{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:07:57Z","timestamp":1762985277684,"version":"3.45.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD07627902"],"award-info":[{"award-number":["R01HD07627902"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1 R01 HD100336-01"],"award-info":[{"award-number":["1 R01 HD100336-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Reports"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.xfre.2020.11.002","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T22:35:27Z","timestamp":1605738927000},"page":"67-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel ploidy analysis in ectopic pregnancy"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9006-657X","authenticated-orcid":false,"given":"Rachel S.","family":"Ruderman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana B.","family":"McQueen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared C.","family":"Robins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt T.","family":"Barnhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa K.","family":"Maisenbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve C.","family":"Feinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfre.2020.11.002_bib1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ajog.2005.12.014","article-title":"Microarray technology in obstetrics and gynecology: a guide for clinicians","volume":"195","author":"Ward","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfre.2020.11.002_bib2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.fertnstert.2013.09.031","article-title":"Reliability of 46,XX results on miscarriage specimens: a review of 1,222 first-trimester miscarriage specimens","volume":"101","author":"Lathi","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2020.11.002_bib3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/AOG.0000000000000325","article-title":"Genomic imbalance in products of conception: single-nucleotide polymorphism chromosomal microarray analysis","volume":"124","author":"Levy","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.xfre.2020.11.002_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/AOG.0000000000000904","article-title":"Single-nucleotide polymorphism-microarray ploidy analysis of paraffin-embedded products of conception in recurrent pregnancy loss evaluations","volume":"126","author":"Maslow","year":"2015","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.xfre.2020.11.002_bib5","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1472-6483(10)61671-9","article-title":"The beneficial effects of preimplantation genetic diagnosis for aneuploidy support extensive clinical application","volume":"10","author":"Gianaroli","year":"2005","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.xfre.2020.11.002_bib6","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.fertnstert.2019.07.1346","article-title":"Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial","volume":"112","author":"Munn\u00e9","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2020.11.002_bib7","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/AOG.0000000000002114","article-title":"Pregnancy-related mortality in the United States, 2011-2013","volume":"130","author":"Creanga","year":"2017","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.xfre.2020.11.002_bib8","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0015-0282(16)58320-4","article-title":"Risk factors for ectopic pregnancy: a meta-analysis","volume":"65","author":"Ankum","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2020.11.002_bib9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.fertnstert.2005.12.023","article-title":"Risk factors for ectopic pregnancy in women with symptomatic first-trimester pregnancies","volume":"86","author":"Barnhart","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2020.11.002_bib10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/jog.12133","article-title":"Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages","volume":"40","author":"Flynn","year":"2014","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.xfre.2020.11.002_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/HUMREP\/11.2.239","article-title":"Chromosomal abnormalities and ectopic pregnancy? New directions for aetiological research","volume":"11","author":"Job-Spira","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfre.2020.11.002_bib12","unstructured":"REPI-g FFPE Handbook. Quiagen: Germantown, MD:7\u201312."},{"key":"10.1016\/j.xfre.2020.11.002_bib13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1445-2197.2012.06092.x","article-title":"Formalin fixation in the '-omics' era: a primer for the surgeon-scientist","volume":"82","author":"Frankel","year":"2012","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.xfre.2020.11.002_bib14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jmoldx.2011.03.007","article-title":"Efficient DNA extraction for HPV genotyping in formalin-fixed, paraffin-embedded tissues","volume":"13","author":"Steinau","year":"2011","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.xfre.2020.11.002_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/gim.2016.69","article-title":"Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits, and challenges","volume":"19","author":"Sahoo","year":"2017","journal-title":"Genet Med"},{"key":"10.1016\/j.xfre.2020.11.002_bib16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/tera.1420140306","article-title":"Embryonic development in ectopic human pregnancy","volume":"14","author":"Poland","year":"1976","journal-title":"Teratology"},{"key":"10.1016\/j.xfre.2020.11.002_bib17","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1177\/107155769800500608","article-title":"Chromosomal abnormalities in ectopic pregnancy chorionic villi","volume":"5","author":"Block","year":"1998","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.xfre.2020.11.002_bib18","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0015-0282(00)01593-4","article-title":"Role of chromosome abnormalities in ectopic pregnancy","volume":"74","author":"Coste","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2020.11.002_bib19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF02894085","article-title":"Cytogenetic studies of ectopic pregnancies","volume":"16","author":"Busch","year":"1974","journal-title":"Virchows Arch B Cell Pathol"},{"key":"10.1016\/j.xfre.2020.11.002_bib20","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0002-9378(15)33314-7","article-title":"Chromosome analysis of ectopic human conceptuses","volume":"141","author":"Elias","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfre.2020.11.002_bib21","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1136\/jcp.43.11.963-a","article-title":"Flow cytometric DNA in ectopic pregnancy","volume":"43","author":"Aine","year":"1990","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.xfre.2020.11.002_bib22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/pd.1970130506","article-title":"Rapid karyotyping in ectopic pregnancies","volume":"13","author":"Cohen","year":"1993","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.xfre.2020.11.002_bib23","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000292617","article-title":"Abnormal embryogenesis in the etiology of ectopic pregnancy","volume":"36","author":"Karikoski","year":"1993","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.xfre.2020.11.002_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0028-2243(93)90184-E","article-title":"DNA aneuploidy in ectopic pregnancy and spontaneous abortions","volume":"51","author":"Toikkanen","year":"1993","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.xfre.2020.11.002_bib25","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1093\/oxfordjournals.humrep.a019207","article-title":"Cytogenetic characteristics of ectopic pregnancy","volume":"11","author":"Goddijn","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfre.2020.11.002_bib26","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3109\/00016349609055021","article-title":"DNA ploidy of ectopic pregnancy and first trimester spontaneous abortion investigated by flow cytometry","volume":"75","author":"Erel","year":"1996","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.xfre.2020.11.002_bib27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000086131","article-title":"Detection of chromosome abnormalities by quantitative fluorescent PCR in ectopic pregnancies","volume":"60","author":"Goddijn","year":"2005","journal-title":"Gynecol Obstetric Invest"},{"key":"10.1016\/j.xfre.2020.11.002_bib28","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1016\/j.fertnstert.2017.07.1093","article-title":"Contribution of embryonic chromosomal abnormality to the etiology of ectopic pregnancy","volume":"108","author":"Furuya","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2020.11.002_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1055\/s-2007-1019412","article-title":"The effect of aging on tubal function and ectopic pregnancy","volume":"9","author":"Yeko","year":"1991","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfre.2020.11.002_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1095\/biolreprod.112.098822","article-title":"Revealing the hidden mechanisms of smoke-induced fallopian tubal implantation","volume":"86","author":"Shao","year":"2012","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfre.2020.11.002_bib31","first-page":"2846","article-title":"Risk of ectopic pregnancy is linked to endometrial thickness in a retrospective cohort study of 8120 assisted reproduction technology cycles","volume":"30","author":"Rombauts","year":"2015","journal-title":"Hum Reeprod"},{"key":"10.1016\/j.xfre.2020.11.002_bib32","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0015-0282(16)58522-7","article-title":"Endometrial stripe thickness as a predictor of ectopic pregnancy","volume":"66","author":"Spandorfer","year":"1996","journal-title":"Fertil Steril"}],"container-title":["F&S Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666334120301215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666334120301215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:03:54Z","timestamp":1762981434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666334120301215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S2666334120301215"],"URL":"https:\/\/doi.org\/10.1016\/j.xfre.2020.11.002","relation":{},"ISSN":["2666-3341"],"issn-type":[{"type":"print","value":"2666-3341"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel ploidy analysis in ectopic pregnancy","name":"articletitle","label":"Article Title"},{"value":"F&S Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfre.2020.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}