{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:03:26Z","timestamp":1790525006897,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Science"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.xfss.2021.11.004","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T02:57:01Z","timestamp":1638413821000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oocyte cytoplasmic diameter of \u2265130 \u03bcm can be used to determine human giant oocytes"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5850-2773","authenticated-orcid":false,"given":"Hiroya","family":"Kitasaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Konuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Tokoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2161-3319","authenticated-orcid":false,"given":"Noritaka","family":"Fukunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-9953","authenticated-orcid":false,"given":"Yoshimasa","family":"Asada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2021.11.004_bib1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","article-title":"To err (meiotically) is human: the genesis of human aneuploidy","volume":"2","author":"Hassold","year":"2001","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.xfss.2021.11.004_bib2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.2741\/1822","article-title":"Meiotic spindle, spindle checkpoint and embryonic aneuploidy","volume":"11","author":"Wang","year":"2006","journal-title":"Front Biosci"},{"key":"10.1016\/j.xfss.2021.11.004_bib3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/humupd\/dmv011","article-title":"Oocyte maturation: gamete-somatic cells interactions, meiotic resumption, cytoskeletal dynamics and cytoplasmic reorganization","volume":"21","author":"Coticchio","year":"2015","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfss.2021.11.004_bib4","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1093\/oxfordjournals.humrep.a019080","article-title":"Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women","volume":"11","author":"Battaglia","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.11.004_bib5","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/humrep\/16.8.1714","article-title":"Morphology of in-vitro matured oocytes: impact on fertility potential and embryo quality","volume":"16","author":"Mikkelsen","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.11.004_bib6","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S1472-6483(10)61187-X","article-title":"Effect of oocyte morphology on embryo development and implantation","volume":"12","author":"Balaban","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.xfss.2021.11.004_bib7","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.fertnstert.2007.09.024","article-title":"Significance of metaphase II human oocyte morphology on ICSI outcome","volume":"90","author":"Rienzi","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2021.11.004_bib8","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.fertnstert.2009.11.039","article-title":"Metaphase II human oocyte morphology: contributing factors and effects on fertilization potential and embryo developmental ability in ICSI cycles","volume":"94","author":"de C\u00e1ssia S Figueira","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2021.11.004_bib9","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/aogs.12941","article-title":"Oocyte competence in in\u00a0vitro fertilization and intracytoplasmic sperm injection patients suffering from endometriosis and its possible association with subsequent treatment outcome: a matched case-control study","volume":"96","author":"Shebl","year":"2017","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.xfss.2021.11.004_bib10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/humrep\/dez010","article-title":"Is it time to reconsider how to manage oocytes affected by smooth endoplasmic reticulum aggregates?","volume":"34","author":"Ferreux","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.11.004_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-43757-8","article-title":"Relationship between the positions of cytoplasmic granulation and the oocytes developmental potential in human","volume":"9","author":"Yi","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2021.11.004_bib12","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.fertnstert.2010.10.026","article-title":"Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization\/intracytoplasmic sperm injection cycles","volume":"95","author":"Marquard","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2021.11.004_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0222390","article-title":"Age, body weight and ovarian function affect oocyte size and morphology in non-PCOS patients undergoing intracytoplasmic sperm injection (ICSI)","volume":"14","author":"Weghofer","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2021.11.004_bib14","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1093\/humrep\/17.9.2394","article-title":"Morphological and cytogenetic analysis of human giant oocytes and giant embryos","volume":"17","author":"Balakier","year":"2002","journal-title":"Hum Reprod"},{"issue":"Suppl 1","key":"10.1016\/j.xfss.2021.11.004_bib15","doi-asserted-by":"crossref","first-page":"i2","DOI":"10.1093\/humrep\/des200","article-title":"The oocyte","volume":"27","author":"Rienzi","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.11.004_bib16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000131526","article-title":"Giant diploid oocytes as a cause of digynic triploidy in mammals","volume":"28","author":"Funaki","year":"1980","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.xfss.2021.11.004_bib17","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1093\/humrep\/17.9.2388","article-title":"Cytogenetic analysis of giant oocytes and zygotes to assess their relevance for the development of digynic triploidy","volume":"17","author":"Rosenbusch","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.11.004_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/rmb2.12378","article-title":"Chromosomal analyses of human giant diploid oocytes by next-generation sequencing","volume":"20","author":"Kawano","year":"2021","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.xfss.2021.11.004_bib19","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.fertnstert.2010.06.037","article-title":"A giant oocyte in a cohort of retrieved oocytes: does it have any effect on the in\u00a0vitro fertilization cycle outcome?","volume":"95","author":"Machtinger","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2021.11.004_bib20","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00404-015-3679-0","article-title":"Giant oocytes in human in\u00a0vitro fertilization treatments","volume":"292","author":"Lehner","year":"2015","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.xfss.2021.11.004_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/rmb2.12271","article-title":"Performance of anti-M\u00fcllerian hormone (AMH) levels measured by Beckman Coulter Access AMH assay to predict oocyte yield following controlled ovarian stimulation for in\u00a0vitro fertilization","volume":"18","author":"Asada","year":"2019","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.xfss.2021.11.004_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078380","article-title":"Latrunculin A treatment prevents abnormal chromosome segregation for successful development of cloned embryos","volume":"8","author":"Terashita","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2021.11.004_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/dbio.2001.0269","article-title":"Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles","volume":"234","author":"Pepling","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.xfss.2021.11.004_bib24","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1210\/en.2007-0088","article-title":"Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in\u00a0vitro and in\u00a0vivo","volume":"148","author":"Chen","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.xfss.2021.11.004_bib25","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jhazmat.2015.05.052","article-title":"DEHP exposure impairs mouse oocyte cyst breakdown and primordial follicle assembly through estrogen receptor-dependent and independent mechanisms","volume":"298","author":"Mu","year":"2015","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.xfss.2021.11.004_bib26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1677\/JOE-09-0109","article-title":"Estrogen can signal through multiple pathways to regulate oocyte cyst breakdown and primordial follicle assembly in the neonatal mouse ovary","volume":"202","author":"Chen","year":"2009","journal-title":"J Endocrinol"},{"key":"10.1016\/j.xfss.2021.11.004_bib27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF01132182","article-title":"Recovery of a preovulatory binucleate oocyte in a patient following induction of ovulation for in\u00a0vitro fertilization","volume":"5","author":"Mahadevan","year":"1988","journal-title":"J In\u00a0Vitro Fert Embryo Transf"},{"key":"10.1016\/j.xfss.2021.11.004_bib28","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1093\/humrep\/17.7.1892","article-title":"A human oocyte with two sets of MII\/PB-structures","volume":"17","author":"Hardarson","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2021.11.004_bib29","first-page":"189","article-title":"Conjoined human oocytes observed during assisted reproduction: description of three cases and review of the literature","volume":"53","author":"Rosenbusch","year":"2012","journal-title":"Rom J Morphol Embryol"},{"key":"10.1016\/j.xfss.2021.11.004_bib30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.rbmo.2015.09.012","article-title":"Live birth resulting from a conjoined oocyte confirmed as euploid using array CGH: a case report","volume":"32","author":"Cummins","year":"2016","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.xfss.2021.11.004_bib31","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2011.02.002","article-title":"Epigenetic centromere propagation and the nature of CENP-a nucleosomes","volume":"144","author":"Black","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.xfss.2021.11.004_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00412-011-0330-0","article-title":"The ABCs of CENPs","volume":"120","author":"Perpelescu","year":"2011","journal-title":"Chromosoma"},{"key":"10.1016\/j.xfss.2021.11.004_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-1-62703-191-2_17","article-title":"Counting chromosomes in intact eggs","volume":"957","author":"Chiang","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.xfss.2021.11.004_bib34","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.fertnstert.2008.12.124","article-title":"Oocyte diameter as a predictor of fertilization and embryo quality in assisted reproduction cycles","volume":"93","author":"Rom\u00e3o","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2021.11.004_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.fertnstert.2007.06.031","article-title":"Mechanisms giving rise to triploid zygotes during assisted reproduction","volume":"90","author":"Rosenbusch","year":"2008","journal-title":"Fertil Steril"}],"container-title":["F&S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X21000896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X21000896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:07:45Z","timestamp":1762981665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X21000896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S2666335X21000896"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2021.11.004","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oocyte cytoplasmic diameter of \u2265130 \u03bcm can be used to determine human giant oocytes","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2021.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}