{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:11:14Z","timestamp":1762985474581,"version":"3.45.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["A368\/A7990","C309\/A11566","C368\/A6743"],"award-info":[{"award-number":["A368\/A7990","C309\/A11566","C368\/A6743"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12GM111726","1R01HD087417","1R01HD094378"],"award-info":[{"award-number":["K12GM111726","1R01HD087417","1R01HD094378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Science"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.xfss.2021.09.003","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T04:02:15Z","timestamp":1631592135000},"page":"383-395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification and characterization of the mediator kinase-dependent myometrial stem cell phosphoproteome"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-0611","authenticated-orcid":false,"given":"Lindsey","family":"Barron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7982-9476","authenticated-orcid":false,"given":"Subash","family":"Khadka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Schenken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-2337","authenticated-orcid":false,"given":"John","family":"Blenis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Blagg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2551-0755","authenticated-orcid":false,"given":"Shin-Fu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang-Lei","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2021.09.003_bib1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1177\/1933719114533728","article-title":"Uterine fibroids: clinical manifestations and contemporary management","volume":"21","author":"Doherty","year":"2014","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2021.09.003_bib2","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1056\/NEJMra1209993","article-title":"Uterine fibroids","volume":"369","author":"Bulun","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.xfss.2021.09.003_bib3","doi-asserted-by":"crossref","first-page":"16043","DOI":"10.1038\/nrdp.2016.43","article-title":"Uterine fibroids","volume":"2","author":"Stewart","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.xfss.2021.09.003_bib4","doi-asserted-by":"crossref","first-page":"211.e1","DOI":"10.1016\/j.ajog.2011.12.002","article-title":"The estimated annual cost of uterine leiomyomata in the United States","volume":"206","author":"Cardozo","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfss.2021.09.003_bib5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/GRF.0000000000000171","article-title":"An evidence-based approach to the medical management of fibroids: a systematic review","volume":"59","author":"Bartels","year":"2016","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.xfss.2021.09.003_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ijgo.13102","article-title":"Epidemiology and management of uterine fibroids","volume":"149","author":"Giuliani","year":"2020","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.xfss.2021.09.003_bib7","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1056\/NEJMoa2008283","article-title":"Treatment of uterine fibroid symptoms with relugolix combination therapy","volume":"384","author":"Al-Hendy","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.xfss.2021.09.003_bib8","first-page":"1","article-title":"Oriahnn: new drug approved for treating heavy menstrual bleeding in women with uterine fibroids","author":"Lynch","year":"2021","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.xfss.2021.09.003_bib9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/humupd\/dmv030","article-title":"Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth","volume":"21","author":"Commandeur","year":"2015","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfss.2021.09.003_bib10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1055\/s-0037-1607205","article-title":"Origin of uterine fibroids: conversion of myometrial stem cells to tumor-initiating cells","volume":"35","author":"Elkafas","year":"2017","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2021.09.003_bib11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1126\/science.1208930","article-title":"MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas","volume":"334","author":"Makinen","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.xfss.2021.09.003_bib12","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1517\/14728222.2015.1075510","article-title":"Genetic alterations in uterine fibroids\u2014a new direction for pharmacological intervention?","volume":"19","author":"Markowski","year":"2015","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.xfss.2021.09.003_bib13","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1073\/pnas.1518752113","article-title":"Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers","volume":"113","author":"Mehine","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2021.09.003_bib14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.fertnstert.2014.06.050","article-title":"Genomics of uterine leiomyomas: insights from high-throughput sequencing","volume":"102","author":"Mehine","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2021.09.003_bib15","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.ejca.2015.04.023","article-title":"MED12 and uterine smooth muscle oncogenesis: state of the art and perspectives","volume":"51","author":"Croce","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.xfss.2021.09.003_bib16","first-page":"393","article-title":"Mediator kinase module and human tumorigenesis","volume":"50","author":"Clark","year":"2015","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.xfss.2021.09.003_bib17","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1172\/JCI81534","article-title":"Med12 gain-of-function mutation causes leiomyomas and genomic instability","volume":"125","author":"Mittal","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xfss.2021.09.003_bib18","article-title":"Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module","volume":"7","author":"Li","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.xfss.2021.09.003_bib19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1080\/21541264.2018.1556915","article-title":"Regulatory functions of the Mediator kinases CDK8 and CDK19","volume":"10","author":"Fant","year":"2019","journal-title":"Transcription"},{"key":"10.1016\/j.xfss.2021.09.003_bib20","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1128\/MCB.00993-08","article-title":"The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator","volume":"29","author":"Knuesel","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.xfss.2021.09.003_bib21","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1074\/jbc.RA118.001725","article-title":"Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8\/19","volume":"293","author":"Park","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xfss.2021.09.003_bib22","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.celrep.2014.03.047","article-title":"Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity","volume":"7","author":"Turunen","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.xfss.2021.09.003_bib23","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1210\/jc.2018-00863","article-title":"Mediator kinase disruption in MED12-mutant uterine fibroids from Hispanic women of South Texas","volume":"103","author":"Park","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2021.09.003_bib24","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrc3805","article-title":"CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers","volume":"14","author":"Ramdzan","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.xfss.2021.09.003_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/gcc.22001","article-title":"Identification of CUX1 as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma","volume":"52","author":"Schoenmakers","year":"2013","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.xfss.2021.09.003_bib26","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1128\/MCB.01275-08","article-title":"CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase","volume":"29","author":"Seguin","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.xfss.2021.09.003_bib27","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1128\/MCB.02089-07","article-title":"p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes","volume":"28","author":"Truscott","year":"2008","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.xfss.2021.09.003_bib28","doi-asserted-by":"crossref","first-page":"11516","DOI":"10.1073\/pnas.93.21.11516","article-title":"CDP\/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1\/S phase cell cycle transition point independent of transcription factor E2F","volume":"93","author":"van Wijnen","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2021.09.003_bib29","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1074\/jbc.M209200200","article-title":"Absence of p21CIP rescues myogenic progenitor cell proliferative and regenerative capacity in Foxk1 null mice","volume":"278","author":"Hawke","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xfss.2021.09.003_bib30","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1634\/stemcells.2004-0077","article-title":"Cellular and molecular regulation of skeletal muscle side population cells","volume":"22","author":"Meeson","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.xfss.2021.09.003_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11010-012-1302-2","article-title":"Sin3 interacts with Foxk1 and regulates myogenic progenitors","volume":"366","author":"Shi","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.xfss.2021.09.003_bib32","first-page":"5329","article-title":"Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2","volume":"125","author":"Shi","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.xfss.2021.09.003_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036935","article-title":"Role of stem cells in human uterine leiomyoma growth","volume":"7","author":"Ono","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2021.09.003_bib34","doi-asserted-by":"crossref","first-page":"19763","DOI":"10.1073\/pnas.1121120109","article-title":"MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling","volume":"109","author":"Zhou","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2021.09.003_bib35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.stem.2011.01.007","article-title":"Critical appraisal of the side population assay in stem cell and cancer stem cell research","volume":"8","author":"Golebiewska","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xfss.2021.09.003_bib36","doi-asserted-by":"crossref","first-page":"18700","DOI":"10.1073\/pnas.0704472104","article-title":"Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells","volume":"104","author":"Ono","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2021.09.003_bib37","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1093\/humrep\/deq163","article-title":"OCT4 expression in human uterine myometrial stem\/progenitor cells","volume":"25","author":"Ono","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.003_bib39","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nchembio.1952","article-title":"A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease","volume":"11","author":"Dale","year":"2015","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.xfss.2021.09.003_bib40","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1021\/jm501436m","article-title":"Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen","volume":"58","author":"Mallinger","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.xfss.2021.09.003_bib41","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.celrep.2016.03.030","article-title":"Identification of Mediator kinase substrates in human cells using cortistatin A and quantitative phosphoproteomics","volume":"15","author":"Poss","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.xfss.2021.09.003_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007454","article-title":"Empirical Bayes analysis of quantitative proteomics experiments","volume":"4","author":"Margolin","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2021.09.003_bib43","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cell.2009.09.035","article-title":"Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways","volume":"139","author":"Alarcon","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.xfss.2021.09.003_bib44","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.immuni.2012.10.017","article-title":"CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response","volume":"38","author":"Bancerek","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.xfss.2021.09.003_bib45","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/gb4184","article-title":"Cyclin-dependent kinases","volume":"15","author":"Malumbres","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.xfss.2021.09.003_bib46","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1038\/sj.onc.1201076","article-title":"Loss of heterozygosity and reduced expression of the CUTL1 gene in uterine leiomyomas","volume":"14","author":"Zeng","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.xfss.2021.09.003_bib47","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1096\/fj.201801752","article-title":"Negative elongation factor is essential for endometrial function","volume":"33","author":"Hewitt","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.xfss.2021.09.003_bib48","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev-genet-110711-155440","article-title":"Control of transcriptional elongation","volume":"47","author":"Kwak","year":"2013","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.xfss.2021.09.003_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215495","article-title":"CiiiDER: a tool for predicting and analysing transcription factor binding sites","volume":"14","author":"Gearing","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2021.09.003_bib50","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1101\/gad.254532.114","article-title":"A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation","volume":"29","author":"Singh","year":"2015","journal-title":"Genes Dev"},{"key":"10.1016\/j.xfss.2021.09.003_bib51","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/ijc.30137","article-title":"A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line","volume":"139","author":"Lasham","year":"2016","journal-title":"Int J Cancer"},{"key":"10.1016\/j.xfss.2021.09.003_bib52","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.febslet.2011.06.020","article-title":"The immediate early genes Fos and Egr1 become STAT1 transcriptional targets in the absence of STAT3","volume":"585","author":"Schiavone","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.xfss.2021.09.003_bib53","article-title":"Inducible expression of immediate early genes is regulated through dynamic chromatin association by NF45\/ILF2 and NF90\/NF110\/ILF3","volume":"14","author":"Wu","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2021.09.003_bib54","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/emmm.201201475","article-title":"Loss of TIMP3 underlies diabetic nephropathy via FoxO1\/STAT1 interplay","volume":"5","author":"Fiorentino","year":"2013","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.xfss.2021.09.003_bib55","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41467-019-13888-7","article-title":"Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions","volume":"11","author":"Ibarra","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.xfss.2021.09.003_bib56","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1096\/fj.12-206177","article-title":"KAP1 regulates gene networks controlling T-cell development and responsiveness","volume":"26","author":"Santoni de Sio","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.xfss.2021.09.003_bib57","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature07179","article-title":"CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity","volume":"455","author":"Firestein","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.xfss.2021.09.003_bib58","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.celrep.2017.10.058","article-title":"CDK8 kinase activity promotes glycolysis","volume":"21","author":"Galbraith","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.xfss.2021.09.003_bib59","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.molcel.2018.04.024","article-title":"mTORC1 promotes metabolic reprogramming by the suppression of GSK3-dependent Foxk1 phosphorylation","volume":"70","author":"He","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.xfss.2021.09.003_bib60","doi-asserted-by":"crossref","first-page":"14066","DOI":"10.1074\/jbc.M602696200","article-title":"Mediator is a transducer of Wnt\/beta-catenin signaling","volume":"281","author":"Kim","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xfss.2021.09.003_bib61","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41586-019-0900-5","article-title":"FOXK1 and FOXK2 regulate aerobic glycolysis","volume":"566","author":"Sukonina","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.xfss.2021.09.003_bib62","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.devcel.2015.01.031","article-title":"FOXKs promote Wnt\/beta-catenin signaling by translocating DVL into the nucleus","volume":"32","author":"Wang","year":"2015","journal-title":"Dev Cell"},{"key":"10.1016\/j.xfss.2021.09.003_bib63","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ijc.10510","article-title":"Expression of N-terminally truncated isoforms of CDP\/CUX is increased in human uterine leiomyomas","volume":"100","author":"Moon","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.xfss.2021.09.003_bib64","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1050>3.0.CO;2-1","article-title":"Loss of heterozygosity at 7q22 and mutation analysis of the CDP gene in human epithelial ovarian tumors","volume":"91","author":"Neville","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.xfss.2021.09.003_bib65","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1038\/sj.onc.1202519","article-title":"Refined mapping of the region of loss of heterozygosity on the long arm of chromosome 7 in human breast cancer defines the location of a second tumor suppressor gene at 7q22 in the region of the CUTL1 gene","volume":"18","author":"Zeng","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.xfss.2021.09.003_bib66","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1182\/blood-2012-04-426965","article-title":"CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia","volume":"121","author":"McNerney","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.xfss.2021.09.003_bib67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/ng.2846","article-title":"Inactivating CUX1 mutations promote tumorigenesis","volume":"46","author":"Wong","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.xfss.2021.09.003_bib68","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.gene.2012.01.039","article-title":"CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases","volume":"497","author":"Hulea","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.xfss.2021.09.003_bib69","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1182\/blood-2017-10-810028","article-title":"Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS","volume":"131","author":"An","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.xfss.2021.09.003_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108018","article-title":"FOXK1 participates in DNA damage response by controlling 53BP1 function","volume":"32","author":"Tang","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.xfss.2021.09.003_bib71","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1095\/biolreprod.108.075648","article-title":"Constitutive activation of beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice","volume":"81","author":"Tanwar","year":"2009","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2021.09.003_bib72","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41556-020-0573-1","article-title":"Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8\/19 Mediator kinases","volume":"22","author":"Lynch","year":"2020","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.xfss.2021.09.003_bib73","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1038\/s41467-021-22181-5","article-title":"Dissection of two routes to naive pluripotency using different kinase inhibitors","volume":"12","author":"Martinez-Val","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.xfss.2021.09.003_bib74","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1158\/0008-5472.CAN-11-3886","article-title":"CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency","volume":"72","author":"Adler","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2021.09.003_bib75","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1038\/s41388-021-01745-1","article-title":"CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c\u2013MYC pathway","volume":"40","author":"Fukasawa","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.xfss.2021.09.003_bib76","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1177\/1933719118783252","article-title":"A preliminary study: human fibroid Stro-1+\/CD44+ stem cells isolated from uterine fibroids demonstrate decreased DNA repair and genomic integrity compared to adjacent myometrial Stro-1+\/CD44+ cells","volume":"26","author":"Prusinski Fernung","year":"2019","journal-title":"Reprod Sci"}],"container-title":["F&amp;S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X21000689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X21000689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:06:55Z","timestamp":1762981615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X21000689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":75,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S2666335X21000689"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2021.09.003","relation":{},"ISSN":["2666-335X"],"issn-type":[{"type":"print","value":"2666-335X"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and characterization of the mediator kinase-dependent myometrial stem cell phosphoproteome","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2021.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}