{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T05:14:11Z","timestamp":1794201251599,"version":"4.8.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R24HD000836"],"award-info":[{"award-number":["R24HD000836"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI145296"],"award-info":[{"award-number":["R01AI145296"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI179722"],"award-info":[{"award-number":["R01AI179722"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["K08AI150996"],"award-info":[{"award-number":["K08AI150996"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01AG080585"],"award-info":[{"award-number":["R01AG080585"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K01AG059841"],"award-info":[{"award-number":["K01AG059841"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01AI183793"],"award-info":[{"award-number":["R01AI183793"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.xcrm.2025.102189","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T11:04:40Z","timestamp":1750158280000},"page":"102189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["The human neural cell atlas of Zika virus infection in developing brain tissue"],"prefix":"10.1016","volume":"6","author":[{"given":"Caleb","family":"Stokes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne S.","family":"Whitmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dante","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Tisoncik-Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Wren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Michael","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2025.102189_bib1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jamapediatrics.2016.3982","article-title":"Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians","volume":"171","author":"Moore","year":"2017","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.xcrm.2025.102189_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010812","article-title":"The global trends and regional differences in incidence of Zika virus infection and implications for Zika virus infection prevention","volume":"16","author":"Guo","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.xcrm.2025.102189_bib3","article-title":"Temperature drives Zika virus transmission: evidence from empirical and mathematical models","volume":"285","author":"Tesla","year":"2018","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.xcrm.2025.102189_bib4","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.stem.2016.04.014","article-title":"Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3","volume":"19","author":"Dang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xcrm.2025.102189_bib5","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1080\/22221751.2019.1637283","article-title":"Zika virus differentially infects human neural progenitor cells according to their state of differentiation and dysregulates neurogenesis through the Notch pathway","volume":"8","author":"Ferraris","year":"2019","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.xcrm.2025.102189_bib6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.stem.2016.08.005","article-title":"Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation","volume":"19","author":"Li","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xcrm.2025.102189_bib7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.stem.2016.02.016","article-title":"Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth","volume":"18","author":"Tang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xcrm.2025.102189_bib8","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1016\/j.celrep.2016.08.038","article-title":"Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia","volume":"16","author":"Onorati","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.xcrm.2025.102189_bib9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cell.2017.11.018","article-title":"Intrinsic Immunity Shapes Viral Resistance of Stem Cells","volume":"172","author":"Wu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2025.102189_bib10","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.4161\/cc.9.17.12792","article-title":"Molecular basis for an attenuated cytoplasmic dsRNA response in human embryonic stem cells","volume":"9","author":"Chen","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.xcrm.2025.102189_bib11","doi-asserted-by":"crossref","first-page":"15926","DOI":"10.1074\/jbc.M112.421438","article-title":"Mouse embryonic stem cells are deficient in type I interferon expression in response to viral infections and double-stranded RNA","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.xcrm.2025.102189_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s13287-019-1521-5","article-title":"Activation of type I interferon antiviral response in human neural stem cells","volume":"10","author":"Lin","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.xcrm.2025.102189_bib13","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.stemcr.2017.01.008","article-title":"Differential Responses of Human Fetal Brain Neural Stem Cells to Zika Virus Infection","volume":"8","author":"McGrath","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.xcrm.2025.102189_bib14","doi-asserted-by":"crossref","first-page":"8610","DOI":"10.1093\/nar\/gkw765","article-title":"Molecular signatures associated with ZIKV exposure in human cortical neural progenitors","volume":"44","author":"Zhang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xcrm.2025.102189_bib15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fncel.2019.00064","article-title":"Zika Virus Impairs Neurogenesis and Synaptogenesis Pathways in Human Neural Stem Cells and Neurons","volume":"13","author":"Rosa-Fernandes","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.xcrm.2025.102189_bib16","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41564-017-0092-4","article-title":"AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling","volume":"3","author":"Chen","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.xcrm.2025.102189_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/v10110646","article-title":"Human Fetal Astrocytes Infected with Zika Virus Exhibit Delayed Apoptosis and Resistance to Interferon: Implications for Persistence. Viruses 10","volume":"10","author":"Limonta","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.xcrm.2025.102189_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01050-20","article-title":"TLR3 activation by Zika virus stimulates inflammatory cytokine production which dampens the antiviral response induced by RIG-I-like receptors","volume":"95","author":"Plociennikowska","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.xcrm.2025.102189_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.24968","article-title":"Differential neuronal susceptibility and apoptosis in congenital Zika virus infection","volume":"82","author":"Ho","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.xcrm.2025.102189_bib20","article-title":"Zika Virus Infects Intermediate Progenitor Cells and Post-mitotic Committed Neurons in Human Fetal Brain Tissues","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2025.102189_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41421-018-0042-1","article-title":"Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice","volume":"4","author":"Li","year":"2018","journal-title":"Cell Discov."},{"key":"10.1016\/j.xcrm.2025.102189_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40478-017-0450-8","article-title":"Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected","volume":"5","author":"Cumberworth","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.xcrm.2025.102189_bib23","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.neuron.2019.06.011","article-title":"A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation","volume":"103","author":"Polioudakis","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2025.102189_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf0834","article-title":"Single-cell analysis of prenatal and postnatal human cortical development","volume":"382","author":"Velmeshev","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2025.102189_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btae145","article-title":"scPathoQuant: A tool for efficient alignment and quantification of pathogen sequence reads from 10x single cell sequencing data sets","volume":"40","author":"Whitmore","year":"2024","journal-title":"Bioinformatics"},{"key":"10.1016\/j.xcrm.2025.102189_bib26","article-title":"West Nile Virus-Inclusive Single-Cell RNA Sequencing Reveals Heterogeneity in the Type I Interferon Response within Single Cells","volume":"93","author":"O'Neal","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.xcrm.2025.102189_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00640-19","article-title":"Comparative Analysis of African and Asian Lineage-Derived Zika Virus Strains Reveals Differences in Activation of and Sensitivity to Antiviral Innate Immunity","volume":"93","author":"Esser-Nobis","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.xcrm.2025.102189_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/cells9061476","article-title":"RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death","volume":"9","author":"Schilling","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.xcrm.2025.102189_bib29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.virol.2015.02.017","article-title":"RIG-I in RNA virus recognition","volume":"479\u2013480","author":"Kell","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.xcrm.2025.102189_bib30","article-title":"Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells","volume":"6","author":"Yuan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2025.102189_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neures.2007.02.017","article-title":"Retinoic acid-inducible gene-I mediates RANTES\/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA","volume":"58","author":"Yoshida","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.xcrm.2025.102189_bib32","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/febs.15480","article-title":"NOXA upregulation by the prohibitin-binding compound fluorizoline is transcriptionally regulated by integrated stress response-induced ATF3 and ATF4","volume":"288","author":"Nunez-Vazquez","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.xcrm.2025.102189_bib33","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1128\/MCB.24.13.5721-5732.2004","article-title":"Role for activating transcription factor 3 in stress-induced beta-cell apoptosis","volume":"24","author":"Hartman","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.xcrm.2025.102189_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/af6dfc34-7211-4e27-be19-298f08ec33f6","article-title":"C\/EBP-beta regulates endoplasmic reticulum stress-triggered cell death in mouse and human models","volume":"5","author":"Meir","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2025.102189_bib35","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201903062","article-title":"Zika NS1-induced ER remodeling is essential for viral replication","volume":"219","author":"Ci","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.xcrm.2025.102189_bib36","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.celrep.2017.02.014","article-title":"Ultrastructural Characterization of Zika Virus Replication Factories","volume":"18","author":"Cortese","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.xcrm.2025.102189_bib37","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12740","article-title":"Zika virus induced cellular remodelling","volume":"19","author":"Rossignol","year":"2017","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.xcrm.2025.102189_bib38","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1038\/s41467-019-11663-2","article-title":"Viral priming of cell intrinsic innate antiviral signaling by the unfolded protein response","volume":"10","author":"Carletti","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102189_bib39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41593-017-0038-4","article-title":"Stress-induced unfolded protein response contributes to Zika virus-associated microcephaly","volume":"21","author":"Gladwyn-Ng","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.xcrm.2025.102189_bib40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12974-018-1311-5","article-title":"ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells","volume":"15","author":"Tan","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.xcrm.2025.102189_bib41","doi-asserted-by":"crossref","first-page":"15974","DOI":"10.1074\/jbc.270.27.15974","article-title":"Vaccinia virus B18R gene encodes a type I interferon-binding protein that blocks interferon alpha transmembrane signaling","volume":"270","author":"Colamonici","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.xcrm.2025.102189_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189308","article-title":"Recombinant Vaccinia virus-coded interferon inhibitor B18R: Expression, refolding and a use in a mammalian expression system with a RNA-vector","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2025.102189_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.654031","article-title":"SOX Transcription Factors as Important Regulators of Neuronal and Glial Differentiation During Nervous System Development and Adult Neurogenesis","volume":"14","author":"Stevanovic","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.xcrm.2025.102189_bib44","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature07106","article-title":"Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA","volume":"454","author":"Saito","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2025.102189_bib45","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1073\/pnas.1812449116","article-title":"Type I interferon response impairs differentiation potential of pluripotent stem cells","volume":"116","author":"Eggenberger","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2025.102189_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00194-24","article-title":"Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells","volume":"98","author":"Moore","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.xcrm.2025.102189_bib47","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ccell.2020.12.001","article-title":"Integrin alphavbeta6-TGFbeta-SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer","volume":"39","author":"Bagati","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.xcrm.2025.102189_bib48","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1080\/21505594.2021.1882775","article-title":"Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks","volume":"12","author":"Shang","year":"2021","journal-title":"Virulence"},{"key":"10.1016\/j.xcrm.2025.102189_bib49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/AOG.0000000000002105","article-title":"Serial Head and Brain Imaging of 17 Fetuses With Confirmed Zika Virus Infection in Colombia, South America","volume":"130","author":"Parra-Saavedra","year":"2017","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.xcrm.2025.102189_bib50","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jpeds.2022.05.016","article-title":"Early Childhood Neurodevelopmental Outcomes in Children with Prenatal Zika Virus Exposure: A Cohort Study in Puerto Rico","volume":"247","author":"Alvarado-Domenech","year":"2022","journal-title":"J. Pediatr."},{"key":"10.1016\/j.xcrm.2025.102189_bib51","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.9303","article-title":"Association Between Antenatal Exposure to Zika Virus and Anatomical and Neurodevelopmental Abnormalities in Children","volume":"3","author":"Cranston","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.xcrm.2025.102189_bib52","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3389\/fmicb.2019.00596","article-title":"Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance","volume":"10","author":"Sher","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.xcrm.2025.102189_bib53","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.scr.2017.10.013","article-title":"Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro","volume":"25","author":"Hofrichter","year":"2017","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.xcrm.2025.102189_bib54","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fncel.2019.00129","article-title":"Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling","volume":"13","author":"Pacitti","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.xcrm.2025.102189_bib55","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1073\/pnas.0910012107","article-title":"Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency","volume":"107","author":"Hu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2025.102189_bib56","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.stem.2019.11.016","article-title":"Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin alpha(v)beta(5) Axis","volume":"26","author":"Zhu","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xcrm.2025.102189_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-55155-4","article-title":"Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity","volume":"15","author":"Darmuzey","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102189_bib58","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/s41467-021-21199-z","article-title":"Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains","volume":"12","author":"Aubry","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102189_bib59","first-page":"4114","article-title":"The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and dengue virus","volume":"144","author":"Shao","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.xcrm.2025.102189_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010623","article-title":"Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus","volume":"16","author":"Raasch","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.xcrm.2025.102189_bib61","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01982-22","article-title":"Viral Protein Accumulation of Zika Virus Variants Links with Regulation of Innate Immunity for Differential Control of Viral Replication, Spread, and Response to Interferon","volume":"97","author":"Lu","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.xcrm.2025.102189_bib62","doi-asserted-by":"crossref","first-page":"242","DOI":"10.15585\/mmwr.mm6509e2","article-title":"Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy - Brazil, 2015","volume":"65","author":"Kleber de Oliveira","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.xcrm.2025.102189_bib63","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrn2252","article-title":"Development of the human cerebral cortex: Boulder Committee revisited","volume":"9","author":"Bystron","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.xcrm.2025.102189_bib64","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/joa.12948","article-title":"Astrogliogenesis in human fetal brain: complex spatiotemporal immunoreactivity patterns of GFAP, S100, AQP4 and YKL-40","volume":"235","author":"Holst","year":"2019","journal-title":"J. Anat."},{"key":"10.1016\/j.xcrm.2025.102189_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.266","article-title":"ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly","volume":"7","author":"Ghouzzi","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.xcrm.2025.102189_bib66","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.virol.2019.08.024","article-title":"PARP-1 mediated cell death is directly activated by ZIKV infection","volume":"537","author":"Xu","year":"2019","journal-title":"Virology"},{"key":"10.1016\/j.xcrm.2025.102189_bib67","article-title":"IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells","volume":"10","author":"Qi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2025.102189_bib68","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neuron.2012.07.006","article-title":"Transsynaptic signaling by activity-dependent cleavage of neuroligin-1","volume":"76","author":"Peixoto","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2025.102189_bib69","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1523\/JNEUROSCI.4757-10.2011","article-title":"Astrocytes control glutamate receptor levels at developing synapses through SPARC-beta-integrin interactions","volume":"31","author":"Jones","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.xcrm.2025.102189_bib70","doi-asserted-by":"crossref","first-page":"E440","DOI":"10.1073\/pnas.1104977108","article-title":"Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC","volume":"108","author":"Kucukdereli","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2025.102189_bib71","doi-asserted-by":"crossref","first-page":"13366","DOI":"10.1073\/pnas.1512202112","article-title":"SPARC triggers a cell-autonomous program of synapse elimination","volume":"112","author":"Lopez-Murcia","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2025.102189_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-17765-5","article-title":"In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus","volume":"8","author":"Azevedo","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2025.102189_bib73","doi-asserted-by":"crossref","DOI":"10.4172\/2314-7326.1000220","article-title":"Neuropathology of Zika Virus Infection","volume":"7","author":"Solomon","year":"2016","journal-title":"J. Neuroinfect. Dis."},{"key":"10.1016\/j.xcrm.2025.102189_bib74","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nm.4485","article-title":"Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain","volume":"24","author":"Adams Waldorf","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.xcrm.2025.102189_bib75","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1038\/s41467-018-04777-6","article-title":"Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease","volume":"9","author":"Coffey","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102189_bib76","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.1038\/s41467-024-49524-2","article-title":"Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection","volume":"15","author":"Tisoncik-Go","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2025.102189_bib77","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/s41593-019-0427-y","article-title":"T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses","volume":"22","author":"Garber","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.xcrm.2025.102189_bib78","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.devcel.2015.01.019","article-title":"Programmed cell death in neurodevelopment","volume":"32","author":"Yamaguchi","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.xcrm.2025.102189_bib79","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1016\/j.neuron.2022.09.002","article-title":"Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells","volume":"110","author":"Bulstrode","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2025.102189_bib80","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12974-022-02668-8","article-title":"Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response","volume":"19","author":"Manet","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.xcrm.2025.102189_bib81","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/hmg\/ddx382","article-title":"Modeling neuro-immune interactions during Zika virus infection","volume":"27","author":"Mesci","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.xcrm.2025.102189_bib82","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.bbrc.2018.02.118","article-title":"Zika virus infected primary microglia impairs NPCs proliferation and differentiation","volume":"497","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.xcrm.2025.102189_bib83","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/jnen\/nly013","article-title":"Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds","volume":"77","author":"Rose","year":"2018","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.xcrm.2025.102189_bib84","article-title":"Anticholinergic drugs and dementia risk: Using stem cell-based studies to complement pharmacoepidemiology","volume":"11","author":"Schwarze-Taufiq","year":"2025","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.xcrm.2025.102189_bib85","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41592-019-0535-3","article-title":"Supervised classification enables rapid annotation of cell atlases","volume":"16","author":"Pliner","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.xcrm.2025.102189_bib86","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.xcrm.2025.102189_bib87","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.xcrm.2025.102189_bib88","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13059-023-02988-9","article-title":"scTour: a deep learning architecture for robust inference and accurate prediction of cellular dynamics","volume":"24","author":"Li","year":"2023","journal-title":"Genome Biol."},{"key":"10.1016\/j.xcrm.2025.102189_bib89","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12859-021-04344-9","article-title":"CellProfiler 4: improvements in speed, utility and usability","volume":"22","author":"Stirling","year":"2021","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.xcrm.2025.102189_bib90","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002839","article-title":"Uridine composition of the poly-U\/UC tract of HCV RNA defines non-self recognition by RIG-I","volume":"8","author":"Schnell","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.xcrm.2025.102189_bib91","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.aab3628","article-title":"Transmission of innate immune signaling by packaging of cGAMP in viral particles","volume":"349","author":"Gentili","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2025.102189_bib92","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1007\/s12035-019-1538-x","article-title":"Reference Gene Validation via RT-qPCR for Human iPSC-Derived Neural Stem Cells and Neural Progenitors","volume":"56","author":"Augustyniak","year":"2019","journal-title":"Mol. Neurobiol."}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379125002629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379125002629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:20:31Z","timestamp":1778919631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379125002629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":92,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S2666379125002629"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2025.102189","relation":{},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The human neural cell atlas of Zika virus infection in developing brain tissue","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2025.102189","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102189"}}