{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:11:59Z","timestamp":1775869919041,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["fertstertreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Reports"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.xfre.2021.12.003","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T02:12:08Z","timestamp":1639793528000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["High-sensitivity C-reactive protein is not independently associated with self-reported infertility in National Health and Nutrition Examination Survey 2015\u20132018 data"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-0614","authenticated-orcid":false,"given":"Rasha A.","family":"Al-Lami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4751-870X","authenticated-orcid":false,"given":"Shaden A.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randa J.","family":"Jalloul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfre.2021.12.003_bib1","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: a critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xfre.2021.12.003_bib2","doi-asserted-by":"crossref","first-page":"8508","DOI":"10.1002\/jcp.26791","article-title":"Serum C-reactive protein in the prediction of cardiovascular diseases: overview of the latest clinical studies and public health practice","volume":"233","author":"Avan","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.xfre.2021.12.003_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cyto.2019.02.005","article-title":"C-reactive protein for predicting cardiovascular and all-cause mortality in type 2 diabetic patients: a meta-analysis","volume":"117","author":"Tian","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.xfre.2021.12.003_bib4","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa040967","article-title":"Inflammatory markers and the risk of coronary heart disease in men and women","volume":"351","author":"Pai","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.xfre.2021.12.003_bib5","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/sj.ijo.0802609","article-title":"Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome","volume":"28","author":"Aronson","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.xfre.2021.12.003_bib6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3109\/1354750X.2010.509811","article-title":"Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women","volume":"15","author":"Nayeem","year":"2010","journal-title":"Biomarkers"},{"key":"10.1016\/j.xfre.2021.12.003_bib7","doi-asserted-by":"crossref","DOI":"10.1177\/1753944719851950","article-title":"Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events","volume":"13","author":"Mattina","year":"2019","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"10.1016\/j.xfre.2021.12.003_bib8","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1210\/jc.2008-2406","article-title":"Sex differences in the relationship between C-reactive protein and body fat","volume":"94","author":"Khera","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfre.2021.12.003_bib9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/aje\/kwr343","article-title":"Endogenous reproductive hormones and C-reactive protein across the menstrual cycle: the BioCycle Study","volume":"175","author":"Gaskins","year":"2012","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.xfre.2021.12.003_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10815-016-0836-8","article-title":"Female infertility, infertility-associated diagnoses, and comorbidities: a review","volume":"34","author":"Hanson","year":"2017","journal-title":"J Assist Reprod and Genet"},{"key":"10.1016\/j.xfre.2021.12.003_bib11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00125-015-3493-z","article-title":"History of infertility and risk of type 2 diabetes mellitus: a prospective cohort study","volume":"58","author":"Tobias","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.xfre.2021.12.003_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.fertnstert.2018.10.009","article-title":"Self-reported infertility, metabolic dysfunction, and cardiovascular events: a cross-sectional analysis among U.S. women","volume":"111","author":"Gleason","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2021.12.003_bib13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5653\/cerm.2017.44.1.28","article-title":"Cardiovascular risk may be increased in women with unexplained infertility","volume":"44","author":"Verit","year":"2017","journal-title":"Clin Exp Reprod Med"},{"key":"10.1016\/j.xfre.2021.12.003_bib14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.mehy.2004.02.025","article-title":"Autonomic dysfunction may be an under-recognized cause of female fertility disorders","volume":"63","author":"Yun","year":"2004","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.xfre.2021.12.003_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1365-2796.2000.00603.x","article-title":"The hypothalamic-pituitary-adrenal axis activity as a predictor of cardiovascular disease, type 2 diabetes and stroke","volume":"247","author":"Rosmond","year":"2000","journal-title":"J Intern Med"},{"key":"10.1016\/j.xfre.2021.12.003_bib16","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1161\/01.CIR.0000038364.26310.BD","article-title":"Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study","volume":"106","author":"Brunner","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.xfre.2021.12.003_bib17","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.3390\/ijms18102224","article-title":"Stress and the HPA axis: balancing homeostasis and fertility","volume":"18","author":"Joseph","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfre.2021.12.003_bib18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1749-6632.1997.tb52128.x","article-title":"The hypothalamic-pituitary-adrenal axis and the female reproductive system","volume":"816","author":"Magiakou","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.xfre.2021.12.003_bib19","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1530\/REP-18-0583","article-title":"Obesity induces ovarian inflammation and reduces oocyte quality","volume":"158","author":"Snider","year":"2019","journal-title":"Reproduction"},{"key":"10.1016\/j.xfre.2021.12.003_bib20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s43032-019-00026-3","article-title":"Pro-inflammatory markers negatively regulate IRS1 in endometrial cells and endometrium from women with obesity and PCOS","volume":"27","author":"Or\u00f3stica","year":"2020","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfre.2021.12.003_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/REP-18-0618","article-title":"Interleukin in endometriosis-associated infertility-pelvic pain: systematic review and meta-analysis","volume":"158","author":"Malvezzi","year":"2019","journal-title":"Reproduction"},{"key":"10.1016\/j.xfre.2021.12.003_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","article-title":"Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association","volume":"107","author":"Pearson","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.xfre.2021.12.003_bib23","doi-asserted-by":"crossref","first-page":"36093","DOI":"10.1038\/srep36093","article-title":"Increasing trend of diabetes combined with hypertension or hypercholesterolemia: NHANES data analysis 1999-2012","volume":"6","author":"Song","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfre.2021.12.003_bib24","doi-asserted-by":"crossref","first-page":"190105","DOI":"10.5888\/pcd16.190105","article-title":"Hypertension and diabetes in non-pregnant women of reproductive age in the United States","volume":"16","author":"Azeez","year":"2019","journal-title":"Prev Chronic Dis"},{"key":"10.1016\/j.xfre.2021.12.003_bib25","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1590\/S0004-27302007000600010","article-title":"High-sensitivity C-reactive protein in subjects with type 2 diabetes mellitus and\/or high blood pressure","volume":"51","author":"Lima","year":"2007","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"10.1016\/j.xfre.2021.12.003_bib26","first-page":"1271","article-title":"Abdominal obesity, body mass index, and hypertension in US adults: NHANES 2007-2010","volume":"25","author":"Ostchega","year":"2012","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.xfre.2021.12.003_bib27","first-page":"e1082","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA Guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"139","author":"Grundy","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.xfre.2021.12.003_bib28","doi-asserted-by":"crossref","DOI":"10.1161\/HCG.0000000000000048","article-title":"Cardiovascular health in turner syndrome: a scientific statement from the American Heart Association","volume":"11","author":"Silberbach","year":"2018","journal-title":"Circ Genom Precis Med"},{"key":"10.1016\/j.xfre.2021.12.003_bib31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12958-018-0336-z","article-title":"Obesity as disruptor of the female fertility","volume":"16","author":"Silvestris","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.xfre.2021.12.003_bib32","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.16509.1","article-title":"Ovarian ageing and the impact on female fertility","volume":"7","author":"Vollenhoven","year":"2018","journal-title":"F1000Res"},{"key":"10.1016\/j.xfre.2021.12.003_bib33","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bpobgyn.2014.10.014","article-title":"Female obesity and infertility","volume":"29","author":"Talmor","year":"2015","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.xfre.2021.12.003_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1300\/J013v44n04_01","article-title":"The impact of lifestyle risk factors on female infertility","volume":"44","author":"Kelly-Weeder","year":"2006","journal-title":"Women Health"},{"key":"10.1016\/j.xfre.2021.12.003_bib35","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/humrep\/der400","article-title":"Subfertility and risk of later life maternal cardiovascular disease","volume":"27","author":"Parikh","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfre.2021.12.003_bib36","doi-asserted-by":"crossref","first-page":"251.e1","DOI":"10.1016\/j.ajog.2019.09.007","article-title":"Infertility and mortality","volume":"222","author":"Stentz","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfre.2021.12.003_bib37","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1161\/CIRCULATIONAHA.115.017854","article-title":"Reproductive risk factors and coronary heart disease in the Women's Health Initiative observational study","volume":"133","author":"Parikh","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.xfre.2021.12.003_bib38","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1097\/GME.0000000000000423","article-title":"Association between some inflammatory markers and primary ovarian insufficiency","volume":"22","author":"Yldrm","year":"2015","journal-title":"Menopause"},{"key":"10.1016\/j.xfre.2021.12.003_bib39","first-page":"54","article-title":"Pathogenesis and causes of premature ovarian failure: an update","volume":"5","author":"Ebrahimi","year":"2011","journal-title":"Int J Fertil Steril"},{"key":"10.1016\/j.xfre.2021.12.003_bib40","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1210\/jc.2003-031096","article-title":"Increased C-reactive protein levels in the polycystic ovary syndrome: a marker of cardiovascular\u00a0disease","volume":"89","author":"Boulman","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfre.2021.12.003_bib41","doi-asserted-by":"crossref","first-page":"611","DOI":"10.5812\/ijem.4020","article-title":"Cardiovascular risk in women with PCOS","volume":"10","author":"Scicchitano","year":"2012","journal-title":"Int J Endocrinol Metab"},{"key":"10.1016\/j.xfre.2021.12.003_bib42","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1161\/CIRCOUTCOMES.115.002224","article-title":"Endometriosis and risk of coronary heart disease","volume":"9","author":"Mu","year":"2016","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.xfre.2021.12.003_bib43","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1210\/jcem.87.5.8471","article-title":"Menstrual cycle irregularity and risk for future cardiovascular disease","volume":"87","author":"Solomon","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfre.2021.12.003_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4092470","article-title":"Inflammatory markers in women with polycystic ovary syndrome","volume":"2020","author":"Rudnicka","year":"2020","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.xfre.2021.12.003_bib45","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.xfre.2021.12.003_bib46","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1177\/1933719108330087","article-title":"Inflammation in reproductive disorders","volume":"16","author":"Weiss","year":"2009","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfre.2021.12.003_bib47","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1210\/jc.2017-01199","article-title":"Systemic inflammation induced by microRNAs: endometriosis-derived alterations in circulating microRNA 125b-5p and Let-7b-5p regulate macrophage cytokine production","volume":"103","author":"Nematian","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfre.2021.12.003_bib48","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.fertnstert.2017.01.017","article-title":"Obesity and female infertility: potential mediators of obesity's impact","volume":"107","author":"Broughton","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2021.12.003_bib49","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1210\/jc.2008-2648","article-title":"Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women","volume":"94","author":"Robker","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfre.2021.12.003_bib50","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.fertnstert.2012.04.004","article-title":"The effect of body mass index on the outcomes of first assisted reproductive technology cycles","volume":"98","author":"Moragianni","year":"2012","journal-title":"Fertil and Steril"},{"key":"10.1016\/j.xfre.2021.12.003_bib51","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/humupd\/dmx027","article-title":"How effective are weight-loss interventions for improving fertility in women and men who are overweight or obese? A systematic review and meta-analysis of the evidence","volume":"23","author":"Best","year":"2017","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfre.2021.12.003_bib52","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.fertnstert.2019.04.044","article-title":"Disparities in accessing infertility care in the United States: results from the National Health and Nutrition Examination Survey, 2013-16","volume":"112","author":"Kelley","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2021.12.003_bib53","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.fertnstert.2018.05.029","article-title":"Successful weight loss interventions before in\u00a0vitro fertilization: fat chance?","volume":"110","author":"Norman","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2021.12.003_bib54","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/AOG.0b013e31816a2476","article-title":"Effects of third-generation oral contraceptives on high-sensitivity C-reactive protein and homocysteine in young women","volume":"111","author":"Cauci","year":"2008","journal-title":"Obstet Gynecol"}],"container-title":["F&S Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666334121001446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666334121001446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:04:56Z","timestamp":1762981496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666334121001446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S2666334121001446"],"URL":"https:\/\/doi.org\/10.1016\/j.xfre.2021.12.003","relation":{},"ISSN":["2666-3341"],"issn-type":[{"value":"2666-3341","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-sensitivity C-reactive protein is not independently associated with self-reported infertility in National Health and Nutrition Examination Survey 2015\u20132018 data","name":"articletitle","label":"Article Title"},{"value":"F&S Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfre.2021.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}