{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:19:28Z","timestamp":1792556368045,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"am","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007188","name":"Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Science"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.xfss.2021.07.003","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T07:42:10Z","timestamp":1628149330000},"page":"396-406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Carcinoembryonic antigen-related cell adhesion molecule 1: a key regulatory protein involved in leiomyoma growth"],"prefix":"10.1016","volume":"2","author":[{"given":"Anthony M.","family":"DeAngelis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minnie","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Britten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Driggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Catherino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2021.07.003_bib1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1067\/mob.2003.99","article-title":"High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence","volume":"188","author":"Baird","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfss.2021.07.003_bib2","first-page":"181","article-title":"The genetic bases of uterine fibroids; a review","volume":"12","author":"Medikare","year":"2011","journal-title":"J Reprod Infertil"},{"key":"10.1016\/j.xfss.2021.07.003_bib3","doi-asserted-by":"crossref","first-page":"e37110","DOI":"10.7554\/eLife.37110","article-title":"Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability","volume":"7","author":"V\u00e4lim\u00e4ki","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.xfss.2021.07.003_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/biolre\/ioaa157","article-title":"Role of DNA damage and repair mechanisms in uterine fibroid\/leiomyomas: a review","volume":"104","author":"Toprani","year":"2021","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2021.07.003_bib5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2119\/molmed.2014.00053","article-title":"Signaling pathways in leiomyoma: understanding pathobiology and implications for therapy","volume":"21","author":"Borahay","year":"2015","journal-title":"Mol Med"},{"key":"10.1016\/j.xfss.2021.07.003_bib6","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0015-0282(00)00418-0","article-title":"Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation","volume":"73","author":"Arici","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2021.07.003_bib7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.matbio.2012.09.005","article-title":"Integrin beta1 regulates leiomyoma cytoskeletal integrity and growth","volume":"31","author":"Malik","year":"2012","journal-title":"Matrix Biol"},{"key":"10.1016\/j.xfss.2021.07.003_bib8","first-page":"900","article-title":"Relative overexpression of collagen type I and collagen type III messenger ribonucleic acids by uterine leiomyomas during the proliferative phase of the menstrual cycle","volume":"79","author":"Stewart","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2021.07.003_bib9","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.3390\/ijms19103110","article-title":"CEACAM1 in liver injury, metabolic and immune regulation","volume":"19","author":"Horst","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfss.2021.07.003_bib10","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10555-013-9444-6","article-title":"Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis","volume":"32","author":"Beauchemin","year":"2013","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.xfss.2021.07.003_bib11","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.2337\/db08-0379","article-title":"Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism","volume":"57","author":"DeAngelis","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.xfss.2021.07.003_bib12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/ng840","article-title":"CEACAM1 regulates insulin clearance in liver","volume":"30","author":"Poy","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.xfss.2021.07.003_bib13","doi-asserted-by":"crossref","first-page":"10744","DOI":"10.1073\/pnas.90.22.10744","article-title":"Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas","volume":"90","author":"Neumaier","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2021.07.003_bib14","first-page":"2354","article-title":"Expression of CD66a (human C-CAM) and other members of the carcinoembryonic antigen gene family of adhesion molecules in human colorectal adenomas","volume":"57","author":"Nollau","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2021.07.003_bib15","first-page":"4938","article-title":"The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues","volume":"53","author":"Rosenberg","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2021.07.003_bib16","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1038\/sj.onc.1200999","article-title":"Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains","volume":"14","author":"Luo","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.xfss.2021.07.003_bib17","first-page":"3431","article-title":"Suppression of human bladder cancer growth by increased expression of C-CAM1 gene in an orthotopic model","volume":"56","author":"Kleinerman","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2021.07.003_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000163912","article-title":"Cell CAM 105 isoform RNA expression is differentially regulated during rat liver regeneration and carcinogenesis","volume":"62","author":"Thompson","year":"1994","journal-title":"Pathobiology"},{"key":"10.1016\/j.xfss.2021.07.003_bib19","first-page":"1401","article-title":"Dysregulated expression of CD66a (BGP, C-CAM), an adhesion molecule of the CEA family, in endometrial cancer","volume":"152","author":"Bamberger","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.xfss.2021.07.003_bib20","first-page":"1215","article-title":"Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: implication as a tumor suppressor","volume":"55","author":"Kleinerman","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2021.07.003_bib21","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1097\/00005392-199909010-00085","article-title":"Differential expression of C-CAM cell adhesion molecule in prostate carcinogenesis in a transgenic mouse model","volume":"162","author":"Pu","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.xfss.2021.07.003_bib22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1083\/jcb.108.2.267","article-title":"Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family","volume":"108","author":"Barnett","year":"1989","journal-title":"J Cell Biol"},{"key":"10.1016\/j.xfss.2021.07.003_bib23","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1074\/jbc.M108415200","article-title":"Shc and CEACAM1 interact to regulate the mitogenic action of insulin","volume":"277","author":"Poy","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xfss.2021.07.003_bib24","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1172\/JCI200421786","article-title":"CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation","volume":"114","author":"Abou-Rjaily","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xfss.2021.07.003_bib25","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1242\/jcs.073635","article-title":"CEACAM1: a key regulator of vascular permeability","volume":"123","author":"Nouvion","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1016\/j.xfss.2021.07.003_bib26","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1210\/jc.2016-4014","article-title":"A role for progesterone-regulated sfrp4 expression in uterine leiomyomas","volume":"102","author":"Delaney","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2021.07.003_bib27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neo.2014.12.007","article-title":"Molecular subtypes of uterine leiomyosarcoma and correlation with clinical outcome","volume":"17","author":"Barlin","year":"2015","journal-title":"Neoplasia"},{"key":"10.1016\/j.xfss.2021.07.003_bib28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/1933719117728802","article-title":"Ulipristal acetate and extracellular matrix production in human leiomyomas in\u00a0vivo: a laboratory analysis of a randomized placebo controlled trial","volume":"25","author":"Cox","year":"2018","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2021.07.003_bib29","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.fertnstert.2008.06.030","article-title":"Activating transcription factor 3 gene expression suggests that tissue stress plays a role in leiomyoma development","volume":"92","author":"Payson","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2021.07.003_bib30","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/AOG.0b013e3181705d0e","article-title":"CDB-2914 for uterine leiomyomata treatment: a randomized controlled trial","volume":"111","author":"Levens","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.xfss.2021.07.003_bib31","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2265.2008.03207.x","article-title":"Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells","volume":"69","author":"Malik","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.xfss.2021.07.003_bib32","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1158\/0008-5472.CAN-03-3730","article-title":"Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis","volume":"64","author":"Phan","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2021.07.003_bib33","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/path.1657","article-title":"The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma","volume":"204","author":"Kammerer","year":"2004","journal-title":"J Pathol"},{"key":"10.1016\/j.xfss.2021.07.003_bib34","doi-asserted-by":"crossref","first-page":"e1517","DOI":"10.1210\/clinem\/dgz227","article-title":"Activation of beta-catenin signaling and its crosstalk with estrogen and histone deacetylases in human uterine fibroids","volume":"105","author":"Ali","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2021.07.003_bib35","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2119\/2007-00101.YU","article-title":"Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas","volume":"14","author":"Yu","year":"2008","journal-title":"Mol Med"}],"container-title":["F&S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X2100063X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X2100063X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:06:30Z","timestamp":1762981590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X2100063X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S2666335X2100063X"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2021.07.003","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carcinoembryonic antigen-related cell adhesion molecule 1: a key regulatory protein involved in leiomyoma growth","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2021.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}