{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:52:54Z","timestamp":1789487574624,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301110"],"award-info":[{"award-number":["32301110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012576","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2025A1515010462"],"award-info":[{"award-number":["2025A1515010462"]}],"id":[{"id":"10.13039\/501100012576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012235","name":"Shenzhen Municipal Human Resources and Social Security Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","award":["RCYX20231211090225039"],"award-info":[{"award-number":["RCYX20231211090225039"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.xcrm.2026.103016","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:16:54Z","timestamp":1788448614000},"page":"103016","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surface display of co-stimulatory ligand B7H2 on engineered bacteria enhances tumor immunotherapy"],"prefix":"10.1016","volume":"7","author":[{"given":"Qiliner","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingran","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-4222","authenticated-orcid":false,"given":"Baizhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2026.103016_bib1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/imr.13244","article-title":"A synthetic biology approach to engineering circuits in immune cells","volume":"320","author":"Hoces","year":"2023","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.xcrm.2026.103016_bib2","article-title":"Bacteria-based cancer immunotherapy","volume":"8","author":"Huang","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.xcrm.2026.103016_bib3","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1021\/acs.chemrev.2c00512","article-title":"Engineered living materials for sustainability","volume":"123","author":"An","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.xcrm.2026.103016_bib4","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nnano.2014.199","article-title":"Strong underwater adhesives made by self-assembling multi-protein nanofibres","volume":"9","author":"Zhong","year":"2014","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.xcrm.2026.103016_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nmat3912","article-title":"Synthesis and patterning of tunable multiscale materials with engineered cells","volume":"13","author":"Chen","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.xcrm.2026.103016_bib6","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2018.06.041","article-title":"A synthetic bacterial cell-cell adhesion toolbox for programming multicellular morphologies and patterns","volume":"174","author":"Glass","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2026.103016_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41589-021-00934-z","article-title":"Programmable living assembly of materials by bacterial adhesion","volume":"18","author":"Chen","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.xcrm.2026.103016_bib8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41589-022-01207-z","article-title":"An E. coli display method for characterization of peptide\u2013sensor kinase interactions","volume":"19","author":"Brink","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.xcrm.2026.103016_bib9","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.1038\/s41467-022-34908-z","article-title":"Biodegradation of highly crystallized poly(ethylene terephthalate) through cell surface codisplay of bacterial PETase and hydrophobin","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103016_bib10","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1038\/s41467-021-24564-0","article-title":"Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer","volume":"12","author":"Huang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103016_bib11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ccell.2020.07.005","article-title":"Engineering CAR-T cells for next-generation cancer therapy","volume":"38","author":"Hong","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.xcrm.2026.103016_bib12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41568-023-00560-y","article-title":"Dynamics and specificities of T cells in cancer immunotherapy","volume":"23","author":"Oliveira","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.xcrm.2026.103016_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aak9537","article-title":"Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin","volume":"9","author":"Zheng","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.xcrm.2026.103016_bib14","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1021\/acssynbio.1c00097","article-title":"Engineered attenuated Salmonella typhimurium expressing neoantigen has anticancer effects","volume":"10","author":"Hyun","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.xcrm.2026.103016_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122248","article-title":"Organic functional substance engineered living materials for biomedical applications","volume":"301","author":"Wang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.xcrm.2026.103016_bib16","article-title":"Engineering Bacteria as Living Therapeutics in Cancer Therapy","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.xcrm.2026.103016_bib17","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1038\/s41467-025-61675-4","article-title":"Living therapeutics of nonpathogenic bacteria as biosynthesis factory and active carriers for enhancing tumor-targeted therapy","volume":"16","author":"Dong","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103016_bib18","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/bjc.2013.206","article-title":"Myeloid-derived suppressor cells have a central role in attenuated Listeria monocytogenes-based immunotherapy against metastatic breast cancer in young and old mice","volume":"108","author":"Chandra","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.xcrm.2026.103016_bib19","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41467-025-67437-6","article-title":"Manganese-engineered Lactobacillus Reuteri with enhanced antitumor and immunomodulatory activities for colorectal cancer prevention and treatment","volume":"17","author":"Cao","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103016_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads1630","article-title":"Leveraging dysregulated tumor metabolism for targeting anticancer bacteria","volume":"11","author":"Santos","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.xcrm.2026.103016_bib21","doi-asserted-by":"crossref","first-page":"12576","DOI":"10.1039\/D0CS01571G","article-title":"Customized materials-assisted microorganisms in tumor therapeutics","volume":"50","author":"Chen","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.xcrm.2026.103016_bib22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2016.09.011","article-title":"Engineering T cells with customized therapeutic response programs using synthetic notch receptors","volume":"167","author":"Roybal","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2026.103016_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202304963","article-title":"Engineered living materials for advanced diseases therapy","volume":"37","author":"Dong","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.xcrm.2026.103016_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature18930","article-title":"Synchronized cycles of bacterial lysis for in vivo delivery","volume":"536","author":"Din","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2026.103016_bib25","article-title":"Engineered bacteria enhance immunotherapy and targeted therapy through stromal remodeling of tumors","volume":"11","author":"Thomas","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.xcrm.2026.103016_bib26","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s41591-019-0498-z","article-title":"Programmable bacteria induce durable tumor regression and systemic antitumor immunity","volume":"25","author":"Chowdhury","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.xcrm.2026.103016_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201805557","article-title":"Nanoparticle-laden macrophages for tumor-tropic drug delivery","volume":"30","author":"Zhang","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.xcrm.2026.103016_bib28","doi-asserted-by":"crossref","first-page":"8668","DOI":"10.1073\/pnas.1211287110","article-title":"Nontoxic radioactive Listeriaat is a highly effective therapy against metastatic pancreatic cancer","volume":"110","author":"Quispe-Tintaya","year":"2013","journal-title":"Proc. Nat. Acad. Sci."},{"key":"10.1016\/j.xcrm.2026.103016_bib29","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jconrel.2022.12.030","article-title":"Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy","volume":"353","author":"Chen","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.xcrm.2026.103016_bib30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41577-021-00574-3","article-title":"CD8+ T cell differentiation and dysfunction in cancer","volume":"22","author":"Philip","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.xcrm.2026.103016_bib31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.xcrm.2026.103016_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104216","article-title":"Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint","volume":"83","author":"Verma","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.xcrm.2026.103016_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.immuni.2021.11.017","article-title":"Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells","volume":"55","author":"Peng","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.xcrm.2026.103016_bib34","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.immuni.2011.03.023","article-title":"ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor bcl6","volume":"34","author":"Choi","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.xcrm.2026.103016_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14340","article-title":"Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity","volume":"8","author":"Zamarin","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103016_bib36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/16717","article-title":"ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28","volume":"397","author":"Hutloff","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2026.103016_bib37","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/s41591-023-02369-6","article-title":"The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment","volume":"29","author":"Lv","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.xcrm.2026.103016_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114443","article-title":"Decorated bacteria and the application in drug delivery","volume":"188","author":"Wu","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.xcrm.2026.103016_bib39","doi-asserted-by":"crossref","first-page":"8069","DOI":"10.2147\/IJN.S329855","article-title":"Nanotechnology-employed bacteria-based delivery strategy for enhanced anticancer therapy","volume":"16","author":"Ye","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.xcrm.2026.103016_bib40","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1021\/acs.chemrev.6b00030","article-title":"Energy transfer with semiconductor quantum dot bioconjugates: A versatile platform for biosensing, energy harvesting, and other developing applications","volume":"117","author":"Hildebrandt","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.xcrm.2026.103016_bib41","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1126\/science.1175439","article-title":"Endogenous nitric oxide protects bacteria against a wide spectrum of antibiotics","volume":"325","author":"Gusarov","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.xcrm.2026.103016_bib42","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/s41467-018-03233-9","article-title":"Optically-controlled bacterial metabolite for cancer therapy","volume":"9","author":"Zheng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103016_bib43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/med.20092","article-title":"Nitric oxide, a double edged sword in cancer biology: Searching for therapeutic opportunities","volume":"27","author":"Mocellin","year":"2007","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.xcrm.2026.103016_bib44","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1039\/c2cs15273h","article-title":"Nitric oxide release: Part II. Therapeutic applications","volume":"41","author":"Carpenter","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.xcrm.2026.103016_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201706356","article-title":"Biocompatible semiconductor quantum dots as cancer imaging agents","volume":"30","author":"McHugh","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.xcrm.2026.103016_bib46","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jconrel.2022.08.047","article-title":"Quantum dots: The cutting-edge nanotheranostics in brain cancer management","volume":"350","author":"Chakraborty","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.xcrm.2026.103016_bib47","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.immuni.2019.04.011","article-title":"T follicular helper cell biology: A decade of discovery and diseases","volume":"50","author":"Crotty","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.xcrm.2026.103016_bib48","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nri.2017.118","article-title":"TH2 cell development and function","volume":"18","author":"Walker","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.xcrm.2026.103016_bib49","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0041-008X(82)90274-5","article-title":"Chemical softness and acute metal toxicity in mice and Drosophila","volume":"63","author":"Williams","year":"1982","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.xcrm.2026.103016_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsle\/fnu002","article-title":"An efficient bacterial surface display system based on a novel outer membrane anchoring element from the Escherichia coli protein YiaT","volume":"362","author":"Han","year":"2015","journal-title":"FEMS Microbiol. Lett."}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379126004337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379126004337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:52:03Z","timestamp":1789483923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379126004337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2666379126004337"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2026.103016","relation":{},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surface display of co-stimulatory ligand B7H2 on engineered bacteria enhances tumor immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2026.103016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103016"}}