{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:01:31Z","timestamp":1781614891091,"version":"3.54.5"},"reference-count":15,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["fertstertreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Reports"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.xfre.2022.08.007","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T10:25:19Z","timestamp":1660904719000},"page":"355-360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Total fertilization failure with in\u00a0vitro fertilization-intracytoplasmic sperm injection related to WEE2 mutation highlights emerging importance of genetic causes of in\u00a0vitro fertilization failure"],"prefix":"10.1016","volume":"3","author":[{"given":"Hillary S.","family":"Weiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole D.","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4209-643X","authenticated-orcid":false,"given":"Lauren","family":"Hipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Hammoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-3649","authenticated-orcid":false,"given":"Samantha B.","family":"Schon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfre.2022.08.007_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/mgg3.1470","article-title":"Novel mutations in the PLCZ1 gene associated with human low or failed fertilization","volume":"8","author":"Yuan","year":"2020","journal-title":"Mol Genet Genomic Med"},{"key":"10.1016\/j.xfre.2022.08.007_bib2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12905-020-01111-5","article-title":"Novel compound heterozygous mutation in WEE2 is associated with fertilization failure: case report of an infertile woman and literature review","volume":"20","author":"Tian","year":"2020","journal-title":"BMC Women Health"},{"key":"10.1016\/j.xfre.2022.08.007_bib3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.fertnstert.2007.06.025","article-title":"Prognosis for clinical pregnancy and delivery after total fertilization failure during conventional in\u00a0vitro fertilization or intracytoplasmic sperm injection","volume":"90","author":"Kinzer","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2022.08.007_bib4","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3109\/09513590.2014.911275","article-title":"Total fertilization failure in intra-cytoplasmic sperm injection cycles--classification and management","volume":"30","author":"Shinar","year":"2014","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.xfre.2022.08.007_bib5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s10815-021-02196-z","article-title":"Genetic factors as potential molecular markers of human oocyte and embryo quality","volume":"38","author":"Sang","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfre.2022.08.007_bib6","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s10815-019-01553-3","article-title":"Novel compound heterozygous mutations in WEE2 causes female infertility and fertilization failure","volume":"36","author":"Zhou","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfre.2022.08.007_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/09513590.2020.1832069","article-title":"A new NLRP5 mutation causes female infertility and total fertilization failure","volume":"37","author":"Li","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.xfre.2022.08.007_bib8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ajhg.2021.02.004","article-title":"Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice","volume":"108","author":"Dai","year":"2021","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.xfre.2022.08.007_bib9","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ajhg.2018.02.015","article-title":"Homozygous mutations in WEE2 cause fertilization failure and female infertility","volume":"102","author":"Sang","year":"2018","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.xfre.2022.08.007_bib10","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1080\/13548506.2021.1893767","article-title":"Family resilience is a protective buffer in the relationship between infertility-related stress and psychological distress among females preparing for their first in\u00a0vitro fertilization-embryo transfer","volume":"27","author":"Kang","year":"2022","journal-title":"Psychol Health Med"},{"key":"10.1016\/j.xfre.2022.08.007_bib11","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1093\/humrep\/dei015","article-title":"A longitudinal, prospective study on emotional adjustment before, during and after consecutive fertility treatment cycles","volume":"20","author":"Verhaak","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfre.2022.08.007_bib12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/cge.13505","article-title":"Novel mutations in WEE2: expanding the spectrum of mutations responsible for human fertilization failure","volume":"95","author":"Zhang","year":"2019","journal-title":"Clin Genet"},{"key":"10.1016\/j.xfre.2022.08.007_bib13","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s10815-019-01418-9","article-title":"Homozygous missense mutation Arg207Cys in the WEE2 gene causes female infertility and fertilization failure","volume":"36","author":"Yang","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfre.2022.08.007_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/humupd\/dmv040","article-title":"Oocyte activation deficiency: a role for an oocyte contribution?","volume":"22","author":"Yeste","year":"2016","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfre.2022.08.007_bib15","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3390\/genes12030410","article-title":"Evaluation of a custom design gene panel as a diagnostic tool for human non-syndromic infertility","volume":"12","author":"Okutman","year":"2021","journal-title":"Genes"}],"container-title":["F&amp;S Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666334122000861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666334122000861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:05:28Z","timestamp":1762981528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666334122000861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S2666334122000861"],"URL":"https:\/\/doi.org\/10.1016\/j.xfre.2022.08.007","relation":{},"ISSN":["2666-3341"],"issn-type":[{"value":"2666-3341","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Total fertilization failure with in\u00a0vitro fertilization-intracytoplasmic sperm injection related to WEE2 mutation highlights emerging importance of genetic causes of in\u00a0vitro fertilization failure","name":"articletitle","label":"Article Title"},{"value":"F&S Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfre.2022.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}