{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:19:20Z","timestamp":1779200360795,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Science"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.xfss.2023.03.005","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T02:13:27Z","timestamp":1680315207000},"page":"151-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endoplasmic reticulum stress response and the regulation of endometrial interferon-beta production"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6514-4975","authenticated-orcid":false,"given":"Ramya","family":"Sethuram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Bukowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Puscheck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5499-3912","authenticated-orcid":false,"given":"Gil","family":"Mor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pancharatnam","family":"Jeyasuria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer C.","family":"Condon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2023.03.005_bib1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr Rev"},{"key":"10.1016\/j.xfss.2023.03.005_bib2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/aja.1000980306","article-title":"A description of 34 human ova within the first 17 days of development","volume":"98","author":"Hertig","year":"1956","journal-title":"Am J Anat"},{"key":"10.1016\/j.xfss.2023.03.005_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2010.04.063","article-title":"A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature","volume":"95","author":"Diaz-Gimeno","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.03.005_bib4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1055\/s-2007-991042","article-title":"Decidualization of the human endometrium: Mechanisms, functions, and clinical perspectives","volume":"25","author":"Gellersen","year":"2007","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2023.03.005_bib5","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1210\/me.2006-0118","article-title":"Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization","volume":"20","author":"Kajihara","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.xfss.2023.03.005_bib6","first-page":"I186","article-title":"FOXO3a inhibition confers resistance to apoptosis induced by oxidative stress in decidualizing human endometrial stromal cells","volume":"21","author":"Kajihara","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.03.005_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoy011","article-title":"The rate of euploid miscarriage is increased in the setting of adenomyosis","volume":"2018","author":"Stanekova","year":"2018","journal-title":"Hum Reprod Open"},{"issue":"Suppl 2","key":"10.1016\/j.xfss.2023.03.005_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humrep\/10.suppl_2.1","article-title":"Physiological and molecular aspects of human implantation","volume":"10","author":"Edwards","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.03.005_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/10.suppl_2.60","article-title":"Clinical approaches to increasing uterine receptivity during human implantation","volume":"10","author":"Edwards","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.03.005_bib10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1530\/ror.0.0030052","article-title":"Cytokines and implantation","volume":"3","author":"Sharkey","year":"1998","journal-title":"Rev Reprod"},{"key":"10.1016\/j.xfss.2023.03.005_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0165-0378(98)00017-5","article-title":"Cytokines and embryo implantation","volume":"39","author":"Simon","year":"1998","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.xfss.2023.03.005_bib12","first-page":"48","article-title":"Regulation of endometrial and trophoblastic metalloproteinases during implantation of the blastocyst","volume":"22","author":"Bischof","year":"1994","journal-title":"Contracept Fertil Sex"},{"key":"10.1016\/j.xfss.2023.03.005_bib13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0092-8674(00)80402-X","article-title":"Multiple female reproductive failures in cyclooxygenase 2-deficient mice","volume":"91","author":"Lim","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.xfss.2023.03.005_bib14","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/humrep\/16.9.1893","article-title":"Endometrial markers of uterine receptivity utilizing the donor oocyte model","volume":"16","author":"Damario","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.03.005_bib15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0301-2115(01)00523-1","article-title":"Pinopode expression during human implantation","volume":"101","author":"Nardo","year":"2002","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.xfss.2023.03.005_bib16","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/s41423-018-0050-y","article-title":"Relevance of placental type I interferon beta regulation for pregnancy success","volume":"15","author":"Kwon","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.xfss.2023.03.005_bib17","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/humrep\/deg139","article-title":"Analysis of intra-uterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer","volume":"18","author":"Inagaki","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.03.005_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2020.103080","article-title":"The uterine immunological changes may be responsible for repeated implantation failure","volume":"138","author":"Amjadi","year":"2020","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.xfss.2023.03.005_bib19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/molehr\/gaq100","article-title":"Transcriptional expression of type-I interferon response genes and stability of housekeeping genes in the human endometrium and endometriosis","volume":"17","author":"Vestergaard","year":"2011","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.xfss.2023.03.005_bib20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1749-6632.2010.05938.x","article-title":"Inflammation and pregnancy: the role of the immune system at the implantation site","volume":"1221","author":"Mor","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.xfss.2023.03.005_bib21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mce.2017.07.006","article-title":"VIP induces the decidualization program and conditions the immunoregulation of the implantation process","volume":"460","author":"Grasso","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.xfss.2023.03.005_bib22","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1038\/srep03894","article-title":"Uterine selection of human embryos at implantation","volume":"4","author":"Brosens","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2023.03.005_bib23","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.fertnstert.2015.03.014","article-title":"Regulatory T cells, inflammation, and endoplasmic reticulum stress in women with defective endometrial receptivity","volume":"103","author":"Galgani","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.03.005_bib24","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/eji.200737882","article-title":"Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1","volume":"38","author":"Smith","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.xfss.2023.03.005_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29779-8","article-title":"Impact of the Reticular Stress and Unfolded Protein Response on the inflammatory response in endometrial stromal cells","volume":"8","author":"Grasso","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2023.03.005_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1600-0897.2011.01048.x","article-title":"Endometrial receptivity and human embryo implantation","volume":"66","author":"Rashid","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.xfss.2023.03.005_bib27","first-page":"856","article-title":"[Regulation of apoptosis in endometrium preparation for menstruation or embryo implantation]","volume":"81","author":"Szmidt","year":"2010","journal-title":"Ginekol Pol"},{"key":"10.1016\/j.xfss.2023.03.005_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1477-7827-1-44","article-title":"Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways","volume":"1","author":"Joswig","year":"2003","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.xfss.2023.03.005_bib29","first-page":"2","article-title":"Changes of apoptosis regulation in the endometrium of infertile women with tubal factor and endometriosis undergoing in\u00a0vitro fertilization treatment","volume":"18","author":"Antsiferova","year":"2014","journal-title":"JBRA Assist Reprod"},{"key":"10.1016\/j.xfss.2023.03.005_bib30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1471-2407-14-98","article-title":"Regulation of Mcl-1 by constitutive activation of NF-\u03baB contributes to cell viability in human esophageal squamous cell carcinoma cells","volume":"14","author":"Liu","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.xfss.2023.03.005_bib31","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1182\/blood.V112.11.2265.2265","article-title":"NF-\u03baB is active in Mcl-1 promoter regulation in human CLL","volume":"112","author":"Hertlein","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.xfss.2023.03.005_bib32","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1073\/pnas.0507809103","article-title":"The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas","volume":"103","author":"Bernal-Mizrachi","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2023.03.005_bib33","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/1477-7819-11-288","article-title":"Prognostic significance of XIAP and NF-\u03baB expression in esophageal carcinoma with postoperative radiotherapy","volume":"11","author":"Zhou","year":"2013","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.xfss.2023.03.005_bib34","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1210\/en.2003-1606","article-title":"A novel immortalized human endometrial stromal cell line with normal progestational response","volume":"145","author":"Krikun","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.xfss.2023.03.005_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physiolgenomics.00066.2003","article-title":"Activation of the protein kinase A pathway in human endometrial stromal cells reveals sequential categorical gene regulation","volume":"16","author":"Tierney","year":"2003","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.xfss.2023.03.005_bib36","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1038\/s41598-018-19834-9","article-title":"Assessment of suitable reference genes for RT-qPCR studies in chronic rhinosinusitis","volume":"8","author":"Nakayama","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2023.03.005_bib37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/oxfordjournals.humrep.a136856","article-title":"Decidualization and insulin-like growth factor (IGF) binding protein: implications for its role in stromal cell differentiation and the decidual cell in haemochorial placentation","volume":"4","author":"Bell","year":"1989","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.03.005_bib38","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.xfss.2023.03.005_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110948","article-title":"VIP conditions human endometrial receptivity by privileging endoplasmic reticulum stress through ATF6\u03b1 pathway","volume":"516","author":"Soczewski","year":"2020","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.xfss.2023.03.005_bib40","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1023\/A:1023668705040","article-title":"Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis","volume":"8","author":"Chawla-Sarkar","year":"2003","journal-title":"Apoptosis"},{"key":"10.1016\/j.xfss.2023.03.005_bib41","doi-asserted-by":"crossref","first-page":"24965","DOI":"10.1074\/jbc.M101161200","article-title":"Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells","volume":"276","author":"Morrison","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xfss.2023.03.005_bib42","first-page":"1821","article-title":"Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: correlation with TRAIL\/Apo2L induction in melanoma cell lines","volume":"7","author":"Chawla-Sarkar","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.xfss.2023.03.005_bib43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jri.2015.02.002","article-title":"The role of apoptosis in human embryo implantation","volume":"108","author":"Boeddeker","year":"2015","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.xfss.2023.03.005_bib44","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1210\/en.2005-1555","article-title":"Importance of uterine cell death, renewal, and their hormonal regulation in hamsters that show progesterone-dependent implantation","volume":"147","author":"Zhang","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.xfss.2023.03.005_bib45","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1038\/sj.onc.1208524","article-title":"Vital functions for lethal caspases","volume":"24","author":"Launay","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.xfss.2023.03.005_bib46","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ceb.2004.09.008","article-title":"Life's smile, death's grin: vital functions of apoptosis-executing proteins","volume":"16","author":"Garrido","year":"2004","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.xfss.2023.03.005_bib47","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.celrep.2015.09.016","article-title":"ER-stress-induced differentiation sensitizes colon cancer stem cells to chemotherapy","volume":"13","author":"Wielenga","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.xfss.2023.03.005_bib48","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1125676","article-title":"Type 1 interferons and the virus-host relationship: a lesson in detente","volume":"312","author":"Garcia-Sastre","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.xfss.2023.03.005_bib49","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1182\/blood.V81.5.1359.1359","article-title":"Differential induction of apoptosis in undifferentiated and differentiated Hl-60 cells by DNA topoisomerase I and II inhibitors","volume":"81","author":"Solary","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.xfss.2023.03.005_bib50","first-page":"937","article-title":"Induction of cell differentiation potentiates apoptosis triggered by prior exposure to DNA-damaging drugs","volume":"6","author":"Bhatia","year":"1995","journal-title":"Cell Growth Differ"},{"key":"10.1016\/j.xfss.2023.03.005_bib51","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1091\/mbc.6.11.1443","article-title":"Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells","volume":"6","author":"Ishizaki","year":"1995","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.xfss.2023.03.005_bib52","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3389\/fimmu.2014.00606","article-title":"M1\/M2 macrophage polarity in normal and complicated pregnancy","volume":"5","author":"Brown","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2023.03.005_bib53","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/labinvest.3780326","article-title":"Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women","volume":"81","author":"Reister","year":"2001","journal-title":"Lab Invest"},{"key":"10.1016\/j.xfss.2023.03.005_bib54","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1038\/s41467-019-10903-9","article-title":"IFN-\u03b2 is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation","volume":"10","author":"Kumaran Satyanarayanan","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.xfss.2023.03.005_bib55","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1477-7827-1-119","article-title":"Potential role of macrophages as immunoregulators of pregnancy","volume":"1","author":"Mor","year":"2003","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.xfss.2023.03.005_bib56","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1128\/MCB.00779-06","article-title":"GRP78\/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development","volume":"26","author":"Luo","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.xfss.2023.03.005_bib57","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/bs.ircmb.2019.10.004","article-title":"Type I interferons and endoplasmic reticulum stress in health and disease","volume":"350","author":"Sprooten","year":"2020","journal-title":"Int Rev Cel Mol Biol"}],"container-title":["F&S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X23000162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X23000162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:07:40Z","timestamp":1762981660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X23000162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S2666335X23000162"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2023.03.005","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endoplasmic reticulum stress response and the regulation of endometrial interferon-beta production","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2023.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}