{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:17:42Z","timestamp":1771550262574,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Science"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.xfss.2023.09.004","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T12:35:47Z","timestamp":1695213347000},"page":"341-349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The combination of natural compounds Crila and epigallocatechin gallate showed enhanced antiproliferative effects on human uterine fibroid cells compared with single treatments"],"prefix":"10.1016","volume":"4","author":[{"given":"Tao","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-4550","authenticated-orcid":false,"given":"Bernard","family":"Somers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3649-5427","authenticated-orcid":false,"given":"Sue","family":"McKinney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8778-4447","authenticated-orcid":false,"given":"Ayman","family":"Al-Hendy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2023.09.004_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1055\/s-0037-1607264","article-title":"Uterine fibroids: burden and unmet medical need","volume":"35","year":"2017","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.xfss.2023.09.004_bib2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1210\/endrev\/bnab039","article-title":"Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment","volume":"43","author":"Yang","year":"2022","journal-title":"Endocr Rev"},{"key":"10.1016\/j.xfss.2023.09.004_bib3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/biolre\/iox094","article-title":"Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids","volume":"97","author":"Ali","year":"2017","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2023.09.004_bib4","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/01.AOG.0000156298.74317.62","article-title":"Predictors of leiomyoma recurrence after myomectomy","volume":"105","author":"Hanafi","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.xfss.2023.09.004_bib5","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3390\/cells12081117","article-title":"Progesterone signaling and uterine fibroid pathogenesis; molecular mechanisms and potential therapeutics","volume":"12","author":"Ali","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.xfss.2023.09.004_bib6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3797\/scipharm.1011-13","article-title":"Crinum latifolium leave extracts suppress immune activation cascades in peripheral blood mononuclear cells and proliferation of prostate tumor cells","volume":"79","author":"Jenny","year":"2011","journal-title":"Sci Pharm"},{"key":"10.1016\/j.xfss.2023.09.004_bib7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00011-010-0244-y","article-title":"In\u00a0vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors","volume":"60","author":"Jenny","year":"2011","journal-title":"Inflamm Res"},{"key":"10.1016\/j.xfss.2023.09.004_bib8","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/S1567-5769(01)00140-0","article-title":"Aqueous extracts of Crinum latifolium (L.) and Camellia sinensis show immunomodulatory properties in human peripheral blood mononuclear cells","volume":"1","author":"Zvetkova","year":"2001","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.xfss.2023.09.004_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12906-022-03617-x","article-title":"Standardization of the ethanolic extract of Crinum latifolium leaves by two bioactive markers with antiproliferative activity against TGF-beta-promoted prostate stromal cells (WPMY-1)","volume":"22","author":"Thongphichai","year":"2022","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.xfss.2023.09.004_bib10","author":"Tho"},{"key":"10.1016\/j.xfss.2023.09.004_bib11","author":"Tho"},{"key":"10.1016\/j.xfss.2023.09.004_bib12","first-page":"1335p","article-title":"Examining the estrogenicity of Crinum latifolium L. var. crilae Tram & Khanh, var n. (Amaryllidaceae) Using Cell-based and Receptor-based Assays","author":"Burton","year":"2014","journal-title":"MENOPAUSE"},{"key":"10.1016\/j.xfss.2023.09.004_bib13","first-page":"477","article-title":"Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study","volume":"5","author":"Roshdy","year":"2013","journal-title":"Int J Womens Health"},{"key":"10.1016\/j.xfss.2023.09.004_bib14","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.fertnstert.2009.08.065","article-title":"Antiproliferative and proapoptotic effects of epigallocatechin gallate on human leiomyoma cells","volume":"94","author":"Zhang","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2023.09.004_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110186","article-title":"A review for physiological activities of EGCG and the role in improving fertility in humans\/mammals","volume":"127","author":"Zhang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.xfss.2023.09.004_bib16","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/01.LAB.0000017499.51216.3E","article-title":"Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics","volume":"82","author":"Carney","year":"2002","journal-title":"Lab Invest"},{"key":"10.1016\/j.xfss.2023.09.004_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cancergencyto.2006.05.003","article-title":"Karyotypic characteristics of human uterine leiomyoma and myometrial cell lines following telomerase induction","volume":"170","author":"Varella-Garcia","year":"2006","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.xfss.2023.09.004_bib18","doi-asserted-by":"crossref","first-page":"289.e1","DOI":"10.1016\/j.ajog.2009.10.885","article-title":"Green tea extract inhibits proliferation of uterine leiomyoma cells in\u00a0vitro and in nude mice","volume":"202","author":"Zhang","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfss.2023.09.004_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv Enzyme Regul"},{"key":"10.1016\/j.xfss.2023.09.004_bib20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.fitote.2018.08.003","article-title":"Amaryllidaceae alkaloids from Crinum latifolium with cytotoxic, antimicrobial, antioxidant, and anti-inflammatory activities","volume":"130","author":"Chen","year":"2018","journal-title":"Fitoterapia"},{"key":"10.1016\/j.xfss.2023.09.004_bib21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jep.2013.06.002","article-title":"Extracts of Crinum latifolium inhibit the cell viability of mouse lymphoma cell line EL4 and induce activation of anti-tumour activity of macrophages in\u00a0vitro","volume":"149","author":"Nguyen","year":"2013","journal-title":"J Ethnopharmacol"},{"issue":"22","key":"10.1016\/j.xfss.2023.09.004_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/ZDEG6110","article-title":"Uterine artery embolisation versus myomectomy for premenopausal women with uterine fibroids wishing to avoid hysterectomy: the FEMME RCT","volume":"26","author":"Daniels","year":"2022","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.xfss.2023.09.004_bib23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ajog.2013.07.017","article-title":"The impact of uterine leiomyomas: a national survey of affected women","volume":"209","author":"Borah","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xfss.2023.09.004_bib24","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/humupd\/dmw023","article-title":"Uterine fibroid management: from the present to the future","volume":"22","author":"Donnez","year":"2016","journal-title":"Hum Reprod Update"}],"container-title":["F&S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X23000526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X23000526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:07:48Z","timestamp":1762981668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X23000526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2666335X23000526"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2023.09.004","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The combination of natural compounds Crila and epigallocatechin gallate showed enhanced antiproliferative effects on human uterine fibroid cells compared with single treatments","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2023.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}