2025.102134_bib21","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1128\/JVI.02603-09","article-title":"Chikungunya Virus Arthritis in Adult Wild-Type Mice","volume":"84","author":"Gardner","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.xcrm.2025.102134_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ajpath.2010.11.018","article-title":"A Mouse Model of Chikungunya Virus\u2013Induced Musculoskeletal Inflammatory Disease: Evidence of Arthritis, Tenosynovitis, Myositis, and Persistence","volume":"178","author":"Morrison","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.xcrm.2025.102134_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02036-19","article-title":"Chikungunya Virus Evades Antiviral CD8+ T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues","volume":"94","author":"Davenport","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.xcrm.2025.102134_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000527","article-title":"Human Muscle Satellite Cells as Targets of Chikungunya Virus Infection","volume":"2","author":"Ozden","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2025.102134_bib24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/infdis\/jis368","article-title":"Interleukin 6, RANKL, and Osteoprotegerin Expression by Chikungunya Virus\u2013Infected Human Osteoblasts","volume":"206","author":"Noret","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.xcrm.2025.102134_bib26","article-title":"Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2. Preprint at bioRxiv","author":"Ware","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.xcrm.2025.102134_bib27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4049\/jimmunol.1202177","article-title":"A Pathogenic Role for CD4+ T Cells during Chikungunya Virus Infection in Mice","volume":"190","author":"Teo","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.xcrm.2025.102134_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal1333","article-title":"Fingolimod treatment abrogates chikungunya virus\u2013induced arthralgia","volume":"9","author":"Teo","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.xcrm.2025.102134_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084695","article-title":"Identical Strength of the T Cell Responses against E2, nsP1 and Capsid CHIKV Proteins in Recovered and Chronic Patients after the Epidemics of 2005-2006 in La Reunion Island","volume":"8","author":"Hoarau","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2025.102134_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186998","article-title":"Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells","volume":"12","author":"Reiss","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2025.102134_bib31","article-title":"Tetanus Vaccination","year":"2023"},{"key":"10.1016\/j.xcrm.2025.102134_bib32","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.chom.2022.07.012","article-title":"Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic","volume":"30","author":"Yu","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.xcrm.2025.102134_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/science.abh1823","article-title":"Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination","volume":"374","author":"Loyal","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2025.102134_bib34","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ijid.2021.03.003","article-title":"Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil","volume":"105","author":"Silva","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.xcrm.2025.102134_bib35","first-page":"1008","article-title":"Profile of The Chikungunya Infection: A Neglected Vector Borne Disease which is Prevalent In The Rajkot District","volume":"7","author":"Bhagwati","year":"2013","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.xcrm.2025.102134_bib36","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/s41598-018-37846-3","article-title":"Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome","volume":"9","author":"Silveira-Mattos","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2025.102134_bib37","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1172\/JCI84417","article-title":"Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies","volume":"127","author":"Silva","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.xcrm.2025.102134_bib38","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.cell.2015.10.050","article-title":"Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress","volume":"163","author":"Fox","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2025.102134_bib39","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1080\/19420862.2015.1083664","article-title":"A potent neutralizing IgM mAb targeting the N218 epitope on E2 protein protects against Chikungunya virus pathogenesis","volume":"7","author":"Lam","year":"2015","journal-title":"mAbs"},{"key":"10.1016\/j.xcrm.2025.102134_bib40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.chom.2015.06.009","article-title":"Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus","volume":"18","author":"Smith","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.xcrm.2025.102134_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003312","article-title":"Development of a Highly Protective Combination Monoclonal Antibody Therapy against Chikungunya Virus","volume":"9","author":"Pal","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.xcrm.2025.102134_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67172-6","article-title":"T-cell responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients","volume":"10","author":"L\u2019Huillier","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2025.102134_bib43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/imm.12399","article-title":"Human T helper type 1 dichotomy: origin, phenotype and biological activities","volume":"144","author":"Annunziato","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.xcrm.2025.102134_bib44","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/JLB.4RU0619-197R","article-title":"Th17 cell pathogenicity and plasticity in rheumatoid arthritis","volume":"106","author":"Yang","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.xcrm.2025.102134_bib45","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.xcrm.2025.102134_bib46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2249.2009.04039.x","article-title":"Translational Mini-Review Series on Th17 Cells: Are T helper 17 cells really pathogenic in autoimmunity?","volume":"159","author":"Koenders","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.xcrm.2025.102134_bib47","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1002\/art.27622","article-title":"Role of Th17 cells in human autoimmune arthritis","volume":"62","author":"Leipe","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.xcrm.2025.102134_bib48","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3343\/alm.2013.33.1.52","article-title":"Elevated Levels of T Helper 17 Cells Are Associated with Disease Activity in Patients with Rheumatoid Arthritis","volume":"33","author":"Kim","year":"2013","journal-title":"Ann. Lab. Med."},{"key":"10.1016\/j.xcrm.2025.102134_bib49","article-title":"Th17 Cells in Autoimmune and Infectious Diseases","volume":"2014","author":"Zambrano-Zaragoza","year":"2014","journal-title":"Int. J. Inflamm."},{"key":"10.1016\/j.xcrm.2025.102134_bib50","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/imm.13583","article-title":"Tumour necrosis factor plays a deleterious role in the pathogenesis of chikungunya virus infection","volume":"168","author":"Moreira","year":"2023","journal-title":"Immunology"},{"key":"10.1016\/j.xcrm.2025.102134_bib51","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2249.2009.04016.x","article-title":"The role of T helper type 17 cells in inflammatory arthritis","volume":"159","author":"Sarkar","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.xcrm.2025.102134_bib52","doi-asserted-by":"crossref","first-page":"D593","DOI":"10.1093\/nar\/gkr859","article-title":"ViPR: an open bioinformatics database and analysis resource for virology research","volume":"40","author":"Pickett","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xcrm.2025.102134_bib53","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.cell.2020.05.015","article-title":"Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals","volume":"181","author":"Grifoni","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2025.102134_bib54","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/cea.12692","article-title":"Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with allergen-specific modulation of immune reactivity","volume":"46","author":"Hinz","year":"2016","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.xcrm.2025.102134_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005760","article-title":"A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans","volume":"12","author":"Lindestam Arlehamn","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.xcrm.2025.102134_bib56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cellimm.2016.05.002","article-title":"Th1 versus Th2 T cell polarization by whole-cell and acellular childhood pertussis vaccines persists upon re-immunization in adolescence and adulthood","volume":"304\u2013305","author":"Bancroft","year":"2016","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.xcrm.2025.102134_bib57","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/infdis\/jiab176","article-title":"Differential T-Cell Reactivity to Endemic Coronaviruses and SARS-CoV-2 in Community and Health Care Workers","volume":"224","author":"da Silva Antunes","year":"2021","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.xcrm.2025.102134_bib58","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.3389\/fimmu.2017.01309","article-title":"Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas","volume":"8","author":"Grifoni","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.xcrm.2025.102134_bib59","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/infdis\/jiv289","article-title":"Human CD8+ T-Cell Responses Against the 4 Dengue Virus Serotypes Are Associated With Distinct Patterns of Protein Targets","volume":"212","author":"Weiskopf","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.xcrm.2025.102134_bib60","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/763461","article-title":"Automatic Generation of Validated Specific Epitope Sets","volume":"2015","author":"Carrasco Pro","year":"2015","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.xcrm.2025.102134_bib61","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00940-21","article-title":"Profiling Human Cytomegalovirus-Specific T Cell Responses Reveals Novel Immunogenic Open Reading Frames","volume":"95","author":"Dhanwani","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.xcrm.2025.102134_bib62","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-020-2550-z","article-title":"SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls","volume":"584","author":"Le Bert","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2025.102134_bib63","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abd7114","article-title":"Comprehensive mapping of immune perturbations associated with severe COVID-19","volume":"5","author":"Kuri-Cervantes","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.xcrm.2025.102134_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanmic.2024.07.014","article-title":"Multiplex sample-sparing assay for detecting type-specific antibodies to Zika and dengue viruses: an assay development and validation study","volume":"6","author":"Hein","year":"2025","journal-title":"The Lancet Microbe"}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379125002071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379125002071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T01:21:01Z","timestamp":1757726461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379125002071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2666379125002071"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2025.102134","relation":{},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2025.102134","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102134"}}