{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:48:01Z","timestamp":1773010081478,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100019110","name":"Institute of Basic Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Science"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.xfss.2020.12.002","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T05:56:43Z","timestamp":1607579803000},"page":"24-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Human umbilical cord perivascular cells prevent chemotherapeutic drug-induced male infertility in a mouse model"],"prefix":"10.1016","volume":"2","author":[{"given":"Jordana","family":"Mashiach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Zohni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianet","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Filice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9266-1962","authenticated-orcid":false,"given":"Brandon","family":"Wyse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Glass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Dviri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shira","family":"Baram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9e","family":"Gauthier-Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford L.","family":"Librach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2020.12.002_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/pbc.22004","article-title":"Male gonadal toxicity","volume":"53","author":"Meistrich","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.xfss.2020.12.002_bib2","first-page":"83","article-title":"Childhood and adolescent cancer statistics, 2014","volume":"64","author":"Ward","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.xfss.2020.12.002_bib3","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/S0140-6736(04)17550-8","article-title":"Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study","volume":"364","author":"Steliarova-Foucher","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.xfss.2020.12.002_bib4","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1093\/humrep\/dev161","article-title":"Fertility preservation in the male pediatric population: factors influencing the decision of parents and children","volume":"30","author":"Wyns","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2020.12.002_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/jayao.2018.0040","article-title":"Adolescent males\u2019 understanding of infertility as a long-term effect of cancer therapy","volume":"8","author":"Roher","year":"2019","journal-title":"J Adolesc Young Adult Oncol"},{"key":"10.1016\/j.xfss.2020.12.002_bib6","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/sctm.17-0051","article-title":"Mesenchymal stem cells: time to change the name!","volume":"6","author":"Caplan","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.xfss.2020.12.002_bib7","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1038\/emm.2013.94","article-title":"Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine","volume":"45","author":"Murphy","year":"2013","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.xfss.2020.12.002_bib8","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1111\/jcmm.12839","article-title":"hi PSC-derived iMSC s: nextGen MSC s as an advanced therapeutically active cell resource for regenerative medicine","volume":"20","author":"Sabapathy","year":"2016","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.xfss.2020.12.002_bib9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1634\/stemcells.2004-0166","article-title":"Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors","volume":"23","author":"Sarugaser","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.xfss.2020.12.002_bib10","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1089\/scd.2012.0552","article-title":"Ontogeny of human umbilical cord perivascular cells: molecular and fate potential changes during gestation","volume":"22","author":"Hong","year":"2013","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.xfss.2020.12.002_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13287-017-0491-8","article-title":"In\u00a0vitro generation of Sertoli-like and haploid spermatid-like cells from human umbilical cord perivascular cells","volume":"8","author":"Shlush","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.xfss.2020.12.002_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1530\/REP-16-0220","article-title":"Human umbilical perivascular cells (HUCPVCs): a novel source of mesenchymal stromal-like (MSC) cells to support the regeneration of the testicular niche","volume":"153","author":"Maghen","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.xfss.2020.12.002_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/7513252","article-title":"In\u00a0vitro differentiation of first trimester human umbilical cord perivascular cells into contracting cardiomyocyte-like cells","volume":"2016","author":"Szaraz","year":"2016","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.xfss.2020.12.002_bib14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/sctm.18-0192","article-title":"Early intravenous infusion of mesenchymal stromal cells exerts a tissue source age-dependent beneficial effect on neurovascular integrity and neurobehavioral recovery after traumatic cervical spinal cord injury","volume":"8","author":"Vawda","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.xfss.2020.12.002_bib15","first-page":"537","article-title":"Mesenchymal stem cells repair germinal cells of seminiferous tubules of sterile rats","volume":"11","author":"Monsefi","year":"2013","journal-title":"Iran J Reprod Med"},{"key":"10.1016\/j.xfss.2020.12.002_bib16","doi-asserted-by":"crossref","first-page":"698","DOI":"10.4103\/1008-682X.129209","article-title":"Enhancement of mouse germ cell-associated genes expression by injection of human umbilical cord mesenchymal stem cells into the testis of chemical-induced azoospermic mice","volume":"16","author":"Yang","year":"2014","journal-title":"Asian J Androl"},{"key":"10.1016\/j.xfss.2020.12.002_bib17","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3892\/mmr.2015.3528","article-title":"Differentiation of human umbilical cord mesenchymal stem cells into germ-like cells in mouse seminiferous tubules","volume":"12","author":"Chen","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.xfss.2020.12.002_bib18","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1007\/s12015-016-9685-1","article-title":"Underlying mechanisms that restore spermatogenesis on transplanting healthy niche cells in busulphan treated mouse testis","volume":"12","author":"Anand","year":"2016","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.xfss.2020.12.002_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/529589","article-title":"Recovery of fertility in azoospermia rats after injection of adipose-tissue-derived mesenchymal stem cells: the sperm generation","volume":"2013","author":"Cakici","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.xfss.2020.12.002_bib20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.15283\/ijsc16010","article-title":"Transplantation of autologous bone marrow mesenchymal stem cells into the testes of infertile male rats\u00a0and new germ cell formation","volume":"9","author":"Ghasemzadeh-Hasankolaei","year":"2016","journal-title":"J Stem Cells"},{"key":"10.1016\/j.xfss.2020.12.002_bib21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13287-018-1065-0","article-title":"Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice","volume":"9","author":"Kadam","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.xfss.2020.12.002_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/0974-1208.158618","article-title":"Adipose tissue-derived mesenchymal stem cells repair germinal cells of seminiferous tubules of busulfan-induced azoospermic rats","volume":"8","author":"Mehrabani","year":"2015","journal-title":"J Hum Reprod Sci"},{"key":"10.1016\/j.xfss.2020.12.002_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.15283\/ijsc.2015.8.2.134","article-title":"Induction of spermatogenesis by bone marrow-derived mesenchymal stem cells in busulfan-induced azoospermia in hamster","volume":"8","author":"Tamadon","year":"2015","journal-title":"Int J Stem Cells"},{"key":"10.1016\/j.xfss.2020.12.002_bib24","first-page":"653","article-title":"Histomorphometric evaluation of treatment of rat azoosper-mic seminiferous tubules by allotransplantation of bone marrow-derived mesenchymal stem cells","volume":"19","author":"Rahmanifar","year":"2016","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.xfss.2020.12.002_bib25","first-page":"660","article-title":"Spermatogenesis after transplantation of adipose tissue-derived mesenchymal stem cells in busulfan-induced azoospermic hamster","volume":"21","author":"Karimaghai","year":"2018","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.xfss.2020.12.002_bib26","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/andr.12713","article-title":"Potential use of stem cells for fertility preservation","volume":"8","author":"Gauthier-Fisher","year":"2019","journal-title":"Andrology"},{"key":"10.1016\/j.xfss.2020.12.002_bib27","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1093\/humrep\/deg483","article-title":"Restoration of fertility in infertile mice by transplantation of cryopreserved male germline stem cells","volume":"18","author":"Kanatsu-Shinohara","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2020.12.002_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/humrep\/der357","article-title":"The efficiency of male fertility restoration is dependent on the recovery kinetics of spermatogonial stem cells after cytotoxic treatment with busulfan in mice","volume":"27","author":"Zohni","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2020.12.002_bib29","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1111\/jcmm.12571","article-title":"Human umbilical cord mesenchymal stem cell transplantation restores damaged ovaries","volume":"19","author":"Zhu","year":"2015","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.xfss.2020.12.002_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2517514","article-title":"Human umbilical cord mesenchymal stem cells therapy in cyclophosphamide-induced premature ovarian failure rat model","volume":"2016","author":"Song","year":"2016","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.xfss.2020.12.002_bib31","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/jemt.22725","article-title":"The effect of bone marrow-derived mesenchymal stem cells on chemotherapy induced ovarian failure in albino rats","volume":"79","author":"Gabr","year":"2016","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.xfss.2020.12.002_bib32","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.fertnstert.2008.09.036","article-title":"Bone marrow stem cells transplanted to the testis of sterile mice do not differentiate into spermatogonial stem cells and have no protective effect on fertility","volume":"91","author":"Van Saen","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2020.12.002_bib33","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13287-017-0631-1","article-title":"Angiogenic potency evaluation of cell therapy candidates by a novel application of the in\u00a0vitro aortic ring assay","volume":"8","author":"Iqbal","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.xfss.2020.12.002_bib34","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.biopsych.2019.07.015","article-title":"Mesenchymal stromal cells modulate peripheral stress-induced innate immune activation indirectly limiting the emergence of neuroinflammation-driven depressive and anxiety-like behaviors","volume":"86","author":"Gallagher","year":"2019","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.xfss.2020.12.002_bib35","first-page":"259","article-title":"Regulation of spermatogenesis by paracrine\/autocrine testicular factors","volume":"6","author":"Huleihel","year":"2004","journal-title":"Asian J Androl"},{"key":"10.1016\/j.xfss.2020.12.002_bib36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.cellbio.24.110707.175355","article-title":"Regulation of spermatogonial stem cell self-renewal in mammals","volume":"24","author":"Oatley","year":"2008","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.xfss.2020.12.002_bib37","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.14202\/vetworld.2018.1349-1356","article-title":"Effects of secretome on cisplatin-induced testicular dysfunction in rats","volume":"11","author":"Prihatno","year":"2018","journal-title":"Vet World"}],"container-title":["F&amp;S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X20300586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X20300586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:06:53Z","timestamp":1762981613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X20300586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S2666335X20300586"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2020.12.002","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human umbilical cord perivascular cells prevent chemotherapeutic drug-induced male infertility in a mouse model","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2020.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}