{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:47:34Z","timestamp":1788299254685,"version":"build-2803163510"},"reference-count":116,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES 028615-02"],"award-info":[{"award-number":["R01 ES 028615-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD094378-04"],"award-info":[{"award-number":["R01 HD094378-04"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD094380-02"],"award-info":[{"award-number":["R01 HD094380-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD100367-01"],"award-info":[{"award-number":["R01 HD100367-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 MD007602"],"award-info":[{"award-number":["U54 MD007602"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Science"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.xfss.2023.05.003","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T02:22:10Z","timestamp":1683858130000},"page":"239-256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["EZH2 activates Wnt\/\u03b2-catenin signaling in human uterine fibroids, which is inhibited by the natural compound methyl jasmonate"],"prefix":"10.1016","volume":"4","author":[{"given":"Mohamed","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Laknaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8778-4447","authenticated-orcid":false,"given":"Ayman","family":"Al-Hendy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2023.05.003_bib1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1210\/endrev\/bnab039","article-title":"Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment","volume":"43","author":"Yang","year":"2022","journal-title":"Endocr Rev"},{"key":"10.1016\/j.xfss.2023.05.003_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.43","article-title":"Uterine fibroids","volume":"2","author":"Stewart","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.xfss.2023.05.003_bib3","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s43032-022-01064-0","article-title":"Importance of fibrosis in the pathogenesis of uterine leiomyoma and the promising anti-fibrotic effects of dipeptidyl peptidase-4 and fibroblast activation protein inhibitors in the treatment of uterine leiomyoma","volume":"30","author":"Bhat","year":"2023","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2023.05.003_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/humupd\/dmx032","article-title":"Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics","volume":"24","author":"Islam","year":"2018","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfss.2023.05.003_bib5","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/onc.2016.304","article-title":"Wnt signaling in cancer","volume":"36","author":"Zhan","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.xfss.2023.05.003_bib6","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.fertnstert.2014.01.017","article-title":"Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth","volume":"101","author":"Ono","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.05.003_bib7","first-page":"61","article-title":"Extracellular matrix (ECM) activates \u03b2-catenin signaling in uterine fibroids","volume":"155","author":"Ko","year":"2018","journal-title":"Reproduction"},{"key":"10.1016\/j.xfss.2023.05.003_bib8","doi-asserted-by":"crossref","first-page":"e1517","DOI":"10.1210\/clinem\/dgz227","article-title":"Activation of \u03b2-catenin Signaling and its crosstalk with estrogen and histone deacetylases in human uterine fibroids","volume":"105","author":"Ali","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2023.05.003_bib9","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1007\/s11010-021-04174-6","article-title":"Wnt\/\u03b2-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities","volume":"476","author":"El Sabeh","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.xfss.2023.05.003_bib10","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1096\/fj.10-175349","article-title":"WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse","volume":"25","author":"Franco","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.xfss.2023.05.003_bib11","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s43032-019-00084-7","article-title":"Introduction of somatic mutation in MED12 induces Wnt4\/\u03b2-catenin and disrupts autophagy in human uterine myometrial cell","volume":"27","author":"El Andaloussi","year":"2020","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2023.05.003_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1095\/biolreprod.115.134924","article-title":"The polycomb group protein EZH2 impairs DNA damage repair gene expression in human uterine fibroids","volume":"94","author":"Yang","year":"2016","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2023.05.003_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jb\/mvab007","article-title":"Targeting EZH2 as cancer therapy","volume":"170","author":"Hanaki","year":"2021","journal-title":"J Biochem"},{"key":"10.1016\/j.xfss.2023.05.003_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13045-020-00990-3","article-title":"Targeting the Wnt\/\u03b2-catenin signaling pathway in cancer","volume":"13","author":"Zhang","year":"2020","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.xfss.2023.05.003_bib15","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1158\/0008-5472.CAN-10-3342","article-title":"EZH2-mediated concordant repression of Wnt antagonists promotes \u03b2-catenin-dependent hepatocarcinogenesis","volume":"71","author":"Cheng","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2023.05.003_bib16","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4149\/neo_2022_211208N1749","article-title":"Epigenetic network of EZH2\/SFRP1\/Wnt in the epithelial-mesenchymal transition of laryngeal carcinoma cells","volume":"69","author":"Chen","year":"2022","journal-title":"Neoplasma"},{"key":"10.1016\/j.xfss.2023.05.003_bib17","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1111\/cas.14840","article-title":"The noncanonical role of EZH2 in cancer","volume":"112","author":"Huang","year":"2021","journal-title":"Cancer Sci"},{"key":"10.1016\/j.xfss.2023.05.003_bib18","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/s41388-023-02618-5","article-title":"Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader","volume":"42","author":"Yu","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.xfss.2023.05.003_bib19","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1128\/MCB.00162-07","article-title":"Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells","volume":"27","author":"Shi","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.xfss.2023.05.003_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/biolre\/iox094","article-title":"Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids","volume":"97","author":"Ali","year":"2017","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2023.05.003_bib21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/14740338.2022.1989409","article-title":"Current approaches to overcome the side effects of GnRH analogs in the treatment of patients with uterine fibroids","volume":"21","author":"Ali","year":"2022","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.xfss.2023.05.003_bib22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/17512433.2021.1900726","article-title":"Elagolix in the treatment of heavy menstrual bleeding associated with uterine fibroids in premenopausal women","volume":"14","author":"Ali","year":"2021","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1016\/j.xfss.2023.05.003_bib23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/14656566.2022.2030705","article-title":"An evaluation of relugolix\/estradiol\/norethindrone acetate for the treatment of heavy menstrual bleeding associated with uterine fibroids in premenopausal women","volume":"23","author":"Ali","year":"2022","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.xfss.2023.05.003_bib24","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1080\/13543784.2021.1957830","article-title":"Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas","volume":"30","author":"Dababou","year":"2021","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.xfss.2023.05.003_bib25","article-title":"A review of GnRH antagonists as treatment for abnormal uterine bleeding-leiomyoma (AUB-L) and their influence on the readiness of service members","author":"Wright","year":"2022","journal-title":"Mil Med"},{"key":"10.1016\/j.xfss.2023.05.003_bib26","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3390\/jcm9051479","article-title":"The evolving role of natural compounds in the medical treatment of uterine fibroids","volume":"9","author":"Ciebiera","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.xfss.2023.05.003_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/572097","article-title":"Methyl jasmonate: putative mechanisms of action on cancer cells cycle, metabolism, and apoptosis","volume":"2014","author":"Cesari","year":"2014","journal-title":"Int J Cell Biol"},{"key":"10.1016\/j.xfss.2023.05.003_bib28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/aob\/mcm079","article-title":"Jasmonates: an update on biosynthesis, signal transduction and action in plant stress response, growth and development","volume":"100","author":"Wasternack","year":"2007","journal-title":"Ann Bot"},{"key":"10.1016\/j.xfss.2023.05.003_bib29","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/jphp.12839","article-title":"Methyl jasmonate: a phytohormone with potential for the treatment of inflammatory bowel diseases","volume":"70","author":"Besson","year":"2018","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.xfss.2023.05.003_bib30","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/bph.12501","article-title":"Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101","volume":"171","author":"Wang","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.xfss.2023.05.003_bib31","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3892\/mmr.2016.6061","article-title":"Methyl jasmonate induces the apoptosis of human colorectal cancer cells via downregulation of EZH2 expression by microRNA-101","volume":"15","author":"Peng","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.xfss.2023.05.003_bib32","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.biopha.2017.08.106","article-title":"Methyl jasmonate reduces testosterone-induced benign prostatic hyperplasia through regulation of inflammatory and apoptotic processes in rats","volume":"95","author":"Adaramoye","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.xfss.2023.05.003_bib33","doi-asserted-by":"crossref","first-page":"45965","DOI":"10.18632\/oncotarget.17469","article-title":"Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.xfss.2023.05.003_bib34","doi-asserted-by":"crossref","DOI":"10.1080\/15592324.2015.1062199","article-title":"Methyl jasmonate and its potential in cancer therapy","volume":"10","author":"Zhang","year":"2015","journal-title":"Plant Signal Behav"},{"key":"10.1016\/j.xfss.2023.05.003_bib35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1471-2407-13-74","article-title":"Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14","volume":"13","author":"Zheng","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.xfss.2023.05.003_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canlet.2011.12.028","article-title":"Methyl jasmonate reduces the survival of cervical cancer cells and downregulates HPV E6 and E7, and survivin","volume":"319","author":"Milrot","year":"2012","journal-title":"Cancer Lett"},{"key":"10.1016\/j.xfss.2023.05.003_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2021.04.054","article-title":"Synergistic effects of autocrine motility factor and methyl jasmonate on human breast cancer cells","volume":"558","author":"Jeoung","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.xfss.2023.05.003_bib38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10863-019-09811-w","article-title":"Effect of methyl jasmonate and 3-bromopyruvate combination therapy on mice bearing the 4 T1 breast cancer cell line","volume":"52","author":"Yousefi","year":"2020","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.xfss.2023.05.003_bib39","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/01.LAB.0000017499.51216.3E","article-title":"Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics","volume":"82","author":"Carney","year":"2002","journal-title":"Lab Invest"},{"key":"10.1016\/j.xfss.2023.05.003_bib40","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1093\/humrep\/det275","article-title":"Targeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas","volume":"28","author":"Nair","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2023.05.003_bib41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000353426","article-title":"Towards gene therapy of postoperative adhesions: fiber and transcriptional modifications enhance adenovirus targeting towards human adhesion cells","volume":"76","author":"Nair","year":"2013","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.xfss.2023.05.003_bib42","first-page":"592","article-title":"Silencing Med12 gene reduces proliferation of human leiomyoma cells mediated via Wnt\/\u03b2-catenin signaling pathway","volume":"158","author":"Al-Hendy","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.xfss.2023.05.003_bib43","doi-asserted-by":"crossref","first-page":"98348","DOI":"10.18632\/oncotarget.21311","article-title":"The EZH2 inhibitor GSK343 suppresses cancer stem-like phenotypes and reverses mesenchymal transition in glioma cells","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.xfss.2023.05.003_bib44","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2102718118","article-title":"EZH2 inhibits NK cell-mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner","volume":"118","author":"Bugide","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2023.05.003_bib45","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12935-019-0800-7","article-title":"PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt\/\u03b2-catenin signaling pathway","volume":"19","author":"Luo","year":"2019","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.xfss.2023.05.003_bib46","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1038\/srep08686","article-title":"WNT-1 inducible signaling pathway protein-1 enhances growth and tumorigenesis in human breast cancer","volume":"5","author":"Chiang","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2023.05.003_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018650","article-title":"Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of \u03b2-catenin","volume":"6","author":"Van Raay","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2023.05.003_bib48","first-page":"16","article-title":"Uterine fibroids: hiding in plain sight","volume":"37","author":"Stewart","year":"2022","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.xfss.2023.05.003_bib49","doi-asserted-by":"crossref","first-page":"E338","DOI":"10.1016\/j.fertnstert.2020.08.1012","article-title":"Natural compound methyl jasmonate shows promising anti-fibroid effects in human uterine fibroids via inhibition of EZH2 mediated WNT\/\u0392-catenin signaling pathway activation","volume":"114","author":"Ali","year":"2020","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.05.003_bib50","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1016\/j.jmb.2014.07.025","article-title":"Histone methyltransferase EZH2 is transcriptionally induced by estradiol as well as estrogenic endocrine disruptors bisphenol-A and diethylstilbestrol","volume":"426","author":"Bhan","year":"2014","journal-title":"J Mol Biol"},{"key":"10.1016\/j.xfss.2023.05.003_bib51","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1158\/1541-7786.MCR-11-0605","article-title":"Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis","volume":"10","author":"Greathouse","year":"2012","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.xfss.2023.05.003_bib52","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1177\/1933719116678686","article-title":"Estrogen receptors and signaling in fibroids: role in pathobiology and therapeutic implications","volume":"24","author":"Borahay","year":"2017","journal-title":"Reprod Sci"},{"key":"10.1016\/j.xfss.2023.05.003_bib53","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1210\/jc.2006-2482","article-title":"Aromatase expression in uterine leiomyomata is regulated primarily by proximal promoters I.3\/II","volume":"92","author":"Imir","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2023.05.003_bib54","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1210\/jc.2008-2327","article-title":"High aromatase expression in uterine leiomyoma tissues of African-American women","volume":"94","author":"Ishikawa","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2023.05.003_bib55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1055\/s-2004-823027","article-title":"Aromatase and leiomyoma of the uterus","volume":"22","author":"Shozu","year":"2004","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2023.05.003_bib56","doi-asserted-by":"crossref","first-page":"E572","DOI":"10.1210\/jc.2014-4011","article-title":"1,25-dihydroxyvitamin D3 regulates expression of sex steroid receptors in human uterine fibroid cells","volume":"100","author":"Al-Hendy","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2023.05.003_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105856","article-title":"Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation","volume":"172","author":"Afrin","year":"2021","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.xfss.2023.05.003_bib58","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3390\/ph15050577","article-title":"Report of exosomes isolated from a human uterine leiomyoma cell line and their impact on endometrial vascular endothelial cells","volume":"15","author":"Navarro","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.xfss.2023.05.003_bib59","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1210\/me.2009-0438","article-title":"Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K\/AKT","volume":"24","author":"Bredfeldt","year":"2010","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.xfss.2023.05.003_bib60","doi-asserted-by":"crossref","first-page":"674","DOI":"10.18632\/oncotarget.201","article-title":"Wnt\/\u0392-catenin and sex hormone signaling in endometrial homeostasis and cancer","volume":"1","author":"Wang","year":"2010","journal-title":"Oncotarget"},{"key":"10.1016\/j.xfss.2023.05.003_bib61","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1210\/en.2009-1225","article-title":"Progesterone is essential for maintenance and growth of uterine leiomyoma","volume":"151","author":"Ishikawa","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.xfss.2023.05.003_bib62","doi-asserted-by":"crossref","first-page":"17053","DOI":"10.1073\/pnas.1313650110","article-title":"Paracrine activation of WNT\/\u03b2-catenin pathway in uterine leiomyoma stem cells promotes tumor growth","volume":"110","author":"Ono","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2023.05.003_bib63","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.xfss.2023.05.003_bib64","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1055\/s-0035-1558451","article-title":"Uterine leiomyoma stem cells: linking progesterone to growth","volume":"33","author":"Bulun","year":"2015","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2023.05.003_bib65","doi-asserted-by":"crossref","first-page":"e776","DOI":"10.1038\/cddis.2013.293","article-title":"Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4","volume":"4","author":"Lu","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.xfss.2023.05.003_bib66","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.mce.2013.05.002","article-title":"Canonical and non-canonical roles of the histone methyltransferase EZH2 in mammary development and cancer","volume":"382","author":"Bae","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.xfss.2023.05.003_bib67","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molcel.2013.08.028","article-title":"PAF and EZH2 induce Wnt\/\u03b2-catenin signaling hyperactivation","volume":"52","author":"Jung","year":"2013","journal-title":"Mol Cell"},{"key":"10.1016\/j.xfss.2023.05.003_bib68","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ijgo.13102","article-title":"Epidemiology and management of uterine fibroids","volume":"149","author":"Giuliani","year":"2020","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.xfss.2023.05.003_bib69","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1055\/s-0037-1607264","article-title":"Uterine fibroids: burden and unmet medical need","volume":"35","author":"Al-Hendy","year":"2017","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2023.05.003_bib70","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ogc.2022.03.001","article-title":"Emerging treatment options for fibroids","volume":"49","author":"Baxter","year":"2022","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.xfss.2023.05.003_bib71","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3390\/nu13041178","article-title":"Nutrition in gynecological diseases: current perspectives","volume":"13","author":"Ciebiera","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.xfss.2023.05.003_bib72","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.fertnstert.2019.09.018","article-title":"Long-term vitamin D treatment decreases human uterine leiomyoma size in a xenograft animal model","volume":"113","author":"Corachan","year":"2020","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.05.003_bib73","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.fertnstert.2020.07.049","article-title":"Vitamin D as an effective treatment in human uterine leiomyomas independent of mediator complex subunit 12 mutation","volume":"115","author":"Corachan","year":"2021","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.05.003_bib74","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.3390\/ijms21155528","article-title":"Vitamins and uterine fibroids: current data on pathophysiology and possible clinical relevance","volume":"21","author":"Ciebiera","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfss.2023.05.003_bib75","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1002\/jcb.25533","article-title":"Biological and mechanistic characterization of novel prodrugs of green tea polyphenol epigallocatechin gallate analogs in human leiomyoma cell lines","volume":"117","author":"Ahmed","year":"2016","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.xfss.2023.05.003_bib76","first-page":"477","article-title":"Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study","volume":"5","author":"Roshdy","year":"2013","journal-title":"Int J Womens Health"},{"key":"10.1016\/j.xfss.2023.05.003_bib77","doi-asserted-by":"crossref","first-page":"289.e1","DOI":"10.1016\/j.ajog.2009.10.885","article-title":"Green tea extract inhibits proliferation of uterine leiomyoma cells in\u00a0vitro and in nude mice","volume":"202","author":"Zhang","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfss.2023.05.003_bib78","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.fct.2018.07.030","article-title":"Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin \u03b1v\u03b23 and IGF-1R","volume":"120","author":"Ho","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.xfss.2023.05.003_bib79","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/antiox8040099","article-title":"Natural antioxidant resveratrol suppresses uterine fibroid cell growth and extracellular matrix formation in\u00a0vitro and in\u00a0vivo","volume":"8","author":"Chen","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.xfss.2023.05.003_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2006.03.001","article-title":"Jasmonates in cancer therapy","volume":"245","author":"Flescher","year":"2007","journal-title":"Cancer Lett"},{"key":"10.1016\/j.xfss.2023.05.003_bib81","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1365-2141.2012.09253.x","article-title":"Methyljasmonate displays in\u00a0vitro and in\u00a0vivo activity against multiple myeloma cells","volume":"159","author":"Klippel","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.xfss.2023.05.003_bib82","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.3390\/molecules26102901","article-title":"Jasmonate compounds and their derivatives in the regulation of the neoplastic processes","volume":"26","author":"Jarocka-Karpowicz","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.xfss.2023.05.003_bib83","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/sj.leu.2402419","article-title":"Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells","volume":"16","author":"Fingrut","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.xfss.2023.05.003_bib84","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1158\/0008-5472.CAN-04-3091","article-title":"Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondria","volume":"65","author":"Rotem","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2023.05.003_bib85","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1111\/nph.17031","article-title":"Jasmonates induce Arabidopsis bioactivities selectively inhibiting the growth of breast cancer cells through CDC6 and mTOR","volume":"229","author":"Bomer","year":"2021","journal-title":"New Phytol"},{"key":"10.1016\/j.xfss.2023.05.003_bib86","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.phytochem.2009.06.007","article-title":"Methyl jasmonate: a plant stress hormone as an anti-cancer drug","volume":"70","author":"Cohen","year":"2009","journal-title":"Phytochemistry"},{"key":"10.1016\/j.xfss.2023.05.003_bib87","doi-asserted-by":"crossref","first-page":"8437","DOI":"10.3390\/ijms22168437","article-title":"Therapeutic potential of jasmonic acid and its derivatives","volume":"22","author":"Jarocka-Karpowicz","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfss.2023.05.003_bib88","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1158\/0008-5472.CAN-07-3220","article-title":"Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling","volume":"68","author":"Guo","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2023.05.003_bib89","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/j.1476-5381.2011.01419.x","article-title":"Methyl jasmonate down-regulates survivin expression and sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity","volume":"164","author":"Raviv","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.xfss.2023.05.003_bib90","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/leu.2008.347","article-title":"Gene expression profiles in differentiating leukemia cells induced by methyl jasmonate are similar to those of cytokinins and methyl jasmonate analogs induce the differentiation of human leukemia cells in primary culture","volume":"23","author":"Tsumura","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.xfss.2023.05.003_bib91","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/sj.leu.2403421","article-title":"Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones","volume":"18","author":"Ishii","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.xfss.2023.05.003_bib92","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.619351","article-title":"Tumor decelerating and chemo-potentiating action of methyl jasmonate on a T cell lymphoma in\u00a0vivo: role of altered regulation of metabolism, cell survival, drug resistance, and intratumoral blood flow","volume":"11","author":"Goel","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.xfss.2023.05.003_bib93","first-page":"1233","article-title":"Methyl jasmonate induces apoptosis through induction of Bax\/Bcl-XS and activation of caspase-3 via ROS production in A549 cells","volume":"12","author":"Kim","year":"2004","journal-title":"Oncol Rep"},{"key":"10.1016\/j.xfss.2023.05.003_bib94","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1038\/onc.2008.108","article-title":"Methyl jasmonate binds to and detaches mitochondria-bound hexokinase","volume":"27","author":"Goldin","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.xfss.2023.05.003_bib95","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10863-006-9061-y","article-title":"Mitochondria-mediated ATP depletion by anti-cancer agents of the jasmonate family","volume":"39","author":"Goldin","year":"2007","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.xfss.2023.05.003_bib96","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1080\/07357900801975272","article-title":"Delayed cytotoxic effects of methyl jasmonate and cis-jasmone induced apoptosis in prostate cancer cells","volume":"26","author":"Yeruva","year":"2008","journal-title":"Cancer Invest"},{"key":"10.1016\/j.xfss.2023.05.003_bib97","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.canlet.2008.05.031","article-title":"Methyl jasmonate induces cell death with mixed characteristics of apoptosis and necrosis in cervical cancer cells","volume":"271","author":"Kniazhanski","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1016\/j.xfss.2023.05.003_bib98","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/CAD.0b013e3282fc46b0","article-title":"Methyl jasmonate downregulates expression of proliferating cell nuclear antigen and induces apoptosis in human neuroblastoma cell lines","volume":"19","author":"Tong","year":"2008","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.xfss.2023.05.003_bib99","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1158\/0008-5472.CAN-04-3995","article-title":"Lost in transcription: p21 repression, mechanisms, and consequences","volume":"65","author":"Gartel","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.xfss.2023.05.003_bib100","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.4161\/cc.7.23.7239","article-title":"Differential regulation of cyclin D1 and D2 in protecting against cardiomyocyte proliferation","volume":"7","author":"Tamamori-Adachi","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.xfss.2023.05.003_bib101","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dnarep.2016.04.008","article-title":"Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage","volume":"42","author":"Karimian","year":"2016","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.xfss.2023.05.003_bib102","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3390\/genes11060593","article-title":"CDK-independent and PCNA-dependent functions of p21 in DNA replication","volume":"11","author":"Mansilla","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.xfss.2023.05.003_bib103","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/783289","article-title":"The extracellular matrix contributes to mechanotransduction in uterine fibroids","volume":"2014","author":"Leppert","year":"2014","journal-title":"Obstet Gynecol Int"},{"key":"10.1016\/j.xfss.2023.05.003_bib104","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.fertnstert.2020.12.011","article-title":"Mechanical stiffness augments ligand-dependent progesterone receptor B activation via MEK 1\/2 and Rho\/ROCK-dependent signaling pathways in uterine fibroid cells","volume":"116","author":"Cordeiro Mitchell","year":"2021","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.05.003_bib105","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/BOR.0b013e32834b3309","article-title":"\u03b2-catenin signaling: a novel mediator of fibrosis and potential therapeutic target","volume":"23","author":"Lam","year":"2011","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.xfss.2023.05.003_bib106","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1164\/rccm.201301-0144ED","article-title":"Considerations for targeting \u03b2-catenin signaling in fibrosis","volume":"187","author":"Gottardi","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.xfss.2023.05.003_bib107","doi-asserted-by":"crossref","first-page":"tkab038","DOI":"10.1093\/burnst\/tkab038","article-title":"Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts","volume":"9","author":"Li","year":"2021","journal-title":"Burns Trauma"},{"key":"10.1016\/j.xfss.2023.05.003_bib108","doi-asserted-by":"crossref","first-page":"361","DOI":"10.7150\/thno.46360","article-title":"Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis","volume":"11","author":"Jiang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.xfss.2023.05.003_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109158","article-title":"Suppression of EZH2 inhibits TGF-\u03b21-induced EMT in human retinal pigment epithelial cells","volume":"222","author":"Peng","year":"2022","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xfss.2023.05.003_bib110","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11033-018-4520-1","article-title":"Methyl jasmonate a stress phytohormone attenuates LPS induced in\u00a0vivo and in\u00a0vitro arthritis","volume":"46","author":"Gunjegaonkar","year":"2019","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.xfss.2023.05.003_bib111","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2056250","article-title":"Anti-inflammatory and antioxidant actions of methyl jasmonate are associated with metabolic modifications in the liver of arthritic rats","volume":"2018","author":"Sa-Nakanishi","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.xfss.2023.05.003_bib112","doi-asserted-by":"crossref","DOI":"10.1080\/15592324.2019.1642038","article-title":"Molecular mechanism of plant stress hormone methyl jasmonate for its anti-inflammatory activity","volume":"14","author":"Gunjegaonkar","year":"2019","journal-title":"Plant Signal Behav"},{"key":"10.1016\/j.xfss.2023.05.003_bib113","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.canlet.2006.10.013","article-title":"Cooperative cytotoxicity of methyl jasmonate with anti-cancer drugs and 2-deoxy-D-glucose","volume":"250","author":"Heyfets","year":"2007","journal-title":"Cancer Lett"},{"key":"10.1016\/j.xfss.2023.05.003_bib114","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1593\/neo.08636","article-title":"PI3K\/Akt pathway activation attenuates the cytotoxic effect of methyl jasmonate toward sarcoma cells","volume":"10","author":"Elia","year":"2008","journal-title":"Neoplasia"},{"key":"10.1016\/j.xfss.2023.05.003_bib115","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10637-012-9870-2","article-title":"Enhanced killing of cervical cancer cells by combinations of methyl jasmonate with cisplatin, X or alpha radiation","volume":"31","author":"Milrot","year":"2013","journal-title":"Invest New Drugs"},{"key":"10.1016\/j.xfss.2023.05.003_bib116","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.canlet.2010.12.009","article-title":"AN N-terminal Smac peptide sensitizes human prostate carcinoma cells to methyl jasmonate-induced apoptosis","volume":"302","author":"Jiang","year":"2011","journal-title":"Cancer Lett"}],"container-title":["F&amp;S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X23000319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X23000319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:07:25Z","timestamp":1762981645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X23000319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":116,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2666335X23000319"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2023.05.003","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EZH2 activates Wnt\/\u03b2-catenin signaling in human uterine fibroids, which is inhibited by the natural compound methyl jasmonate","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2023.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}