{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:39:42Z","timestamp":1758397182048,"version":"3.40.5"},"reference-count":77,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Science"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.xfss.2025.02.002","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:27:27Z","timestamp":1740158847000},"page":"130-140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic insights into the immunological basis of male infertility: a translational perspective"],"prefix":"10.1016","volume":"6","author":[{"given":"Yi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4507-0093","authenticated-orcid":false,"given":"Yanggang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2025.02.002_bib1","doi-asserted-by":"crossref","first-page":"e377","DOI":"10.1097\/AOG.0000000000003271","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.xfss.2025.02.002_bib2","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1007\/s10815-024-03251-1","article-title":"Unlocking the potential of artificial intelligence in reproductive medicine: a bibliometric analysis from 1999 to 2024","volume":"41","author":"Wang","year":"2024","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2025.02.002_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108749","article-title":"Assessing male reproductive toxicity of environmental pollutant di-ethylhexyl phthalate with network toxicology and molecular docking strategy","volume":"130","author":"Hong","year":"2024","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.xfss.2025.02.002_bib4","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1007\/s10815-024-03155-0","article-title":"Integrative bioinformatics analysis to identify ferroptosis-related genes in non-obstructive azoospermia","volume":"41","author":"Hong","year":"2024","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2025.02.002_bib5","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.12968\/bjon.2016.25.18.S35","article-title":"Male infertility: an overview of causes and treatment options","volume":"25","author":"Leaver","year":"2016","journal-title":"Br J Nurs"},{"key":"10.1016\/j.xfss.2025.02.002_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.semcdb.2016.01.019","article-title":"Testicular immunoregulation and spermatogenesis","volume":"59","author":"Chen","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.xfss.2025.02.002_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.729539","article-title":"Varicocele-mediated male infertility: from the perspective of testicular immunity and inflammation","volume":"12","author":"Fang","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev-immunol-093019-112809","article-title":"Tissue-resident immune cells in humans","volume":"40","author":"Gray","year":"2022","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.649893","article-title":"Localized and systemic immune response in human reproductive tract","volume":"11","author":"Gudisa","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.xfss.2025.02.002_bib11","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12967-020-02306-y","article-title":"Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy","volume":"18","author":"Raza","year":"2020","journal-title":"J Transl Med"},{"key":"10.1016\/j.xfss.2025.02.002_bib12","article-title":"Microbiology and immune mechanisms associated with male infertility","volume":"14","author":"Chen","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib13","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2306797120","article-title":"Regulatory T cells play a crucial role in maintaining sperm tolerance and male fertility","volume":"120","author":"Barrachina","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2025.02.002_bib14","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.3390\/cancers13122881","article-title":"Male and female fertility: prevention and monitoring Hodgkin' lymphoma and diffuse large B-cell lymphoma adult survivors. A systematic review by the Fondazione Italiana Linfomi","volume":"13","author":"Viviani","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.xfss.2025.02.002_bib15","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S0022-5347(05)65170-1","article-title":"Dendritic cell infiltration in a patient with seminomatous germ cell tumor of the testis: is there a relationship with infertility and tumor stage?","volume":"167","author":"Saint","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.xfss.2025.02.002_bib16","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1039\/D4FO01559B","article-title":"The protective role of water intake in age-related eye diseases: insights from a Mendelian randomization study","volume":"15","author":"Mi","year":"2024","journal-title":"Food Funct"},{"key":"10.1016\/j.xfss.2025.02.002_bib17","article-title":"Mendelian randomization","volume":"12","author":"Birney","year":"2022","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.xfss.2025.02.002_bib18","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1161\/STROKEAHA.120.032617","article-title":"Mendelian randomization studies in stroke: exploration of risk factors and drug targets with human genetic data","volume":"52","author":"Georgakis","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.xfss.2025.02.002_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jad.2024.11.002","article-title":"Deciphering the genetic underpinnings of neuroticism: a Mendelian randomization study of druggable gene targets","volume":"370","author":"Hong","year":"2025","journal-title":"J Affect Disord"},{"key":"10.1016\/j.xfss.2025.02.002_bib20","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1007\/s10815-024-03295-3","article-title":"No direct association between male infertility and multiple sclerosis: evidence from Mendelian randomization analysis","volume":"41","author":"Shu","year":"2024","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2025.02.002_bib21","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.3390\/nu14194042","article-title":"Insights into modifiable risk factors of infertility: a Mendelian randomization study","volume":"14","author":"Xu","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.xfss.2025.02.002_bib22","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41588-020-0684-4","article-title":"Complex genetic signatures in immune cells underlie autoimmunity and inform therapy","volume":"52","author":"Orr\u00f9","year":"2020","journal-title":"Nat Genet"},{"key":"10.1016\/j.xfss.2025.02.002_bib23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.xfss.2025.02.002_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/aji.70036","article-title":"Causal relationship between antibody-mediated immune responses of Chlamydia trachomatis infection and reproductive tract complications: a bidirectional Mendelian randomization study","volume":"93","author":"Hong","year":"2025","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib25","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41588-019-0350-x","article-title":"Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases","volume":"51","author":"Sanna","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.xfss.2025.02.002_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"Abecasis","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.xfss.2025.02.002_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.xfss.2025.02.002_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbi.2024.02.015","article-title":"Bidirectional two-sample Mendelian randomization study of differential white blood cell counts and schizophrenia","volume":"118","author":"Leung","year":"2024","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.xfss.2025.02.002_bib29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.xfss.2025.02.002_bib30","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1093\/ije\/dyu005","article-title":"Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome","volume":"43","author":"Burgess","year":"2014","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.xfss.2025.02.002_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009922","article-title":"Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model","volume":"17","author":"Lin","year":"2021","journal-title":"PLOS Genet"},{"key":"10.1016\/j.xfss.2025.02.002_bib32","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1002\/sim.6522","article-title":"Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome","volume":"34","author":"Greco","year":"2015","journal-title":"Stat Med"},{"key":"10.1016\/j.xfss.2025.02.002_bib33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41585-018-0003-3","article-title":"Genetics of male infertility","volume":"15","author":"Krausz","year":"2018","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.xfss.2025.02.002_bib34","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4103\/aja.aja_11_19","article-title":"The epididymal immune balance: a key to preserving male fertility","volume":"21","author":"Voisin","year":"2019","journal-title":"Asian J Androl"},{"key":"10.1016\/j.xfss.2025.02.002_bib35","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/humupd\/dmaa034","article-title":"Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout\/mutated mice","volume":"27","author":"Jiao","year":"2021","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfss.2025.02.002_bib36","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1210\/clinem\/dgaa781","article-title":"Male infertility due to testicular disorders","volume":"106","author":"Sharma","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2025.02.002_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117878","article-title":"Analysis of toxicity and mechanisms of busulfan in non-obstructive azoospermia: a genomic and toxicological approach integrating molecular docking, single-cell sequencing, and experimentation in vivo","volume":"291","author":"Hong","year":"2025","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.xfss.2025.02.002_bib38","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12958-018-0431-1","article-title":"Radiations and male fertility","volume":"16","author":"Kesari","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.xfss.2025.02.002_bib39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/imr.13090","article-title":"Fetal-placental antigens and the maternal immune system: reproductive immunology comes of age","volume":"308","author":"Petroff","year":"2022","journal-title":"Immunol Rev"},{"key":"10.1016\/j.xfss.2025.02.002_bib40","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2022.35","article-title":"Metabolic signatures of immune cells in chronic kidney disease","volume":"24","author":"Li","year":"2022","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.xfss.2025.02.002_bib41","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1172\/JCI122182","article-title":"Regulatory T cells in embryo implantation and the immune response to pregnancy","volume":"128","author":"Robertson","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xfss.2025.02.002_bib42","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3389\/fimmu.2020.01032","article-title":"Endometrial immune profiling: a method to design personalized care in assisted reproductive medicine","volume":"11","author":"L\u00e9d\u00e9e","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib43","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.3390\/ijms25094802","article-title":"Immune dysregulation in endometriomas: implications for inflammation","volume":"25","author":"Dymanowska-Dyjak","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfss.2025.02.002_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.583135","article-title":"Pathomechanisms of autoimmune based testicular inflammation","volume":"11","author":"Lustig","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib45","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12889-024-17699-4","article-title":"Inflammatory markers are associated with infertility prevalence: a cross-sectional analysis of the NHANES 2013-2020","volume":"24","author":"Chen","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.xfss.2025.02.002_bib46","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.86454","article-title":"The role of B cells in immune cell activation in polycystic ovary syndrome","volume":"12","author":"Ascani","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.xfss.2025.02.002_bib47","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/humupd\/dmac032","article-title":"Defensins: defenders of human reproductive health","volume":"29","author":"Zhai","year":"2023","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfss.2025.02.002_bib48","first-page":"123","article-title":"Impact of inflammation on male reproductive tract","volume":"16","author":"Azenabor","year":"2015","journal-title":"J Reprod Infertil"},{"key":"10.1016\/j.xfss.2025.02.002_bib49","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41577-020-0376-4","article-title":"Targeting CD39 in cancer","volume":"20","author":"Moesta","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib50","doi-asserted-by":"crossref","first-page":"8068","DOI":"10.3390\/ijms22158068","article-title":"CD39 Regulation and functions in T Cells","volume":"22","author":"Timperi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfss.2025.02.002_bib51","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3389\/fphar.2018.00546","article-title":"Increased ATP and ADO overflow from sympathetic nerve endings and mesentery endothelial cells plus reduced nitric oxide are involved in diabetic neurovascular dysfunction","volume":"9","author":"Donoso","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.xfss.2025.02.002_bib52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0014-2999(84)90318-2","article-title":"Inhibition of excitatory junction potentials in guinea-pig vas deferens by alpha, beta-methylene-ATP: further evidence for ATP and noradrenaline as cotransmitters","volume":"100","author":"Sneddon","year":"1984","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.xfss.2025.02.002_bib53","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1113\/jphysiol.1984.sp015083","article-title":"Pharmacological evidence that adenosine triphosphate and noradrenaline are co-transmitters in the guinea-pig vas deferens","volume":"347","author":"Sneddon","year":"1984","journal-title":"J Physiol"},{"key":"10.1016\/j.xfss.2025.02.002_bib54","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-385526-8.00009-6","article-title":"Impact of ectoenzymes on p2 and p1 receptor signaling","volume":"61","author":"Kukulski","year":"2011","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.xfss.2025.02.002_bib55","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bbamcr.2008.01.024","article-title":"Nucleotide- and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade","volume":"1783","author":"Yegutkin","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.xfss.2025.02.002_bib56","doi-asserted-by":"crossref","first-page":"28629","DOI":"10.1074\/jbc.M114.604082","article-title":"Nucleoside triphosphate diphosphohydrolase-1 ectonucleotidase is required for normal vas deferens contraction and male fertility through maintaining P2X1 receptor function","volume":"289","author":"Kauffenstein","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xfss.2025.02.002_bib57","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1530\/REP-10-0362","article-title":"CD4+ and CD8+ T cells producing Th1 and Th17 cytokines are involved in the pathogenesis of autoimmune orchitis","volume":"141","author":"Jacobo","year":"2011","journal-title":"Reproduction"},{"key":"10.1016\/j.xfss.2025.02.002_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2024.104272","article-title":"Immunodeviation towards T cell-mediated immune response in the testes of LPS-induced mouse epididymo-orchitis","volume":"164","author":"Wang","year":"2024","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib59","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jaci.2013.01.046","article-title":"B-cell biology and development","volume":"131","author":"Pieper","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005456","article-title":"Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells","volume":"4","author":"Rauch","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2025.02.002_bib61","doi-asserted-by":"crossref","first-page":"807","DOI":"10.4049\/jimmunol.173.2.807","article-title":"B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells","volume":"173","author":"Ng","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib62","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.3389\/fimmu.2018.02285","article-title":"BAFF and BAFF-receptor in B cell selection and survival","volume":"9","author":"Smulski","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib63","article-title":"Immunotherapy: a promising novel endometriosis therapy","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib64","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s11418-022-01619-0","article-title":"Phytomedicinal therapeutics for male infertility: critical insights and scientific updates","volume":"76","author":"Ramgir","year":"2022","journal-title":"J Nat Med"},{"key":"10.1016\/j.xfss.2025.02.002_bib65","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa197","article-title":"Naive B cells in neuromyelitis optica spectrum disorders: impact of steroid use and relapses","volume":"2","author":"Janssen","year":"2020","journal-title":"Brain Commun"},{"key":"10.1016\/j.xfss.2025.02.002_bib66","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.4049\/jimmunol.1700557","article-title":"T cells regulate peripheral naive mature B cell survival by cell-cell contact mediated through SLAMF6 and SAP","volume":"199","author":"Radomir","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.xfss.2025.02.002_bib67","article-title":"Insulin resistance adversely affect IVF outcomes in lean women without PCOS","volume":"12","author":"Wang","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.xfss.2025.02.002_bib68","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.3390\/cells9081813","article-title":"Toll-like receptor 2 expression as a new hallmark of advanced endometriosis","volume":"9","author":"Sobstyl","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.xfss.2025.02.002_bib69","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1073\/pnas.1017615108","article-title":"Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy","volume":"108","author":"Wheeler","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2025.02.002_bib70","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1016\/j.vaccine.2010.05.050","article-title":"CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB\/c mice","volume":"28","author":"Cunningham","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.xfss.2025.02.002_bib71","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.autrev.2010.09.026","article-title":"Testicular autoimmunity","volume":"10","author":"Jacobo","year":"2011","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.xfss.2025.02.002_bib72","article-title":"Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis","volume":"118","author":"Wang","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xfss.2025.02.002_bib73","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.3390\/ijms23074013","article-title":"Effect of chemotherapy cytarabine and acute myeloid leukemia on the development of spermatogenesis at the adult age of immature treated mice","volume":"23","author":"Khaleel","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfss.2025.02.002_bib74","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.022560","article-title":"Causal effect of obstructive sleep apnea on atrial fibrillation: a Mendelian randomization study","volume":"10","author":"Chen","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.xfss.2025.02.002_bib75","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.xfss.2025.02.002_bib76","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: a review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res Synth Methods"},{"key":"10.1016\/j.xfss.2025.02.002_bib77","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41588-022-01054-7","article-title":"Improving polygenic prediction in ancestrally diverse populations","volume":"54","author":"Ruan","year":"2022","journal-title":"Nat Genet"}],"container-title":["F&amp;S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X25000163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X25000163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T05:29:22Z","timestamp":1747286962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X25000163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2666335X25000163"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2025.02.002","relation":{},"ISSN":["2666-335X"],"issn-type":[{"type":"print","value":"2666-335X"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic insights into the immunological basis of male infertility: a translational perspective","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2025.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}