{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:24:02Z","timestamp":1788531842736,"version":"build-2803163510"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007928","name":"University of Pennsylvania Perelman School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008638","name":"The Children's Hospital of Philadelphia Center for Childhood Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008638","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006458","name":"Children's Hospital of Philadelphia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Science"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.xfss.2026.05.004","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:44:36Z","timestamp":1779781476000},"page":"361-370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Generation of spermatid-like cells from testicular biopsies obtained from prepubertal boys"],"prefix":"10.1016","volume":"7","author":[{"given":"Bang-Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yub","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Trigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dasom","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire A.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhyong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buom-Yong","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Kolon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin C.","family":"Conine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill P.","family":"Ginsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9869-4455","authenticated-orcid":false,"given":"Sandra","family":"Ryeom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2026.05.004_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1089\/jayao.2010.0003","article-title":"Assessing the reproductive concerns of children and adolescents with cancer: challenges and potential solutions","volume":"1","author":"Knapp","year":"2011","journal-title":"J Adolesc Young Adult Oncol"},{"key":"10.1016\/j.xfss.2026.05.004_bib2","doi-asserted-by":"crossref","first-page":"7837","DOI":"10.1073\/pnas.1914963117","article-title":"Autologous transplantation of spermatogonial stem cells restores fertility in congenitally infertile mice","volume":"117","author":"Kanatsu-Shinohara","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xfss.2026.05.004_bib3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.stem.2012.07.017","article-title":"Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm","volume":"11","author":"Hermann","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xfss.2026.05.004_bib4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.fertnstert.2018.04.033","article-title":"Ninety babies born after round spermatid injection into oocytes: survey of their development from fertilization to 2 years of age","volume":"110","author":"Tanaka","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.xfss.2026.05.004_bib5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1152\/physrev.1972.52.1.198","article-title":"Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal","volume":"52","author":"Clermont","year":"1972","journal-title":"Physiol Rev"},{"key":"10.1016\/j.xfss.2026.05.004_bib6","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/ncomms1478","article-title":"In vitro production of fertile sperm from murine spermatogonial stem cell lines","volume":"2","author":"Sato","year":"2011","journal-title":"Nat Commun"},{"key":"10.1016\/j.xfss.2026.05.004_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1095\/biolreprod.110.083899","article-title":"In vitro murine spermatogenesis in an organ culture system","volume":"83","author":"Gohbara","year":"2010","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2026.05.004_bib8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41418-017-0015-1","article-title":"Efficient generation of functional haploid spermatids from human germline stem cells by three-dimensional-induced system","volume":"25","author":"Sun","year":"2018","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.xfss.2026.05.004_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-1-61779-436-0_4","article-title":"Isolation of human male germ-line stem cells using enzymatic digestion and magnetic-activated cell sorting","volume":"825","author":"He","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.xfss.2026.05.004_bib10","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1038\/s41467-018-06881-z","article-title":"Testicular endothelial cells are a critical population in the germline stem cell niche","volume":"9","author":"Bhang","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.xfss.2026.05.004_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/dvdy.21401","article-title":"SMAD expression in the testis: an insight into BMP regulation of spermatogenesis","volume":"237","author":"Itman","year":"2008","journal-title":"Dev Dyn"},{"key":"10.1016\/j.xfss.2026.05.004_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.02.012","article-title":"The regulation of spermatogenesis by androgens","volume":"30","author":"Smith","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.xfss.2026.05.004_bib13","doi-asserted-by":"crossref","first-page":"E10132","DOI":"10.1073\/pnas.1710837114","article-title":"Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis","volume":"114","author":"Endo","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xfss.2026.05.004_bib14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1210\/en.2005-0953","article-title":"Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis","volume":"147","author":"Vernet","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.xfss.2026.05.004_bib15","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/biolre\/ioac037","article-title":"Mysteries and unsolved problems of mammalian fertilization and related topics","volume":"106","author":"Yanagimachi","year":"2022","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2026.05.004_bib16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1470-2045(05)70092-9","article-title":"Fertility preservation for young patients with cancer: who is at risk and what can be offered?","volume":"6","author":"Wallace","year":"2005","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.xfss.2026.05.004_bib17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11764-014-0354-6","article-title":"Male infertility in long-term survivors of pediatric cancer: a report from the childhood cancer survivor study","volume":"8","author":"Wasilewski-Masker","year":"2014","journal-title":"J Cancer Surviv"},{"key":"10.1016\/j.xfss.2026.05.004_bib18","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic health conditions in adult survivors of childhood cancer","volume":"355","author":"Oeffinger","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.xfss.2026.05.004_bib19","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.celrep.2018.10.026","article-title":"The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids","volume":"25","author":"Hermann","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.xfss.2026.05.004_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.897062","article-title":"Sertoli cell-germ cell interactions within the niche: paracrine and juxtacrine molecular communications","volume":"13","author":"Hofmann","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.xfss.2026.05.004_bib21","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature09850","article-title":"In vitro production of functional sperm in cultured neonatal mouse testes","volume":"471","author":"Sato","year":"2011","journal-title":"Nature"}],"container-title":["F&amp;S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X26000340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X26000340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:49:52Z","timestamp":1788529792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X26000340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2666335X26000340"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2026.05.004","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of spermatid-like cells from testicular biopsies obtained from prepubertal boys","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2026.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}