{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:46:05Z","timestamp":1785912365069,"version":"3.56.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Foundation","doi-asserted-by":"publisher","award":["17-3517"],"award-info":[{"award-number":["17-3517"]}],"id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovation Fund Denmark","doi-asserted-by":"publisher","award":["9122-00012B"],"award-info":[{"award-number":["9122-00012B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R344-2020-1063"],"award-info":[{"award-number":["R344-2020-1063"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R389-2021-1596"],"award-info":[{"award-number":["R389-2021-1596"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R347-2020-2339"],"award-info":[{"award-number":["R347-2020-2339"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R322-2019-1816"],"award-info":[{"award-number":["R322-2019-1816"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R433-2023-1585"],"award-info":[{"award-number":["R433-2023-1585"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006442","name":"Det Sundhedsvidenskabelige Fakultet, K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005747","name":"AP M\u00f8ller and Chastine McKinney M\u00f8ller Foundation","doi-asserted-by":"publisher","award":["L-2021-0031"],"award-info":[{"award-number":["L-2021-0031"]}],"id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005747","name":"AP M\u00f8ller and Chastine McKinney M\u00f8ller Foundation","doi-asserted-by":"publisher","award":["18-L-0213"],"award-info":[{"award-number":["18-L-0213"]}],"id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF19SA0059305"],"award-info":[{"award-number":["NNF19SA0059305"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["2025-00028B"],"award-info":[{"award-number":["2025-00028B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.xcrm.2026.102800","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:52:48Z","timestamp":1778766768000},"page":"102800","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics"],"prefix":"10.1016","volume":"7","author":[{"given":"Gith","family":"Noes-Holt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine L.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Comaposada-Bar\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Jager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Richner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Goddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco B.K.","family":"Kowenicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Sivertsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Jim\u00e9nez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita C.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamila H.","family":"Lilja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas H.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie P.","family":"Boesgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace A.","family":"Houser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaj R.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Tappe-Theodor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wierer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian B.","family":"V\u00e6gter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini","family":"Kuner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-9247","authenticated-orcid":false,"given":"Andreas T.","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2026.102800_bib1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nrd.2018.110","article-title":"Gene therapy for neurological disorders: progress and prospects","volume":"17","author":"Deverman","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.xcrm.2026.102800_bib2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/d41573-021-00017-7","article-title":"The clinical landscape for AAV gene therapies","volume":"20","author":"Kuzmin","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.xcrm.2026.102800_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molmed.2025.08.008","article-title":"AAV vectors: an emerging strategy for chronic pain management","volume":"32","author":"Nassini","year":"2026","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.xcrm.2026.102800_bib4","series-title":"Drug Overdose Deaths in the United States, 1999-2019","first-page":"1","author":"Hedegaard","year":"2020"},{"key":"10.1016\/j.xcrm.2026.102800_bib5","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.15585\/mmwr.mm6736a2","article-title":"Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults - United States, 2016","volume":"67","author":"Dahlhamer","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.xcrm.2026.102800_bib6","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","article-title":"Neuropathic pain in the general population: a systematic review of epidemiological studies","volume":"155","author":"van Hecke","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.xcrm.2026.102800_bib7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic Pain: From Mechanisms to Treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.xcrm.2026.102800_bib8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neuron.2019.03.020","article-title":"Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality","volume":"102","author":"Hudry","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2026.102800_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s40122-017-0091-4","article-title":"Pharmacotherapy for Neuropathic Pain: A Review","volume":"6","author":"Fornasari","year":"2017","journal-title":"Pain Ther."},{"key":"10.1016\/j.xcrm.2026.102800_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrn2540","article-title":"Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density","volume":"10","author":"Feng","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.xcrm.2026.102800_bib11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn1517","article-title":"PDZ domain proteins of synapses","volume":"5","author":"Kim","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.xcrm.2026.102800_bib12","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1126\/science.1072873","article-title":"Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions","volume":"298","author":"Aarts","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2026.102800_bib13","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1126\/science.1116894","article-title":"Nucleus accumbens long-term depression and the expression of behavioral sensitization","volume":"310","author":"Brebner","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2026.102800_bib14","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1073\/pnas.1113761109","article-title":"A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage","volume":"109","author":"Bach","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2026.102800_bib15","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201911248","article-title":"A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain","volume":"12","author":"Christensen","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.xcrm.2026.102800_bib16","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/14771","article-title":"AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses","volume":"2","author":"Li","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.xcrm.2026.102800_bib17","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/mt.2011.42","article-title":"Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain","volume":"19","author":"D'Mello","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.xcrm.2026.102800_bib18","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1038\/mt.2008.192","article-title":"Cell-permeable peptide Tat-PSD-95 PDZ2 inhibits chronic inflammatory pain behaviors in mice","volume":"16","author":"Tao","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.xcrm.2026.102800_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.750902","article-title":"A Novel Peripheral Action of PICK1 Inhibition in Inflammatory Pain","volume":"15","author":"Jensen","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.xcrm.2026.102800_bib20","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.170976","article-title":"Peripherally restricted PICK1 inhibitor mPD5 ameliorates pain behaviors in murine inflammatory and neuropathic pain models","volume":"9","author":"Jensen","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.xcrm.2026.102800_bib21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pharmthera.2008.02.002","article-title":"PICK1: a multi-talented modulator of AMPA receptor trafficking","volume":"118","author":"Hanley","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.xcrm.2026.102800_bib22","doi-asserted-by":"crossref","first-page":"6360","DOI":"10.1523\/JNEUROSCI.6276-09.2010","article-title":"PICK1 regulates incorporation of calcium-permeable AMPA receptors during cortical synaptic strengthening","volume":"30","author":"Clem","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.xcrm.2026.102800_bib23","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.neuron.2005.02.026","article-title":"Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF","volume":"45","author":"Gardner","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2026.102800_bib24","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.1239403","article-title":"Constitutive mu-opioid receptor activity leads to long-term endogenous analgesia and dependence","volume":"341","author":"Corder","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2026.102800_bib25","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/dvg.20656","article-title":"Hoxb8-Cre mice: A tool for brain-sparing conditional gene deletion","volume":"48","author":"Witschi","year":"2010","journal-title":"Genesis"},{"key":"10.1016\/j.xcrm.2026.102800_bib26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neulet.2012.02.053","article-title":"Periaqueductal gray stimulation suppresses spontaneous pain behavior in rats","volume":"514","author":"Lee","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.xcrm.2026.102800_bib27","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1073\/pnas.0914725107","article-title":"Deletion of PIK3C3\/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway","volume":"107","author":"Zhou","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2026.102800_bib28","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/gene.20010","article-title":"Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia","volume":"38","author":"Agarwal","year":"2004","journal-title":"Genesis"},{"key":"10.1016\/j.xcrm.2026.102800_bib29","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/nn.4593","article-title":"Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems","volume":"20","author":"Chan","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.xcrm.2026.102800_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay9056","article-title":"Long-lasting analgesia via targeted in situ repression of Na(V)1.7 in mice","volume":"13","author":"Moreno","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.xcrm.2026.102800_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adh3839","article-title":"A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons","volume":"15","author":"Perez-Sanchez","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.xcrm.2026.102800_bib32","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2217800120","article-title":"Identification and targeting of a unique Na(V)1.7 domain driving chronic pain","volume":"120","author":"Gomez","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2026.102800_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/cells11081255","article-title":"The Scaffold Protein PICK1 as a Target in Chronic Pain","volume":"11","author":"S\u00f8rensen","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.xcrm.2026.102800_bib34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1744-8069-7-11","article-title":"Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1","volume":"7","author":"Wang","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.xcrm.2026.102800_bib35","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.pain.2010.07.017","article-title":"Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain","volume":"151","author":"Atianjoh","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.xcrm.2026.102800_bib36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S1044-7431(03)00134-9","article-title":"Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit","volume":"24","author":"Garry","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.xcrm.2026.102800_bib37","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1213\/ANE.0000000000001442","article-title":"PICK1 Regulates the Expression and Trafficking of AMPA Receptors in Remifentanil-Induced Hyperalgesia","volume":"123","author":"Wang","year":"2016","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.xcrm.2026.102800_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.683527","article-title":"Emerging Role of Serum Glucocorticoid-Regulated Kinase 1 in Pathological Pain","volume":"14","author":"Liu","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.xcrm.2026.102800_bib39","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1523\/JNEUROSCI.4452-12.2013","article-title":"Spinal serum-inducible and glucocorticoid-inducible kinase 1 mediates neuropathic pain via kalirin and downstream PSD-95-dependent NR2B phosphorylation in rats","volume":"33","author":"Peng","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.xcrm.2026.102800_bib40","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.mcn.2012.03.002","article-title":"AAV8(gfp) preferentially targets large diameter dorsal root ganglion neurones after both intra-dorsal root ganglion and intrathecal injection","volume":"49","author":"Jacques","year":"2012","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.xcrm.2026.102800_bib41","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/384360a0","article-title":"Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons","volume":"384","author":"Neumann","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2026.102800_bib42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3959(00)00392-4","article-title":"Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections","volume":"90","author":"Sun","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.xcrm.2026.102800_bib43","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0450-17.2018","article-title":"Optogenetic Activation of Non-Nociceptive Abeta Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats","volume":"5","author":"Tashima","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.xcrm.2026.102800_bib44","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1038\/s41467-024-47245-0","article-title":"Distinct local and global functions of mouse Abeta low-threshold mechanoreceptors in mechanical nociception","volume":"15","author":"Gautam","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.102800_bib45","first-page":"S209","article-title":"Transforaminal Epidural Steroid Injections: A Systematic Review and Meta-Analysis of Efficacy and Safety","volume":"24","author":"Helm Ii","year":"2021","journal-title":"Pain Physician"},{"key":"10.1016\/j.xcrm.2026.102800_bib46","doi-asserted-by":"crossref","first-page":"20539","DOI":"10.1074\/jbc.M500577200","article-title":"Molecular determinants for the complex binding specificity of the PDZ domain in PICK1","volume":"280","author":"Madsen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.xcrm.2026.102800_bib47","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/brainsci10010006","article-title":"Selection of Reliable Reference Genes for Analysis of Gene Expression in Spinal Cord during Rat Postnatal Development and after Injury","volume":"10","author":"Ko\u0161uth","year":"2019","journal-title":"Brain Sci."},{"key":"10.1016\/j.xcrm.2026.102800_bib48","doi-asserted-by":"crossref","first-page":"101361","DOI":"10.1016\/j.jbc.2021.101361","article-title":"Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation","volume":"297","author":"S\u00f8rensen","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.xcrm.2026.102800_bib49","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2026.102800_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.xcrm.2026.102800_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2026.102800_bib52","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s41587-021-01145-6","article-title":"A knowledge graph to interpret clinical proteomics data","volume":"40","author":"Santos","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.xcrm.2026.102800_bib53","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76603-3","article-title":"VolcaNoseR is a web app for creating, exploring, labeling and sharing volcano plots","volume":"10","author":"Goedhart","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2026.102800_bib54","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s41592-023-01943-7","article-title":"Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender","volume":"20","author":"Fleming","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.xcrm.2026.102800_bib55","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data","volume":"8","author":"Wolock","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.xcrm.2026.102800_bib56","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41592-019-0466-z","article-title":"Joint analysis of heterogeneous single-cell RNA-seq dataset collections","volume":"16","author":"Barkas","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.xcrm.2026.102800_bib57","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0092-8674(05)80070-4","article-title":"The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex","volume":"71","author":"Ellenberger","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2026.102800_bib58","doi-asserted-by":"crossref","DOI":"10.1063\/1.2408420","article-title":"Canonical sampling through velocity rescaling","volume":"126","author":"Bussi","year":"2007","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.xcrm.2026.102800_bib59","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1080\/00268978300102851","article-title":"Constant pressure molecular dynamics for molecular systems","volume":"50","author":"Nos\u00e9","year":"1983","journal-title":"Mol. Phys."},{"key":"10.1016\/j.xcrm.2026.102800_bib60","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1021\/ct100494z","article-title":"g_wham\u2014A Free Weighted Histogram Analysis Implementation Including Robust Error and Autocorrelation Estimates","volume":"6","author":"Hub","year":"2010","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.xcrm.2026.102800_bib61","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/sj.gt.3301905","article-title":"Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area","volume":"10","author":"K\u00fcgler","year":"2003","journal-title":"Gene Ther."},{"key":"10.1016\/j.xcrm.2026.102800_bib62","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1126\/science.8248779","article-title":"A switch between two-three-and four-stranded coiled coils in GCN4 leucine zipper mutants","volume":"262","author":"Harbury","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2026.102800_bib63","doi-asserted-by":"crossref","first-page":"25327","DOI":"10.1074\/jbc.M114.548743","article-title":"Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95\/discs-large\/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands","volume":"289","author":"Erlendsson","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.xcrm.2026.102800_bib64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jmb.2004.05.044","article-title":"The hyperthermophile protein Sso10a is a dimer of winged helix DNA-binding domains linked by an antiparallel coiled coil rod","volume":"341","author":"Chen","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.xcrm.2026.102800_bib65","article-title":"ACCORD: an assessment tool to determine the orientation of homodimeric coiled-coils","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2026.102800_bib66","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1083\/jcb.201005046","article-title":"Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes","volume":"191","author":"Koirala","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.xcrm.2026.102800_bib67","article-title":"High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice","volume":"6","author":"Kim","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2026.102800_bib68","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41596-018-0097-3","article-title":"Systemic AAV vectors for widespread and targeted gene delivery in rodents","volume":"14","author":"Challis","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.xcrm.2026.102800_bib69","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","article-title":"iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging","volume":"159","author":"Renier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2026.102800_bib70","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.xcrm.2026.102800_bib71","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.4102","article-title":"Isolation of Nuclei from Mouse Dorsal Root Ganglia for Single-nucleus Genomics","volume":"11","author":"Yang","year":"2021","journal-title":"Bio. Protoc."},{"key":"10.1016\/j.xcrm.2026.102800_bib72","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuron.2020.07.026","article-title":"Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury","volume":"108","author":"Renthal","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2026.102800_bib73","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1021\/acs.jproteome.5b00981","article-title":"Accounting for the Multiple Natures of Missing Values in Label-Free Quantitative Proteomics Data Sets to Compare Imputation Strategies","volume":"15","author":"Lazar","year":"2016","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.xcrm.2026.102800_bib74","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-1-4939-7493-1_7","article-title":"Perseus: A Bioinformatics Platform for Integrative Analysis of Proteomics Data in Cancer Research","volume":"1711","author":"Tyanova","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.xcrm.2026.102800_bib75","doi-asserted-by":"crossref","first-page":"D609","DOI":"10.1093\/nar\/gkae1010","article-title":"UniProt: the Universal Protein Knowledgebase in 2025","volume":"53","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xcrm.2026.102800_bib76","doi-asserted-by":"crossref","first-page":"D512","DOI":"10.1093\/nar\/gku1267","article-title":"PhosphoSitePlus, 2014: mutations, PTMs and recalibrations","volume":"43","author":"Hornbeck","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xcrm.2026.102800_bib77","doi-asserted-by":"crossref","first-page":"D253","DOI":"10.1093\/nar\/gkq1159","article-title":"PHOSIDA 2011: the posttranslational modification database","volume":"39","author":"Gnad","year":"2011","journal-title":"Nucleic Acids Res."}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266637912600217X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266637912600217X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:57:57Z","timestamp":1785909477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266637912600217X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S266637912600217X"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2026.102800","relation":{},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2026.102800","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102800"}}