{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:41:13Z","timestamp":1793504473119,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2021SHZDZX0102"],"award-info":[{"award-number":["2021SHZDZX0102"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0509202"],"award-info":[{"award-number":["2023ZD0509202"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0509201"],"award-info":[{"award-number":["2023ZD0509201"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2407000"],"award-info":[{"award-number":["2022YFC2407000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502800"],"award-info":[{"award-number":["2022YFC2502800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["82388101"],"award-info":[{"award-number":["82388101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62272298"],"award-info":[{"award-number":["62272298"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["IS23096"],"award-info":[{"award-number":["IS23096"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["104443"],"award-info":[{"award-number":["104443"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.xcrm.2025.102203","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T10:37:12Z","timestamp":1750847832000},"page":"102203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["A deep learning system for detecting systemic lupus erythematosus from retinal images"],"prefix":"10.1016","volume":"6","author":[{"given":"Tingyao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouyu","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinqi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ran (Joyce)","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangzhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huating","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih-Chung","family":"Tham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charumathi","family":"Sabanayagam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Feng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried K.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pearse A.","family":"Keane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Yin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongping","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8678-2784","authenticated-orcid":false,"given":"Bin","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2025.102203_bib1","doi-asserted-by":"crossref","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic lupus erythematosus","volume":"2","author":"Kaul","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.xcrm.2025.102203_bib2","doi-asserted-by":"crossref","first-page":"101569","DOI":"10.1016\/j.xcrm.2024.101569","article-title":"Uncoupling interferons and the interferon signature explains clinical and transcriptional subsets in SLE","volume":"5","author":"G\u00f3mez-Ba\u00f1uelos","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.xcrm.2025.102203_bib3","article-title":"Mendelian randomization and pathway analysis demonstrate shared genetic associations between lupus and coronary artery disease","volume":"3","author":"Kain","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.xcrm.2025.102203_bib4","article-title":"Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease","volume":"2","author":"Jiang","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.xcrm.2025.102203_bib5","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1001\/jama.2024.2315","article-title":"Systemic Lupus Erythematosus: A Review","volume":"331","author":"Siegel","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.xcrm.2025.102203_bib6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.semarthrit.2008.10.007","article-title":"Understanding the Epidemiology and Progression of Systemic Lupus Erythematosus","volume":"39","author":"Pons-Estel","year":"2010","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.xcrm.2025.102203_bib7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/art.1780380415","article-title":"The prevalence and incidence of systemic lupus erythematosus in Birmingham, England","volume":"38","author":"Johnson","year":"1995","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.xcrm.2025.102203_bib8","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/rheumatology\/keu412","article-title":"Birmingham SLE cohort: Outcomes of a large inception cohort followed for up to 21 years","volume":"54","author":"Yee","year":"2015","journal-title":"Rheumatology"},{"key":"10.1016\/j.xcrm.2025.102203_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/ard-2023-224762","article-title":"EULAR recommendations for the management of systemic lupus erythematosus: 2023 update","volume":"83","author":"Fanouriakis","year":"2024","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.xcrm.2025.102203_bib10","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1038\/s41433-020-01292-1","article-title":"Retinal and choroidal thickness changes in systemic lupus erythematosus patients: a longitudinal study","volume":"35","author":"Dias-Santos","year":"2021","journal-title":"Eye"},{"key":"10.1016\/j.xcrm.2025.102203_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.sjopt.2016.02.001","article-title":"Ocular findings in systemic lupus erythematosus","volume":"30","author":"Shoughy","year":"2016","journal-title":"Saudi J. Ophthalmol."},{"key":"10.1016\/j.xcrm.2025.102203_bib12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10238-017-0479-9","article-title":"Systemic lupus erythematosus and ocular involvement: an overview","volume":"18","author":"Dammacco","year":"2018","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.xcrm.2025.102203_bib13","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1177\/0961203317698050","article-title":"Retinal vasculopathy in patients with systemic lupus erythematosus","volume":"26","author":"Gao","year":"2017","journal-title":"Lupus"},{"key":"10.1016\/j.xcrm.2025.102203_bib14","doi-asserted-by":"crossref","first-page":"8112","DOI":"10.3390\/ijerph110808112","article-title":"Atopic diseases and systemic lupus erythematosus: An epidemiological study of the risks and correlations","volume":"11","author":"Hsiao","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.xcrm.2025.102203_bib15","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1109\/TMI.2022.3223683","article-title":"TMM-Nets: Transferred Multi- to Mono-Modal Generation for Lupus Retinopathy Diagnosis","volume":"42","author":"Liu","year":"2023","journal-title":"IEEE Trans. Med. Imag."},{"key":"10.1016\/j.xcrm.2025.102203_bib16","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1007\/s00371-023-02945-4","article-title":"Deep learning-enabled automatic screening of SLE diseases and LR using OCT images","volume":"39","author":"Lin","year":"2023","journal-title":"Vis. Comput."},{"key":"10.1016\/j.xcrm.2025.102203_bib17","first-page":"1434","article-title":"Racial Discrimination, Disease Activity, and Organ Damage: The Black Women\u2019s Experiences Living With Lupus (BeWELL) Study","volume":"188","author":"Chae","year":"2019","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.xcrm.2025.102203_bib18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/tvst.11.7.12","article-title":"AutoMorph: Automated Retinal Vascular Morphology Quantification Via a Deep Learning Pipeline","volume":"11","author":"Zhou","year":"2022","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.xcrm.2025.102203_bib19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/0002-9394(74)90457-7","article-title":"General caliber of the retinal arteries expressed as the equivalent width of the central retinal artery","volume":"77","author":"Parr","year":"1974","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.xcrm.2025.102203_bib20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1177\/0961203320983445","article-title":"Delayed diagnosis adversely affects outcome in systemic lupus erythematosus: Cross sectional analysis of the LuLa cohort","volume":"30","author":"Kernder","year":"2021","journal-title":"Lupus"},{"key":"10.1016\/j.xcrm.2025.102203_bib21","doi-asserted-by":"crossref","first-page":"e806","DOI":"10.1016\/S2589-7500(22)00169-8","article-title":"A deep learning model for detection of Alzheimer\u2019s disease based on retinal photographs: a retrospective, multicentre case-control study","volume":"4","author":"Cheung","year":"2022","journal-title":"Lancet Digit. Health"},{"key":"10.1016\/j.xcrm.2025.102203_bib22","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/s41591-024-03113-4","article-title":"The limits of fair medical imaging AI in real-world generalization","volume":"30","author":"Yang","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.xcrm.2025.102203_bib23","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1177\/0961203315582285","article-title":"Retinal nerve fiber layer and macular thinning in systemic lupus erythematosus: an optical coherence tomography study comparing SLE and neuropsychiatric SLE","volume":"24","author":"Liu","year":"2015","journal-title":"Lupus"},{"key":"10.1016\/j.xcrm.2025.102203_bib24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/ard.59.9.705","article-title":"Retinal disease in patients with systemic lupus erythematosus","volume":"59","author":"Ushiyama","year":"2000","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.xcrm.2025.102203_bib25","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1093\/rheumatology\/keac626","article-title":"Preclinical ocular changes in systemic lupus erythematosus patients by optical coherence tomography","volume":"62","author":"Pelegr\u00edn","year":"2023","journal-title":"Rheumatology"},{"key":"10.1016\/j.xcrm.2025.102203_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adk5395","article-title":"Deep learning assists detection of esophageal cancer and precursor lesions in a prospective, randomized controlled study","volume":"16","author":"Li","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.xcrm.2025.102203_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-058552","article-title":"AlzEye: longitudinal record-level linkage of ophthalmic imaging and hospital admissions of 353 157 patients in London, UK","volume":"12","author":"Wagner","year":"2022","journal-title":"BMJ Open"},{"key":"10.1016\/j.xcrm.2025.102203_bib28","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00296-018-4083-4","article-title":"Lupus retinopathy: a marker of active systemic lupus erythematosus","volume":"38","author":"Seth","year":"2018","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.xcrm.2025.102203_bib29","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/S0161-6420(03)00475-5","article-title":"Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales","volume":"110","author":"Wilkinson","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xcrm.2025.102203_bib30","first-page":"15979","article-title":"Masked Autoencoders Are Scalable Vision Learners","author":"He","year":"2022","journal-title":"Proc. IEEE Comput. Soc. Conf. Comput. Vis. Pattern Recognit."},{"key":"10.1016\/j.xcrm.2025.102203_bib31","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41586-023-06555-x","article-title":"A foundation model for generalizable disease detection from retinal images","volume":"622","author":"Zhou","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2025.102203_bib32","article-title":"An Image Is Worth 16X16 Words: Transformers for Image Recognition At Scale","author":"Dosovitskiy","year":"2021","journal-title":"ICLR 2021 - 9th Int. Conf. Learn. Represent"},{"key":"10.1016\/j.xcrm.2025.102203_bib33","first-page":"782","article-title":"Transformer Interpretability Beyond Attention Visualization","author":"Chefer","year":"2021","journal-title":"Proc. IEEE Comput. Soc. Conf. Comput. Vis. Pattern Recognit."},{"key":"10.1016\/j.xcrm.2025.102203_bib34","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1097\/HJH.0b013e328347266c","article-title":"Quantitative and qualitative retinal microvascular characteristics and blood pressure","volume":"29","author":"Cheung","year":"2011","journal-title":"J. Hypertens."}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379125002769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379125002769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:42:07Z","timestamp":1762638127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379125002769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2666379125002769"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2025.102203","relation":{},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A deep learning system for detecting systemic lupus erythematosus from retinal images","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2025.102203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102203"}}