{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:07:42Z","timestamp":1788538062425,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["EU952516"],"award-info":[{"award-number":["EU952516"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002301","name":"Eesti Teadusagentuur","doi-asserted-by":"publisher","award":["PRG1076"],"award-info":[{"award-number":["PRG1076"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006598","name":"Enterprise Estonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006598","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Science"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.xfss.2023.04.003","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T17:42:04Z","timestamp":1683049324000},"page":"219-228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["An integrative analysis of endometrial steroid metabolism and transcriptome in relation to endometrial receptivity in in\u00a0vitro fertilization patients"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7650-8837","authenticated-orcid":false,"given":"Linda B.P.M.","family":"Stevens Brentjens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0992-6745","authenticated-orcid":false,"given":"Darina","family":"Obukhova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke E.","family":"den Hartog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Delvoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-1206","authenticated-orcid":false,"given":"Johanna","family":"Koskivuori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Auriola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merja R.","family":"H\u00e4kkinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3542-6215","authenticated-orcid":false,"given":"Bich N.","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9057-1306","authenticated-orcid":false,"given":"Nienke E.","family":"van Hoogenhuijze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari","family":"Mackens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6892-5574","authenticated-orcid":false,"given":"Femke","family":"Mol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6909-5912","authenticated-orcid":false,"given":"Jan Peter","family":"de Bruin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Besselink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijs","family":"Teklenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2135-9245","authenticated-orcid":false,"given":"Viktorija","family":"Kukushkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-8160","authenticated-orcid":false,"given":"Andres","family":"Salumets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.M.","family":"Broekmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron J.T.","family":"van Golde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3909-0050","authenticated-orcid":false,"given":"Masoud Zamani","family":"Esteki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2023.04.003_bib1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0015-0282(16)58144-8","article-title":"Estimates of human fertility and pregnancy loss","volume":"65","author":"Zinaman","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.04.003_bib2","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.xfss.2023.04.003_bib3","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1073\/pnas.0530162100","article-title":"Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation","volume":"100","author":"Ma","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2023.04.003_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0301-2115(97)00126-7","article-title":"Hormonal patterns, steroid receptors and morphological pictures of endometrium in hyperstimulated IVF cycles","volume":"75","author":"Noci","year":"1997","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.xfss.2023.04.003_bib5","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0015-0282(16)58337-X","article-title":"Lower implantation rates in high responders: evidence for an altered endocrine milieu during the preimplantation period","volume":"65","author":"Pellicer","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.04.003_bib6","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1093\/oxfordjournals.humrep.a136313","article-title":"Clinical evidence for a detrimental effect on uterine receptivity of high serum oestradiol concentrations in high and normal responder patients","volume":"10","author":"Simon","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.04.003_bib7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tem.2004.01.009","article-title":"Reproductive biology and IVF: ovarian stimulation and endometrial receptivity","volume":"15","author":"Devroey","year":"2004","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.xfss.2023.04.003_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fendo.2020.00255","article-title":"Impact of serum estradiol levels prior to progesterone administration in artificially prepared frozen embryo transfer cycles","volume":"11","author":"Mackens","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.xfss.2023.04.003_bib9","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10815-014-0402-1","article-title":"Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement","volume":"32","author":"Bocca","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2023.04.003_bib10","doi-asserted-by":"crossref","first-page":"T1","DOI":"10.1530\/JME-19-0212","article-title":"90 years of progesterone: new insights into progesterone receptor signaling in the endometrium required for embryo implantation","volume":"65","author":"DeMayo","year":"2020","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.xfss.2023.04.003_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jri.2012.10.011","article-title":"The role of progesterone in implantation and trophoblast invasion","volume":"97","author":"Halasz","year":"2013","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.xfss.2023.04.003_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.repbio.2018.01.001","article-title":"Premature progesterone rise in ART-cycles","volume":"18","author":"Lawrenz","year":"2018","journal-title":"Reprod Biol"},{"key":"10.1016\/j.xfss.2023.04.003_bib13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jsbmb.2014.06.001","article-title":"All sex steroids are made intracellularly in peripheral tissues by the mechanisms of intracrinology after menopause","volume":"145","author":"Labrie","year":"2015","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.xfss.2023.04.003_bib14","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1093\/humrep\/dem310","article-title":"Estrogen metabolizing enzymes in endometrium and endometriosis","volume":"22","author":"Dassen","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.04.003_bib15","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.3390\/ijms19103276","article-title":"Endometrial intracrinology: oestrogens, androgens and endometrial disorders","volume":"19","author":"Gibson","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfss.2023.04.003_bib16","doi-asserted-by":"crossref","first-page":"940","DOI":"10.3389\/fphar.2018.00940","article-title":"Intracrine regulation of estrogen and other sex steroid levels in endometrium and non-gynecological tissues; pathology, physiology, and drug discovery","volume":"9","author":"Konings","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.xfss.2023.04.003_bib17","doi-asserted-by":"crossref","first-page":"C113","DOI":"10.1016\/0303-7207(91)90116-A","volume":"78","author":"Labrie","year":"1991","journal-title":"Intracrinology. Mol Cell Endocrinol"},{"key":"10.1016\/j.xfss.2023.04.003_bib18","doi-asserted-by":"crossref","first-page":"E591","DOI":"10.1210\/jc.2011-2994","article-title":"Overexpression of 17beta-hydroxysteroid dehydrogenase type 1 increases the exposure of endometrial cancer to 17beta-estradiol","volume":"97","author":"Cornel","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2023.04.003_bib19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1210\/jc.2013-2851","article-title":"Inhibition of type 1 17beta-hydroxysteroid dehydrogenase impairs the synthesis of 17beta-estradiol in endometriosis lesions","volume":"99","author":"Delvoux","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2023.04.003_bib20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/humrep\/deh075","article-title":"High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome","volume":"19","author":"Brosens","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.04.003_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12905-017-0378-y","article-title":"Endometrial scratching in women with implantation failure after a first IVF\/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342)","volume":"17","author":"van Hoogenhuijze","year":"2017","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.xfss.2023.04.003_bib22","first-page":"87","article-title":"Endometrial scratching in women with one failed IVF\/ICSI cycle-outcomes of a randomised controlled trial (SCRaTCH)","volume":"36","author":"van Hoogenhuijze","year":"2021","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.04.003_bib23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jpba.2018.01.034","article-title":"Analysis by LC-MS\/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue","volume":"152","author":"Hakkinen","year":"2018","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.xfss.2023.04.003_bib24","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1210\/jc.2012-1154","article-title":"Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels","volume":"97","author":"Huhtinen","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2023.04.003_bib25","doi-asserted-by":"crossref","first-page":"E2188","DOI":"10.1210\/jc.2014-1913","article-title":"Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions","volume":"99","author":"Huhtinen","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2023.04.003_bib26","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1093\/humrep\/deab184","article-title":"Analysis of serum and endometrial progesterone in determining endometrial receptivity","volume":"36","author":"Labarta","year":"2021","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.04.003_bib27","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0002-9378(78)90288-0","article-title":"Effect of obesity on conversion of plasma androstenedione to estrone in ovulatory and anovulator young women","volume":"130","author":"Edman","year":"1978","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfss.2023.04.003_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2021.105849","article-title":"Adipose tissue estrogen production and metabolism in premenopausal women","volume":"209","author":"Hetemaki","year":"2021","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.xfss.2023.04.003_bib29","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/humupd\/dmac026","article-title":"Lipid metabolism and endometrial receptivity","volume":"28","author":"Yang","year":"2022","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfss.2023.04.003_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.mce.2011.07.027","article-title":"The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling","volume":"358","author":"Large","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.xfss.2023.04.003_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1530\/JOE-19-0349","article-title":"Progesterone-regulated Hsd11b2 as a barrier to balance mouse uterine corticosterone","volume":"244","author":"Zheng","year":"2020","journal-title":"J Endocrinol"},{"key":"10.1016\/j.xfss.2023.04.003_bib32","first-page":"dev196931","article-title":"Loss of ESRP1 blocks mouse oocyte development and leads to female infertility","volume":"148","author":"Yu","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.xfss.2023.04.003_bib33","article-title":"Genome-wide placental gene methylations in gestational diabetes mellitus, fetal growth and metabolic health biomarkers in cord blood","volume":"13","author":"Wang","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.xfss.2023.04.003_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.900767","article-title":"A systematic review and integrated bioinformatic analysis of candidate genes and pathways in the endometrium of patients with polycystic ovary syndrome during the implantation window","volume":"13","author":"Sutaji","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.xfss.2023.04.003_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2019.104284","article-title":"Identification of a novel diagnostic gene expression signature to discriminate uterine leiomyoma from leiomyosarcoma","volume":"110","author":"Adams","year":"2019","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.xfss.2023.04.003_bib36","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/mc.23487","article-title":"KIF4A promotes genomic stability and progression of endometrial cancer through regulation of TPX2 protein degradation","volume":"62","author":"Zhang","year":"2023","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.xfss.2023.04.003_bib37","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s43032-019-00096-3","article-title":"NAV3, a tumor suppressor gene, is decreased in uterine leiomyoma tissue and cells","volume":"27","author":"Aly","year":"2020","journal-title":"Reprod Sci"}],"container-title":["F&S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X23000277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X23000277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:07:37Z","timestamp":1762981657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X23000277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2666335X23000277"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2023.04.003","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An integrative analysis of endometrial steroid metabolism and transcriptome in relation to endometrial receptivity in in\u00a0vitro fertilization patients","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2023.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}