{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:11:26Z","timestamp":1762985486244,"version":"3.45.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:00:00Z","timestamp":1716076800000},"content-version":"am","delay-in-days":384,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12 HD000849"],"award-info":[{"award-number":["K12 HD000849"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002603","name":"American Society for Reproductive Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006668","name":"Oregon Health and Science University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007269","name":"OHSU SOM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008143","name":"Oregon National Primate Research Center","doi-asserted-by":"publisher","award":["P51 OD011092"],"award-info":[{"award-number":["P51 OD011092"]}],"id":[{"id":"10.13039\/100008143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008235","name":"School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Science"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.xfss.2023.03.002","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T11:32:42Z","timestamp":1678534362000},"page":"163-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hormonal regulation of non-cystic fibrosis transmembrane conductance regulator ion channels in the endocervix"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-3321","authenticated-orcid":false,"given":"Mackenzie","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey T.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2023.03.002_bib1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0002-9378(72)90617-5","article-title":"A composite picture of the menstrual cycle","volume":"114","author":"Moghissi","year":"1972","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfss.2023.03.002_bib2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nprot.2016.174","article-title":"Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens","volume":"12","author":"Liu","year":"2017","journal-title":"Nat Protoc"},{"key":"10.1016\/j.xfss.2023.03.002_bib3","doi-asserted-by":"crossref","first-page":"D1245","DOI":"10.2741\/Gipson","article-title":"Mucins of the human endocervix","volume":"6","author":"Gipson","year":"2001","journal-title":"Front Biosci"},{"key":"10.1016\/j.xfss.2023.03.002_bib4","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1113\/jphysiol.2010.187237","article-title":"A new role for bicarbonate secretion in cervico-uterine mucus release","volume":"588","author":"Muchekehu","year":"2010","journal-title":"J Physiol"},{"key":"10.1016\/j.xfss.2023.03.002_bib5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0015-0282(16)43454-0","article-title":"Human cervical mucus. IV. Viscoelasticity and sperm penetrability during the ovulatory menstrual cycle","volume":"30","author":"Wolf","year":"1978","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.03.002_bib6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/13625187.2018.1437134","article-title":"Appraising cervical mucus: a new approach to evaluating contraceptives","volume":"23","author":"Han","year":"2018","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.xfss.2023.03.002_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcf.2017.10.006","article-title":"Ion channels as targets to treat cystic fibrosis lung disease","volume":"17","author":"Martin","year":"2018","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.xfss.2023.03.002_bib8","doi-asserted-by":"crossref","first-page":"42138","DOI":"10.1074\/jbc.M112.410282","article-title":"Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain control calcium-activated chloride channel activation","volume":"287","author":"Yurtsever","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xfss.2023.03.002_bib9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1165\/rcmb.2013-0228OC","article-title":"Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis","volume":"50","author":"Lambert","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.xfss.2023.03.002_bib10","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/biolre\/ioaa039","article-title":"Conditionally reprogrammed macaque endocervical cells retain steroid receptor expression and produce mucus","volume":"102","author":"Han","year":"2020","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2023.03.002_bib11","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/biolre\/ioac090","article-title":"Functional evaluation of the cystic fibrosis transmembrane conductance regulator (CFTR) in the endocervix","volume":"107","author":"Han","year":"2022","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2023.03.002_bib12","first-page":"159","article-title":"Mucus secretions from a conditionally reprogrammed primary endocervical cell culture","volume":"3","author":"Park","year":"2022","journal-title":"F S Sci"},{"key":"10.1016\/j.xfss.2023.03.002_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jri.2011.08.002","article-title":"Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix","volume":"92","author":"Bucker","year":"2011","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.xfss.2023.03.002_bib14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1677\/jme.1.01550","article-title":"Regulation of functional steroid receptors and ligand-induced responses in telomerase immortalized human endometrial epithelial cells","volume":"34","author":"Hombach-Klonisch","year":"2005","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.xfss.2023.03.002_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/molehr\/gap005","article-title":"The effects of luteinizing hormone ablation\/replacement versus steroid ablation\/replacement on gene expression in the primate corpus luteum","volume":"15","author":"Bishop","year":"2009","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.xfss.2023.03.002_bib16","doi-asserted-by":"crossref","first-page":"17455","DOI":"10.18632\/oncotarget.8159","article-title":"Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus","volume":"7","author":"Mehta","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.xfss.2023.03.002_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"10.1016\/j.xfss.2023.03.002_bib18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/jmp.12357","article-title":"Hormonal regulation of oviductal glycoprotein 1 (OVGP1; MUC9) in the rhesus macaque cervix","volume":"47","author":"Slayden","year":"2018","journal-title":"J Med Primatol"},{"key":"10.1016\/j.xfss.2023.03.002_bib19","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1093\/humrep\/des086","article-title":"Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque","volume":"27","author":"Almeida-Francia","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.03.002_bib20","doi-asserted-by":"crossref","first-page":"17124","DOI":"10.1074\/jbc.M114.571257","article-title":"The protein synthesis inhibitor blasticidin senters mammalian cells via leucine-rich repeat-containing protein 8D","volume":"289","author":"Lee","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xfss.2023.03.002_bib21","doi-asserted-by":"crossref","first-page":"29155","DOI":"10.1073\/pnas.2016539117","article-title":"LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses","volume":"117","author":"Li","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2023.03.002_bib22","doi-asserted-by":"crossref","first-page":"L991","DOI":"10.1152\/ajplung.00077.2007","article-title":"Basolateral chloride current in human airway epithelia","volume":"293","author":"Itani","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.xfss.2023.03.002_bib23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1586\/17476348.2015.1081064","article-title":"CLCA1 and TMEM16A: the link towards a potential cure for airway diseases","volume":"9","author":"Brett","year":"2015","journal-title":"Expert Rev Respir Med"},{"key":"10.1016\/j.xfss.2023.03.002_bib24","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1242\/jcs.02525","article-title":"Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif","volume":"118","author":"Pe\u00f1a-M\u00fcnzenmayer","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.xfss.2023.03.002_bib25","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1007\/s00424-016-1862-1","article-title":"Relationship between TMEM16A\/anoctamin 1 and LRRC8A","volume":"468","author":"Benedetto","year":"2016","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.xfss.2023.03.002_bib26","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99767","article-title":"Deficient LRRC8A dependent volume-regulated anion channel activity is associated with male infertility in mice","volume":"3","author":"Bao","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.xfss.2023.03.002_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025013118","article-title":"LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions","volume":"118","author":"Serra","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2023.03.002_bib28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1172\/JCI2729","article-title":"The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways","volume":"102","author":"Mall","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xfss.2023.03.002_bib29","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.coph.2018.09.007","article-title":"The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis","volume":"43","author":"Shei","year":"2018","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.xfss.2023.03.002_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00232-001-0117-y","article-title":"Distribution and regulation of ENaC subunit and CFTR mRNA expression in murine female reproductive tract","volume":"185","author":"Chan","year":"2002","journal-title":"J Membr Biol"},{"key":"10.1016\/j.xfss.2023.03.002_bib31","first-page":"1","article-title":"Changes in fluid composition and expression of ion channels in rat cervix during different phases of the estrus cycle","volume":"0","author":"Salleh","year":"2021","journal-title":"Biotech Histochem"},{"key":"10.1016\/j.xfss.2023.03.002_bib32","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1152\/physiolgenomics.00088.2012","article-title":"Molecular aspects of mucin biosynthesis and mucus formation in the bovine cervix during the periestrous period","volume":"44","author":"Pluta","year":"2012","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.xfss.2023.03.002_bib33","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1113\/jphysiol.2001.013300","article-title":"Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3","volume":"538","author":"Cowley","year":"2002","journal-title":"J Physiol"},{"key":"10.1016\/j.xfss.2023.03.002_bib34","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/sj.bjp.0705846","article-title":"4-chlorobenzo[F]isoquinoline (CBIQ) activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells","volume":"142","author":"Szkotak","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.xfss.2023.03.002_bib35","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1007\/s00268-002-4059-z","article-title":"Molecular regulation of Na+-K+-2C1-cotransporter (NKCC1) and epithelial chloride secretion","volume":"26","author":"Matthews","year":"2002","journal-title":"World J Surg"},{"key":"10.1016\/j.xfss.2023.03.002_bib36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1096\/fba.2020-00012","article-title":"Pendrin stimulates a chloride absorption pathway to increase CFTR-mediated chloride secretion from Cystic Fibrosis airway epithelia","volume":"2","author":"Bajko","year":"2020","journal-title":"FASEB Bioadv"},{"key":"10.1016\/j.xfss.2023.03.002_bib37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fimmu.2017.00393","article-title":"Cytokine-regulation of Na+-K+-Cl-cotransporter 1 and cystic fibrosis transmembrane conductance regulator\u2014potential role in pulmonary inflammation and edema formation","volume":"8","author":"Weidenfeld","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2023.03.002_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.201800336","article-title":"Single cell transcriptomes derived from human cervical and uterine tissue during pregnancy","volume":"3","author":"Koh","year":"2019","journal-title":"Adv Biosyst"},{"key":"10.1016\/j.xfss.2023.03.002_bib39","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1165\/rcmb.2010-0484OC","article-title":"Measurement of the airway surfaceliquid volume with simple light refraction microscopy","volume":"45","author":"Harvey","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.xfss.2023.03.002_bib40","doi-asserted-by":"crossref","first-page":"L498","DOI":"10.1152\/ajplung.00238.2019","article-title":"Endotracheal tube mucus as a source of airway mucus for rheological study","volume":"317","author":"Markovetz","year":"2019","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.xfss.2023.03.002_bib41","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1074\/mcp.M600439-MCP200","article-title":"Large scale identification of proteins, mucins, and their O-glycosylation in the endocervical mucus during the menstrual cycle","volume":"6","author":"Andersch-Bj\u00f6rkman","year":"2007","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.xfss.2023.03.002_bib42","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1039\/C5MB00071H","article-title":"Proteomic characterization of the qualitative and quantitative differences in cervical mucus composition during the menstrual cycle","volume":"11","author":"Grande","year":"2015","journal-title":"Mol Biosyst"}],"container-title":["F&amp;S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X23000149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X23000149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:07:15Z","timestamp":1762981635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X23000149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S2666335X23000149"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2023.03.002","relation":{},"ISSN":["2666-335X"],"issn-type":[{"type":"print","value":"2666-335X"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hormonal regulation of non-cystic fibrosis transmembrane conductance regulator ion channels in the endocervix","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2023.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}