{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:50:25Z","timestamp":1772592625615,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Science"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.xfss.2022.08.001","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T01:59:23Z","timestamp":1660355963000},"page":"2-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing male gamete genome integrity to ameliorate poor assisted reproductive technology clinical outcome"],"prefix":"10.1016","volume":"4","author":[{"given":"Olena M.","family":"Kocur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney","family":"Souness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zev","family":"Rosenwaks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-4560","authenticated-orcid":false,"given":"Gianpiero D.","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2022.08.001_bib1","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1007\/s10815-021-02191-4","article-title":"Single-center thorough evaluation and targeted treatment of globozoospermic men","volume":"38","author":"Cheung","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2022.08.001_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113671","article-title":"Intracytoplasmic sperm injection (ICSI) in extreme cases of male infertility","volume":"9","author":"Palermo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2022.08.001_bib3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.fertnstert.2012.12.049","article-title":"The clinical utility of sperm DNA integrity testing: a guideline","volume":"99","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2022.08.001_bib4","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1007\/s10815-018-1270-x","article-title":"A treatment algorithm for couples with unexplained infertility based on sperm chromatin assessment","volume":"35","author":"O\u2019Neill","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2022.08.001_bib5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/JU.0000000000000659","article-title":"Sperm genomic integrity by TUNEL varies throughout the male genital tract","volume":"203","author":"Xie","year":"2020","journal-title":"J Urol"},{"key":"10.1016\/j.xfss.2022.08.001_bib6","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s10815-019-01543-5","article-title":"A treatment approach for couples with disrupted sperm DNA integrity and recurrent ART failure","volume":"36","author":"Parrella","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2022.08.001_bib7","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.fertnstert.2014.10.008","article-title":"Perspectives on the assessment of human sperm chromatin integrity","volume":"102","author":"Palermo","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2022.08.001_bib8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/humrep\/deh590","article-title":"Efficient treatment of infertility due to sperm DNA damage by ICSI with testicular spermatozoa","volume":"20","author":"Greco","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2022.08.001_bib9","series-title":"WHO laboratory manual for the examination and processing of human semen","year":"2021"},{"key":"10.1016\/j.xfss.2022.08.001_bib10","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0022-5347(05)67724-5","article-title":"Microsurgical testis biopsy: a novel technique for retrieval of testicular tissue","volume":"163","author":"Dardashti","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.xfss.2022.08.001_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ceca.2013.10.006","article-title":"Understanding fertilization through intracytoplasmic sperm injection (ICSI)","volume":"55","author":"Neri","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.xfss.2022.08.001_bib12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/978-1-4939-0659-8_18","article-title":"Treatment of male infertility","volume":"1154","author":"Palermo","year":"2014","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.xfss.2022.08.001_bib13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fertnstert.2018.03.032","article-title":"Blastocyst development rate influences implantation and live birth rates of similarly graded euploid blastocysts","volume":"110","author":"Irani","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2022.08.001_bib14","first-page":"133","article-title":"Blastocyst score, a blastocyst quality ranking tool, is a predictor of blastocyst ploidy and implantation potential","volume":"1","author":"Zhan","year":"2020","journal-title":"F S Rep"},{"key":"10.1016\/j.xfss.2022.08.001_bib15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1055\/s-0035-1546825","article-title":"To ICSI or not to ICSI","volume":"33","author":"Palermo","year":"2015","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2022.08.001_bib16","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.rbmo.2016.08.009","article-title":"Adjuvant gonadotrophin-releasing hormone agonist trigger with human chorionic gonadotrophin to enhance ooplasmic maturity","volume":"33","author":"Pereira","year":"2016","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.xfss.2022.08.001_bib17","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1056\/NEJMsa013491","article-title":"Insurance coverage and outcomes of in\u00a0vitro fertilization","volume":"347","author":"Jain","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.xfss.2022.08.001_bib18","first-page":"182","article-title":"Selection of spermatozoa with higher chromatin integrity through a microfluidics device","volume":"32","author":"Parrella","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2022.08.001_bib19","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.fertnstert.2014.10.021","article-title":"Limitations of semen analysis as a test of male fertility and anticipated needs from newer tests","volume":"102","author":"Wang","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2022.08.001_bib20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ijir.2016.15","article-title":"Sperm DNA damage-the effect of stress and everyday life factors","volume":"28","author":"Radwan","year":"2016","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.xfss.2022.08.001_bib21","doi-asserted-by":"crossref","first-page":"412","DOI":"10.5534\/wjmh.200128","article-title":"Sperm DNA fragmentation: a new guideline for clinicians","volume":"38","author":"Agarwal","year":"2020","journal-title":"World J Mens Health"},{"key":"10.1016\/j.xfss.2022.08.001_bib22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2164\/jandrol.108.006908","article-title":"Are tests of sperm DNA damage clinically useful? Pros and cons","volume":"30","author":"Zini","year":"2009","journal-title":"J Androl"},{"key":"10.1016\/j.xfss.2022.08.001_bib23","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.rbmo.2011.07.010","article-title":"Impact of sperm DNA fragmentation on the outcome of IVF with own or donated oocytes","volume":"23","author":"Esbert","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.xfss.2022.08.001_bib24","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/andr.12551","article-title":"High sperm DNA fragmentation delays human embryo kinetics when oocytes from young and healthy donors are microinjected","volume":"6","author":"Esbert","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.xfss.2022.08.001_bib25","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/humrep\/deh127","article-title":"Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation","volume":"19","author":"Tesarik","year":"2004","journal-title":"Hum Reprod"}],"container-title":["F&S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X22000581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X22000581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:07:41Z","timestamp":1762981661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X22000581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S2666335X22000581"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2022.08.001","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing male gamete genome integrity to ameliorate poor assisted reproductive technology clinical outcome","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2022.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}