{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:20:48Z","timestamp":1778768448832,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["RCYX20210609104608036"],"award-info":[{"award-number":["RCYX20210609104608036"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201851"],"award-info":[{"award-number":["82201851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&S Science"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.xfss.2026.01.001","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:24:18Z","timestamp":1769012658000},"page":"246-259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The metabolic landscape of the maternal-fetal interface in missed miscarriage: a cross-sectional pilot multiomics study"],"prefix":"10.1016","volume":"7","author":[{"given":"Haoyue","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuwei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanfang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2026.01.001_bib1","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.xfss.2026.01.001_bib2","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1001\/jama.2023.0933","article-title":"Management of early pregnancy loss","volume":"329","author":"Neill","year":"2023","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.xfss.2026.01.001_bib3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0140-6736(20)31788-8","article-title":"Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial","volume":"396","author":"Chu","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.xfss.2026.01.001_bib4","article-title":"Predictive value of NLR and PLR in missed miscarriage","volume":"36","author":"Liu","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.xfss.2026.01.001_bib5","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.fertnstert.2023.08.955","article-title":"Interventions to prevent miscarriage","volume":"120","author":"Dhillon-Smith","year":"2023","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2026.01.001_bib6","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.fertnstert.2023.08.952","article-title":"Genetic causes of sporadic and recurrent miscarriage","volume":"120","author":"Melo","year":"2023","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2026.01.001_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/humupd\/dmr043","article-title":"Human leucocyte antigen class Ib molecules in pregnancy success and early pregnancy loss","volume":"18","author":"Dahl","year":"2012","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.xfss.2026.01.001_bib8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10815-017-1108-y","article-title":"Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss","volume":"35","author":"Arias-Sosa","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.xfss.2026.01.001_bib9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.fertnstert.2022.12.016","article-title":"Single-cell profiling of the microenvironment in decidual tissue from women with missed abortions","volume":"119","author":"Hou","year":"2023","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2026.01.001_bib10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bpobgyn.2011.02.006","article-title":"Placental bed disorders in preterm labor, preterm PROM, spontaneous abortion and abruptio placentae","volume":"25","author":"Romero","year":"2011","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.xfss.2026.01.001_bib11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature10897","article-title":"Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy","volume":"484","author":"Cui","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.xfss.2026.01.001_bib12","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nm.3160","article-title":"Fetomaternal immune cross-talk and its consequences for maternal and offspring's health","volume":"19","author":"Arck","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.xfss.2026.01.001_bib13","article-title":"Multiomics studies investigating recurrent pregnancy loss: an effective tool for mechanism exploration","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2026.01.001_bib14","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202088","article-title":"Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism","volume":"150","author":"Kramer","year":"2023","journal-title":"Development"},{"key":"10.1016\/j.xfss.2026.01.001_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s40001-023-01161-z","article-title":"The impact of early pregnancy metabolic disorders on pregnancy outcome and the specific mechanism","volume":"28","author":"Zhu","year":"2023","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.xfss.2026.01.001_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.717014","article-title":"Metabolic reprogramming of immune cells at the maternal-fetal interface and the development of techniques for immunometabolism","volume":"12","author":"Wei","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2026.01.001_bib17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1095\/biolreprod.113.113217","article-title":"The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice","volume":"90","author":"Tsai","year":"2014","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2026.01.001_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jmoldx.2010.11.013","article-title":"Laboratory guidelines for detection, interpretation, and reporting of maternal cell contamination in prenatal analyses a report of the association for molecular pathology","volume":"13","author":"Nagan","year":"2011","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.xfss.2026.01.001_bib19","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/GIM.0b013e3182217a3a","article-title":"American College of Medical Genetics standards and guidelines for interpretation and reporting of postnatal constitutional copy number variants","volume":"13","author":"Kearney","year":"2011","journal-title":"Genet Med"},{"key":"10.1016\/j.xfss.2026.01.001_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ejogrb.2009.02.051","article-title":"The detection of aneuploidy and maternal contamination by QF-PCR in samples undergoing prenatal diagnosis for thalassemia in Southern China","volume":"144","author":"Liao","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.xfss.2026.01.001_bib21","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.xfss.2026.01.001_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S0954422419000052","article-title":"Molecular mechanisms relating to amino acid regulation of protein synthesis","volume":"32","author":"Cao","year":"2019","journal-title":"Nutr Res Rev"},{"key":"10.1016\/j.xfss.2026.01.001_bib23","doi-asserted-by":"crossref","first-page":"599","DOI":"10.7150\/ijbs.67816","article-title":"Trophoblast-derived lactic acid orchestrates decidual macrophage differentiation via SRC\/LDHA signaling in early pregnancy","volume":"18","author":"Gao","year":"2022","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.xfss.2026.01.001_bib24","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201219RR","article-title":"LDHA deficiency inhibits trophoblast proliferation via the PI3K\/AKT\/FOXO1\/CyclinD1 signaling pathway in unexplained recurrent spontaneous abortion","volume":"37","author":"Zhu","year":"2023","journal-title":"FASEB J"},{"key":"10.1016\/j.xfss.2026.01.001_bib28","doi-asserted-by":"crossref","DOI":"10.1199\/tab.0018","article-title":"Purine and pyrimidine nucleotide synthesis and metabolism","volume":"1","author":"Moffatt","year":"2002","journal-title":"Arabidopsis Book"},{"key":"10.1016\/j.xfss.2026.01.001_bib29","doi-asserted-by":"crossref","first-page":"9483","DOI":"10.3390\/ijms26199483","article-title":"Molecular insights into human placentation: from villous morphogenesis to pathological pathways and translational biomarkers","volume":"26","author":"Vornic","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfss.2026.01.001_bib30","article-title":"Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth","volume":"15","author":"Ali","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2026.01.001_bib31","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.3390\/ijms24087273","article-title":"Placental remote control of fetal metabolism: trophoblast mTOR signaling regulates liver IGFBP-1 phosphorylation and IGF-1 bioavailability","volume":"24","author":"Rosario","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfss.2026.01.001_bib32","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1007\/s11010-021-04215-0","article-title":"Bioenergetics adaptations and redox homeostasis in pregnancy and related disorders","volume":"476","author":"Sanchez-Aranguren","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.xfss.2026.01.001_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113999","article-title":"HMGB1 induces unexplained recurrent spontaneous abortion by mediating decidual macrophage autophagy","volume":"147","author":"Han","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.xfss.2026.01.001_bib36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.theriogenology.2017.09.036","article-title":"De novo synthesis of sphingolipids is essential for decidualization in mice","volume":"106","author":"Ding","year":"2018","journal-title":"Theriogenology"},{"key":"10.1016\/j.xfss.2026.01.001_bib37","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/s41419-019-2071-6","article-title":"Nucleolar stress regulation of endometrial receptivity in mouse models and human cell lines","volume":"10","author":"Hu","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.xfss.2026.01.001_bib38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrc.2017.96","article-title":"Sphingolipid metabolism in cancer signalling and therapy","volume":"18","author":"Ogretmen","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.xfss.2026.01.001_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1203719","article-title":"Energy metabolism and maternal-fetal tolerance working in decidualization","volume":"14","author":"Meng","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2026.01.001_bib40","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.xfss.2026.01.001_bib41","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","volume":"25","author":"Dey","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.xfss.2026.01.001_bib42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/aji.12466","article-title":"Decidual control of trophoblast invasion","volume":"75","author":"Sharma","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.xfss.2026.01.001_bib43","doi-asserted-by":"crossref","first-page":"8690","DOI":"10.1038\/s41598-017-05947-0","article-title":"Invasive trophoblast promote stromal fibroblast decidualization via Profilin 1 and ALOX5","volume":"7","author":"Menkhorst","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.xfss.2026.01.001_bib44","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.tem.2021.09.002","article-title":"Mechanisms of lipid metabolism in uterine receptivity and embryo development","volume":"32","author":"Ye","year":"2021","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.xfss.2026.01.001_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12597","article-title":"Roles of lipid mediators in early pregnancy events","volume":"23","author":"Aikawa","year":"2024","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.xfss.2026.01.001_bib46","article-title":"Metabolomics and proteomics analyses reveal the role of the glycerophospholipid metabolism pathway in unexplained recurrent spontaneous abortion","volume":"13","author":"Chen","year":"2025","journal-title":"PeerJ"},{"key":"10.1016\/j.xfss.2026.01.001_bib47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.placenta.2021.07.001","article-title":"The metabolic landscape of decidua in recurrent pregnancy loss using a global metabolomics approach","volume":"112","author":"Wang","year":"2021","journal-title":"Placenta"}],"container-title":["F&S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X26000029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X26000029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:55:27Z","timestamp":1778766927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X26000029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2666335X26000029"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2026.01.001","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The metabolic landscape of the maternal-fetal interface in missed miscarriage: a cross-sectional pilot multiomics study","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2026.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}