{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:57:05Z","timestamp":1782817025728,"version":"3.54.5"},"reference-count":55,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Science"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.xfss.2024.07.005","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T07:51:37Z","timestamp":1720943497000},"page":"318-330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Skoochies and its component substances induced testicular damage and impaired sperm function via increased generation of reactive oxygen species and impairment of the glutathione system in rats"],"prefix":"10.1016","volume":"5","author":[{"given":"Ayodeji Folorunsho","family":"Ajayi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufemi Ogundeji","family":"Ogundipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-6794","authenticated-orcid":false,"given":"Moses Agbomhere","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-3871","authenticated-orcid":false,"given":"David Tolulope","family":"Oluwole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2024.07.005_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/and.13672","article-title":"The physiology of male reproduction: impact of drugs and their abuse on male fertility","volume":"52","author":"Ajayi","year":"2020","journal-title":"Andrologia"},{"key":"10.1016\/j.xfss.2024.07.005_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuro.2023.08.005","article-title":"Modulatory effects of Cannabis sativa co-administration with tramadol and codeine on cognitive function in male rats","volume":"99","author":"Ademosun","year":"2023","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.xfss.2024.07.005_bib4","author":"Lemon"},{"key":"10.1016\/j.xfss.2024.07.005_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0973-7847.112832","article-title":"Exploring scientifically proven herbal aphrodisiacs","volume":"7","author":"Kotta","year":"2013","journal-title":"Pharmacogn Rev"},{"key":"10.1016\/j.xfss.2024.07.005_bib6","series-title":"Neuroscience in the 21st century","article-title":"Opioids and opiates: pharmacology, abuse, and addiction","author":"Cruz","year":"2016"},{"key":"10.1016\/j.xfss.2024.07.005_bib7","first-page":"88","article-title":"The health effects of cannabis and cannabinoids","volume":"15","author":"Klimkiewicz","year":"2018","journal-title":"Psychiatria"},{"key":"10.1016\/j.xfss.2024.07.005_bib8","first-page":"1416","article-title":"Gram-scale preparation of cannflavin A from hemp (Cannabis sativa L.) and its inhibitory effect on tryptophan catabolism enzyme kynurenine-3-monooxygenase","volume":"11","author":"Puopolo","year":"2022","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.xfss.2024.07.005_bib9","first-page":"26","article-title":"Effect of Cannabis sativa on the indomethacin-induced gastric mucosal damage","volume":"3","author":"Abdel-Salam","year":"2019","journal-title":"J Basic Pharmacol Toxicol"},{"key":"10.1016\/j.xfss.2024.07.005_bib10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/1440-1681.12213","article-title":"Effects of opioid (tramadol) treatment on testicular functions in adult male rats: the role of nitric oxide and oxidative stress","volume":"41","author":"Ahmed","year":"2014","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.xfss.2024.07.005_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224052","article-title":"Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO\/TNF-\u03b1 and caspase 3 activities","volume":"15","author":"Akhigbe","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2024.07.005_bib12","first-page":"63","article-title":"Testicular function following oral exposure to tramadol and Cannabis sativa ethanol extracts in male Wistar rats","volume":"8","author":"Ige","year":"2020","journal-title":"Res J Health Sci"},{"key":"10.1016\/j.xfss.2024.07.005_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/13510002.2020.1752003","article-title":"Codeine-induced sperm DNA damage is mediated predominantly by oxidative stress rather than apoptosis","volume":"25","author":"Ajayi","year":"2020","journal-title":"Redox Rep"},{"key":"10.1016\/j.xfss.2024.07.005_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12958-023-01098-2","article-title":"Psychoactive drugs and male fertility: impacts and mechanisms","volume":"21","author":"Hamed","year":"2023","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.xfss.2024.07.005_bib15","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/JU.0000000000000248","article-title":"Cannabis and male fertility: a systematic review","volume":"202","author":"Payne","year":"2019","journal-title":"J Urol"},{"key":"10.1016\/j.xfss.2024.07.005_bib16","article-title":"The effect of marijuana on the incidence and evolution of male infertility: a systematic review","volume":"13","author":"Srinivasan","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.xfss.2024.07.005_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/0748233709354553","article-title":"Testicular toxicity in cannabis extract treated mice: association with oxidative stress and role of antioxidant enzyme systems","volume":"26","author":"Mandal","year":"2010","journal-title":"Toxicol Ind Health"},{"key":"10.1016\/j.xfss.2024.07.005_bib18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.30574\/gscbps.2020.12.3.0299","article-title":"Qualitative phytochemical and GC-MS analysis of some commonly consumed vegetables","volume":"12","author":"Sunday","year":"2020","journal-title":"GSC Biol Pharm Sci"},{"key":"10.1016\/j.xfss.2024.07.005_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/and.13454","article-title":"Vitamin E administration does not ameliorate tramadol-associated impairment of testicular function in Wistar rats","volume":"52","author":"Udefa","year":"2020","journal-title":"Andrologia"},{"key":"10.1016\/j.xfss.2024.07.005_bib20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1515\/jbcpp-2015-0061","article-title":"Melatonin and vitamin C exacerbate Cannabis sativa-induced testicular damage when administered separately but ameliorate it when combined in rats","volume":"27","author":"Alagbonsi","year":"2016","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"10.1016\/j.xfss.2024.07.005_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111443","article-title":"Suppression of uric acid generation and blockade of glutathione dysregulation by L-arginine ameliorates dichlorvos-induced oxidative hepatorenal damage in rats","volume":"138","author":"Saka","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.xfss.2024.07.005_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2023\/7215328","article-title":"Proton pump dysfunction and upregulation of caspase-3 activity via oxidative-sensitive signaling mediate Rohypnol-induced testicular toxicity","volume":"2023","author":"Ajayi","year":"2023","journal-title":"Andrologia"},{"key":"10.1016\/j.xfss.2024.07.005_bib23","first-page":"30","article-title":"Differences in morphology of Bull l spermatozoa from normal and pathological testis during epididymal transit","volume":"14","author":"Akusu","year":"1985","journal-title":"Niger Vet J"},{"key":"10.1016\/j.xfss.2024.07.005_bib24","series-title":"Diagnostic and therapeutic techniques in animal reproduction","author":"Zemjanis","year":"1977"},{"key":"10.1016\/j.xfss.2024.07.005_bib25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4067\/S0717-95022005000300008","article-title":"Spermiogram and morphological characteristics in testicular and epididymal spermatozoa of large white boar in Nigeria","volume":"23","author":"Oyeyemi","year":"2005","journal-title":"Int J Morphol"},{"key":"10.1016\/j.xfss.2024.07.005_bib26","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.xfss.2024.07.005_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111309","article-title":"Concomitant administration of HAART aggravates anti-Koch-induced oxidative hepatorenal damage via dysregulation of glutathione and elevation of uric acid production","volume":"137","author":"Hamed","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.xfss.2024.07.005_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067976","article-title":"Measuring myeloperoxidase activity in biological samples","volume":"8","author":"Pulli","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2024.07.005_bib29","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/13510002.2018.1540675","article-title":"Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus","volume":"23","author":"Ebokaiwe","year":"2018","journal-title":"Redox Rep"},{"key":"10.1016\/j.xfss.2024.07.005_bib30","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4103\/1008-682X.179161","article-title":"Current updates on laboratory techniques for the diagnosis of male reproductive failure","volume":"18","author":"Sikka","year":"2016","journal-title":"Asian J Androl"},{"key":"10.1016\/j.xfss.2024.07.005_bib31","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mce.2005.12.031","article-title":"Insights into sperm cell motility signaling through sNHE and the CatSpers","volume":"250","author":"Quill","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.xfss.2024.07.005_bib32","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/andr.12717","article-title":"Assessment of sexual behaviour and fertility indices in male rabbits following chronic codeine use","volume":"8","author":"Ajayi","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.xfss.2024.07.005_bib33","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/ar.21042","article-title":"Human sperm anatomy: ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction","volume":"293","author":"Aquila","year":"2010","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.xfss.2024.07.005_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/bdrb.20295","article-title":"Effects of chronic bhang (cannabis) administration on the reproductive system of male mice","volume":"92","author":"Banerjee","year":"2011","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"key":"10.1016\/j.xfss.2024.07.005_bib35","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.juro.2012.03.131","article-title":"Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study","volume":"188","author":"Safarinejad","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.xfss.2024.07.005_bib36","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s11154-022-09767-0","article-title":"The role of testosterone, the androgen receptor, and hypothalamic-pituitary-gonadal axis in depression in ageing Men","volume":"23","author":"Hauger","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.xfss.2024.07.005_bib37","first-page":"16","article-title":"Revisiting the role of testosterone: are we missing something?","volume":"19","author":"Tyagi","year":"2017","journal-title":"Rev Urol"},{"key":"10.1016\/j.xfss.2024.07.005_bib38","article-title":"Long-term opioids linked to hypogonadism and the role of testosterone supplementation therapy","volume":"12","author":"Marudhai","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.xfss.2024.07.005_bib39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41585-020-00391-8","article-title":"Cannabinoid signalling and effects of cannabis on the male reproductive system","volume":"18","author":"Maccarrone","year":"2021","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.xfss.2024.07.005_bib40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4103\/0971-6580.97224","article-title":"Rutin ameliorates cyclophosphamide-induced reproductive toxicity in male rats","volume":"19","author":"Abarikwu","year":"2012","journal-title":"Toxicol Int"},{"key":"10.1016\/j.xfss.2024.07.005_bib41","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.reprotox.2021.06.007","article-title":"HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content","volume":"103","author":"Akhigbe","year":"2021","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.xfss.2024.07.005_bib42","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1071\/RD9950659","article-title":"Free radicals, lipid peroxidation and sperm function","volume":"7","author":"Aitken","year":"1995","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.xfss.2024.07.005_bib43","first-page":"357","article-title":"Oxidative stress & male infertility","volume":"129","author":"Makker","year":"2009","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.xfss.2024.07.005_bib44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1095\/biolreprod41.1.183","article-title":"Generation of reactive oxygen species, lipid peroxidation, and human sperm function","volume":"41","author":"Aitken","year":"1989","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2024.07.005_bib45","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/bies.950160409","article-title":"Reactive oxygen species generation and human spermatozoa: the balance of benefit and risk","volume":"16","author":"Aitken","year":"1994","journal-title":"Bioessays"},{"key":"10.1016\/j.xfss.2024.07.005_bib46","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0015-0282(03)00756-8","article-title":"Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility","volume":"80","author":"Wang","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2024.07.005_bib47","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/humrep\/der132","article-title":"The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy","volume":"26","author":"Gharagozloo","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2024.07.005_bib48","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1095\/biolreprod.103.025627","article-title":"Cryopreservation and thawing is associated with varying extent of activation of apoptotic machinery in subsets of ejaculated human spermatozoa","volume":"71","author":"Paasch","year":"2004","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2024.07.005_bib49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.aju.2017.11.002","article-title":"Role of sperm DNA fragmentation in male factor infertility: a systematic review","volume":"16","author":"Cho","year":"2017","journal-title":"Arab J Urol"},{"key":"10.1016\/j.xfss.2024.07.005_bib50","doi-asserted-by":"crossref","DOI":"10.1111\/and.14492","article-title":"Cannabis sativa exacerbate testicular function by increased oxidative stress, altered male reproductive hormones, sperm quality\/quantity and cellular architecture of the testis","volume":"54","author":"Mobisson","year":"2022","journal-title":"Andrologia"},{"key":"10.1016\/j.xfss.2024.07.005_bib51","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12906-019-2541-5","article-title":"Cannabinoid-deficient Benin republic hemp (Cannabis sativa L.) improves semen parameters by reducing prolactin and enhancing anti-oxidant status","volume":"19","author":"Alagbonsi","year":"2019","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.xfss.2024.07.005_bib52","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.mefs.2016.12.004","article-title":"Role of oxidative stress in Cannabis sativa - associated spermatotoxicity: evidence for ameliorative effect of combined but not separate melatonin and vitamin C","volume":"22","author":"Alagbonsi","year":"2017","journal-title":"Middle East Fertil Soc J"},{"key":"10.1016\/j.xfss.2024.07.005_bib53","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.4067\/S0717-95022017000401342","article-title":"Therapeutic effect of resveratrol on morphine-induced damage in male reproductive system of mice by reducing nitric oxide serum level","volume":"35","author":"Jalili","year":"2017","journal-title":"Int J Morphol"},{"key":"10.1016\/j.xfss.2024.07.005_bib54","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/abr.abr_69_17","article-title":"Effect of thymoquinone on reproductive parameter in morphine-treated male mice","volume":"7","author":"Salahshoor","year":"2018","journal-title":"Adv Biomed Res"},{"key":"10.1016\/j.xfss.2024.07.005_bib55","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s10815-015-0553-8","article-title":"Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility","volume":"32","author":"du Plessis","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2024.07.005_bib56","doi-asserted-by":"crossref","DOI":"10.1111\/and.12669","article-title":"Testicular toxicity following separate and combined administration of PDE5 inhibitors and opioid: assessment of recovery following their withdrawal","volume":"49","author":"Nna","year":"2017","journal-title":"Andrologia"}],"container-title":["F&amp;S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X24000405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X24000405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T17:13:12Z","timestamp":1732295592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X24000405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S2666335X24000405"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2024.07.005","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skoochies and its component substances induced testicular damage and impaired sperm function via increased generation of reactive oxygen species and impairment of the glutathione system in rats","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2024.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}