{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:46:05Z","timestamp":1792615565267,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.xcrm.2026.103103","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:05:10Z","timestamp":1792508710000},"page":"103103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["CD47 fuels intestinal fibrosis by inducing fibroblast phagocytic evasion and represents a therapeutic target"],"prefix":"10.1016","volume":"7","author":[{"given":"Xiangyu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingman","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sishen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qidi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youqiong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taojing","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duowu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2026.103103_bib1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1152\/physrev.00005.2021","article-title":"Development of antifibrotic therapy for stricturing Crohn\u2019s disease: lessons from randomized trials in other fibrotic diseases","volume":"102","author":"Lin","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.xcrm.2026.103103_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2023-100006","article-title":"Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: advances and future directions","volume":"2","author":"Little","year":"2024","journal-title":"eGastroenterology"},{"key":"10.1016\/j.xcrm.2026.103103_bib3","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/CM9.0000000000003545","article-title":"Intestinal fibrosis associated with inflammatory bowel disease: known and unknown","volume":"138","author":"Zhang","year":"2025","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.xcrm.2026.103103_bib4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5217\/ir.2019.09148","article-title":"Fibrostenotic strictures in Crohn\u2019s disease","volume":"18","author":"Yoo","year":"2020","journal-title":"Intest. Res."},{"key":"10.1016\/j.xcrm.2026.103103_bib5","doi-asserted-by":"crossref","first-page":"6536","DOI":"10.1016\/j.cell.2025.08.029","article-title":"Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn\u2019s disease strictures","volume":"188","author":"Bauer-Rowe","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.xcrm.2026.103103_bib6","doi-asserted-by":"crossref","DOI":"10.1172\/JCI179472","article-title":"TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn\u2019s disease","volume":"134","author":"Zhang","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.xcrm.2026.103103_bib7","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1053\/j.gastro.2023.07.014","article-title":"Stricturing Crohn\u2019s disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions","volume":"165","author":"Mukherjee","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.xcrm.2026.103103_bib8","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.immuni.2021.04.021","article-title":"Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer","volume":"54","author":"Buechler","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.xcrm.2026.103103_bib9","doi-asserted-by":"crossref","DOI":"10.1172\/JCI173835","article-title":"Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn\u2019s disease","volume":"134","author":"Ke","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.xcrm.2026.103103_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110203","article-title":"Cellular crosstalk in fibrosis: insights into macrophage and fibroblast dynamics","volume":"301","author":"Froom","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.xcrm.2026.103103_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13578-022-00856-w","article-title":"New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction","volume":"12","author":"Zhao","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.xcrm.2026.103103_bib12","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0002-9440(10)63874-6","article-title":"Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36","volume":"162","author":"Moodley","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.xcrm.2026.103103_bib13","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the resolution of liver fibrosis","volume":"10","author":"Wang","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.xcrm.2026.103103_bib14","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2023-100040","article-title":"Extracellular vesicles targeting non-parenchymal cells: the therapeutical effect on liver fibrosis","volume":"2","author":"Liu","year":"2024","journal-title":"eGastroenterology"},{"key":"10.1016\/j.xcrm.2026.103103_bib15","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1038\/s41467-025-59621-5","article-title":"USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity","volume":"16","author":"Dai","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103103_bib16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41392-023-01365-z","article-title":"Emerging phagocytosis checkpoints in cancer immunotherapy","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.xcrm.2026.103103_bib17","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.immuni.2020.04.011","article-title":"The CD47-SIRP\u03b1 immune checkpoint","volume":"52","author":"Logtenberg","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.xcrm.2026.103103_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.immuni.2020.07.008","article-title":"CD47 ligation repositions the inhibitory receptor SIRPA to suppress integrin activation and phagocytosis","volume":"53","author":"Morrissey","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.xcrm.2026.103103_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e20507","article-title":"Don\u2019t eat me\/eat me signals as a novel strategy in cancer immunotherapy","volume":"9","author":"Khalaji","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.xcrm.2026.103103_bib20","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jtho.2024.03.019","article-title":"EGFR oncogenic mutations in NSCLC impair macrophage phagocytosis and mediate innate immune evasion through up-regulation of CD47","volume":"19","author":"Hu","year":"2024","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.xcrm.2026.103103_bib21","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1002\/mog2.87","article-title":"CoCl2-induced glioma hypoxia environment enhances CD47-SIRP\u03b1 to promote tumor immune evasion","volume":"3","author":"Ding","year":"2024","journal-title":"MedComm Oncol"},{"key":"10.1016\/j.xcrm.2026.103103_bib22","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.apsb.2024.11.018","article-title":"Beyond cancer: the potential application of CD47-based therapy in non-cancer diseases","volume":"15","author":"Deng","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.xcrm.2026.103103_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abp8309","article-title":"CD47-SIRP\u03b1 axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis","volume":"14","author":"Shi","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.xcrm.2026.103103_bib24","doi-asserted-by":"crossref","DOI":"10.1164\/ajrccm.2025.211.Abstracts.A6873","article-title":"CD47\/SIRP\u03b1 expression and potential roles in pulmonary fibrosis","volume":"211","author":"Liu","year":"2025","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.xcrm.2026.103103_bib25","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2025-100242","article-title":"CD47: an immunoregulatory nexus in liver and gastrointestinal disorders","volume":"3","author":"Otuagomah","year":"2025","journal-title":"eGastroenterology"},{"key":"10.1016\/j.xcrm.2026.103103_bib26","series-title":"Gut, Gutjnl-2025-337952","article-title":"SMOC2 mediates GLI1+ mesenchymal cell-driven fibrostenosis and predicts postoperative recurrence in Crohn's disease","author":"Wang","year":"2026"},{"key":"10.1016\/j.xcrm.2026.103103_bib27","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1136\/gutjnl-2018-318081","article-title":"Assessment of Crohn\u2019s disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic review","volume":"68","author":"Bettenworth","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.xcrm.2026.103103_bib28","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/gutjnl-2023-329963","article-title":"Fibrosis in IBD: from pathogenesis to therapeutic targets","volume":"73","author":"Rieder","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.xcrm.2026.103103_bib29","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bbi.2021.02.001","article-title":"Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36","volume":"94","author":"Li","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.xcrm.2026.103103_bib30","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1038\/s41467-020-16466-4","article-title":"Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity","volume":"11","author":"Cui","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103103_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140458","article-title":"CD47 prevents the elimination of diseased fibroblasts in scleroderma","volume":"5","author":"Lerbs","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.xcrm.2026.103103_bib32","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.3390\/cancers16244238","article-title":"Phosphoproteomic profiling reveals mTOR signaling in sustaining macrophage phagocytosis of cancer cells","volume":"16","author":"Wang","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.xcrm.2026.103103_bib33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41573-025-01145-0","article-title":"Thirty years of NRF2: advances and therapeutic challenges","volume":"24","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.xcrm.2026.103103_bib34","article-title":"MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1\/NRF2 interaction","volume":"69","author":"Luo","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.xcrm.2026.103103_bib35","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1136\/gutjnl-2022-328608","article-title":"Milk fat globule-epidermal growth factor 8 (MFGE8) prevents intestinal fibrosis","volume":"73","author":"Lin","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.xcrm.2026.103103_bib36","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.3390\/ijms24065517","article-title":"Contribution of blood vessel activation, remodeling and barrier function to inflammatory bowel diseases","volume":"24","author":"Britzen-Laurent","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.xcrm.2026.103103_bib37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.32604\/or.2023.042383","article-title":"Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy","volume":"32","author":"Chen","year":"2023","journal-title":"Oncol. Res."},{"key":"10.1016\/j.xcrm.2026.103103_bib38","article-title":"Targeting the CD47\/SIRP\u03b1 pathway in malignancies: recent progress, difficulties and future perspectives","volume":"14","author":"Jiang","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.xcrm.2026.103103_bib39","article-title":"Phase 0\/1 local application of the monoclonal antibody (MAb) sB24M in patients with purulent pyoderma","year":"2023","journal-title":"ClinicalTrials.gov, NCT04895566"},{"key":"10.1016\/j.xcrm.2026.103103_bib40","article-title":"A phase 1, randomized, double-blind, placebo-controlled single ascending dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of subcutaneous BRB-002 in healthy male volunteers","year":"2024","journal-title":"ANZCTR, ACTRN12624000405516"},{"key":"10.1016\/j.xcrm.2026.103103_bib41","series-title":"A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Phase 1b\/II Study to Evaluate the Safety and Efficacy of IMC-002 for the Treatment of Active Systemic Lupus Erythematosus","year":"2024"},{"key":"10.1016\/j.xcrm.2026.103103_bib42","series-title":"A Phase Ib\/III Multi-Center, Randomized, and Positive-Control Study to Evaluate IMC-002 Safety and Efficacy in Neuromyelitis Optica Spectrum Disorder (NMOSD) Patients","year":"2024"}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379126005203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379126005203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:02:35Z","timestamp":1792612955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379126005203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2666379126005203"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2026.103103","relation":{},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD47 fuels intestinal fibrosis by inducing fibroblast phagocytic evasion and represents a therapeutic target","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2026.103103","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103103"}}