{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:15:53Z","timestamp":1740183353516,"version":"3.37.3"},"reference-count":64,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007188","name":"Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Science"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.xfss.2020.09.003","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T15:41:41Z","timestamp":1601998901000},"page":"219-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Three-dimensional human leiomyoma xenografts induce angiogenesis by inducing hypoxia inducible factor-1 alpha"],"prefix":"10.1016","volume":"2","author":[{"given":"Joy L.","family":"Britten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minnie","family":"Malik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carissa","family":"Pekny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"DeAngelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Catherino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2020.09.003_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ogc.2005.12.004","article-title":"Epidemiology of myomas","volume":"33","author":"Payson","year":"2006","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.xfss.2020.09.003_bib2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1067\/mob.2003.99","article-title":"High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence","volume":"188","author":"Baird","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfss.2020.09.003_bib3","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1089\/jwh.2013.4334","article-title":"The burden of uterine fibroids for African-American women: results of a national survey","volume":"22","author":"Stewart","year":"2013","journal-title":"J. Womens Health (Larchmt)"},{"key":"10.1016\/j.xfss.2020.09.003_bib4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1055\/s-0037-1607264","article-title":"Uterine fibroids: burden and unmet medical need","volume":"35","author":"Al-Hendy","year":"2017","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2020.09.003_bib5","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1056\/NEJMra1209993","article-title":"Uterine fibroids","volume":"369","author":"Bulun","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.xfss.2020.09.003_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1055\/s-0030-1251475","article-title":"Why leiomyomas are called fibroids: the central role of extracellular matrix in symptomatic women","volume":"28","author":"Malik","year":"2010","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2020.09.003_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12079-014-0234-x","article-title":"Matrix production and remodeling as therapeutic targets for uterine leiomyoma","volume":"8","author":"Fujisawa","year":"2014","journal-title":"J Cell Commun Signal"},{"key":"10.1016\/j.xfss.2020.09.003_bib8","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.fertnstert.2004.04.030","article-title":"Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium","volume":"82","author":"Leppert","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.09.003_bib9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1933719118816836","article-title":"Ulipristal acetate mediates decreased proteoglycan expression through regulation of nuclear factor of activated T cells (NFAT5)","volume":"26","author":"Britten","year":"2019","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2020.09.003_bib10","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0140-6736(05)73879-4","article-title":"Influence of hysterectomy on pelvic-floor dysfunction","volume":"356","author":"Petros","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.xfss.2020.09.003_bib11","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s43032-019-00123-3","article-title":"Development and validation of hormonal impact of a mouse xenograft model for human uterine leiomyoma","volume":"27","author":"Malik","year":"2020","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2020.09.003_bib12","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.fertnstert.2012.02.037","article-title":"Development and validation of a three-dimensional in\u00a0vitro model for uterine leiomyoma and patient-matched myometrium","volume":"97","author":"Malik","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.09.003_bib13","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1177\/1933719114545240","article-title":"Leiomyoma cells in 3-dimensional cultures demonstrate an attenuated response to fasudil, a Rho-kinase inhibitor, when compared to 2-dimensional cultures","volume":"21","author":"Malik","year":"2014","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2020.09.003_bib14","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1158\/0008-5472.CAN-07-6339","article-title":"Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia","volume":"68","author":"Mayer","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2020.09.003_bib15","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/humupd\/dmt042","article-title":"The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy","volume":"20","author":"Tal","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfss.2020.09.003_bib16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.fertnstert.2014.07.008","article-title":"Alternative therapies in management of leiomyomas","volume":"102","author":"Patel","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.09.003_bib17","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1148\/radiol.2343031697","article-title":"Midterm results of uterine artery embolization for symptomatic adenomyosis: initial experience","volume":"234","author":"Pelage","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.xfss.2020.09.003_bib18","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.15252\/embj.201696150","article-title":"Endothelial cell metabolism in health and disease: impact of hypoxia","volume":"36","author":"Wong","year":"2017","journal-title":"EMBO J"},{"key":"10.1016\/j.xfss.2020.09.003_bib19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/10520295.2014.952339","article-title":"The role of hypoxia related angiogenesis in uterine smooth muscle tumors","volume":"90","author":"Uluer","year":"2015","journal-title":"Biotech Histochem"},{"key":"10.1016\/j.xfss.2020.09.003_bib20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2407-6-26","article-title":"Hypoxia-inducible transcription factor-1alpha promotes hypoxia-induced A549 apoptosis via a mechanism that involves the glycolysis pathway","volume":"6","author":"Luo","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.xfss.2020.09.003_bib21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2174\/1566524018666181109121849","article-title":"Role of HIF-1 in cancer progression: novel insights. A review","volume":"18","author":"Pezzuto","year":"2018","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.xfss.2020.09.003_bib22","first-page":"2808","article-title":"Expression of the hypoxically regulated angiogenic factor correlates with uterine leiomyoma vascular density","volume":"6","author":"Hague","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.xfss.2020.09.003_bib23","doi-asserted-by":"crossref","first-page":"R209","DOI":"10.1152\/ajpregu.00305.2014","article-title":"Cohort of estrogen-induced microRNAs regulate adrenomedullin expression","volume":"310","author":"Wetzel-Strong","year":"2016","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.xfss.2020.09.003_bib24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mce.2004.06.002","article-title":"Estrogen and phytoestrogen regulate the mRNA expression of adrenomedullin and adrenomedullin receptor components in the rat uterus","volume":"223","author":"Ikeda","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.xfss.2020.09.003_bib25","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.fertnstert.2006.08.111","article-title":"Novel method to characterize primary cultures of leiomyoma and myometrium with the use of confirmatory biomarker gene arrays","volume":"87","author":"Malik","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.09.003_bib26","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.fertnstert.2006.11.093","article-title":"Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure","volume":"87","author":"Catherino","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.09.003_bib27","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/stem.1661","article-title":"Concise review: evidence for CD34 as a common marker for diverse progenitors","volume":"32","author":"Sidney","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.xfss.2020.09.003_bib28","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature17638","article-title":"Age-dependent modulation of vascular niches for haematopoietic stem cells","volume":"532","author":"Kusumbe","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.xfss.2020.09.003_bib29","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.fertnstert.2012.04.044","article-title":"Identification and characterization of the human leiomyoma side population as putative tumor-initiating cells","volume":"98","author":"Mas","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.09.003_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036935","article-title":"Role of stem cells in human uterine leiomyoma growth","volume":"7","author":"Ono","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2020.09.003_bib31","doi-asserted-by":"crossref","first-page":"E601","DOI":"10.1210\/jc.2014-2134","article-title":"Human uterine leiomyoma stem\/progenitor cells expressing CD34 and CD49b initiate tumors in\u00a0vivo","volume":"100","author":"Yin","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2020.09.003_bib32","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/1933719118776793","article-title":"hypoxia induces hypoxia-inducible factor 1\u03b1 and potential HIF-responsive gene expression in uterine leiomyoma","volume":"26","author":"Ishikawa","year":"2019","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2020.09.003_bib33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/cvr\/cvq045","article-title":"Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodeling","volume":"86","author":"Rey","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.xfss.2020.09.003_bib34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/1471-2407-8-335","article-title":"Prognostic significance of hypoxia-inducible factor 1 alpha (HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study","volume":"8","author":"Daponte","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.xfss.2020.09.003_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.oraloncology.2008.05.007","article-title":"Hypoxia-inducible factor 1 alpha in oral squamous cell carcinoma and its relation to prognosis","volume":"45","author":"Uehara","year":"2009","journal-title":"Oral Oncology"},{"key":"10.1016\/j.xfss.2020.09.003_bib36","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.fertnstert.2016.11.008","article-title":"Estrogen stabilizes hypoxia-inducible factor 1\u03b1 through G protein-coupled estrogen receptor 1 in eutopic endometrium of endometriosis","volume":"107","author":"Zhang","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.09.003_bib37","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s10815-013-0029-7","article-title":"Uterine fibroids are characterized by an impaired antioxidant cellular system: potential role of hypoxia in the pathophysiology of uterine fibroids","volume":"30","author":"Fletcher","year":"2013","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2020.09.003_bib38","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2174\/157340211799304761","article-title":"Adrenomedullin function in vascular endothelial cells: insights from genetic mouse models","volume":"7","author":"Karpinich","year":"2011","journal-title":"Curr Hypertens Rev"},{"key":"10.1016\/j.xfss.2020.09.003_bib39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1677\/jme.1.01825","article-title":"The estrogen-responsive adrenomedullin and receptor-modifying protein 3 gene identified by DNA microarray analysis are directly regulated by estrogen receptor","volume":"36","author":"Watanabe","year":"2006","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.xfss.2020.09.003_bib40","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1177\/1933719109336615","article-title":"Murine xenograft model for human uterine fibroids: an in\u00a0vivo imaging approach","volume":"16","author":"Suo","year":"2009","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2020.09.003_bib41","doi-asserted-by":"crossref","first-page":"156.e1","DOI":"10.1016\/j.ajog.2008.02.010","article-title":"Memy I: a novel murine model for uterine leiomyoma using adenovirus-enhanced human fibroid explants in severe combined immune deficiency mice","volume":"199","author":"Hassan","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfss.2020.09.003_bib42","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1210\/en.2009-1225","article-title":"Progesterone is essential for maintenance and growth of uterine leiomyoma","volume":"151","author":"Ishikawa","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.xfss.2020.09.003_bib43","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.fertnstert.2012.11.032","article-title":"A novel mouse model that closely mimics human uterine leiomyomas","volume":"99","author":"Drosch","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.09.003_bib44","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.fertnstert.2014.01.054","article-title":"Nonobese diabetic\/severe combined immunodeficient murine xenograft model for human uterine leiomyoma","volume":"101","author":"Wang","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.09.003_bib45","doi-asserted-by":"crossref","first-page":"e252","DOI":"10.1016\/j.fertnstert.2014.07.858","article-title":"Subrenal xenograft model for human uterine leiomyoma in nonobese diabetic severe combined immunodeficient mice","volume":"102","author":"Ishikawa","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.09.003_bib46","doi-asserted-by":"crossref","first-page":"8872","DOI":"10.1038\/s41598-018-27138-1","article-title":"Establishment of a novel mouse xenograft model of human uterine leiomyoma","volume":"8","author":"Suzuki","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2020.09.003_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142429","article-title":"Application a patient derived xenograft model for predictive study of uterine fibroid disease","volume":"10","author":"Fritsch","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2020.09.003_bib48","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/humrep\/deg213","article-title":"Vascular system of intramural leiomyomata revealed by corrosion casting and scanning electron microscopy","volume":"18","author":"Walocha","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2020.09.003_bib49","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1096\/fj.02-1209fje","article-title":"Angiogenic role of adrenomedullin through activation of Akt, mitogen-activated protein kinase, and focal adhesion kinase in endothelial cells","volume":"17","author":"Kim","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.xfss.2020.09.003_bib50","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/ijc.11663","article-title":"Effects of adrenomedullin on endothelial cells in the multistep process of angiogenesis: involvement of CRLR\/RAMP2 and CRLR\/RAMP3 receptors","volume":"108","author":"Fernandez-Sauze","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1016\/j.xfss.2020.09.003_bib51","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.bbamcr.2007.12.006","article-title":"Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha\/beta pathway","volume":"1783","author":"Depping","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.xfss.2020.09.003_bib52","doi-asserted-by":"crossref","first-page":"9763","DOI":"10.1073\/pnas.1503497112","article-title":"Hypoxia-induced force increase (HIFI) is a novel mechanism underlying the strengthening of labor contractions, produced by hypoxic stresses","volume":"112","author":"Alotaibi","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2020.09.003_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113865","article-title":"Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1\u03b1 by inhibiting prolyl-4-hydroxylase PHD2","volume":"9","author":"Hou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2020.09.003_bib54","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1124\/mol.107.042283","article-title":"Pharmacological and kinetic characterization of adrenomedullin 1 and calcitonin gene-related peptide 1 receptor reporter cell lines","volume":"73","author":"Wunder","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.xfss.2020.09.003_bib55","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1095\/biolreprod.109.076117","article-title":"Estrogen rapidly activates the PI3K\/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus","volume":"81","author":"Kazi","year":"2009","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2020.09.003_bib56","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1055\/s-0028-1096130","article-title":"The expression and potential regulatory function of microRNAs in the pathogenesis of leiomyoma","volume":"26","author":"Luo","year":"2008","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2020.09.003_bib57","doi-asserted-by":"crossref","first-page":"40524","DOI":"10.1038\/srep40524","article-title":"Adrenomedullin promotes angiogenesis in epithelial ovarian cancer through upregulating hypoxia-inducible factor-1\u03b1 and vascular endothelial growth factor","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2020.09.003_bib58","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1530\/REP-13-0580","article-title":"Common fibroid-associated genes are differentially expressed in phenotypically dissimilar cell populations isolated from within human fibroids and myometrium","volume":"147","author":"Holdsworth-Carson","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.xfss.2020.09.003_bib59","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1530\/REP-16-0216","article-title":"Differences in the cellular composition of small versus large uterine fibroids","volume":"152","author":"Holdsworth-Carson","year":"2016","journal-title":"Reproduction"},{"key":"10.1016\/j.xfss.2020.09.003_bib60","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/embo-reports\/kve130","article-title":"Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm","volume":"2","author":"Berra","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1016\/j.xfss.2020.09.003_bib61","doi-asserted-by":"crossref","first-page":"e5077","DOI":"10.1371\/journal.pone.0005077","article-title":"Real-time imaging of HIF-1alpha stabilization and degradation","volume":"4","author":"Moroz","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2020.09.003_bib62","doi-asserted-by":"crossref","first-page":"15172","DOI":"10.1073\/pnas.1422015112","article-title":"Estrogen receptor-\u03b1 directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer","volume":"112","author":"Yang","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2020.09.003_bib63","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4293\/108680812X13291597716302","article-title":"surgical management of neurovascular bundle in uterine fibroid pseudocapsule","volume":"16","author":"Tinelli","year":"2012","journal-title":"JSLS"},{"key":"10.1016\/j.xfss.2020.09.003_bib64","doi-asserted-by":"crossref","first-page":"10333","DOI":"10.1021\/bi0347508","article-title":"N-Glycosylation and conserved cysteine residues in RAMP3 play a critical role for the functional expression of CRLR\/RAMP3 adrenomedullin receptor","volume":"42","author":"Flahaut","year":"2003","journal-title":"Biochemistry"}],"container-title":["F&S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X20300343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X20300343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T05:16:34Z","timestamp":1716527794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X20300343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S2666335X20300343"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2020.09.003","relation":{},"ISSN":["2666-335X"],"issn-type":[{"type":"print","value":"2666-335X"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Three-dimensional human leiomyoma xenografts induce angiogenesis by inducing hypoxia inducible factor-1 alpha","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2020.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}