{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:47:41Z","timestamp":1794019661195,"version":"4.8.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018202","name":"AIRC","doi-asserted-by":"publisher","award":["A22792"],"award-info":[{"award-number":["A22792"]}],"id":[{"id":"10.13039\/100018202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA270108"],"award-info":[{"award-number":["R01CA270108"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U2CCA271894"],"award-info":[{"award-number":["U2CCA271894"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24CA248265"],"award-info":[{"award-number":["U24CA248265"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA218526"],"award-info":[{"award-number":["R01CA218526"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA234557"],"award-info":[{"award-number":["R01CA234557"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.xcrm.2025.102161","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T07:55:41Z","timestamp":1749196541000},"page":"102161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Extracellular vesicle heterogeneity through the lens of multiomics"],"prefix":"10.1016","volume":"6","author":[{"given":"Taylon F.","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hutchins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yari","family":"Ciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Mariscal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuyu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Bedier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Kittel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Galasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Reiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Van Eyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Posadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jlenia","family":"Guarnerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clotilde","family":"Th\u00e9ry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andries","family":"Zijlstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Stott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungyong","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Demichelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Boutros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Van Keuren-Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Di Vizio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2025.102161_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12144","article-title":"A brief history of nearly EV-erything - The rise and rise of extracellular vesicles","volume":"10","author":"Couch","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.xcrm.2025.102161_bib2","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.3390\/cancers13051056","article-title":"Large Extracellular Vesicle Characterization and Association with Circulating Tumor Cells in Metastatic Castrate Resistant Prostate Cancer","volume":"13","author":"Gerdtsson","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.xcrm.2025.102161_bib3","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1689784","article-title":"Large and small extracellular vesicles released by glioma cells in vitro and in vivo","volume":"9","author":"Yekula","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.xcrm.2025.102161_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41523-022-00480-4","article-title":"Multianalyte liquid biopsy to aid the diagnostic workup of breast cancer","volume":"8","author":"Setayesh","year":"2022","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.xcrm.2025.102161_bib5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41556-018-0049-8","article-title":"Size matters in nanoscale communication","volume":"20","author":"Zijlstra","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.xcrm.2025.102161_bib6","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202403051","article-title":"Migrasomes: Biogenesis, physiological roles, and therapeutic potentials","volume":"223","author":"Jiao","year":"2024","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.xcrm.2025.102161_bib7","doi-asserted-by":"crossref","first-page":"11327","DOI":"10.18632\/oncotarget.3598","article-title":"Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles","volume":"6","author":"Minciacchi","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.xcrm.2025.102161_bib8","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-019-1317-6","article-title":"Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation","volume":"38","author":"Ciardiello","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.xcrm.2025.102161_bib9","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.ajpath.2012.07.030","article-title":"Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease","volume":"181","author":"Di Vizio","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.xcrm.2025.102161_bib10","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1158\/0008-5472.CAN-16-2942","article-title":"MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer","volume":"77","author":"Minciacchi","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.xcrm.2025.102161_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202201974","article-title":"Large Oncosome-Loaded VAPA Promotes Bone-Tropic Metastasis of Hepatocellular Carcinoma Via Formation of Osteoclastic Pre-Metastatic Niche","volume":"9","author":"Zhang","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.xcrm.2025.102161_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ebiom.2019.01.051","article-title":"A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes","volume":"41","author":"Bertolini","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.xcrm.2025.102161_bib13","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1505403","article-title":"Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma","volume":"7","author":"Vagner","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.xcrm.2025.102161_bib14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41556-021-00693-y","article-title":"Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker","volume":"23","author":"Kugeratski","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.xcrm.2025.102161_bib15","doi-asserted-by":"crossref","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2025.102161_bib16","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2107394119","article-title":"Extracellular vesicles from triple negative breast cancer promote pro-inflammatory macrophages associated with better clinical outcome","volume":"119","author":"Tkach","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2025.102161_bib17","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.07.009","article-title":"Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers","volume":"182","author":"Hoshino","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2025.102161_bib18","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2019.02.029","article-title":"Reassessment of Exosome Composition","volume":"177","author":"Jeppesen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2025.102161_bib19","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41596-020-00466-1","article-title":"Isolation and characterization of extracellular vesicle subpopulations from tissues","volume":"16","author":"Crescitelli","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.xcrm.2025.102161_bib20","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/acs.jproteome.8b00647","article-title":"Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs","volume":"18","author":"Jimenez","year":"2019","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.xcrm.2025.102161_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28485-9","article-title":"Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome","volume":"8","author":"Sork","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2025.102161_bib22","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-022-04164-x","article-title":"Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth","volume":"79","author":"Jiang","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.xcrm.2025.102161_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10081886","article-title":"miRNome and Proteome Profiling of Small Extracellular Vesicles Secreted by Human Glioblastoma Cell Lines and Primary Cancer Stem Cells","volume":"10","author":"Cifola","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.xcrm.2025.102161_bib24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/15476286.2016.1259061","article-title":"High-throughput sequencing of two populations of extracellular vesicles provides an mRNA signature that can be detected in the circulation of breast cancer patients","volume":"14","author":"Conley","year":"2017","journal-title":"RNA Biol."},{"key":"10.1016\/j.xcrm.2025.102161_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.xcrm.2025.102161_bib26","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2020.1764192","article-title":"Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles","volume":"9","author":"Mariscal","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.xcrm.2025.102161_bib27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4196\/kjpp.2023.27.4.375","article-title":"Rectal cancer-derived exosomes activate the nuclear factor kappa B pathway and lung fibroblasts by delivering integrin beta-1","volume":"27","author":"Gao","year":"2023","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"key":"10.1016\/j.xcrm.2025.102161_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12164","article-title":"Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform","volume":"10","author":"Rai","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.xcrm.2025.102161_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28104227","article-title":"Proteomic Signature of Extracellular Vesicles Associated with Colorectal Cancer","volume":"28","author":"Soloveva","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.xcrm.2025.102161_bib30","doi-asserted-by":"crossref","first-page":"D1694","DOI":"10.1093\/nar\/gkad1007","article-title":"Vesiclepedia 2024: an extracellular vesicles and extracellular particles repository","volume":"52","author":"Chitti","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xcrm.2025.102161_bib31","doi-asserted-by":"crossref","first-page":"D516","DOI":"10.1093\/nar\/gky1029","article-title":"Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles","volume":"47","author":"Pathan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xcrm.2025.102161_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121314","article-title":"A mass spectrometric-derived cell surface protein atlas","volume":"10","author":"Bausch-Fluck","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2025.102161_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112728","article-title":"On the surface-to-bulk partition of proteins in extracellular vesicles","volume":"218","author":"Zendrini","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.xcrm.2025.102161_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49424-5","article-title":"Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes","volume":"15","author":"Khoo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102161_bib35","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1158\/0008-5472.CAN-16-0902","article-title":"Integrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome","volume":"76","author":"You","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.xcrm.2025.102161_bib36","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41391-021-00325-4","article-title":"A comparative study of PCS and PAM50 prostate cancer classification schemes","volume":"24","author":"Yoon","year":"2021","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.xcrm.2025.102161_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/jex2.112","article-title":"Blebs and former blebs: From surface protrusions to extracellular vesicles in cancer signalling, anoikis resistance and beyond","volume":"2","author":"Di Vizio","year":"2023","journal-title":"J. Extracell. Biol."},{"key":"10.1016\/j.xcrm.2025.102161_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2023113590","article-title":"Extracellular vesicles and co-isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells","volume":"42","author":"Cocozza","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.xcrm.2025.102161_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21984-w","article-title":"Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs","volume":"12","author":"Todkar","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102161_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001166","article-title":"Neural stem cells traffic functional mitochondria via extracellular vesicles","volume":"19","author":"Peruzzotti-Jametti","year":"2021","journal-title":"PLoS Biol."},{"key":"10.1016\/j.xcrm.2025.102161_bib41","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cell.2020.08.031","article-title":"A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart","volume":"183","author":"Nicol\u00e1s-\u00c1vila","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2025.102161_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms9472","article-title":"Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs","volume":"6","author":"Phinney","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102161_bib43","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1635420","article-title":"Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma","volume":"8","author":"Jang","year":"2019","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.xcrm.2025.102161_bib44","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41556-025-01611-2","article-title":"A class of large cell-like extracellular vesicles","volume":"27","author":"D\u2019Souza-Schorey","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.xcrm.2025.102161_bib45","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41556-025-01621-0","article-title":"Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties","volume":"27","author":"Jeppesen","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.xcrm.2025.102161_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01196-x","article-title":"Coding and noncoding landscape of extracellular RNA released by human glioma stem cells","volume":"8","author":"Wei","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102161_bib47","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ccell.2019.02.005","article-title":"The Proteogenomic Landscape of Curable Prostate Cancer","volume":"35","author":"Sinha","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.xcrm.2025.102161_bib48","first-page":"1","article-title":"Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol","volume":"5","author":"Livshts","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2025.102161_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8545347","article-title":"Isolation of Extracellular Vesicles: General Methodologies and Latest Trends","volume":"2018","author":"Konoshenko","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.xcrm.2025.102161_bib50","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2020.1722433","article-title":"Subpopulations of extracellular vesicles from human metastatic melanoma tissue identified by quantitative proteomics after optimized isolation","volume":"9","author":"Crescitelli","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.xcrm.2025.102161_bib51","doi-asserted-by":"crossref","DOI":"10.1186\/s12014-019-9236-2","article-title":"Quantitative proteomic analysis of prostate tissue specimens identifies deregulated protein complexes in primary prostate cancer","volume":"16","author":"Zhou","year":"2019","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.xcrm.2025.102161_bib52","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.4161\/cc.7.14.6475","article-title":"Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase","volume":"7","author":"Di Vizio","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.xcrm.2025.102161_bib53","doi-asserted-by":"crossref","first-page":"8202","DOI":"10.1038\/s41598-017-08392-1","article-title":"Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA","volume":"7","author":"N\u00e9meth","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2025.102161_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12028","article-title":"Methamphetamine use alters human plasma extracellular vesicles and their microRNA cargo: An exploratory study","volume":"10","author":"Sandau","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.xcrm.2025.102161_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.668609","article-title":"Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release","volume":"12","author":"Shpigelman","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.xcrm.2025.102161_bib56","article-title":"Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis","volume":"13","author":"Yan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102161_bib57","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1021\/pr900748n","article-title":"Combination of FASP and StageTip-based fractionation allows in-depth analysis of the hippocampal membrane proteome","volume":"8","author":"Wi\u015bniewski","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.xcrm.2025.102161_bib58","doi-asserted-by":"crossref","first-page":"9858","DOI":"10.1021\/acs.analchem.9b01520","article-title":"Low-Background Acyl-Biotinyl Exchange Largely Eliminates the Coisolation of Non- S-Acylated Proteins and Enables Deep S-Acylproteomic Analysis","volume":"91","author":"Zhou","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.xcrm.2025.102161_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102161_bib60","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2025.102161_bib61","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integration of genomic datasets with the R\/Bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379125002344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379125002344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:42:51Z","timestamp":1762638171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379125002344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2666379125002344"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2025.102161","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.08.14.607999","asserted-by":"object"}]},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular vesicle heterogeneity through the lens of multiomics","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2025.102161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102161"}}