{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:18:19Z","timestamp":1789323499244,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","award":["A19-1294"],"award-info":[{"award-number":["A19-1294"]}],"id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Science"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.xfss.2021.09.004","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T12:15:45Z","timestamp":1632399345000},"page":"330-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessing the use of tumor-specific DARPin-toxin fusion proteins for ex\u00a0vivo purging of cancer metastases from human ovarian cortex before autotransplantation"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-5472","authenticated-orcid":false,"given":"Lotte","family":"Eijkenboom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Palacio-Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freek","family":"Groenman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0847-3684","authenticated-orcid":false,"given":"Didi","family":"Braat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3179-3763","authenticated-orcid":false,"given":"Catharina","family":"Beerendonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1395-6127","authenticated-orcid":false,"given":"Roland","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2463-277X","authenticated-orcid":false,"given":"Wouter","family":"Verdurmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Peek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2021.09.004_bib1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.fertnstert.2020.04.050","article-title":"Importance of patient selection to analyze in\u00a0vitro fertilization outcome with transplanted cryopreserved ovarian tissue","volume":"114","author":"Dolmans","year":"2020","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2021.09.004_bib2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/humupd\/dmt020","article-title":"Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review","volume":"19","author":"Bastings","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfss.2021.09.004_bib3","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/humrep\/dey105","article-title":"Defining quality assurance and quality control measures in connection with ovarian tissue cryopreservation and transplantation: a call to action","volume":"33","author":"Andersen","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/molehr\/gay002","article-title":"Metaphase II oocytes from human unilaminar follicles grown in a multi-step culture system","volume":"24","author":"McLaughlin","year":"2018","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib5","doi-asserted-by":"crossref","first-page":"17323","DOI":"10.1038\/srep17323","article-title":"In\u00a0vitro follicle growth supports human oocyte meiotic maturation","volume":"5","author":"Xiao","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2021.09.004_bib6","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1071\/RD16233","article-title":"Extracellular-like matrices and leukaemia inhibitory factor for in\u00a0vitro culture of human primordial follicles","volume":"29","author":"Younis","year":"2017","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.xfss.2021.09.004_bib7","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.bbrc.2019.04.100","article-title":"Absence of mitochondrial DNA methylation in mouse oocyte maturation, aging and early embryo development","volume":"513","author":"Fan","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.xfss.2021.09.004_bib8","doi-asserted-by":"crossref","first-page":"15680","DOI":"10.1038\/ncomms15680","article-title":"In\u00a0vitro differentiation of human embryonic stem cells into ovarian follicle-like cells","volume":"8","author":"Jung","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.xfss.2021.09.004_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/861460","article-title":"Expression of pluripotency and oocyte-related genes in single putative stem cells from human adult ovarian surface epithelium cultured in\u00a0vitro in the presence of follicular fluid","volume":"2013","author":"Virant-Klun","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.xfss.2021.09.004_bib10","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/humrep\/dex377","article-title":"In\u00a0vitro differentiation of human oocyte-like cells from oogonial stem cells: single-cell isolation and molecular characterization","volume":"33","author":"Silvestris","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib11","first-page":"444","article-title":"From isolation of human ovarian follicles to the artificial ovary: tips and tricks","volume":"70","author":"Chiti","year":"2018","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.xfss.2021.09.004_bib12","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/humrep\/dez077","article-title":"Initial steps in reconstruction of the human ovary: survival of pre-antral stage follicles in a decellularized human ovarian scaffold","volume":"34","author":"Pors","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.theriogenology.2020.01.021","article-title":"Engineering a bioprosthetic ovary for fertility and hormone restoration","volume":"150","author":"Laronda","year":"2020","journal-title":"Theriogenology"},{"key":"10.1016\/j.xfss.2021.09.004_bib14","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/humrep\/dey384","article-title":"Enhancing the safety of ovarian cortex autotransplantation: cancer cells are purged completely from human ovarian tissue fragments by pharmacological inhibition of YAP\/TAZ oncoproteins","volume":"34","author":"Mulder","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib15","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1007\/s10815-021-02081-9","article-title":"Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway","volume":"38","author":"Eijkenboom","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2021.09.004_bib16","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/humrep\/dez115","article-title":"Dexamethasone does not prevent malignant cell reintroduction in leukemia patients undergoing ovarian transplant: risk assessment of leukemic cell transmission by a xenograft model","volume":"34","author":"Diaz-Garcia","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib17","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.drudis.2008.04.013","article-title":"DARPins: a new generation of protein therapeutics","volume":"13","author":"Stumpp","year":"2008","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.xfss.2021.09.004_bib18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-pharmtox-010611-134654","article-title":"Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy","volume":"55","author":"Pl\u00fcckthun","year":"2015","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.xfss.2021.09.004_bib19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1158\/1078-0432.CCR-10-1303","article-title":"A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity","volume":"17","author":"Martin-Killias","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.xfss.2021.09.004_bib20","doi-asserted-by":"crossref","first-page":"13194","DOI":"10.1038\/s41598-017-13469-y","article-title":"A quantitative comparison of cytosolic delivery via different protein uptake systems","volume":"7","author":"Verdurmen","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2021.09.004_bib21","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1111\/j.1742-4658.2011.08182.x","article-title":"A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer","volume":"278","author":"Weldon","year":"2011","journal-title":"FEBS J"},{"key":"10.1016\/j.xfss.2021.09.004_bib22","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jmb.2011.09.016","article-title":"DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency","volume":"413","author":"Stefan","year":"2011","journal-title":"J Mol Biol"},{"key":"10.1016\/j.xfss.2021.09.004_bib23","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.jmb.2008.07.085","article-title":"Efficient selection of DARPins with sub-nanomolar affinities using SRP phage display","volume":"382","author":"Steiner","year":"2008","journal-title":"J Mol Biol"},{"key":"10.1016\/j.xfss.2021.09.004_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.3798106","article-title":"Human breast cancer: correlation of relapse and survival with amplification of the HER-2\/neu oncogene","volume":"235","author":"Slamon","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.xfss.2021.09.004_bib25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/s12885-016-2587-4","article-title":"Comparison of the HER2, estrogen and progesterone receptor expression profile of primary tumor, metastases and circulating tumor cells in metastatic breast cancer patients","volume":"16","author":"Aktas","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.xfss.2021.09.004_bib26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jconrel.2016.05.020","article-title":"Recombinant targeted toxin based on HER2-specific DARPin possesses a strong selective cytotoxic effect in\u00a0vitro and a potent antitumor activity in\u00a0vivo","volume":"233","author":"Sokolova","year":"2016","journal-title":"J Control Release"},{"key":"10.1016\/j.xfss.2021.09.004_bib27","doi-asserted-by":"crossref","first-page":"13366","DOI":"10.18632\/oncotarget.24351","article-title":"Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin\u00ae protein MP0250: a preclinical study","volume":"9","author":"Rao","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.xfss.2021.09.004_bib28","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.SABCS16-P4-21-18","article-title":"Abstract P4-21-18: Pre-clinical antitumor activity, tumor localization, and pharmacokinetics of MP0274, an apoptosis inducing, biparatopic HER2-targeting DARPin \u00ae","volume":"77","author":"Fiedler","year":"2017","journal-title":"Cancer Research"},{"key":"10.1016\/j.xfss.2021.09.004_bib29","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.xfss.2021.09.004_bib30","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/sj.bjc.6602787","article-title":"Clinical characteristics of different histologic types of breast cancer","volume":"93","author":"Li","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.xfss.2021.09.004_bib31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10815-013-9952-x","article-title":"A review of 15 years of ovarian tissue bank activities","volume":"30","author":"Dolmans","year":"2013","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2021.09.004_bib32","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.celrep.2017.09.058","article-title":"Combinatorial microenvironments impose a continuum of cellular responses to a single pathway-targeted anti-cancer compound","volume":"21","author":"Lin","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.xfss.2021.09.004_bib33","doi-asserted-by":"crossref","first-page":"12126","DOI":"10.1073\/pnas.1611338113","article-title":"Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias","volume":"113","author":"Shin","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2021.09.004_bib34","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/humrep\/dev013","article-title":"A preliminary study on a new model system to evaluate tumour-detection and tumour-purging protocols in ovarian cortex tissue intended for fertility preservation","volume":"30","author":"Peek","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib35","doi-asserted-by":"crossref","first-page":"44623","DOI":"10.18632\/oncotarget.5977","article-title":"EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low","volume":"6","author":"Ring","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.xfss.2021.09.004_bib36","doi-asserted-by":"crossref","unstructured":"Nami B, Ghanaeian A, Wang Z. Epigenetic downregulation of HER2 during EMT leads to tumor resistance to HER2-targeted therapies in breast cancer. bioRxiv 2020:2020.03.24.006379.","DOI":"10.1101\/2020.03.24.006379"},{"key":"10.1016\/j.xfss.2021.09.004_bib37","first-page":"35","article-title":"The expression patterns of ER, PR, HER2, CK5\/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines","volume":"4","author":"Subik","year":"2010","journal-title":"Breast Cancer (Auckl)"},{"key":"10.1016\/j.xfss.2021.09.004_bib38","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ccr.2006.10.008","article-title":"A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes","volume":"10","author":"Neve","year":"2006","journal-title":"Cancer Cell"},{"issue":"Suppl 7","key":"10.1016\/j.xfss.2021.09.004_bib39","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/s12864-016-2911-z","article-title":"Comprehensive comparison of molecular portraits between cell lines and tumors in breast cancer","volume":"17","author":"Jiang","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.xfss.2021.09.004_bib40","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1007\/s10815-016-0816-z","article-title":"Clinically applied procedures for human ovarian tissue cryopreservation result in different levels of efficacy and efficiency","volume":"33","author":"Bastings","year":"2016","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2021.09.004_bib41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jconrel.2014.12.019","article-title":"Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems","volume":"200","author":"Verdurmen","year":"2015","journal-title":"J Control Release"},{"key":"10.1016\/j.xfss.2021.09.004_bib42","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.3390\/cancers13102461","article-title":"A hybrid in silico and tumor-on-a-chip approach to model targeted protein behavior in 3D microenvironments","volume":"13","author":"Palacio-Casta\u00f1eda","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.xfss.2021.09.004_bib43","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.fertnstert.2014.11.001","article-title":"Searching for metastases in ovarian tissue before autotransplantation: a tailor-made approach","volume":"103","author":"Hoekman","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2021.09.004_bib44","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1530\/jrf.0.0780389","article-title":"Germinal vesicle breakdown in oocytes of human atretic follicles during the menstrual cycle","volume":"78","author":"Gougeon","year":"1986","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.xfss.2021.09.004_bib45","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1093\/humrep\/dep079","article-title":"Vitrification versus controlled-rate freezing in cryopreservation of human ovarian tissue","volume":"24","author":"Keros","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib46","first-page":"2276","article-title":"A simple method to quantify follicle survival in cryopreserved human ovarian tissue","volume":"33","author":"Kristensen","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib47","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/molehr\/gau037","article-title":"Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in\u00a0vitro results in increased activation of primordial follicles but compromises development of growing follicles","volume":"20","author":"McLaughlin","year":"2014","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib48","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/humrep\/den070","article-title":"A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin","volume":"23","author":"Telfer","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.09.004_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.xfss.2021.09.004_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0234991","article-title":"Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines","volume":"15","author":"Burguin","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2021.09.004_bib51","doi-asserted-by":"crossref","first-page":"40252","DOI":"10.1074\/jbc.M602506200","article-title":"Isolation of intracellular proteinase inhibitors derived from designed ankyrin repeat proteins by genetic screening","volume":"281","author":"Kawe","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xfss.2021.09.004_bib52","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jmb.2007.03.028","article-title":"A designed ankyrin repeat protein evolved to picomolar affinity to Her2","volume":"369","author":"Zahnd","year":"2007","journal-title":"J Mol Biol"},{"key":"10.1016\/j.xfss.2021.09.004_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12071762","article-title":"EpCAM-binding DARPins for targeted photodynamic therapy of ovarian cancer","volume":"12","author":"van den Brand","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.xfss.2021.09.004_bib54","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1158\/1535-7163.MCT-13-0523","article-title":"Increasing the antitumor effect of an EpCAM-targeting fusion toxin by facile click PEGylation","volume":"13","author":"Simon","year":"2014","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.xfss.2021.09.004_bib55","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jconrel.2020.08.004","article-title":"Optimizing the anti-tumor efficacy of protein-drug conjugates by engineering the molecular size and half-life","volume":"327","author":"Brandl","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.xfss.2021.09.004_bib56","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3390\/pharmaceutics13040562","article-title":"A computational investigation of in\u00a0vivo cytosolic protein delivery for cancer therapy","volume":"13","author":"Torres","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.xfss.2021.09.004_bib57","article-title":"Highly potent anti-SARS-CoV-2 multi-DARPin therapeutic candidates","author":"Walser","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.xfss.2021.09.004_bib58","doi-asserted-by":"crossref","unstructured":"Stumpp MA-O, Dawson KM, Binz HK. Beyond antibodies: the DARPin(\u00ae) drug platform 2020.","DOI":"10.1007\/s40259-020-00429-8"},{"key":"10.1016\/j.xfss.2021.09.004_bib59","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3390\/toxins9080236","article-title":"Bacterial toxins for cancer therapy","volume":"9","author":"Zahaf","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.xfss.2021.09.004_bib60","doi-asserted-by":"crossref","first-page":"R617","DOI":"10.1186\/bcr1264","article-title":"Phase I clinical study of the recombinant antibody toxin scFv(FRP5)-ETA specific for the ErbB2\/HER2 receptor in patients with advanced solid malignomas","volume":"7","author":"von Minckwitz","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.xfss.2021.09.004_bib61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1515\/med-2017-0007","article-title":"Clinicopathology of EpCAM and EGFR in human epithelial ovarian carcinoma","volume":"12","author":"Zheng","year":"2017","journal-title":"Open Med (Wars)"}],"container-title":["F&amp;S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X21000690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X21000690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:06:45Z","timestamp":1762981605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X21000690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S2666335X21000690"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2021.09.004","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing the use of tumor-specific DARPin-toxin fusion proteins for ex\u00a0vivo purging of cancer metastases from human ovarian cortex before autotransplantation","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2021.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}