{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:01:21Z","timestamp":1781614881074,"version":"3.54.5"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","fertstertreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Reports"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.xfre.2022.12.006","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T20:24:18Z","timestamp":1672345458000},"page":"72-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assisted gamete treatment to pinpoint acquired meiotic maturity and overcome oocyte activation deficiency contributed by both gametes"],"prefix":"10.1016","volume":"4","author":[{"given":"Philip","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Aluko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2092-7001","authenticated-orcid":false,"given":"Stephanie","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Goldschlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zev","family":"Rosenwaks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-4560","authenticated-orcid":false,"given":"Gianpiero D.","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfre.2022.12.006_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00001703-200306000-00001","article-title":"Failed fertilization: is it predictable?","volume":"15","author":"Mahutte","year":"2003","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.xfre.2022.12.006_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0140-6736(92)92425-F","article-title":"Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte","volume":"340","author":"Palermo","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.xfre.2022.12.006_bib3","doi-asserted-by":"crossref","first-page":"F93","DOI":"10.1530\/REP-17-0374","article-title":"Intracytoplasmic sperm injection: state of the art in humans","volume":"154","author":"Palermo","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.xfre.2022.12.006_bib4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.fertnstert.2020.05.032","article-title":"Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive TechnologyIntracytoplasmic sperm injection (ICSI) for non-male factor indications: a committee opinion","volume":"114","year":"2020","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2022.12.006_bib5","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s10815-014-0281-5","article-title":"Total fertilization failure: is it the end of the story?","volume":"31","author":"Kahyaoglu","year":"2014","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfre.2022.12.006_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/humrep\/13.suppl_1.155","article-title":"Fertilization failures and abnormal fertilization after intracytoplasmic sperm injection","volume":"13","author":"Flaherty","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfre.2022.12.006_bib7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jbior.2017.10.012","article-title":"Phospholipase C zeta and calcium oscillations at fertilisation: the evidence, applications, and further questions","volume":"67","author":"Kashir","year":"2018","journal-title":"Adv Biol Regul"},{"key":"10.1016\/j.xfre.2022.12.006_bib8","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1093\/humrep\/dez094","article-title":"Novel phospholipase C zeta 1 mutations associated with fertilization failures after ICSI","volume":"34","author":"Torra-Massana","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfre.2022.12.006_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.fertnstert.2019.04.006","article-title":"Assisted oocyte activation significantly increases fertilization and pregnancy outcome in patients with low and total failed fertilization after intracytoplasmic sperm injection: a 17-year retrospective study","volume":"112","author":"Bonte","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2022.12.006_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.fertnstert.2020.04.044","article-title":"Identification and treatment of men with phospholipase C\u03b6\u2013defective spermatozoa","volume":"114","author":"Cheung","year":"2020","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2022.12.006_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1152\/physrev.00023.2005","article-title":"Calcium at fertilization and in early development","volume":"86","author":"Whitaker","year":"2006","journal-title":"Physiol Rev"},{"key":"10.1016\/j.xfre.2022.12.006_bib12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0015-0282(16)55680-5","article-title":"Maturational asynchrony between oocyte cumulus-coronal morphology and nuclear maturity in gonadotropin-releasing hormone agonist stimulations","volume":"59","author":"Hammitt","year":"1993","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2022.12.006_bib13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.rbmo.2016.01.007","article-title":"The role of in-vivo and in-vitro maturation time on ooplasmic dysmaturity","volume":"32","author":"Pereira","year":"2016","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.xfre.2022.12.006_bib14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/15362300260339557","article-title":"Spindle observation in living mammalian oocytes with the polarization microscope and its practical use","volume":"4","author":"Wang","year":"2002","journal-title":"Cloning Stem Cells"},{"key":"10.1016\/j.xfre.2022.12.006_bib15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/rmb2.12100","article-title":"Meiotic spindle size is a strong indicator of human oocyte quality","volume":"17","author":"Tomari","year":"2018","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.xfre.2022.12.006_bib16","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.rbmo.2014.01.008","article-title":"Assisted oocyte activation following ICSI fertilization failure","volume":"28","author":"Vanden Meerschaut","year":"2014","journal-title":"Reprod BioMed Online"},{"key":"10.1016\/j.xfre.2022.12.006_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ceca.2013.10.006","article-title":"Understanding fertilization through intracytoplasmic sperm injection (ICSI)","volume":"55","author":"Neri","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.xfre.2022.12.006_bib18","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1093\/humrep\/16.11.2374","article-title":"Limited recovery of meiotic spindles in living human oocytes after cooling\u2013rewarming observed using polarized light microscopy","volume":"16","author":"Wang","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfre.2022.12.006_bib19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0015-0282(00)01692-7","article-title":"The spindle observation and its relationship with fertilization after intracytoplasmic sperm injection in living human oocytes","volume":"75","author":"Wang","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfre.2022.12.006_bib20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/humupd\/dmv011","article-title":"Oocyte maturation: gamete-somatic cells interactions, meiotic resumption, cytoskeletal dynamics and cytoplasmic reorganization","volume":"21","author":"Coticchio","year":"2015","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfre.2022.12.006_bib21","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.rbmo.2019.06.005","article-title":"High proportion of immature oocytes in a cohort reduces fertilization, embryo development, pregnancy and live birth rates following ICSI","volume":"39","author":"Parrella","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.xfre.2022.12.006_bib22","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10815-022-02401-7","article-title":"Human germline nuclear transfer to overcome mitochondrial disease and failed fertilization after ICSI","volume":"39","author":"Tang","year":"2022","journal-title":"J Assist Reprod Genet"}],"container-title":["F&S Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266633412200143X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266633412200143X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:23:43Z","timestamp":1775067823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266633412200143X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S266633412200143X"],"URL":"https:\/\/doi.org\/10.1016\/j.xfre.2022.12.006","relation":{},"ISSN":["2666-3341"],"issn-type":[{"value":"2666-3341","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assisted gamete treatment to pinpoint acquired meiotic maturity and overcome oocyte activation deficiency contributed by both gametes","name":"articletitle","label":"Article Title"},{"value":"F&S Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfre.2022.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}