{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:30:26Z","timestamp":1785198626782,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100014965","name":"Endometriosis Foundation of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Science"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.xfss.2022.03.001","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T02:04:36Z","timestamp":1648605876000},"page":"197-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Methylation of microribonucleic acid Let-7b regulatory regions in endometriosis"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-2557","authenticated-orcid":false,"given":"Dana A.","family":"Meixell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4022-8910","authenticated-orcid":false,"given":"Ramanaiah","family":"Mamillapalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2022.03.001_bib1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.xfss.2022.03.001_bib2","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1210\/er.2018-00242","volume":"40","author":"Bulun","year":"2019","journal-title":"Endometriosis. Endocr Rev"},{"key":"10.1016\/j.xfss.2022.03.001_bib3","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.3390\/jcm10163457","article-title":"Role of miRNAs in normal endometrium and in endometrial disorders: comprehensive review","volume":"10","author":"Kolanska","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.xfss.2022.03.001_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12958-019-0480-0","article-title":"Adipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression","volume":"17","author":"Zolbin","year":"2019","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.xfss.2022.03.001_bib5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1177\/1933719116667228","article-title":"Circulating miRNAs in murine experimental endometriosis","volume":"24","author":"Seifer","year":"2017","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2022.03.001_bib6","doi-asserted-by":"crossref","first-page":"996","DOI":"10.15252\/emmm.201505245","article-title":"H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis","volume":"7","author":"Ghazal","year":"2015","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.xfss.2022.03.001_bib7","first-page":"1646","article-title":"Let-7b acts as a tumor suppressor in osteosarcoma via targeting IGF1R","volume":"17","author":"Zhang","year":"2019","journal-title":"Oncol Lett"},{"key":"10.1016\/j.xfss.2022.03.001_bib8","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1177\/1933719114532841","article-title":"Altered genome-wide methylation in endometriosis","volume":"21","author":"Naqvi","year":"2014","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2022.03.001_bib9","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/humrep\/dev005","article-title":"The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival","volume":"30","author":"Graham","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2022.03.001_bib10","doi-asserted-by":"crossref","first-page":"E1925","DOI":"10.1210\/jc.2011-1231","article-title":"MicroRNA 135 regulates HOXA10 expression in endometriosis","volume":"96","author":"Petracco","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2022.03.001_bib11","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1007\/s43032-021-00604-4","article-title":"hsa-miR-199a-3p inhibits motility, invasiveness, and contractility of ovarian endometriotic stromal cells","volume":"28","author":"Zhu","year":"2021","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2022.03.001_bib12","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.fertnstert.2015.02.013","article-title":"Circulating microRNAs as potential biomarkers for endometriosis","volume":"103","author":"Cho","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2022.03.001_bib13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1055\/s-0037-1599089","article-title":"MicroRNAs and endometriosis: distinguishing drivers from passengers in disease pathogenesis","volume":"35","author":"Nothnick","year":"2017","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2022.03.001_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-3-030-51856-1_5","article-title":"Deciphering the role of miRNAs in endometriosis pathophysiology using experimental endometriosis mouse models","volume":"232","author":"Vashisht","year":"2020","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"10.1016\/j.xfss.2022.03.001_bib15","article-title":"Decreased let-7b is associated with poor prognosis in glioma","volume":"98","author":"Zhang","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.xfss.2022.03.001_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109506","article-title":"Feedback repression of PPAR\u03b1 signaling by Let-7 microRNA","volume":"36","author":"Yagai","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.xfss.2022.03.001_bib17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cas.14708","article-title":"Inhibition of microRNA let-7b expression by KDM2B promotes cancer progression by targeting EZH2 in ovarian cancer","volume":"112","author":"Kuang","year":"2021","journal-title":"Cancer Sci"},{"key":"10.1016\/j.xfss.2022.03.001_bib18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.fertnstert.2016.05.020","article-title":"Aromatase inhibitor regulates let-7 expression and let-7f-induced cell migration in endometrial cells from women with endometriosis","volume":"106","author":"Cho","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2022.03.001_bib19","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/ncb3395","article-title":"G9a\/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS\/\u03b2-catenin pathway","volume":"18","author":"Cha","year":"2016","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.xfss.2022.03.001_bib20","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1111\/jcmm.13807","article-title":"microRNA Let-7b: a novel treatment for endometriosis","volume":"22","author":"Sahin","year":"2018","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.xfss.2022.03.001_bib21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/leu.2012.242","article-title":"Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements","volume":"27","author":"Nishi","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.xfss.2022.03.001_bib22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/molehr\/gam005","article-title":"Altered expression of HOXA10 in endometriosis: potential role in decidualization","volume":"13","author":"Kim","year":"2007","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.xfss.2022.03.001_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1095\/biolreprod.108.070391","article-title":"Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium","volume":"80","author":"Lee","year":"2009","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2022.03.001_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/1933719116630427","article-title":"Aberrant HOXA10 methylation in patients with common gynecologic disorders: implications for reproductive outcomes","volume":"23","author":"Kulp","year":"2016","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2022.03.001_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-0031-1299596","article-title":"Role of estrogen receptor-\u03b2 in endometriosis","volume":"30","author":"Bulun","year":"2012","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2022.03.001_bib26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1055\/s-0029-1242991","article-title":"Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis","volume":"28","author":"Bulun","year":"2010","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2022.03.001_bib27","doi-asserted-by":"crossref","first-page":"D884","DOI":"10.1093\/nar\/gkaa942","article-title":"Ensembl 2021","volume":"49","author":"Howe","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.xfss.2022.03.001_bib28","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res"},{"key":"10.1016\/j.xfss.2022.03.001_bib29","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/emmm.201100200","article-title":"A polymorphism in a let-7 microRNA binding site of KRAS in women with endometriosis","volume":"4","author":"Grechukhina","year":"2012","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.xfss.2022.03.001_bib30","doi-asserted-by":"crossref","first-page":"557.e1","DOI":"10.1016\/j.ajog.2020.02.050","article-title":"Accurate diagnosis of endometriosis using serum microRNAs","volume":"223","author":"Moustafa","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfss.2022.03.001_bib31","doi-asserted-by":"crossref","first-page":"D100","DOI":"10.1093\/nar\/gky1128","article-title":"GTRD: a database on gene transcription regulation-2019 update","volume":"47","author":"Yevshin","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.xfss.2022.03.001_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pharmthera.2015.05.008","article-title":"Sp1 transcription factor: a long-standing target in cancer chemotherapy","volume":"152","author":"Vizca\u00edno","year":"2015","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.xfss.2022.03.001_bib33","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1210\/jc.2006-1694","article-title":"Differential cell-specific modulation of HOXA10 by estrogen and specificity protein 1 response elements","volume":"92","author":"Martin","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2022.03.001_bib34","doi-asserted-by":"crossref","DOI":"10.1177\/0300060520918437","article-title":"The miR-25-3p\/Sp1 pathway is dysregulated in ovarian endometriosis","volume":"48","author":"Shen","year":"2020","journal-title":"J Int Med Res"},{"key":"10.1016\/j.xfss.2022.03.001_bib35","doi-asserted-by":"crossref","first-page":"13444","DOI":"10.1074\/jbc.M109.062430","article-title":"Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex","volume":"285","author":"Suzuki","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xfss.2022.03.001_bib36","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.2147\/CMAR.S168043","article-title":"Novel endocrine therapeutic strategy in endometrial carcinoma targeting estrogen-related receptor \u03b1 by XCT790 and siRNA","volume":"10","author":"Sun","year":"2018","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.xfss.2022.03.001_bib37","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.fertnstert.2011.04.032","article-title":"Involvement of estrogen receptor-related receptors in human ovarian endometriosis","volume":"96","author":"Cavallini","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2022.03.001_bib38","doi-asserted-by":"crossref","first-page":"24826","DOI":"10.1074\/jbc.M202952200","article-title":"Estrogen-related receptor alpha 1 actively antagonizes estrogen receptor-regulated transcription in MCF-7 mammary cells","volume":"277","author":"Kraus","year":"2002","journal-title":"J Biol Chem"}],"container-title":["F&amp;S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X22000210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X22000210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:05:21Z","timestamp":1778918721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X22000210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S2666335X22000210"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2022.03.001","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylation of microribonucleic acid Let-7b regulatory regions in endometriosis","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2022.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}