{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T21:26:38Z","timestamp":1786742798107,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K05903"],"award-info":[{"award-number":["21K05903"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K09198"],"award-info":[{"award-number":["24K09198"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["fertstertscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["F&amp;S Science"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.xfss.2026.07.002","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:11:07Z","timestamp":1784247067000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selection of blastocysts with higher implantation potential based on reactive oxygen species levels before embryo transfer in mice"],"prefix":"10.1016","author":[{"given":"Haruka","family":"Asano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoka","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-6866","authenticated-orcid":false,"given":"Hiromichi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xfss.2026.07.002_bib1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1093\/humrep\/deaf049","article-title":"International Committee for Monitoring Assisted Reproductive Technologies (ICMART): world report for cycles conducted in 2017\u20132018","volume":"40","author":"Baker","year":"2025","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2026.07.002_bib2","article-title":"Assisted reproductive technology in Japan: a summary report for 2023 by the Committee on Professional Scientific Conduct and Clinical Ethics of the Japan Society of Obstetrics and Gynecology","volume":"25","author":"Katagiri","year":"2025","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib3","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1093\/humrep\/deaf179","article-title":"ART in Europe, 2020: results generated from European registries by ESHRE","volume":"40","author":"Smeenk","year":"2025","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2026.07.002_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7104a1","article-title":"Assisted reproductive technology surveillance \u2013 United States, 2018","volume":"71","author":"Sunderam","year":"2022","journal-title":"MMWR Surveill Summ"},{"key":"10.1016\/j.xfss.2026.07.002_bib5","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/molehr\/gau004","article-title":"Degradation of estrogen receptor \u03b1 in activated blastocysts is associated with implantation in the delayed implantation mouse model","volume":"20","author":"Saito","year":"2014","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.xfss.2026.07.002_bib6","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/molehr\/gax035","article-title":"Improvement of implantation potential in mouse blastocysts derived from IVF by combined treatment with prolactin, epidermal growth factor and 4-hydroxyestradiol","volume":"23","author":"Takeuchi","year":"2017","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.xfss.2026.07.002_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12522-015-0222-8","article-title":"Molecular and cellular events involved in the completion of blastocyst implantation","volume":"15","author":"Matsumoto","year":"2016","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib8","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1262\/jrd.2017-047","article-title":"Molecular and cellular events during blastocyst implantation in the receptive uterus: clues from mouse models","volume":"63","author":"Matsumoto","year":"2017","journal-title":"J Reprod Dev"},{"key":"10.1016\/j.xfss.2026.07.002_bib9","article-title":"Arginine with leucine drives reactive oxygen species-mediated integrin \u03b15\u03b21 expression and promotes implantation in mouse blastocysts","volume":"3","author":"Nakazato","year":"2024","journal-title":"Proc Natl Acad Sci USA Nexus"},{"key":"10.1016\/j.xfss.2026.07.002_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12633","article-title":"Molecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF-derived blastocysts","volume":"24","author":"Liu","year":"2025","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib11","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/humrep\/17.4.999","article-title":"Non-invasive amino acid turnover predicts human embryo developmental capacity","volume":"17","author":"Houghton","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2026.07.002_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0262661","article-title":"Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences","volume":"17","author":"Berntsen","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.xfss.2026.07.002_bib13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/humrep\/dead268","article-title":"Metabolic imaging of human embryos is predictive of ploidy status but is not associated with clinical pregnancy outcomes: a pilot trial","volume":"39","author":"Sakkas","year":"2024","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2026.07.002_bib14","series-title":"Laboratory animal medicine","first-page":"43","article-title":"Biology and diseases of mice","author":"Whary","year":"2015"},{"key":"10.1016\/j.xfss.2026.07.002_bib15","first-page":"48","article-title":"Which precocial rodent species is more suitable as the experimental model of microgravity influence on prenatal musculosketal development on international space station?","volume":"33","author":"Sekulic","year":"2022","journal-title":"Life Sci Space Res (Amst)"},{"issue":"Suppl 3","key":"10.1016\/j.xfss.2026.07.002_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/humrep\/13.suppl_3.247","article-title":"Endometrial integrins and the establishment of uterine receptivity","volume":"13","author":"Lessey","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xfss.2026.07.002_bib17","first-page":"4991","article-title":"Osteopontin and its receptor alphavbeta(3) integrin are coexpressed in the human endometrium during the menstrual cycle but regulated differentially","volume":"86","author":"Apparao","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xfss.2026.07.002_bib18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/dbio.2001.0461","article-title":"Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway","volume":"240","author":"Martin","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0165-0378(01)00139-5","article-title":"Adhesion molecules and implantation","volume":"55","author":"Lessey","year":"2002","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.xfss.2026.07.002_bib20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ydbio.2005.02.009","article-title":"Blastocysts don't go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells","volume":"280","author":"Armant","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1387\/ijdb.140011da","article-title":"Cell signaling in trophoblast-uterine communication","volume":"58","author":"Fritz","year":"2014","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib22","first-page":"136","article-title":"Reactive oxygen species in embryo development: sources, impacts, and implications for in vitro culture systems","volume":"16","author":"Sunuwar","year":"2026","journal-title":"Life (Basel)"},{"key":"10.1016\/j.xfss.2026.07.002_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2008.04.041","article-title":"Function of reactive oxygen species during animal development: passive or active?","volume":"320","author":"Covarrubias","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib24","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3390\/antiox15060674","article-title":"The positive roles for reactive oxygen species in human reproduction; implications for the therapeutic application of antioxidants","volume":"15","author":"Pyneandee","year":"2026","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.xfss.2026.07.002_bib25","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ydbio.2011.10.021","article-title":"Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo","volume":"361","author":"Gonz\u00e1lez","year":"2012","journal-title":"Dev Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12545","article-title":"Upregulation of iNOS and phosphorylated eNOS in the implantation-induced blastocysts of mice","volume":"22","author":"Seki","year":"2023","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph182111374","article-title":"Redox regulation and oxidative stress in mammalian oocytes and embryos developed in vivo and in vitro","volume":"18","author":"Hardy","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.xfss.2026.07.002_bib28","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3390\/antiox11030477","article-title":"Oxidative stress and assisted reproduction: a comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment","volume":"11","author":"Agarwal","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.xfss.2026.07.002_bib29","doi-asserted-by":"crossref","first-page":"F95","DOI":"10.1530\/REP-22-0121","article-title":"Oxidative stress and reproductive function: reactive oxygen species in the mammalian pre-implantation embryo","volume":"164","author":"Deluao","year":"2022","journal-title":"Reproduction"},{"key":"10.1016\/j.xfss.2026.07.002_bib30","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.3390\/cimb45020083","article-title":"Oxidative stress in assisted reproductive techniques, with a focus on an underestimated risk factor","volume":"45","author":"Mauchart","year":"2023","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1017\/S0967199420000660","article-title":"Effect of antioxidants on preimplantation embryo development in vitro: a review","volume":"29","author":"Zarbakhsh","year":"2021","journal-title":"Zygote"},{"key":"10.1016\/j.xfss.2026.07.002_bib32","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3390\/antiox9060472","article-title":"An update on mitochondrial reactive oxygen species production","volume":"9","author":"Mailloux","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.xfss.2026.07.002_bib33","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of Reactive Oxygen Species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xfss.2026.07.002_bib34","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1073\/pnas.95.6.2956","article-title":"Bcl-2 expression causes redistribution of glutathione to the nucleus","volume":"95","author":"Voehringer","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xfss.2026.07.002_bib35","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/10715760802317663","article-title":"Glutathione and apoptosis","volume":"42","author":"Circu","year":"2008","journal-title":"Free Radic Res"},{"key":"10.1016\/j.xfss.2026.07.002_bib36","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","article-title":"GPX4 in cell death, autophagy, and disease","author":"Xie","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.xfss.2026.07.002_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","volume":"25","author":"Dey","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.xfss.2026.07.002_bib38","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1262\/jrd.2022-061","article-title":"Recent progress of interferon-tau research and potential direction beyond pregnancy recognition","volume":"68","author":"Bai","year":"2022","journal-title":"J Reprod Dev"},{"key":"10.1016\/j.xfss.2026.07.002_bib39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/biolre\/ioy049","article-title":"Hemochorial placentation: development, function, and adaptations","volume":"99","author":"Soares","year":"2018","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xfss.2026.07.002_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1385762","article-title":"Placenta: an old organ with new functions","volume":"15","author":"Khorami-Sarvestani","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.xfss.2026.07.002_bib41","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrg1808","article-title":"Roadmap to embryo implantation: clues from mouse models","volume":"7","author":"Wang","year":"2006","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.xfss.2026.07.002_bib42","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.xfss.2026.07.002_bib43","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/rmb2.12280","article-title":"Uterine receptivity, embryo attachment, and embryo invasion: multistep processes in embryo implantation","volume":"18","author":"Fukui","year":"2019","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.70042","article-title":"Toward implantation-assisting technologies: lessons from in vivo and ex vivo models","volume":"25","author":"Hiraoka","year":"2026","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.xfss.2026.07.002_bib45","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1600-0897.2010.00853.x","article-title":"Research on blastocyst implantation essential factors (BIEFs)","volume":"63","author":"Yoshinaga","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.xfss.2026.07.002_bib46","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.rbmo.2021.01.006","article-title":"Prolactin receptor expression and its role in trophoblast outgrowth in human embryos","volume":"42","author":"Ezoe","year":"2021","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.xfss.2026.07.002_bib47","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12958-023-01062-0","article-title":"Post-warming culture of human vitrified blastocysts with prolactin improves trophoblast outgrowth","volume":"21","author":"Ezoe","year":"2023","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.xfss.2026.07.002_bib48","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.3390\/jcm11175056","article-title":"DNA methylation in offspring conceived after assisted reproductive techniques: a systematic review and meta-analysis","volume":"11","author":"Cannarella","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.xfss.2026.07.002_bib49","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/andr.12379","article-title":"Impairment of sperm DNA methylation in male infertility: a meta-analytic study","volume":"5","author":"Santi","year":"2017","journal-title":"Andrology"},{"key":"10.1016\/j.xfss.2026.07.002_bib50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/19396368.2021.1909667","article-title":"Relevance of sperm imprinted gene methylation on assisted reproductive technique outcomes and pregnancy loss: a systematic review","volume":"67","author":"Cannarella","year":"2021","journal-title":"Syst Biol Reprod Med"}],"container-title":["F&amp;S Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X26000509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666335X26000509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:26:57Z","timestamp":1786739217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666335X26000509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":50,"alternative-id":["S2666335X26000509"],"URL":"https:\/\/doi.org\/10.1016\/j.xfss.2026.07.002","relation":{},"ISSN":["2666-335X"],"issn-type":[{"value":"2666-335X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selection of blastocysts with higher implantation potential based on reactive oxygen species levels before embryo transfer in mice","name":"articletitle","label":"Article Title"},{"value":"F&S Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xfss.2026.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.","name":"copyright","label":"Copyright"}]}}